公开(公告)号：US20030009064A1

公开(公告)日：2003-01-09

申请号：US10188428

申请日：2002-07-03

Inventor： Paul A. Gillis ,  Helge Braun ,  Joerg Schmidt ,  Jan Willem Verwijs ,  Harald Velten ,  Kristina Platkowski

IPC: B32B027/42 ,  C07C21/08

CPC classification number: B01J19/243 ,  B01F3/08 ,  B01F5/0682 ,  B01F5/0688 ,  B01F13/1013 ,  B01F2013/1091 ,  B01J14/00 ,  B01J19/006 ,  B01J19/2415 ,  B01J2219/00094 ,  B01J2219/00166 ,  B01J2219/00184 ,  B01J2219/00768 ,  C07C201/08 ,  Y10S210/05 ,  C07C205/06

Abstract: A tubular reactor characterized by having short static mixing elements separated by coalescing zones is used to conduct multiphase liquid/liquid reactions. Small droplets of one of the phases are dispersed into the other phase by the static mixing elements. These droplets coalesce and at least partially phase separate as the mixture passes through the subsequent coalescing zone. The tubular reactor is particularly suitable for nitrating organic compounds while forming low levels of improperly nitrated by-products and low levels of nitrophenolics.

Abstract translation: 特征在于具有由聚结区分离的短静态混合元件的管式反应器用于进行多相液/液反应。 一个相的小液滴通过静态混合元件分散到另一相中。 当混合物通过随后的聚结区时，这些液滴聚结并且至少部分相分离。 管状反应器特别适用于硝化有机化合物，同时形成低水平的不适当硝化的副产物和低水平的硝基苯酚。

公开(公告)号：US20020161269A1

公开(公告)日：2002-10-31

申请号：US10078655

申请日：2002-02-19

Inventor： Ralf Demuth ,  Bernd-Michael Konig ,  Thomas Linn ,  Hans-Joachim Raatz ,  Hans-Martin Weber ,  Eberhard Zirngiebl ,  Ricarda Leiberich

IPC: C07C21/08

CPC classification number: C07C201/08 ,  C07C205/12

Abstract: The present invention relates to a continuous adiabatic process for preparing nitrochlorobenzene, in which the waste sulfuric acid produced during the practice of the process is reconcentrated and recycled into the nitration reaction.

Abstract translation: 本发明涉及一种用于制备硝基氯苯的连续绝热方法，其中在该方法的实施过程中产生的废硫酸被再浓缩并再循环到硝化反应中。

公开(公告)号：US06392097B1

公开(公告)日：2002-05-21

申请号：US09812514

申请日：2001-03-20

Applicant: William R. Dolbier, Jr. ,  Jian-Xin Duan ,  Alex J. Roche

Inventor： William R. Dolbier, Jr. ,  Jian-Xin Duan ,  Alex J. Roche

IPC: C07C20900

CPC classification number: C07C17/23 ,  C07B2200/07 ,  C07C17/093 ,  C07C17/12 ,  C07C17/263 ,  C07C17/32 ,  C07C25/22 ,  C07C201/08 ,  C07C209/365 ,  C07C211/61 ,  C07C2603/92 ,  C07C23/18 ,  C07C205/12

Abstract: Processes for the preparation of parylene dimers, and more particularly to processes for the preparation of derivatives of octafluoro-[2,2]paracylophane, otherwise known as AF4.

Abstract translation: 用于制备聚对二甲苯二聚体的方法，更具体地涉及制备八氟 - [2,2]二磷杂叶烷的衍生物的方法，也称为AF4。

公开(公告)号：US06388073B1

公开(公告)日：2002-05-14

申请号：US09625962

申请日：2000-07-26

Applicant: Philip C. Lang ,  Roxanne P. Spencer ,  Wen-Lung Yeh ,  Michael Joseph Roth

Inventor： Philip C. Lang ,  Roxanne P. Spencer ,  Wen-Lung Yeh ,  Michael Joseph Roth

IPC: C07D48704

CPC classification number: C07D487/04 ,  C07C201/08 ,  C07C201/12 ,  C07C227/04 ,  C07C227/16 ,  C07C229/16 ,  C07C205/12 ,  C07C205/26 ,  C07C205/44

Abstract: Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from 2,3-dichlorobenzaldehyde and for reducing the glycine compound using either SnCl2 or a specially defined catalyst. A cyclization method to form Anagrelide base from the corresponding iminoquinazoline compound is further provided.

Abstract translation: 提供了从2,3-二氯苯甲醛制备阿那格雷碱的方法。 还提供了一种制备中间体化合物N-（2,3-二氯-6-硝基苄基）甘氨酸由2,3-二氯苯甲醛制备的乙腈和用于使用SnCl 2或特别定义的催化剂还原甘氨酸化合物的方法。 进一步提供了从相应的亚氨基喹唑啉化合物形成阿那格雷碱的环化方法。

公开(公告)号：US20010043894A1

公开(公告)日：2001-11-22

申请号：US09797256

申请日：2001-03-01

Inventor： Paul A. Gillis ,  Helge Braun ,  Joerg Schmidt ,  Jan Willem Verwijs ,  Harald Velten ,  Kristina Platkowski

IPC: B01J002/00

CPC classification number: B01J19/243 ,  B01F3/08 ,  B01F5/0682 ,  B01F5/0688 ,  B01F13/1013 ,  B01F2013/1091 ,  B01J14/00 ,  B01J19/006 ,  B01J19/2415 ,  B01J2219/00094 ,  B01J2219/00166 ,  B01J2219/00184 ,  B01J2219/00768 ,  C07C201/08 ,  Y10S210/05 ,  C07C205/06

Abstract: A tubular reactor characterized by having short static mixing elements separated by coalescing zones is used to conduct multiphase liquid/liquid reactions. Small droplets of one of the phases are dispersed into the other phase by the static mixing elements. These droplets coalesce and at least partially phase separate as the mixture passes through the subsequent coalescing zone. The tubular reactor is particularly suitable for nitrating organic compounds while forming low levels of improperly nitrated by-products and low levels of nitrophenolics.

Abstract translation: 特征在于具有由聚结区分离的短静态混合元件的管式反应器用于进行多相液/液反应。 一个相的小液滴通过静态混合元件分散到另一相中。 当混合物通过随后的聚结区时，这些液滴聚结并且至少部分相分离。 管状反应器特别适用于硝化有机化合物，同时形成低水平的不适当硝化的副产物和低水平的硝基苯酚。

公开(公告)号：US06278022B1

公开(公告)日：2001-08-21

申请号：US09431197

申请日：1999-11-01

Applicant: Haihong Jin

Inventor： Haihong Jin

IPC: C07C20900

CPC classification number: C07C201/08 ,  C07C201/12 ,  C07C213/02 ,  C07C241/02 ,  C07C245/22 ,  C07C281/02 ,  C07C217/84 ,  C07C243/22 ,  C07C205/22 ,  C07C205/37

Abstract: Disclosed herein is an improvement in a method for making compounds having the structural formulae (I) or (II): wherein: X is a) phenyl; lower phenylalkoxy; phenoxy; or benzyl; or b) one substituent from group a) and one or more substituents selected from C1-C4 alkoxy; hydroxyl; halogen; lower alkyl; and lower alkylthio; or c) along with the phenyl to which it is attached, forms a multiple fused ring heterocycle such as dibenzofuranyl; Y is H, C1-C4 alkanoyl, C1-C4 haloalkenoyl, dialkoxyphosphoryl, alkylaminocarbonyl, haloalkylsulfonyl, or C1-C4 alkoxy carbonyl; and R is H, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkoxy, haloalkyl, alkoxyalkyl, arylalkoxy, alkenyl, alkylthio, alkoxycarbonyl, alkylamino, heteroaryl, arylalkyl, haloalkoxy, aryloxy, or C3-C6 cycloalkyl; and Z is O or S, wherein the improvement comprises the steps of: A) selecting as a starting material a compound of the structural formula B) dissolving compound III in an organic solvent selected from the group consisting of methyl t-butyl ether, ethylene glycol dimethyl ether, 2-methoxyethyl ether, acetonitrile, and acetic acid, and C) nitrating with nitric acid to form a compound of the structural formula

Abstract translation: 本文公开了具有结构式（I）或（II）的化合物的制备方法的改进：其中：X为a）苯基; 低级苯基烷氧基; 苯氧基 或苄基; 或b）a）中的一个取代基和一个或多个选自C 1 -C 4烷氧基的取代基; 羟; 卤素; 低级烷基 和低级烷硫基; 或c）与其连接的苯基一起形成多重稠环杂环，例如二苯并呋喃基; Y是H，C 1 -C 4烷酰基，C 1 -C 4卤代烯酰基，二烷氧基磷酰基，烷基氨基羰基，卤代烷基磺酰基或C 1 -C 4烷氧基羰基; C 1 -C 6烷基，C 1 -C 6烷氧基，C 3 -C 6环烷氧基，卤代烷基，烷氧基烷基，芳基烷氧基，烯基，烷硫基，烷氧基羰基，烷基氨基，杂芳基，芳烷基，卤代烷氧基，芳氧基或C 3 -C 6环烷基; 并且Z为O或S，其中改进包括以下步骤：A）将化合物III溶于选自甲基叔丁基醚，乙二醇的有机溶剂中的结构式B）化合物作为起始原料 二甲醚，2-甲氧基乙醚，乙腈和乙酸，和C）用硝酸硝化形成结构式的化合物

公开(公告)号：US06254789B1

公开(公告)日：2001-07-03

申请号：US09485498

申请日：2000-05-03

Applicant: Philippe Marion ,  Louis Le Bris ,  Gérard Berrod ,  Georges Dovergne ,  Philippe Perrona

Inventor： Philippe Marion ,  Louis Le Bris ,  Gérard Berrod ,  Georges Dovergne ,  Philippe Perrona

IPC: C02F104

CPC classification number: C07C201/16 ,  C07C201/08 ,  Y10S210/903 ,  Y10S210/909 ,  C07C205/06

Abstract: The invention concerns a method for treating an aqueous solution derived from sluicing of crude mononitrated or dinitrated aromatic compounds obtained by nitration of the corresponding aromatic compounds, consisting in: (a) contacting said aqueous solution with said aromatic compound thereby obtaining an aqueous phase and an organic phase; (b) recycling said organic phase in the nitration process; (c) distilling said aqueous phase; (d) recycling the resulting concentrated acid solution in the nitration process; (e) recycling or eliminating the recuperated water after distillation.

Abstract translation: 本发明涉及一种处理衍生自通过硝化相应芳族化合物而得到的粗单硝化或二硝化芳族化合物的水溶液的方法，其包括：（a）使所述水溶液与所述芳族化合物接触，从而获得水相和 有机相; （b）在硝化过程中回收所述有机相; （c）蒸馏所述水相; （d）在硝化过程中回收所得浓酸溶液; （e）蒸馏后回收或除去回收的水。

公开(公告)号：US06191325B1

公开(公告)日：2001-02-20

申请号：US09130348

申请日：1998-08-13

Applicant: Philippe Marion ,  Pascal Metivier

Inventor： Philippe Marion ,  Pascal Metivier

IPC: C07C20500

CPC classification number: C07C201/16 ,  C07C201/08 ,  C07C205/06

Abstract: Dinitro aromatic compounds are improvedly prepared by reacting an aromatic compound with a nitric acid nitrating agent and thence separating the nitrating acid from the process stream thus formed, the process stream containing said at least one dinitro aromatic compound and also having a fraction of the nitrating acid dissolved therein, the subject process also comprising (a) distilling/stripping nitric acid from said process stream, (b) recovering nitric acid from the top of the distillation/stripping vessel and recycling same to the nitration reaction and (c) washing the process stream which contains the at least one dinitro aromatic compound, but having the nitric acid removed therefrom.

Abstract translation: 二硝基芳族化合物通过使芳族化合物与硝酸硝化剂反应，然后从所形成的工艺流中分离硝酸而改进制备，所述工艺流含有所述至少一种二硝基芳族化合物，并且还含有一部分硝酸 本方法还包括（a）从所述工艺流中蒸馏/除去硝酸，（b）从蒸馏/汽提容器的顶部回收硝酸并将其再循环到硝化反应，和（c）洗涤该过程 其含有至少一种二硝基芳族化合物，但其中除去硝酸。

公开(公告)号：US06160190A

公开(公告)日：2000-12-12

申请号：US324931

申请日：1999-06-03

Applicant: Mark Andrew Harmer ,  Qun Sun

Inventor： Mark Andrew Harmer ,  Qun Sun

IPC: C08J5/20 ,  B01J21/08 ,  B01J31/08 ,  B01J31/10 ,  B01J31/16 ,  B01J31/24 ,  B01J31/40 ,  B01J35/10 ,  C07B61/00 ,  C07C2/02 ,  C07C2/08 ,  C07C2/66 ,  C07C5/22 ,  C07C5/25 ,  C07C11/02 ,  C07C15/46 ,  C07C41/30 ,  C07C45/46 ,  C07C49/784 ,  C07C67/04 ,  C07C69/145 ,  C07C201/08 ,  C07C205/06 ,  C08G65/02 ,  C08G65/20 ,  C07C2/68 ,  C07C2/70

CPC classification number: B01J21/08 ,  B01J31/10 ,  B01J31/165 ,  B01J31/2419 ,  B01J31/4007 ,  B01J35/10 ,  B01J35/1019 ,  B01J35/1023 ,  B01J35/1038 ,  B01J35/1042 ,  B01J35/1047 ,  B01J35/1057 ,  B01J35/1061 ,  B01J35/1066 ,  B01J35/1071 ,  B01J35/109 ,  B01J2231/10 ,  B01J2231/323 ,  B01J2231/4205 ,  B01J2231/52 ,  B01J2231/54 ,  B01J2531/38 ,  B01J2531/821 ,  B01J2531/825 ,  B01J2531/842 ,  B01J2531/847 ,  C07C2/02 ,  C07C2/66 ,  C07C5/2266 ,  C07C5/2273 ,  C07C5/2562 ,  C07C41/30 ,  C07C45/46 ,  C07C67/04 ,  C07C201/08 ,  C07C2521/04 ,  C07C2521/06 ,  C07C2521/08 ,  C07C2521/12 ,  C07C2523/10 ,  C07C2523/14 ,  C07C2523/26 ,  C07C2523/28 ,  C07C2523/745 ,  C07C2531/08 ,  C07C2531/10 ,  C07C2531/20 ,  C07C2531/26 ,  C07C2531/34 ,  Y02P20/584 ,  C07C11/02 ,  C07C49/784 ,  C07C69/013 ,  C07C69/14 ,  C07C205/06 ,  C07C43/263

Abstract: Porous microcomposites have been prepared from perfluorinated ion-exchange polymer and metal oxides such as silica using the sol-gel process. Such microcomposites possess high surface area and exhibit extremely high catalytic activity. The microcomposites catalyze, among others, the reaction between organic aromatic compounds and olefins.

Abstract translation: 使用溶胶 - 凝胶法从全氟化离子交换聚合物和金属氧化物如二氧化硅制备多孔微复合材料。 这样的微复合材料具有高的表面积并且表现出极高的催化活性。 微复合材料催化有机芳族化合物和烯烃之间的反应。

公开(公告)号：US6063967A

公开(公告)日：2000-05-16

申请号：US94595

申请日：1998-06-15

Applicant: Laurent Bernard ,  Pascal Metivier

Inventor： Laurent Bernard ,  Pascal Metivier

IPC: C07C201/08 ,  C06B25/04 ,  C07C205/24 ,  C07C205/00

CPC classification number: C07C201/16 ,  C07C201/08

Abstract: Picric acid, namely, 2,4,6-trinitrophenol, is readily and effectively prepared by nitrating o-nitrophenol and/or p-nitrophenol into at least one dinitrophenol in a nitric acid medium of reaction, characteristically essentially consisting of nitric acid or immixture thereof with a strong co-acid, the at least one dinitrophenol remaining soluble in the medium of reaction, and therein completing nitration of the at least one dinitrophenol and precipitating picric acid therefrom.

Abstract translation: 苦味酸，即2,4,6-三硝基苯酚，通过在硝酸反应介质中将邻硝基苯酚和/或对硝基苯酚硝化成至少一种二硝基酚而容易且有效地制备，其特征在于主要由硝酸或杂质组成 其中所述至少一种二硝基苯酚仍然可溶于所述反应介质中，并且其中完成所述至少一种二硝基苯酚的硝化并从其沉淀出苦味酸。