公开(公告)号：US20100220314A1

公开(公告)日：2010-09-02

申请号：US12641047

申请日：2009-12-17

Applicant: Adrian von Orelli

Inventor： Adrian von Orelli

IPC: G01J3/46 ,  G01J3/00

CPC classification number: G01J3/02 ,  B41F33/0081 ,  B41P2233/51 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0289 ,  G01J3/46 ,  G01J3/463 ,  G01J3/50 ,  G01J3/501

Abstract: In a method for gauging a color measurement chart which includes at least one row of adjacently arranged color measurement fields, a hand-held color measurement device is used which is moved over the color measurement fields in the row and gauges the color measurement fields in a multitude of individual measurements. The hand-held color measurement device is guided over the color measurement fields in the row in two measurement runs. In a first measurement run, first color measurement data of the color measurement fields is measured using a first type of illumination light, and the fields are identified on the basis of the first color measurement data. The first type of illumination light (typically, white) covers a sufficient portion of the spectrum to enable the fields to be identified by means of the first color measurement data. In a subsequent second measurement run, second color measurement data of the color measurement fields is measured using a second type of illumination light which does not cover a sufficient portion of the spectrum for identifying the fields (typically, UV). The second color measurement data is then assigned to the color measurement fields on the basis of the fields identified in the first measurement run.

Abstract translation: 在用于测量包括至少一行相邻排列的颜色测量场的颜色测量图的方法中，使用在该行中的颜色测量场上移动的手持式颜色测量装置，并且在 大量的单独测量。 在两次测量运行中，手持式彩色测量装置被引导到行中的颜色测量场。 在第一测量运行中，使用第一类型的照明光来测量颜色测量场的第一颜色测量数据，并且基于第一颜色测量数据识别场。 第一类型的照明光（通常为白色）覆盖光谱的足够部分，以使得能够通过第一颜色测量数据识别场。 在随后的第二测量运行中，使用不覆盖用于识别场（通常为UV）的光谱的足够部分的第二类型的照明光来测量颜色测量场的第二颜色测量数据。 然后，基于第一测量运行中识别的场，将第二颜色测量数据分配给色彩测量场。

公开(公告)号：US07776907B2

公开(公告)日：2010-08-17

申请号：US10699110

申请日：2003-10-30

Applicant: Jerome B. Zeldis

Inventor： Jerome B. Zeldis

IPC: A61K31/40

CPC classification number: A61K38/185 ,  A61K31/454 ,  A61K31/522 ,  A61K31/545 ,  A61K31/557 ,  A61K31/56 ,  A61K38/21 ,  A61K38/27 ,  G01J3/0208 ,  G01J3/0286 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/501 ,  G01J3/524 ,  Y10S514/912 ,  A61K2300/00

Abstract: Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Abstract translation: 公开了治疗，预防和/或治疗黄斑变性的方法。 具体实施方案包括单独或与第二活性剂和/或手术组合施用选择性细胞因子抑制药物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

公开(公告)号：US20100145659A1

公开(公告)日：2010-06-10

申请号：US12329432

申请日：2008-12-05

Applicant: Darryl Busch ,  Michael John Flanagan ,  Kwong Wing Au ,  Saad J. Bedros ,  Mirela Onorica Popa

Inventor： Darryl Busch ,  Michael John Flanagan ,  Kwong Wing Au ,  Saad J. Bedros ,  Mirela Onorica Popa

IPC: G06F15/00 ,  G01J3/28

CPC classification number: G01J3/28 ,  G01J3/0289 ,  G01N21/3504 ,  G01N2021/1795 ,  G01N2021/3531 ,  G01N2021/3595

Abstract: A detection system which provides for continuous background estimation removal from a sequence of spectra. A panoramic field of regard may be partitioned into a large number of fields of view (FOVs). An FOV may have a chemical vapor cloud. The small FOV may maximize detection of the cloud. Such detection may require removing the spectral characteristics other than that of the target cloud. This may amount to removal of background spectra with an estimated background developed from one or more FOVs which may or may not be similar to the background of the FOV with the target cloud. A number of estimated background spectra of the other FOVs may be used individually to greatly increase the detection probability of the target chemical.

Abstract translation: 一种提供从光谱序列中去除连续背景估计的检测系统。 全景视域可以划分成大量的视野（FOV）。 FOV可能具有化学气相云。 小FOV可以最大限度地发现云的检测。 这种检测可能需要去除与目标云不同的光谱特征。 这可能相当于从一个或多个FOV开发的估计背景的背景光谱的去除，其可以或可以不类似于具有目标云的FOV的背景。 可以单独使用其他FOV的多个估计背景光谱，以大大增加目标化学物质的检测概率。

公开(公告)号：US07732751B2

公开(公告)日：2010-06-08

申请号：US11796603

申请日：2007-04-28

Applicant: David M. Kane

Inventor： David M. Kane

IPC: H01J5/16

CPC classification number: G01S17/023 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0256 ,  G01J3/0289 ,  G01S7/4804 ,  G01S7/495 ,  G01S17/89 ,  G02B26/0833 ,  G02B26/101 ,  G02B26/105

Abstract: A detector and aperture determine radiation characteristics, including angular direction throughout a specified range, of external articles. Preferably an afocal aperture element enlarges/reduces the article and volume FOR. Mirror(s) along a path between detector and aperture, rotatable about plural axes, make the detector address varying regions. Preferably each mirror is MEMS, exceeding five to thirty microns. The detector “sees” articles throughout the range, at constant magnification. Other aspects rotate magnetically controlled dual-axis MEMS mirrors, each with electrical coils opposed across an axis, and anther magnet whose field interacts with coil-current fields, generating force components: one includes oppositely directed forces, torquing the mirrors; another thrusts mirrors outward from the array rest plane, causing variable “piston”. Alternatively, other forces pull mirror(s) outward—and the second component attracts them inward. Components are adjusted to steer a beam in a desired direction, and wavefronts from adjacent mirrors are in phase for finer diffraction limit.

Abstract translation: 检测器和孔径确定外部物品的辐射特性，包括整个指定范围内的角度方向。 优选地，无焦点孔径元件放大/缩小物品和体积FOR。 检测器和光圈之间的路径上的反射镜可围绕多个轴线旋转，使探测器寻址变化的区域。 每个镜子最好是MEMS，超过5到30微米。 检测器在整个范围内以恒定的倍率“看到”物品。 其他方面旋转磁力控制的双轴MEMS反射镜，每个具有相对于轴线的电线圈，以及磁场与磁场与线圈电流场相互作用，产生力分量：一个包括相反的力，扭转反射镜; 另一个推力从阵列搁板平面向外反射，造成可变的“活塞”。 或者，其他力将镜子向外拉，而第二部件将它们向内吸引。 调整组件以在期望的方向上引导光束，并且来自相邻反射镜的波前相位相位更好的衍射极限。

公开(公告)号：US07728845B2

公开(公告)日：2010-06-01

申请号：US11216784

申请日：2005-08-31

Applicant: Richard A. Holub

Inventor： Richard A. Holub

IPC: G09G5/02

CPC classification number: H04N9/735 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/18 ,  G01J3/28 ,  G01J3/462 ,  G01J3/463 ,  G01J3/50 ,  G01J3/506 ,  G01J2003/2866 ,  G01J2003/466 ,  G01N21/274 ,  G03B27/547 ,  G06T7/80 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/20072 ,  G09G3/3413 ,  G09G5/02 ,  G09G2320/0285 ,  G09G2320/0626 ,  G09G2320/0666 ,  G09G2320/0693 ,  G09G2330/021 ,  G09G2360/144 ,  G09G2360/147 ,  H04N1/6033 ,  H04N1/6052 ,  H04N9/09 ,  H04N9/12 ,  H04N9/3182 ,  H04N9/3194 ,  H04N9/68 ,  H04N9/73 ,  H04N17/02 ,  H04N17/045

Abstract: Color calibration of color image rendering devices, such as large color displays, which operate by either projection or emission of images, utilize internal color measurement instrument or external color measurement modules locatable on a wall or speaker. A dual use camera is provided for a portable or laptop computer, or a cellular phone, handset, personal digital assistant or other handheld device with a digital camera, in which one of the camera or a display is movable with respect to the other to enable the camera in a first mode to capture images of the display for enabling calibration of the display, and in a second mode for capturing image other than of the display. The displays may represent rendering devices for enabling virtual proofing in a network, or may be part of stand-alone systems and apparatuses for color calibration. Improved calibration is also provided for sensing and correcting for non-uniformities of rendering devices, such as color displays, printer, presses, or other color image rendering device.

Abstract translation: 彩色图像渲染设备的颜色校准，例如通过投影或发射图像进行操作的大型彩色显示器，可利用位于墙壁或扬声器上的内部颜色测量仪器或外部颜色测量模块。 提供了一种用于便携式或膝上型计算机或具有数字照相机的便携式电话，手机，个人数字助理或其他手持设备的双用途照相机，其中照相机或显示器中的一个相对于另一个可移动以使得能够 所述相机处于第一模式以捕获所述显示器的图像，以使得能够校准所述显示器，以及用于捕获除了所述显示器之外的图像的第二模式。 显示器可以表示用于在网络中启用虚拟打样的渲染设备，或者可以是用于颜色校准的独立系统和设备的一部分。 还提供了改进的校准以用于感测和校正诸如彩色显示器，打印机，印刷机或其它彩色图像渲染装置之类的再现装置的不均匀性。

公开(公告)号：US07626696B2

公开(公告)日：2009-12-01

申请号：US11890517

申请日：2007-08-07

Applicant: Jingyun Zhang

Inventor： Jingyun Zhang

IPC: G01J3/02 ,  G01J3/28 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/0237 ,  G01J3/0289 ,  G01J3/2823 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423 ,  G01N2021/6484

Abstract: A system and method to obtain a variable field of view (FOV) of a sample without requiring an increase in an imaging CCD array size. In a fiber array spectral translator (FAST) based chemical imaging system, the fibers in the fiber bundle may be organized in different 2D “zones”. Each zone may include a predetermined number of fibers. Each 2D zone of fibers at the signal input end is organized as a separate linear array (1D) at the spectrometer slit input end. Depending on the user-selected FOV, one or more zones of fibers may be selected for signal input (into the spectrometer) by a motorized mobile slit port or linear translating stage, which will sequentially scan output from each selected linear fiber array into the spectrometer slit. The user can switch from one FOV size to another, thereby activating the linear translating stage to gather signals from appropriate linear fiber arrays corresponding to fiber zones associated with the selected FOV. A CCD imager may be used to collect optical data and generate 2D spatially accurate wavelength resolved images of the user-selected FOV.

Abstract translation: 获得样本的可变视场（FOV）的系统和方法，而不需要增加成像CCD阵列尺寸。 在基于光纤阵列光谱转换器（FAST）的化学成像系统中，纤维束中的纤维可以被组织在不同的2D“区域”中。 每个区域可以包括预定数量的纤维。 在信号输入端的每个2D区域的纤维在光谱仪狭缝输入端被组织为单独的线性阵列（1D）。 根据用户选择的FOV，可以通过电动移动狭缝端口或线性平移台来选择一个或多个光纤区域用于信号输入（进入光谱仪），其将从每个所选择的线性光纤阵列依次扫描输出到光谱仪 狭缝 用户可以从一个FOV大小切换到另一个，从而激活线性平移阶段以从对应于与所选FOV相关联的光纤区域的适当的线性光纤阵列收集信号。 可以使用CCD成像器来收集光学数据并生成用户选择的FOV的2D空间准确的波长分辨图像。

公开(公告)号：US07557925B2

公开(公告)日：2009-07-07

申请号：US11504187

申请日：2006-08-15

Applicant: Jon K. Nisper ,  Michael J. Mater ,  Bernard J. Berg

Inventor： Jon K. Nisper ,  Michael J. Mater ,  Bernard J. Berg

IPC: G01J3/51

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0275 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/26 ,  G01J3/28 ,  G01J3/50 ,  G01J3/501 ,  G01J3/51 ,  G01J3/513 ,  G01J3/524 ,  G01J2003/1213 ,  G01J2003/1282 ,  G01J2003/2866 ,  G01J2003/467

Abstract: An optical assembly is disclosed that includes an illumination source, a detection sensor, a monitor sensor, and an optical piece having a first side adapted to face a sample. The optical piece defines an illumination channel extending from the illumination source toward the first side, a detection channel extending from the first side toward the detection sensor, and a monitor channel extending from the illumination channel toward the monitor sensor. A spectrophotometer is also disclosed that includes a circuit board, illumination source and one or more sensors. The circuit board includes an optically transparent region, wherein the illumination source is mounted and situated relative to a first surface of the circuit board, so as to direct light through the optically transparent region. Each sensor is mounted and situated relative to a second surface of the circuit board opposite the first surface.

Abstract translation: 公开了一种光学组件，其包括照明源，检测传感器，监视器传感器和具有适于面向样品的第一侧的光学片。 光学片限定从照明源向第一侧延伸的照明通道，从第一侧向检测传感器延伸的检测通道，以及从照明通道向监视传感器延伸的监视通道。 还公开了一种分光光度计，其包括电路板，照明源和一个或多个传感器。 电路板包括光学透明区域，其中相对于电路板的第一表面安装和定位照明源，以便将光引导通过光学透明区域。 每个传感器相对于与第一表面相对的电路板的第二表面安装和定位。

公开(公告)号：US07535569B2

公开(公告)日：2009-05-19

申请号：US11512541

申请日：2006-08-30

Applicant: Loris De Vries

Inventor： Loris De Vries

IPC: G01N21/25

CPC classification number: G01N21/272 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0272 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/51 ,  G01J3/524

Abstract: A handheld photoelectric measurement device includes a housing (G) which is provided with a measurement window (F). An illumination arrangement is positioned in the housing for impinging the measurement object through the measurement window with illumination light from two mutually perpendicular directions. The housing further includes an optical pickup arrangement for the capture of the measurement light through the measurement window, a photoelectric converter arrangement provided by the pickup arrangement with the captured measurement light for conversion of the measurement light into corresponding electric measurement signals, and an electronic processing arrangement. The housing (G) is at its forward side provided with a lateral measurement niche (N) which can be opened or closed to the outside by a movable wall portion. The measurement window (F) is freely visible when the measurement niche is opened. Furthermore, a motor drive is provided for movement of the wall portion.

Abstract translation: 手持式光电测量装置包括具有测量窗（F）的壳体（G）。 照明装置定位在壳体中，用于通过来自两个相互垂直的方向的照明光照射测量对象。 壳体还包括用于通过测量窗口捕获测量光的光学拾取装置，由拾取装置提供的具有捕获的测量光的光电转换器装置，用于将测量光转换成相应的电测量信号，以及电子处理 安排。 壳体（G）在其前侧设置有侧向测量小生境（N），其可通过可移动壁部分打开或关闭到外部。 当测量位置打开时，测量窗口（F）可以自由地看到。 此外，电动机驱动装置用于使壁部移动。

公开(公告)号：US07477378B2

公开(公告)日：2009-01-13

申请号：US11527839

申请日：2006-09-27

Applicant: Jeffrey Cohen ,  John S. Maier

Inventor： Jeffrey Cohen ,  John S. Maier

IPC: G01N3/44

CPC classification number: G01J3/02 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/0291 ,  G01N21/6458 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/656

Abstract: A system and method of correlating Raman measurements with digital images of a sample so to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, a database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set.

Abstract translation: 将拉曼测量与样本的数字图像相关联的系统和方法，以对样本的疾病状态进行分类。 对于位于分光装置的视野中的样品获得光谱数据集。 从样品中取出样品后，用对比度增强剂处理样品。 经处理的样品在分光装置的视野中重新定位，并获得处理过的样品的数字图像。 通过定义将数字图像的图像空间坐标映射到光谱数据的光谱空间坐标的变换，光谱数据集与数字图像相关联。 对于样本的光谱数据集，搜索数据库以识别具有良好表征的病理学的已知样品的光谱数据集，其与样品的光谱数据集相匹配。

公开(公告)号：US07460229B2

公开(公告)日：2008-12-02

申请号：US11332675

申请日：2006-01-13

Applicant: Francis J. Deck ,  Joe Hodkiewicz

Inventor： Francis J. Deck ,  Joe Hodkiewicz

IPC: G01J3/42 ,  G01J3/40 ,  G01B11/00

CPC classification number: G01J3/02 ,  G01J3/0289 ,  G02B7/003

Abstract: A spectroscopic microscope includes a laser or other light source which emits light from the entrance aperture of its spectrograph, and also includes a light sensor situated on the microscope sample stage upon which a specimen is to be situated for microscopic/spectrometric analysis. The sample stage is positioned such that the signal from the light sensor is maximized, thereby indicating good alignment between the sample stage and spectrograph. Additionally, the microscope sample stage bears a light source which can emit light to be detected by a light sensor situated at the vantage point of a user/viewer utilizing the microscope, and such a light sensor can simply take the form of a video camera or other image recordation unit associated with the microscope. The sample stage can also be positioned to optimize the signal at the light sensor to signify good alignment between the sample stage and the microscope.

Abstract translation: 光谱显微镜包括从其光谱仪的入射孔发射光的激光器或其他光源，并且还包括位于显微镜样品台上的光传感器，在该样品台上放置用于显微/光谱分析的样品。 样品台被定位成使得来自光传感器的信号最大化，从而表明样品台和光谱仪之间的良好对准。 此外，显微镜样品台具有可以发射光的光源，以便由位于使用者/观察者的有利位置处的光传感器利用显微镜检测，并且这种光传感器可以简单地采取摄像机的形式或 与显微镜相关的其他图像记录单元。 样品台也可以定位成优化光传感器处的信号，以表示样品台和显微镜之间的良好对准。