Abstract:
In a method for gauging a color measurement chart which includes at least one row of adjacently arranged color measurement fields, a hand-held color measurement device is used which is moved over the color measurement fields in the row and gauges the color measurement fields in a multitude of individual measurements. The hand-held color measurement device is guided over the color measurement fields in the row in two measurement runs. In a first measurement run, first color measurement data of the color measurement fields is measured using a first type of illumination light, and the fields are identified on the basis of the first color measurement data. The first type of illumination light (typically, white) covers a sufficient portion of the spectrum to enable the fields to be identified by means of the first color measurement data. In a subsequent second measurement run, second color measurement data of the color measurement fields is measured using a second type of illumination light which does not cover a sufficient portion of the spectrum for identifying the fields (typically, UV). The second color measurement data is then assigned to the color measurement fields on the basis of the fields identified in the first measurement run.
Abstract:
Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Abstract:
A detection system which provides for continuous background estimation removal from a sequence of spectra. A panoramic field of regard may be partitioned into a large number of fields of view (FOVs). An FOV may have a chemical vapor cloud. The small FOV may maximize detection of the cloud. Such detection may require removing the spectral characteristics other than that of the target cloud. This may amount to removal of background spectra with an estimated background developed from one or more FOVs which may or may not be similar to the background of the FOV with the target cloud. A number of estimated background spectra of the other FOVs may be used individually to greatly increase the detection probability of the target chemical.
Abstract:
A detector and aperture determine radiation characteristics, including angular direction throughout a specified range, of external articles. Preferably an afocal aperture element enlarges/reduces the article and volume FOR. Mirror(s) along a path between detector and aperture, rotatable about plural axes, make the detector address varying regions. Preferably each mirror is MEMS, exceeding five to thirty microns. The detector “sees” articles throughout the range, at constant magnification. Other aspects rotate magnetically controlled dual-axis MEMS mirrors, each with electrical coils opposed across an axis, and anther magnet whose field interacts with coil-current fields, generating force components: one includes oppositely directed forces, torquing the mirrors; another thrusts mirrors outward from the array rest plane, causing variable “piston”. Alternatively, other forces pull mirror(s) outward—and the second component attracts them inward. Components are adjusted to steer a beam in a desired direction, and wavefronts from adjacent mirrors are in phase for finer diffraction limit.
Abstract:
Color calibration of color image rendering devices, such as large color displays, which operate by either projection or emission of images, utilize internal color measurement instrument or external color measurement modules locatable on a wall or speaker. A dual use camera is provided for a portable or laptop computer, or a cellular phone, handset, personal digital assistant or other handheld device with a digital camera, in which one of the camera or a display is movable with respect to the other to enable the camera in a first mode to capture images of the display for enabling calibration of the display, and in a second mode for capturing image other than of the display. The displays may represent rendering devices for enabling virtual proofing in a network, or may be part of stand-alone systems and apparatuses for color calibration. Improved calibration is also provided for sensing and correcting for non-uniformities of rendering devices, such as color displays, printer, presses, or other color image rendering device.
Abstract:
A system and method to obtain a variable field of view (FOV) of a sample without requiring an increase in an imaging CCD array size. In a fiber array spectral translator (FAST) based chemical imaging system, the fibers in the fiber bundle may be organized in different 2D “zones”. Each zone may include a predetermined number of fibers. Each 2D zone of fibers at the signal input end is organized as a separate linear array (1D) at the spectrometer slit input end. Depending on the user-selected FOV, one or more zones of fibers may be selected for signal input (into the spectrometer) by a motorized mobile slit port or linear translating stage, which will sequentially scan output from each selected linear fiber array into the spectrometer slit. The user can switch from one FOV size to another, thereby activating the linear translating stage to gather signals from appropriate linear fiber arrays corresponding to fiber zones associated with the selected FOV. A CCD imager may be used to collect optical data and generate 2D spatially accurate wavelength resolved images of the user-selected FOV.
Abstract:
An optical assembly is disclosed that includes an illumination source, a detection sensor, a monitor sensor, and an optical piece having a first side adapted to face a sample. The optical piece defines an illumination channel extending from the illumination source toward the first side, a detection channel extending from the first side toward the detection sensor, and a monitor channel extending from the illumination channel toward the monitor sensor. A spectrophotometer is also disclosed that includes a circuit board, illumination source and one or more sensors. The circuit board includes an optically transparent region, wherein the illumination source is mounted and situated relative to a first surface of the circuit board, so as to direct light through the optically transparent region. Each sensor is mounted and situated relative to a second surface of the circuit board opposite the first surface.
Abstract:
A handheld photoelectric measurement device includes a housing (G) which is provided with a measurement window (F). An illumination arrangement is positioned in the housing for impinging the measurement object through the measurement window with illumination light from two mutually perpendicular directions. The housing further includes an optical pickup arrangement for the capture of the measurement light through the measurement window, a photoelectric converter arrangement provided by the pickup arrangement with the captured measurement light for conversion of the measurement light into corresponding electric measurement signals, and an electronic processing arrangement. The housing (G) is at its forward side provided with a lateral measurement niche (N) which can be opened or closed to the outside by a movable wall portion. The measurement window (F) is freely visible when the measurement niche is opened. Furthermore, a motor drive is provided for movement of the wall portion.
Abstract:
A system and method of correlating Raman measurements with digital images of a sample so to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, a database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set.
Abstract:
A spectroscopic microscope includes a laser or other light source which emits light from the entrance aperture of its spectrograph, and also includes a light sensor situated on the microscope sample stage upon which a specimen is to be situated for microscopic/spectrometric analysis. The sample stage is positioned such that the signal from the light sensor is maximized, thereby indicating good alignment between the sample stage and spectrograph. Additionally, the microscope sample stage bears a light source which can emit light to be detected by a light sensor situated at the vantage point of a user/viewer utilizing the microscope, and such a light sensor can simply take the form of a video camera or other image recordation unit associated with the microscope. The sample stage can also be positioned to optimize the signal at the light sensor to signify good alignment between the sample stage and the microscope.