公开(公告)号：US20080180661A1

公开(公告)日：2008-07-31

申请号：US11668083

申请日：2007-01-29

Applicant: Gordon C. Brown ,  Michael Burka ,  Brian Cranton ,  David Erickson ,  James Grassi ,  Matthew Patrick Hammond ,  Maximillan Ben Shaffer ,  Pierre Villeneuve

Inventor： Gordon C. Brown ,  Michael Burka ,  Brian Cranton ,  David Erickson ,  James Grassi ,  Matthew Patrick Hammond ,  Maximillan Ben Shaffer ,  Pierre Villeneuve

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/1269 ,  G01N2021/1793 ,  G01N2021/8416 ,  G01N2201/0245 ,  G01N2201/067

Abstract: An optical apparatus for measurement of industrial chemical processes. The analyzer uses Raman scattering and performs measurement of chemical concentrations in continuous or batch processes. The analyzer operates at a standoff distance from the analyte (or analytes) and can measure concentrations through an optical port, facilitating continuous, non-destructive, and non-invasive analysis without extracting the analyte or analytes from the process. The analyzer can measure one or several solid, liquid, or gaseous analytes, or a mixture thereof.

Abstract translation: 一种用于测量工业化学工艺的光学装置。 分析仪使用拉曼散射，并在连续或间歇过程中进行化学浓度的测量。 分析仪与分析物（或分析物）隔开距离，并且可以通过光学端口测量浓度，有助于连续，非破坏性和非侵入性分析，而无需从该过程中提取分析物或分析物。 分析仪可以测量一种或多种固体，液体或气体分析物或其混合物。

公开(公告)号：US07295316B2

公开(公告)日：2007-11-13

申请号：US10758667

申请日：2004-01-14

Applicant: Steven J. Boege ,  Jon A. Hoshizaki ,  Mark F. Oldham ,  Liana Ilkova

Inventor： Steven J. Boege ,  Jon A. Hoshizaki ,  Mark F. Oldham ,  Liana Ilkova

IPC: G01N21/25

CPC classification number: G01N21/6452 ,  G01N21/253 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2021/6476 ,  G01N2021/6478 ,  G01N2201/0245

Abstract: A fluorometry device and method adapted to determine concentration of spectrally distinguishable species in a biological sample with a plurality of movable optical devices.

Abstract translation: 一种荧光测定装置和方法，其适于用多个可移动光学装置确定生物样品中光谱可区分物质的浓度。

公开(公告)号：US07289217B2

公开(公告)日：2007-10-30

申请号：US10929320

申请日：2004-08-30

Applicant: Steven J. Boege ,  Mark F. Oldham ,  Liana Ilkova

Inventor： Steven J. Boege ,  Mark F. Oldham ,  Liana Ilkova

IPC: G01N21/25

CPC classification number: G01N21/6452 ,  G01N21/253 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2021/6476 ,  G01N2021/6478 ,  G01N2201/0245

Abstract: A fluorometry device and method adapted to determine concentration of spectrally distinguishable species in a biological sample with a plurality of movable optical devices.

公开(公告)号：US07184141B2

公开(公告)日：2007-02-27

申请号：US10806874

申请日：2004-03-23

Applicant: John F Brewer ,  Joseph P Kolp ,  David W Miller ,  Paul C Schweigert ,  Thomas J Sebok

Inventor： John F Brewer ,  Joseph P Kolp ,  David W Miller ,  Paul C Schweigert ,  Thomas J Sebok

IPC: G01N1/10 ,  G01N21/00

CPC classification number: G01N21/05 ,  G01N15/0227 ,  G01N21/276 ,  G01N2015/0294 ,  G01N2201/0228 ,  G01N2201/0245

Abstract: An optical flow is disclosed having a shell with a first portion and a second portion. The first portion provides a light entry aperture, and the second portion provides an imaging aperture. An inlet tube and an outlet tube are retained between the first portion and the second portion. A viewing assembly is retained between the first portion and the second portion. The viewing assembly includes a reference plate and a flow channel. The flow channel fluidly communicates with the inlet tube and the outlet tube. The reference plate extends from the shell to serve as a repeatable reference point for properly positioning the optical flow cell.

Abstract translation: 公开了一种具有带有第一部分和第二部分的壳体的光学流动。 第一部分提供光入射孔，第二部分提供成像孔。 入口管和出口管保持在第一部分和第二部分之间。 观察组件保持在第一部分和第二部分之间。 观察组件包括参考板和流动通道。 流动通道与入口管和出口管流畅地连通。 参考板从壳体延伸以用作可重复的参考点，以适当地定位光学流动池。

公开(公告)号：US20060199259A1

公开(公告)日：2006-09-07

申请号：US11406148

申请日：2006-04-18

Applicant: Anthony Cerrone ,  Edward Lakatos ,  Michael Gambini ,  Eugene Young ,  Susan Stone ,  Judith Atwood ,  John Atwood

Inventor： Anthony Cerrone ,  Edward Lakatos ,  Michael Gambini ,  Eugene Young ,  Susan Stone ,  Judith Atwood ,  John Atwood

IPC: C12M1/34

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An instrument for monitoring replication of DNA is provided.

Abstract translation: 提供了一种用于监测DNA复制的工具。

公开(公告)号：US20060139649A1

公开(公告)日：2006-06-29

申请号：US10560440

申请日：2004-06-03

Applicant: Willis Howard

Inventor： Willis Howard

IPC: G01N21/55

CPC classification number: G01N21/8483 ,  B01L9/52 ,  B01L2300/0825 ,  G01J2003/2866 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/78 ,  G01N2021/0325 ,  G01N2201/0245 ,  G01N2201/12792

Abstract: A wavelength correction function provides corrected reflectance values from actual reflectance values taken in a reflectance-base instrument. The correction is provided as a function of measured reflectance values and a predefined set of high resolution reflectance values established for the reflectance-based instrument implementing the wavelength correction function.

Abstract translation: 波长校正功能提供从反射率仪器中获取的实际反射率值的校正反射率值。 根据测量的反射率值和为实现波长校正功能的基于反射率的仪器建立的预定的一组高分辨率反射率值提供校正。

公开(公告)号：US07008789B2

公开(公告)日：2006-03-07

申请号：US10216620

申请日：2002-08-09

Applicant: Michael R. Gambini ,  Susan Atwood Stone, legal representative ,  Judith K. Atwood, legal representative ,  Eugene F. Young ,  Edward J. Lakatos ,  Anthony L. Cerrone

Inventor： John G. Atwood, deceased

IPC: C12M1/34

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

公开(公告)号：US06959211B2

公开(公告)日：2005-10-25

申请号：US10213730

申请日：2002-08-06

Applicant: Peter Rule ,  James R. Braig ,  Daniel S. Goldberger ,  Julian M. Cortella ,  Heidi M. Smith ,  Roger O. Herrera ,  Kenneth G. Witte ,  Philip C. Hartstein ,  Mark D. Agostino

Inventor： Peter Rule ,  James R. Braig ,  Daniel S. Goldberger ,  Julian M. Cortella ,  Heidi M. Smith ,  Roger O. Herrera ,  Kenneth G. Witte ,  Philip C. Hartstein ,  Mark D. Agostino

IPC: A61B5/00 ,  G01N21/01 ,  G01N21/03 ,  G01N21/35

CPC classification number: A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/6824 ,  G01J3/0286 ,  G01J3/0291 ,  G01N21/01 ,  G01N21/35 ,  G01N2021/0389 ,  G01N2201/021 ,  G01N2201/0245

Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.

Abstract translation: 提供了一种用于无创光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。 在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。 穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。 当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。 当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。

公开(公告)号：US20050157304A1

公开(公告)日：2005-07-21

申请号：US10760438

申请日：2004-01-20

Applicant: Caibin Xiao ,  Scott Boyette ,  Radislav Potyrailo

Inventor： Caibin Xiao ,  Scott Boyette ,  Radislav Potyrailo

IPC: G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/55 ,  G01N21/77 ,  G01N21/86 ,  G01N33/543 ,  G01N21/47

CPC classification number: G01N21/7703 ,  G01N21/253 ,  G01N21/272 ,  G01N21/274 ,  G01N21/314 ,  G01N21/552 ,  G01N21/8483 ,  G01N2021/7783 ,  G01N2021/8488 ,  G01N2201/0221 ,  G01N2201/0245 ,  G01N2201/0461 ,  G01N2201/122

Abstract: A portable system and method for measuring the concentration of multiple chemical or biological substances where an onsite analysis of such substances is needed. The new and original handheld sensor system uses a disposable optical test element and a spectroscopic detector that measures the test element response to specific analytes through a change in light absorbance, luminescence, and other forms of light-based response. In this way, reflection light intensities indicative of the test element response can be used to measure the concentration of the target analytes. The sensor system is also capable of being interfaced to an information processing unit or computer so that analytical data can be manipulated or stored electronically.

Abstract translation: 用于测量需要对这些物质进行现场分析的多种化学或生物物质的浓度的便携式系统和方法。 新的和原始的手持传感器系统使用一次性光学测试元件和光谱检测器，其通过光吸收，发光和其他形式的基于光的响应的变化来测量测试元件对特定分析物的响应。 以这种方式，可以使用指示测试元件响应的反射光强度来测量目标分析物的浓度。 传感器系统还能够连接到信息处理单元或计算机，从而可以电子地操纵或存储分析数据。

公开(公告)号：US20020192808A1

公开(公告)日：2002-12-19

申请号：US10216620

申请日：2002-08-09

Inventor： Michael R. Gambini ,  Susan Atwood Stone ,  Judith K. Atwood ,  Eugene F. Young ,  Edward J. Lakatos ,  Anthony L. Cerrone

IPC: C12M001/34

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

Abstract translation: 光学仪器监测具有温度循环阻滞的反应装置中DNA的PCR复制，所述反应装置具有小瓶的反应成分，包括在双链DNA存在下发荧光的染料。 分束器将激发光束传递到小瓶以使染料发荧光。 来自染料的发射光束通过分束器传递到CCD检测器，处理器从该CCD检测器计算DNA浓度。 具有多个参考发射器的参考条发射不同强度的参考光束，处理器从该参考光束选择用于补偿漂移的最佳发射器。 自动调整曝光时间以保持CCD和处理器的最佳动态范围。 分束器和相关的滤光器的模块与选定的染料相关联，并且可替代不同的染料。