公开(公告)号：US20190104944A1

公开(公告)日：2019-04-11

申请号：US16116038

申请日：2018-08-29

Applicant: illumiSonics, Inc.

Inventor： Parsin Haji REZA ,  Roger ZEMP

IPC: A61B5/00 ,  G01N21/17

CPC classification number: A61B5/0095 ,  G01N21/1702 ,  G01N21/1717 ,  G01N2021/1706 ,  G01N2021/1725 ,  G01N2201/06113 ,  G01N2201/08 ,  G01N2201/0846

Abstract: A photoacoustic remote sensing system (PARS) for imaging a subsurface structure in a sample has an excitation beam configured to generate ultrasonic signals in the sample at an excitation location; an interrogation beam incident on the sample at the excitation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic signals; an optical system that focuses at least one of the excitation beam and the interrogation beam with a focal point that is below the surface of the sample; and a detector that detects the returning portion of the interrogation beam.

公开(公告)号：US10054540B2

公开(公告)日：2018-08-21

申请号：US15114631

申请日：2015-01-23

Applicant: DIAFIR

Inventor： Hugues Tariel ,  Frédéric Charpentier

IPC: G01N21/35 ,  G01N21/3577 ,  G01N21/43 ,  G01N21/49 ,  G01N21/552 ,  A61B5/00 ,  G01N33/487 ,  B01L3/00 ,  G02B6/02 ,  G01N21/47

CPC classification number: G01N21/3577 ,  A61B5/0075 ,  A61B2562/0233 ,  B01L3/5088 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2400/065 ,  G01N21/431 ,  G01N21/49 ,  G01N21/552 ,  G01N33/487 ,  G01N2021/4769 ,  G01N2201/0846 ,  G01N2201/0886 ,  G02B6/02395

Abstract: The invention relates to a device (10) comprising a support (14) having a wave guide (42) allowing the propagation of light of at least one wavelength, generating evanescent waves outwards. According to the invention, the device comprises means for receiving a liquid sample, designed to receive the liquid sample upon contact of the wave guide (42) in such a way as to impregnate the wave guide with a portion of the liquid sample, and actuatable means for breaking the contact between the liquid sample and the wave guide (42).

公开(公告)号：US09891105B2

公开(公告)日：2018-02-13

申请号：US15209843

申请日：2016-07-14

Applicant: Otsuka Electronics Co., Ltd.

Inventor： Hisashi Shiraiwa

IPC: G01J3/28 ,  G01J3/44 ,  G02B21/00 ,  G01N21/64 ,  G01N21/65 ,  G01J3/02 ,  G01J3/18

CPC classification number: G01J3/28 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/0846 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0064

Abstract: A microspectroscope includes: a light source; a plurality of light projecting optical fibers that receive light from the light source; a spectroscope; a plurality of light receiving optical fibers for guiding received light to the spectroscope; and a confocal optical system for causing each of a plurality of beams from the plurality of light projecting optical fibers to be condensed and irradiated onto a sample, and forming images of a plurality of beams from a plurality of condensing points on the sample, respectively on the plurality of light receiving optical fibers.

公开(公告)号：US20180031475A1

公开(公告)日：2018-02-01

申请号：US15550325

申请日：2016-02-06

Applicant: EyeSense GmbH

Inventor： Ralf MUELLER ,  Hans-Georg ORTLEPP

IPC: G01N21/64 ,  G02B27/14

CPC classification number: G01N21/645 ,  G01N2021/6471 ,  G01N2201/0846 ,  G02B21/0008 ,  G02B21/16 ,  G02B27/141 ,  G02B27/142 ,  G02B27/145

Abstract: An arrangement for examining a sample which can be excited by means of electromagnetic radiation comprises a first dichroitic beam splitter having a first and a second prism, which are connected to one another on the base surfaces thereof, and a dichroitic layer arranged between the base surfaces of the two prisms, wherein an entry surface of the first prism encloses an angle (β) in the range from 10° to

公开(公告)号：US20170328836A1

公开(公告)日：2017-11-16

申请号：US15418350

申请日：2017-01-27

Applicant: UVic Industry Partnerships Inc.

Inventor： Tao Lu

IPC: G01N21/65 ,  G02B6/032 ,  G02B6/255

CPC classification number: G01N21/658 ,  G01N21/65 ,  G01N2201/0612 ,  G01N2201/08 ,  G01N2201/0846 ,  G02B6/032 ,  G02B6/2551 ,  G02B6/2821 ,  G02B6/2856

Abstract: A system and a method for optical sensing of single molecule or molecules in various concentrations are provided. The optical sensor system comprises a first fiber, a second fiber, a light source and a detection device. The first fiber and the second fiber are fused together to form an optical coupler. The first fiber serves as the passageway for the analyte, while the second fiber serves as the waveguide for the light that will interact with the said analyte. One end of the second fiber is connected to the light source (e.g. laser), and the opposite end is connected to the detection device (e.g. spectrometer). The analyte is introduced into the first fiber through one of its ends, and is allowed to flow through inside the hollow core of the said first fiber. When light is delivered through the input end of the second fiber, the evanescent light is formed in the optical coupler and is allowed to interact with the analyte in the first fiber. One scenario in this analyte-light interaction results in, for example, the generation of Raman emission that is used as the probing signal. The spectrum of the Raman emission is analyzed by the detection device to determine the presence of target molecule.

公开(公告)号：US20170227460A1

公开(公告)日：2017-08-10

申请号：US15019974

申请日：2016-02-10

Applicant: TIAN YANG

Inventor： TIAN YANG ,  XIAOLONG HE

IPC: G01N21/49 ,  G01N33/497 ,  G01N33/487 ,  G02B6/28 ,  G02B6/26

CPC classification number: G01N21/49 ,  G01N21/554 ,  G01N21/7703 ,  G01N33/487 ,  G01N33/497 ,  G01N2021/7773 ,  G01N2201/06113 ,  G01N2201/0621 ,  G01N2201/0683 ,  G01N2201/0846 ,  G02B6/262 ,  G02B6/2808 ,  G02B6/354 ,  G02B6/3624

Abstract: The present invention provides a multichannel label-free biosensing fiber-optic system, which comprises one or more light sources coupled into optical fibers, one or more optical fiber circuits for performing coupling or/and directional transmission of optical-fiber guided lightwaves, one or more optical-fiber-input and optical-fiber-output optical switches, a plurality of optical fibers provided with label-free optical sensing elements working in the reflection manner on the optical fiber ends, and the light detection parts, wherein the optical-fiber-input and optical-fiber-output optical switch is provided with a plurality of outputs and/or a plurality of inputs, and with the plurality of outputs and/or plurality of inputs, by the switching function, the reflected light from the label-free optical sensing elements working in the reflection manner on the designated optical fiber ends is received by the light detection part, so that multichannel sensing is realized.

公开(公告)号：US20170188899A1

公开(公告)日：2017-07-06

申请号：US14987427

申请日：2016-01-04

Applicant: xuan zhong ni

Inventor： Xuan Zhong Ni

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/00 ,  G01N21/65

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/6826 ,  G01N21/65 ,  G01N2201/0846

Abstract: The present invention relates to a device which uses optical fibers to form a tube hat for a finger tip to collect all Raman photons.

公开(公告)号：US20170176253A1

公开(公告)日：2017-06-22

申请号：US15304871

申请日：2015-07-07

Applicant: EINST Technology Pte Ltd

Inventor： Khay Ming Eddie TAN ,  Wee Lee Tok ,  Wee Keong Tok

IPC: G01J3/02 ,  G01J3/42 ,  G02B6/44 ,  G01N21/552

CPC classification number: G01J3/0218 ,  G01J3/42 ,  G01N21/552 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0846 ,  G02B6/00 ,  G02B6/24 ,  G02B6/4471

Abstract: According to various embodiments, an optical arrangement may be provided. The optical arrangement may include: a bifurcated fiber comprising a distal end and a bifurcated end; wherein the bifurcated end comprises a first end configured to be connected to a spectrometer and a second end configured to be connected to an illuminator; wherein the bifurcated end is connected to the distal end via a 1-to-2 spliced fiber.

公开(公告)号：US09683927B2

公开(公告)日：2017-06-20

申请号：US14362206

申请日：2012-11-08

Applicant: Biochrom Limited

Inventor： Graham Eric Gifford

IPC: G01N21/01 ,  G01J3/02 ,  G01N21/31 ,  G01N21/03

CPC classification number: G01N21/0303 ,  G01J3/02 ,  G01J3/0218 ,  G01N21/01 ,  G01N2021/035 ,  G01N2201/0846

Abstract: Improvements in and relating to devices for receiving liquid samples A device for receiving a liquid sample may form part of a micro sampling head for an instrument such as a spectrophotometer. The device receives a liquid sample to be analyzed by a process involving the passing of electromagnetic radiation through the sample, and comprises a light inlet guide (20) for directing electromagnetic radiation into the sample, a light receiving element (23) situated in an opposed relationship to the guide and spaced from the guide by a fixed distance to define a fixed path length gap (21), which is, in use, filled with the sample. In use, radiation is passed from the light inlet guide to the light receiving element (23), and the path length of radiation through the sample is defined by the gap (23). The device is open or openable to allow a droplet of sample to be deposited directly in the gap.

公开(公告)号：US20160356705A1

公开(公告)日：2016-12-08

申请号：US15114631

申请日：2015-01-23

Applicant: DIAFIR

Inventor： Hugues Tariel ,  Frédéric Charpentier

IPC: G01N21/3577 ,  A61B5/00 ,  B01L3/00 ,  G02B6/02 ,  G01N33/487

CPC classification number: G01N21/3577 ,  A61B5/0075 ,  A61B2562/0233 ,  B01L3/5088 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2400/065 ,  G01N21/431 ,  G01N21/49 ,  G01N21/552 ,  G01N33/487 ,  G01N2021/4769 ,  G01N2201/0846 ,  G01N2201/0886 ,  G02B6/02395

Abstract: The invention relates to a device (10) comprising a support (14) having a wave guide (42) allowing the propagation of light of at least one wavelength, generating evanescent waves outwards. According to the invention, the device comprises means for receiving a liquid sample, designed to receive the liquid sample upon contact of the wave guide (42) in such a way as to impregnate the wave guide with a portion of the liquid sample, and actuatable means for breaking the contact between the liquid sample and the wave guide (42).

Abstract translation: 本发明涉及一种装置（10），其包括具有允许传播至少一个波长的光的波导（42）的支撑件（14），从而产生向外的ev逝波。 根据本发明，该装置包括用于接收液体样品的装置，其被设计成在与波导件接触时接收液体样品，以便将波导浸入一部分液体样品中，并且可致动 用于破坏液体样品和波导件（42）之间的接触的装置。