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公开(公告)号：US09239409B2
公开(公告)日：2016-01-19
申请号：US14571350
申请日：2014-12-16
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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Patent Agency Ranking
公开(公告)号：US09096025B2
公开(公告)日：2015-08-04
申请号：US13713681
申请日：2012-12-13
Applicant: Novartis AG
Inventor： Yongxing Qiu
IPC: B29D11/00 , C08F30/08 , C08F130/08 , C08F230/08 , C08F283/12 , C08F290/00 , C08F290/06 , C08F290/14 , C08F299/08 , G02B1/04 , C08J3/28
CPC classification number: B29D11/00038 , B29D11/00 , C08F8/42 , C08F30/08 , C08F130/08 , C08F230/08 , C08F283/12 , C08F283/124 , C08F290/00 , C08F290/06 , C08F290/068 , C08F290/14 , C08F290/148 , C08F299/08 , C08F2810/20 , C08J3/28 , G02B1/04 , G02B1/043 , C08L51/085 , C08F222/06 , C08F236/06
Abstract: The invention provides a silicone hydrogel contact lens including a hydrolyzable polymer. The hydrolyzable polymer can be converted by hydrolysis into a hydrophilic polymer which is capable of imparting the silicone hydrogel contact lens a hydrophilic surface without post-curing surface treatment.
Abstract translation: 本发明提供了包含可水解聚合物的硅酮水凝胶隐形眼镜。 可水解聚合物可以通过水解转化成亲水聚合物，其能够赋予硅氧水凝胶隐形眼镜亲水性表面，而无需后固化表面处理。
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公开(公告)号：US20150166205A1
公开(公告)日：2015-06-18
申请号：US14571851
申请日：2014-12-16
Applicant: Novartis AG
Inventor： Yongxing Qiu
CPC classification number: B65B31/00 , B65B7/16 , G02B1/043 , G02B1/14 , G02B2207/109 , C08L83/04 , C08L101/14
Abstract: The present invention generally relates to a cost-effective and time-efficient method for applying a crosslinked hydrophilic coating onto a silicone hydrogel contact lens to reduce its positively charged preservatives such as PHMB uptake and to improve its hydrophilicity and lubricity.
Abstract translation: 本发明一般涉及将交联的亲水涂层施用到硅氧水凝胶隐形眼镜上以降低其带正电荷的防腐剂如PHMB吸收并提高其亲水性和润滑性的成本有效且时间有效的方法。
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公开(公告)号：US08939577B2
公开(公告)日：2015-01-27
申请号：US13900136
申请日：2013-05-22
Applicant: Novartis AG
Inventor： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
Abstract translation: 本发明涉及具有层状结构构型的水合硅氧水凝胶隐形眼镜：完全被完全或基本上不含有硅酮的较高水含量水凝胶层覆盖的较低水含量的硅氧烷水凝胶核（或本体材料）。 本发明的水合硅氧水凝胶隐形眼镜具有高的透氧性，用于维持角膜健康和柔软，富水，润滑的表面，用于穿戴舒适。
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公开(公告)号：US20130337160A1
公开(公告)日：2013-12-19
申请号：US13913734
申请日：2013-06-10
Applicant: Novartis AG
Inventor： Troy Vernon Holland , Frank Chang , Yongxing Qiu , John Dallas Pruitt , Chung-Yuan Chiang , Manivakkam J. Shankernarayanan , Robert Scott , Yash Kapoor
IPC: C09D139/04
CPC classification number: C09D133/24 , B29D11/00865 , C07D205/04 , C08F20/00 , C08F26/00 , C08F220/54 , C08F220/56 , C08F224/00 , C08F283/124 , C08F2500/26 , C09D133/26 , C09D137/00 , C09D139/04 , C09D151/085
Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.
Abstract translation: 本发明涉及含吖啶啶的共聚物和乙烯基单体及其在硅酮水凝胶隐形眼镜上形成非硅氧烷水凝胶涂层的用途。
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公开(公告)号：US20130308093A1
公开(公告)日：2013-11-21
申请号：US13948206
申请日：2013-07-23
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: G02B1/04
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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