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    Micro-fluidic system using micro-apertures for high throughput detection of cells
    65.
    发明授权
    Micro-fluidic system using micro-apertures for high throughput detection of cells 有权
    微流体系统使用微孔用于细胞的高通量检测

    公开(公告)号：US09500625B2

    公开(公告)日：2016-11-22

    申请号：US14037476

    申请日：2013-09-26

    Applicant: Purdue Research Foundation

    Inventor： Cagri A. Savran ,  Philip S. Low ,  Chun-Li Chang ,  Wanfeng Huang

    IPC: G01N33/553 ,  G01N27/74 ,  G01N33/543 ,  B01L3/00 ,  G01N33/574 ,  G01N1/40

    CPC classification number: B01L3/502761 ,  B01L3/50273 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0877 ,  B01L2400/043 ,  G01N27/745 ,  G01N33/54326 ,  G01N33/574 ,  G01N33/57434 ,  G01N33/57492 ,  G01N2001/4016

    Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target entities bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target entities from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target entities bound to magnetic beads on the surface of the plate. In a further feature, the microfluidic detection system is configured to pass target molecules through the plate to be bound to a functionalized surface of the lower chamber.

    Abstract translation: 用于微米尺寸实体（例如生物细胞）的微流体检测系统包括结合有多个开口的板的检测器部件，该板分离两个室，一个与包含与磁珠结合的目标实体的流体源连通。 这些开口的尺寸设置成总是允许磁珠通过其进入下部的一个室，并且进一步的尺寸以防止目标实体从上部的一个室中通过。 检测器部件还包括磁铁，该磁体定位成将未结合的磁珠拉过开口并且捕获与板的表面上的磁珠接合的目标实体。 在另一个特征中，微流体检测系统被配置成使目标分子穿过板结合到下腔室的官能化表面。

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