公开(公告)号：US07434912B2

公开(公告)日：2008-10-14

申请号：US10504536

申请日：2003-02-20

Applicant: Kazuhiro Murata

Inventor： Kazuhiro Murata

IPC: B41J2/135

CPC classification number: B05B5/0533 ,  B05B5/0255 ,  B41J2/01 ,  B41J2/04 ,  B41J2/14 ,  B41J2002/14395

Abstract: An ultrafine fluid jet apparatus including a substrate arranged near a distal end of an ultrafine-diameter nozzle to which a solution is supplied, and an optional-waveform voltage is applied to the solution in the nozzle to eject an ultrafine-diameter fluid droplet onto a surface of the substrate; wherein an electric field intensity near the distal end of the nozzle according to a diameter reduction of the nozzle is sufficiently larger than an electric field acting between the nozzle and the substrate; and wherein Maxwell stress and an electro-wetting effect being utilized, a conductance is decreased by a reduction in the nozzle diameter or the like, and controllability of an ejection rate by a voltage is improved; and wherein landing accuracy is exponentially improved by moderation of evaporation by a charged droplet and acceleration of the droplet by an electric field.

Abstract translation: 一种超细流体喷射装置，其包括布置在超细直径喷嘴的远端附近提供溶液的基板和可选波形电压施加到喷嘴中的溶液以将超细直径流体液滴喷射到 基材表面; 其中根据所述喷嘴的直径减小而在所述喷嘴的远端附近的电场强度充分大于在所述喷嘴和所述基板之间作用的电场; 并且其中使用麦克斯韦应力和电润湿效应，通过降低喷嘴直径等降低电导，并且提高通过电压的喷射速度的可控性; 并且其中通过充电液滴的蒸发调节和通过电场加速液滴来使着陆精度指数地增加。

公开(公告)号：US07411184B2

公开(公告)日：2008-08-12

申请号：US10578175

申请日：2004-11-09

Applicant: Nicolas Sarrut

Inventor： Nicolas Sarrut

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/165 ,  B05B5/0255 ,  G01N35/1016 ,  Y10T137/8242 ,  Y10T137/8326

Abstract: A microfluidic device including a microfluidic chip assembled to an electrospray structure. The microfluidic chip includes at least one microfluidic channel leading through an outlet aperture to a surface area of the microfluidic chip. The electrospray structure includes at least one thin, planar point provided with a capillary slot that terminates at the end of the point so as to form an aperture for ejection of a liquid to be sprayed. The electrospray structure is arranged on the surface area of the microfluidic chip so that the point is cantilivered with respect to the microfluidic chip and so that the outlet aperture of the microfluidic device leads to the capillary slot of the point, which microfluidic device also has a mechanism to apply an electrospray voltage to the liquid to be sprayed.

Abstract translation: 一种微流体装置，其包括组装到电喷雾结构的微流体芯片。 微流体芯片包括至少一个通过出口孔通向微流体芯片的表面区域的微流体通道。 电喷雾结构包括至少一个薄的平面点，该点设置有毛细管狭槽，该毛细管槽终止于该点的末端以便形成用于喷射待喷射液体的孔。 电喷雾结构布置在微流体芯片的表面区域上，使得该点相对于微流体芯片是突出的，并且使得微流体装置的出口孔通向该点的毛细管狭槽，该微流体装置还具有 将电喷雾电压施加到待喷射的液体的机构。

公开(公告)号：US20080119772A1

公开(公告)日：2008-05-22

申请号：US11711378

申请日：2007-02-27

Applicant: Ronald Alan Coffee

Inventor： Ronald Alan Coffee

IPC: A61F13/00

CPC classification number: A61F13/00063 ,  A61F13/069 ,  A61F13/36 ,  A61F2013/0011 ,  A61F2013/00157 ,  A61F2013/00519 ,  A61F2013/0091 ,  A61F2013/00914 ,  A61F2013/00923 ,  A61F2013/00927 ,  A61M15/0003 ,  A61M15/0011 ,  A61M15/02 ,  B05B1/044 ,  B05B1/06 ,  B05B1/14 ,  B05B5/0255 ,  B05B5/1691 ,  B05B7/061 ,  B05B12/1472 ,  D01D5/0084 ,  D01F1/10

Abstract: A dispensing device and method for forming a least partially solid or gel-like material from a liquid. At least one liquid issuing from an outlet is subjected to an electric field causing the liquid to form at least one electrically charged jet which, after formation, forms a fiber (F) or breaks up into fiber fragments (FF) or particles (D). The thus formed at least partially solid or gel-like material may be directly deposited, by virtue of the energy in the electrical field, onto a surface area, for example an area of skin enabling, for example, formation of a dressing for a wound or burn which is of high specific area and extremely absorbent. A biologically active ingredient such as a pharmaceutical ingredient or biological matter such as DNA may be incorporated into the fibers (F), fragments (FF) or particles (D). Fibrils, particles or microcapsules incorporating a biologically active ingredient may be supplied for oral or nasal administration to an animal such as a human being.

Abstract translation: 一种用于从液体形成至少部分固体或凝胶状材料的分配装置和方法。 从出口排出的至少一种液体经受电场，导致液体形成至少一个带电的射流，其在形成后形成纤维（F）或分解成纤维碎片（FF）或颗粒（D） 。 由此形成的至少部分固体或凝胶状材料可以通过电场中的能量直接沉积到表面区域上，例如能够形成伤口敷料的皮肤区域 或具有高比表面积和极度吸收性的燃烧。 生物活性成分如药物成分或生物物质如DNA可以并入纤维（F），碎片（FF）或颗粒（D）中。 可以向动物如人提供包含生物活性成分的原纤维，颗粒或微胶囊用于口服或鼻腔给药。

公开(公告)号：US20080105546A1

公开(公告)日：2008-05-08

申请号：US11931256

申请日：2007-10-31

Applicant: Lee Davies ,  David Davies ,  Margaret Wan ,  Ronald Coffee

Inventor： Lee Davies ,  David Davies ,  Margaret Wan ,  Ronald Coffee

IPC: A61M15/00

CPC classification number: A61M15/00 ,  A61M11/00 ,  A61M11/001 ,  A61M15/02 ,  A61M15/08 ,  B05B5/0255 ,  B05B5/1691

Abstract: Methods are described of delivering biological material, which methods include the steps of providing a liquid formulation containing the biological material, supplying the liquid formulation to an outlet and subjecting liquid issuing from the outlet to an electrical field thereby causing electrohydrodynamic processing of the liquid without denaturing the biological material. In one example, the liquid formulation is provided by removing salts from a formulation containing biological material that does not denature in alcohol and then adding an alcohol to the formulation before supplying the liquid formulation to the outlet. An acid may be added to the liquid formulation before supplying the liquid formulation to the outlet.

Abstract translation: 描述了递送生物材料的方法，该方法包括以下步骤：提供含有生物材料的液体制剂，将液体制剂供应到出口并使从出口发出的液体经受电场，从而引起液体的电流动力学处理而不变性 生物材料。 在一个实例中，通过从含有在醇中不变性的生物材料的制剂中除去盐，然后在将液体制剂供应到出口之前向制剂中加入醇来提供液体制剂。 在将液体制剂供应到出口之前，可以向液体制剂中加入酸。

公开(公告)号：US07341211B2

公开(公告)日：2008-03-11

申请号：US10503509

申请日：2003-02-04

Applicant: Alfonso M. Ganan Calvo ,  Jose M. Lopez-Herrera Sanchez

Inventor： Alfonso M. Ganan Calvo ,  Jose M. Lopez-Herrera Sanchez

IPC: B05B5/00

CPC classification number: B05B5/0255 ,  B05B7/04

Abstract: The invention relates to a method and devices for the production of capillary microjets and microparticles that can have a size of between hundreds of micrometers and several nanometers. The inventive method makes use of the combined effects of electrohydrodynamic forces, fluid-dynamic forces and a specific geometry in order to produce micro- and nano-capsules or fluid jets, single- or multi-component, which, upon disintegrating or splitting, form a significantly monodispersed spray of drops which have a controlled micro- or nanometric size and which can also comprise a specific internal structure, such as, for example, a nucleus which is surrounded by a cortex of a different substance or several concentric or non-concentric nuclei or vesicles which are surrounded by a cortex.

Abstract translation: 本发明涉及一种用于生产毛细管微粒和微粒的方法和装置，其可以具有几百微米到几纳米之间的尺寸。 本发明的方法利用电动力学，流体动力学和特定几何结构的组合效应，以产生单组分或纳米胶囊或流体射流，单分子或多组分，其在分解或分裂时形成 具有受控的微米或纳米尺寸的显着的单分散喷雾剂，其还可以包含特定的内部结构，例如由不同物质的皮质或几个同心或不同心的皮质包围的细胞核 细胞核或囊泡被皮层包围。

公开(公告)号：US20070296099A1

公开(公告)日：2007-12-27

申请号：US11743560

申请日：2007-05-02

Applicant: Gustavo Larsen ,  Ruben Spretz ,  Raffet Velarde-Ortiz ,  David Vu ,  Luis Nunez

Inventor： Gustavo Larsen ,  Ruben Spretz ,  Raffet Velarde-Ortiz ,  David Vu ,  Luis Nunez

IPC: A61K9/00

CPC classification number: A61K9/5146 ,  A61K9/5094 ,  A61K9/5115 ,  A61K9/5192 ,  A61K47/551 ,  A61K47/642 ,  A61K47/6425 ,  A61K47/6849 ,  A61K47/6925 ,  A61K49/0043 ,  A61K49/0047 ,  A61K49/0056 ,  A61K49/0065 ,  A61K49/0093 ,  A61K49/1878 ,  A61K51/1244 ,  B01J13/04 ,  B05B5/0255 ,  B05B7/061 ,  B82Y5/00

Abstract: Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.

Abstract translation: 具有至少一种包封和/或包埋的试剂（例如治疗剂，成像剂和其它成分）的胶囊和颗粒可以通过电动力学方法制备。 更具体地，封装在载体，胶囊，颗粒，载体或载体中的试剂可以最大限度地减少治疗和/或成像的不利影响，从而最大化恶性癌症的治疗和/或成像。

公开(公告)号：US07259109B2

公开(公告)日：2007-08-21

申请号：US10947016

申请日：2004-09-22

Applicant: Robert P. Meagley

Inventor： Robert P. Meagley

IPC: H01L21/469 ,  C23C4/00

CPC classification number: B05B5/0255 ,  B05D1/04 ,  B05D3/067 ,  B05D3/068 ,  B05D3/145 ,  C23C4/123 ,  C23C26/00

Abstract: A method of forming a thin film on a substrate to fabricate a microelectronic device, a microelectronic device comprising a thin film deposited according to the method, and a system comprising the microelectronic device. The thin film may include on of a low k thin film, a thin film comprising photoresist, and a sacrificial polymer. The method comprises dispersing a precursor preparation into a spray of charged droplets through subjecting the liquid precursor preparation to electrostatic forces; directing the charged droplets to move toward the substrate; and allowing the charged droplets to generate a beam of gas-phase ions as the charged droplets move toward the substrate. The method further includes directing the gas-phase ions to impinge upon the substrate to deposit the thin film thereon to yield a deposited thin film on the substrate.

Abstract translation: 一种在衬底上形成薄膜以制造微电子器件的方法，包括根据该方法沉积的薄膜的微电子器件以及包括该微电子器件的系统。 薄膜可以包括低k薄膜，包含光致抗蚀剂的薄膜和牺牲聚合物。 该方法包括通过使液体前体制剂经受静电力将前体制剂分散在带电液滴的喷雾中; 引导带电液滴朝向衬底移动; 并且随着带电液滴向衬底移动，允许带电液滴产生气相离子束。 该方法还包括引导气相离子冲击衬底以在其上沉积薄膜以在衬底上产生沉积的薄膜。

公开(公告)号：US20070119993A1

公开(公告)日：2007-05-31

申请号：US10583913

申请日：2004-12-13

Applicant: Tomohiro Yamaguchi ,  Hiroshi Suda ,  Takayuki Nakada ,  Tomonori Tanaka

Inventor： Tomohiro Yamaguchi ,  Hiroshi Suda ,  Takayuki Nakada ,  Tomonori Tanaka

IPC: B05B5/00

CPC classification number: B05B5/057 ,  B05B5/0255 ,  B05B5/16

Abstract: Water is fed from a tank to a capillary carrier having an emitter end from which an ionized water particle is emitted by a voltage being applied across the emitter end and an opposed electrode. A cation exchanger is provided to remove minerals such as Ca2+ and Mg2+ from the water being fed through the capillary carrier or from the water to be fed to the carrier from the tank, thereby avoiding the ions from precipitating at the emitter end as CaCO3 or MgO in reaction with C02 in the surrounding air, and therefore assure reliable electrostatic atomization over a long period of time.

Abstract translation: 水从罐进料到具有发射端的毛细管载体，通过施加在发射极端和相对电极上的电压，从其发射电离水颗粒。 提供了一种阳离子交换器，用于从供给毛细管载体的水中或从供给到载体的水中除去诸如Ca 2+和Mg 2+之类的矿物质， 从而避免离子在发射极端作为CaCO 3或MgO与周围空气中的CO 2 2反应而沉淀，因此确保了可靠的静电雾化 很长一段时间。

公开(公告)号：US20060214020A1

公开(公告)日：2006-09-28

申请号：US10552743

申请日：2004-05-26

Applicant: Hiroshi Suda ,  Yasunori Matsui ,  Narimasa Iwamoto ,  Toshiyuki Yamauchi ,  Shigekazu Azukizawa ,  Takayuki Nakada ,  Tomonori Tanaka ,  Tomohiro Yamaguchi

Inventor： Hiroshi Suda ,  Yasunori Matsui ,  Narimasa Iwamoto ,  Toshiyuki Yamauchi ,  Shigekazu Azukizawa ,  Takayuki Nakada ,  Tomonori Tanaka ,  Tomohiro Yamaguchi

IPC: B05B5/025 ,  F23D11/32

CPC classification number: C01B15/01 ,  A61L2/22 ,  A61L9/14 ,  B03C3/014 ,  B05B1/14 ,  B05B5/0255 ,  C01B5/00

Abstract: Charged fine particulate water is provided, which has a nanometer particle size, for example, a particle size of 3 to 100 nm, and contains radicals such as hydroxyl radicals and superoxides. This charged fine particulate water can be generated by applying an electric-field intensity of 700 to 1200 V/mm between a pair of electrodes, while supplying water between the electrodes. By allowing the thus obtained charged fine particulate water to diffuse into an indoor space, it is possible to effectively remove bad odor components/bacteria from the indoor space.

公开(公告)号：US20060177573A1

公开(公告)日：2006-08-10

申请号：US11390606

申请日：2006-03-28

Applicant: David Pui ,  Da-Ren Chen

Inventor： David Pui ,  Da-Ren Chen

IPC: A61L33/00 ,  B05D3/00 ,  B05D1/12

CPC classification number: B05B5/0255 ,  A61F2/86 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/622 ,  A61L2420/02 ,  B05B1/14 ,  B05B5/025 ,  B05B5/03 ,  B05B5/0533 ,  B05B5/08 ,  B05B5/082 ,  B05B7/066 ,  B05B7/0884 ,  B05B13/0228 ,  B05D1/002 ,  B05D1/04 ,  B05D1/045

Abstract: Methods and systems for coating at least a portion of a medical device (e.g., a stent structure) include providing a plurality of coating particles (e.g., monodisperse coating particles) in a defined volume. For example, the particles may be provided using one or more nozzle structures, wherein each nozzle structure includes at least one opening terminating at a dispensing end. The plurality of coating particles may be provided in the defined volume by dispensing a plurality of microdroplets having an electrical charge associated therewith from the dispensing ends of the one or more nozzle structures through use of a nonuniform electrical field between the dispensing ends and the medical device. Electrical charge is concentrated on the particle as the microdroplet evaporates. With a plurality of coating particles provided in the defined volume, such particles can be moved towards at least one surface of the medical device to form a coating thereon (e.g., using an electric field and/or a thermophoretic effect).