公开(公告)号：US20100110426A1

公开(公告)日：2010-05-06

申请号：US12611176

申请日：2009-11-03

Applicant: Marcus T. Cicerone ,  Young Jong Lee

Inventor： Marcus T. Cicerone ,  Young Jong Lee

IPC: G01J3/44

CPC classification number: G01J3/4412 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/027 ,  G01J11/00 ,  G01N2021/653

Abstract: Methods and systems are described for suppressing nonresonant background in broadband coherent anti-Stokes Raman scattering (CARS) microscopy and spectroscopy. The methods and systems improve sensitivity and signal to noise ratio in CARS.

Abstract translation: 描述了用于抑制宽带相干反斯托克斯拉曼散射（CARS）显微镜和光谱学中的非共振背景的方法和系统。 方法和系统提高CARS的灵敏度和信噪比。

公开(公告)号：US07595889B2

公开(公告)日：2009-09-29

申请号：US11548468

申请日：2006-10-11

Applicant: Adam Wax ,  John W. Pyhtila

Inventor： Adam Wax ,  John W. Pyhtila

IPC: G01B9/02 ,  G01J3/45 ,  G01B11/02

CPC classification number: G01J3/4412 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/7257 ,  G01B9/02044 ,  G01B9/02084 ,  G01B9/02087 ,  G01B9/0209 ,  G01J3/4531 ,  G01N21/31 ,  G01N21/4795 ,  G01N2021/4704 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2201/08

Abstract: Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

Abstract translation: 傅里叶域a / LCI（faLCI）系统和方法，使用单次扫描能够以快速的速率进行体内数据采集。 通过一次扫描获得角度分辨和深度分辨的光谱信息。 由于仅需要一次扫描，参考臂可以相对于样品保持固定。 参考信号和反射的采样信号以相对于样本的多个反射角度相互相关并分散，从而同时并行地表示来自样品上的多个点的反射。 可以通过大约40毫秒量级的一次扫描获得关于样本上多个不同点的每个样本的所有深度的信息。 从空间相互关联的参考信号，也可以使用允许从角度分辨数据获得散射体的尺寸信息的技术来获得结构（尺寸）信息。

公开(公告)号：US07586618B2

公开(公告)日：2009-09-08

申请号：US11068739

申请日：2005-02-28

Applicant: Daniel L. Marks ,  Stephen A. Boppart

Inventor： Daniel L. Marks ,  Stephen A. Boppart

IPC: G01J3/45

CPC classification number: G01N21/65 ,  B33Y80/00 ,  G01J3/4412 ,  G01N2021/653 ,  G01N2021/656

Abstract: A method of examining a sample comprises exposing the sample to a pump pulse of electromagnetic radiation for a first period of time, exposing the sample to a stimulant pulse of electromagnetic radiation for a second period of time which overlaps in time with at least a portion of the first exposing, to produce a signal pulse of electromagnetic radiation for a third period of time, and interfering the signal pulse with a reference pulse of electromagnetic radiation, to determine which portions of the signal pulse were produced during the exposing of the sample to the stimulant pulse. The first and third periods of time are each greater than the second period of time.

Abstract translation: 检查样品的方法包括将样品暴露于第一时间段的电磁辐射的泵脉冲，将样品暴露于电磁辐射的刺激脉冲持续第二时间段，时间上与至少一部分时间重叠 第一次曝光，以产生第三时间段的电磁辐射的信号脉冲，并用电磁辐射的参考脉冲干扰信号脉冲，以确定信号脉冲的哪些部分在样品暴露于 兴奋脉冲。 第一和第三个时间段都大于第二个时间段。

公开(公告)号：US20090073432A1

公开(公告)日：2009-03-19

申请号：US12210656

申请日：2008-09-15

Applicant: Bahram Jalali ,  Daniel Solli ,  Jason Chou

Inventor： Bahram Jalali ,  Daniel Solli ,  Jason Chou

IPC: G01J3/44

CPC classification number: G01J3/4412 ,  G01J3/10 ,  G01J3/457 ,  G01N21/636 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/653 ,  G01N2021/655

Abstract: An apparatus and method for measuring Raman-type spectra using optical dispersion to convert an optical spectrum into a waveform which can be detected directly in the time domain without the use of a conventional spectrometer. In the example of stimulated Raman spectroscopy, the apparatus and method exposes a sample to a chirped, pulsed probe beam and a Raman pump beam and the resulting Raman spectra is detected by an optical detector in the time domain, and analyzed. Alternatively, the Raman spectra from the probe and pump beams is chirped with a dispersive element prior to detection and analysis. Each probe pulse provides a snapshot of the Raman spectrum that is sampled in time so that neither repetitive waveforms nor static samples are required. Therefore, high speed acquisitions and high throughput assays can be conducted. To facilitate detection, these spectral signals can also be amplified using distributed Raman amplification directly in the dispersive element.

Abstract translation: 一种使用光学色散测量拉曼光谱的装置和方法，用于将光谱转换成可在时域中直接检测的波形，而不需要使用常规光谱仪。 在受激拉曼光谱的实例中，该装置和方法将样品暴露于啁啾脉冲探针光束和拉曼泵浦光束，并且通过时域中的光学检测器检测所得拉曼光谱，并进行分析。 或者，来自探针和泵浦光束的拉曼光谱在检测和分析之前用分散元件啁啾。 每个探针脉冲提供了在时间上采样的拉曼光谱的快照，以便不需要重复波形和静态样本。 因此，可以进行高速采集和高通量测定。 为了便于检测，这些光谱信号也可以直接在分散元件中使用分布式拉曼放大进行放大。

公开(公告)号：US07504618B2

公开(公告)日：2009-03-17

申请号：US11772997

申请日：2007-07-03

Applicant: Arthur H. Hartog ,  Gareth P. Lees

Inventor： Arthur H. Hartog ,  Gareth P. Lees

IPC: G01J1/42 ,  G01N21/00 ,  G01B11/16

CPC classification number: G01J3/4412 ,  G01D5/35364 ,  G01K11/32

Abstract: To perform distributed sensing with an optical fiber using Brillouin scattering, a light pulse is transmitted into the optical fiber, where the transmitted light pulse has a first frequency. Backscattered light and optical local oscillator light are combined, where the backscattered light is received from the optical fiber in response to the transmitted light pulse, and where the optical local oscillator light has a second frequency. A frequency offset is caused to be present between the first frequency of the transmitted light pulse and the second frequency of the optical local oscillator light, where the frequency offset is at least 1 GHz less than a Brillouin frequency shift of the backscattered light. Spectra representing Stokes and anti-Stokes components of the backscattered light are acquired, where the Stokes and anti-Stokes components are separated by a frequency span that is based on the frequency offset.

Abstract translation: 为了使用布里渊散射使用光纤执行分布式感测，将光脉冲传输到光纤中，其中透射光脉冲具有第一频率。 组合后向散射光和光学本地振荡器光，其中响应于透射的光脉冲从光纤接收反向散射光，并且其中光学本地振荡器光具有第二频率。 使得频率偏移存在于透射光脉冲的第一频率和光学本地振荡器光的第二频率之间，其中频偏比背散射光的布里渊频移小至少1GHz。 获取表示反向散射光的斯托克斯和反斯托克斯分量的光谱，其中斯托克斯和反斯托克斯分量由基于频率偏移的频率间隔分开。

公开(公告)号：US20090040516A1

公开(公告)日：2009-02-12

申请号：US11837359

申请日：2007-08-10

Applicant: Bernard S. Fritz ,  Paul E. Bauhahn ,  James A. Cox ,  Brian C. Krafthefer ,  Tzu-Yu Wang

Inventor： Bernard S. Fritz ,  Paul E. Bauhahn ,  James A. Cox ,  Brian C. Krafthefer ,  Tzu-Yu Wang

IPC: G01J3/44 ,  G01J3/28

CPC classification number: G01J3/4412 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229

Abstract: A spectroscopic system having a coded aperture as a gating device. Light of a Raman scattering may enter the system and encounter a mask gate. The mask may have a matrix of micro mirrors some of which pass light on to a diffraction grating when the gate is on. Some of the mirrors will not pass on light thereby resulting in coded light to the grating. If the gate is off, then no light is passed on to the grating. The grating may pass the coded and spectrally spread light on to a detector array. The array signals representing the light on the array may go to a processor so one can obtain information about the target that emanated the Raman scatter when impinged by a light beam.

Abstract translation: 具有编码孔径作为选通装置的分光系统。 拉曼散射光可能进入系统并遇到掩模门。 掩模可以具有微镜的矩阵，当门打开时，其中的一些矩阵将光通向衍射光栅。 一些镜子不会通过光，从而导致光栅的编码光。 如果门关闭，则光不会传递到光栅。 光栅可以将编码和光谱扩散的光通过检测器阵列。 表示阵列上的光的阵列信号可以去处理器，所以可以获得关于当被光束照射时发出拉曼散射的目标的信息。

公开(公告)号：US20090008536A1

公开(公告)日：2009-01-08

申请号：US11772997

申请日：2007-07-03

Applicant: Arthur H. Hartog ,  Gareth P. Lees

Inventor： Arthur H. Hartog ,  Gareth P. Lees

IPC: G02B27/42 ,  G01J1/04

CPC classification number: G01J3/4412 ,  G01D5/35364 ,  G01K11/32

Abstract: To perform distributed sensing with an optical fiber using Brillouin scattering, a light pulse is transmitted into the optical fiber, where the transmitted light pulse has a first frequency. Backscattered light and optical local oscillator light are combined, where the backscattered light is received from the optical fiber in response to the transmitted light pulse, and where the optical local oscillator light has a second frequency. A frequency offset is caused to be present between the first frequency of the transmitted light pulse and the second frequency of the optical local oscillator light, where the frequency offset is at least 1 GHz less than a Brillouin frequency shift of the backscattered light. Spectra representing Stokes and anti-Stokes components of the backscattered light are acquired, where the Stokes and anti-Stokes components are separated by a frequency span that is based on the frequency offset.

Abstract translation: 为了使用布里渊散射使用光纤执行分布式感测，将光脉冲传输到光纤中，其中透射光脉冲具有第一频率。 组合后向散射光和光学本地振荡器光，其中响应于透射的光脉冲从光纤接收反向散射光，并且其中光学本地振荡器光具有第二频率。 使得频率偏移存在于透射光脉冲的第一频率和光学本地振荡器光的第二频率之间，其中频偏比背散射光的布里渊频移小至少1GHz。 获取表示反向散射光的斯托克斯和反斯托克斯分量的光谱，其中斯托克斯和反斯托克斯分量由基于频率偏移的频率间隔分开。

公开(公告)号：US20090004190A1

公开(公告)日：2009-01-01

申请号：US12162658

申请日：2007-01-23

Applicant: Adnan M.M. Mjalli ,  Jeffrey C. Webster ,  Robert Rothlein ,  Ye E. Tian

Inventor： Adnan M.M. Mjalli ,  Jeffrey C. Webster ,  Robert Rothlein ,  Ye E. Tian

IPC: A61K39/395 ,  A61P37/00

CPC classification number: C07K14/70503 ,  A61B5/0059 ,  A61B5/4088 ,  A61B5/412 ,  A61B5/413 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/70 ,  G01J3/4412 ,  G01N21/4795 ,  G01N2021/638 ,  G01N2800/042 ,  G01N2800/387

Abstract: Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.

Abstract translation: 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点和直接连接到免疫球蛋白CH2结构域的域间连接体的RAGE多肽结构域。 这样的融合蛋白可以提供与RAGE配体的特异的高亲和力结合。 还公开了RAGE融合蛋白作为RAGE介导的病理学的治疗剂的用途。

公开(公告)号：US20080291444A1

公开(公告)日：2008-11-27

申请号：US11914960

申请日：2006-05-19

Applicant: Paul Donaldson ,  David Klug

Inventor： Paul Donaldson ,  David Klug

IPC: G01N21/63

CPC classification number: G01J3/4412 ,  G01J3/4338 ,  G01N21/636

Abstract: A method of multidimensional spectroscopy has a controllable excitation source parameter and comprises controlling said controllable parameter to excite a vibrational mode of the sample, generating a homodyne reflected signal from the sample and obtaining a spectrum of the sample from the reflected signal.

Abstract translation: 多维光谱学的方法具有可控的激发源参数，并且包括控制所述可控参数以激发样品的振动模式，从样品产生零差反射信号，并从反射信号获得样品的光谱。

公开(公告)号：US20080101657A1

公开(公告)日：2008-05-01

申请号：US11927396

申请日：2007-10-29

Applicant: Anthony J. Durkin ,  David Cuccia ,  Frederic Bevilacqua ,  Bruce J. Tromberg

Inventor： Anthony J. Durkin ,  David Cuccia ,  Frederic Bevilacqua ,  Bruce J. Tromberg

IPC: G06K9/00

CPC classification number: G01J3/4412 ,  G01J3/02 ,  G01J3/021 ,  G01J3/10 ,  G01J3/32 ,  G01N21/4795 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/94 ,  G01N33/025 ,  G01N2021/1787 ,  G01N2021/6421

Abstract: A method and an apparatus for noninvasively and quantitatively determining spatially resolved absorption and reduced scattering coefficients over a wide field-of-view of a food object, including fruit or produce, uses spatial-frequency-domain imaging (SFDI). A single modulated imaging platform is employed. It includes a broadband light source, a digital micromirror optically coupled to the light source to control a modulated light pattern directed onto the food object at a plurality of selected spatial frequencies, a multispectral camera for taking a spectral image of a reflected modulated light pattern from the food object, a spectrally variable filter optically coupled between the food object and the multispectral camera to select a discrete number of wavelengths for image capture, and a computer coupled to the digital micromirror, camera and variable filter to enable acquisition of the reflected modulated light pattern at the selected spatial frequencies.

Abstract translation: 使用空间 - 频域成像（SFDI），在食品物体（包括果实或产品）的宽视野范围内非侵入和定量地测定空间分辨吸收和降低的散射系数的方法和装置。 采用单一调制成像平台。 其包括宽带光源，光学耦合到光源的数字微镜，以以多个选定的空间频率来控制指向食物的调制光图案;多光谱相机，用于从反射调制光图案中获取反射调制光图案的光谱图像， 食品对象，光学耦合在食物和多光谱相机之间的光谱可变滤光器，用于选择用于图像捕获的离散数量的波长，以及耦合到数字微镜，照相机和可变滤波器的计算机，以使得能够获取反射的调制光 图案在所选择的空间频率。