公开(公告)号：US20070114383A1

公开(公告)日：2007-05-24

申请号：US11603159

申请日：2006-11-22

Applicant: Yoshihiro Ueno

Inventor： Yoshihiro Ueno

IPC: H01J49/00

CPC classification number: H01J49/30 ,  H01J49/408

Abstract: In a time of flight mass spectrometer (TOFMS) having a flight space in which ions fly in a loop orbit formed by a plurality of electric sector fields, the present invention provides a simple structure that creates a spiral path by deflecting the ions in the axial direction of the electric fields at every turn of the ions. In a mode of the present invention, the TOFMS has cylindrical electrodes 11 and 12 for creating electric sector fields E1 and E2, between which a parallel pair of planer magnetic poles 15a and 15b are provided. The planer magnetic poles 15a and 15b create a deflecting magnetic field B1 for shifting the ions in the axial direction (Y-direction) of the electric sector fields. The ions experience a Lorenz force once every turn when they pass through the deflecting magnetic field B1. This construction uses only one pair of magnetic poles facing each other across the ion path P to deflect every ion irrespective of its number of turns. There is no need to provide one deflector for each turn of the ions, as in the case of conventional TOFMSs.

Abstract translation: 在具有飞行空间的飞行时间质谱仪（TOFMS）中，离子飞行在由多个电扇区形成的环轨道中，本发明提供了一种简单的结构，其通过在轴向上偏转离子而产生螺旋路径 方向的电场每转一圈的离子。 在本发明的模式中，TOFMS具有用于产生电扇区场E 1和E 2的圆柱形电极11和12，平行的一对平面磁极15a和15b设置在平行的一对平面磁极之间。 平面磁极15a和15b产生偏转磁场B 1，用于在电扇区的轴向（Y方向）上移动离子。 当离子穿过偏转磁场B 1时，离子经历一次洛伦茨力。 这种结构仅使一对磁极彼此跨过离子路径P，以偏转每个离子而不考虑其匝数。 对于常规TOFMS的情况，不需要为每一圈的离子提供一个偏转器。

公开(公告)号：US20060219890A1

公开(公告)日：2006-10-05

申请号：US11390109

申请日：2006-03-28

Applicant: Shinichi Yamaguchi

Inventor： Shinichi Yamaguchi

IPC: H01J49/00

CPC classification number: H01J49/0036 ,  H01J49/408

Abstract: The present invention relates to a time of flight mass spectrometer (TOFMS) having a flight space in which ions to be analyzed repeatedly fly in a loop orbit or reciprocal path. In an example of the present invention, the TOFMS carries out two rounds of measurement for one sample under two conditions differing in the effective flight distance of the ions to create two flight time spectrums. The data processor of the TOFMS compares the central points of the peaks in the two spectrums to identify peaks that have resulted from the same kind of ion (Step S3). If any peak is found to be unidentifiable (“No” in Step S4), the data processor examines the similarity of the peak shapes (e.g. half-value width) to identify peaks that have resulted from the same kind of ion (Step S5). After the correspondence of all the peaks have been determined, the data processor calculates the approximate mass to charge ratio of each ion from the difference in flight time (Step S6) and determines the number of turns of the ion based on the approximation (Step S7). Finally, it calculates the exact mass to charge ratio, using the number of turns and the flight time (Step S8). Thus, even if the sample contains many components and the spectrums accordingly have many peaks mixed together, the TOFMS can identify all the peaks.

Abstract translation: 本发明涉及具有飞行空间的飞行时间质谱仪（TOFMS），其中待分析的离子重复地以循环轨道或往复路径飞行。 在本发明的一个实例中，TOFMS在两个条件下对一个样品进行两轮测量，这两个条件不同于离子的有效飞行距离，以产生两个飞行时间谱。 TOFMS的数据处理器比较两个光谱中的峰的中心点，以识别由相同种类的离子产生的峰（步骤S 3）。 如果发现任何峰值无法识别（步骤S 4中为“否”），则数据处理器检查峰形状（例如半值宽度）的相似性，以识别由相同种类的离子产生的峰（步骤S 5）。 在确定了所有峰的对应关系之后，数据处理器根据飞行时间差计算每个离子的近似质荷比（步骤S6），并根据近似值确定离子的匝数（步骤 S 7）。 最后，使用匝数和飞行时间来计算确切的充电比例（步骤S 8）。 因此，即使样品含有许多组分，并且光谱相应地具有多个混合在一起的峰，则TOFMS可以鉴定所有峰。

公开(公告)号：US07091480B2

公开(公告)日：2006-08-15

申请号：US10959433

申请日：2004-10-07

Applicant: Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda

Inventor： Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda

IPC: H01J49/40

CPC classification number: H01J49/408

Abstract: In an analysis using a mass spectrometer having a loop orbit along which ions are made to fly a plurality of times, the present invention provides a method of determining the mass-to-charge ratio of an ion without limiting the range of the mass-to-charge ratio of the ions to be brought into the loop orbit while allowing the lapping of the orbiting ions. The measurement is carried out two or more times under different conditions (Tg=500[μs], 400[μs]) under which the number of turns of the ion concerned is different. Flight times are determined from the flight time spectrums obtained by at least two measurements. Though the numbers of turns themselves are unknown, it is possible to calculate possible mass-to-charge ratios for each flight time by incrementally setting the number of turns at plural values. The two sets of possible mass-to-charge ratios derived from the two flight time values (525[μs], 441[μs]) determined by the two measurements are compared with each other, and a value that is found in both measurement results is selected as the mass-to-charge ratio of the ion concerned. Thus, it is possible to determine the mass-to-charge ratio without limiting the range of the mass-to-charge ratio before the ions are brought into the loop orbit.

Abstract translation: 在使用具有环形轨道的质谱仪进行分析时，离子通过该轨道多次飞行，本发明提供了一种确定离子的质荷比而不限制质量 - 进入环轨道的离子的充电比例，同时允许研磨轨道离子。 在不同条件下（Tg = 500 [mus]，400 [mus]）进行两次以上的测定，在该条件下，有关离子的匝数不同。 从通过至少两次测量获得的飞行时间谱确定飞行时间。 虽然转弯数量本身是未知的，但是可以通过逐个设定多个值的匝数来计算每个飞行时间的可能的质荷比。 将由两个测量确定的两个飞行时间值（525 [mus]，441 [mus]）得到的两组可能的质荷比相互比较，并在两个测量结果中找到 被选为相关离子的质荷比。 因此，可以在离子进入环轨道之前不限制质荷比的范围来确定质荷比。

公开(公告)号：US06998606B2

公开(公告)日：2006-02-14

申请号：US10758326

申请日：2004-01-14

Applicant: Sidney E. Buttrill, Jr.

Inventor： Sidney E. Buttrill, Jr.

IPC: H01J49/40

CPC classification number: H01J49/282 ,  H01J49/408

Abstract: The invention provides apparatus and methods for performing time-of-flight (TOF) mass spectrometry. A TOF mass spectrometer of the present invention comprises one or more ion focusing electric sectors. At least one of the electric sectors is associated with an ion optical element. The ion optical elements comprise at least one adjustable electrode, such that the adjustable electrode is able to modify the potential experienced by an ion entering or exiting the electric sector with which it is associated.

Abstract translation: 本发明提供了用于执行飞行时间（TOF）质谱的装置和方法。 本发明的TOF质谱仪包括一个或多个离子聚焦电扇区。 电扇区中的至少一个与离子光学元件相关联。 离子光学元件包括至少一个可调电极，使得可调节电极能够改变进入或离开与其相关联的电扇区的离子所经历的电位。

公开(公告)号：US06949738B2

公开(公告)日：2005-09-27

申请号：US10983571

申请日：2004-11-09

Applicant: Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda

Inventor： Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda

IPC: G01N27/62 ,  B01D59/44 ,  H01J49/00 ,  H01J49/06 ,  H01J49/40

CPC classification number: H01J49/408 ,  H01J49/0027

Abstract: The present invention provides a time of flight mass spectrometer having a spiral flight path, whose mass resolution can be appropriately changed with respect to the analysis object or other factor without any complicated alteration or addition of the mechanical construction. In a specific form of the invention, the mass spectrometer includes deflecting electrodes 20-23 located between semi-cylindrical electrodes 11 and 12 for making ions fly along a spiral path. The deflecting electrodes 20-23 generate deflecting electric fields for shifting the ions in the axial direction of the semi-cylindrical electrodes 11 and 12. The voltage applied to the deflecting electrodes 20-23 is changed according to the mass resolution required. The deflecting electric fields are generated or removed with the change of the voltage, which makes the ions fly either along a spiral path or in the same loop orbit. The flight distance of the ions can be controlled as desired by regulating the voltage so that the ions fly in the loop orbit an appropriate number of times. Thus, the mass resolution can be arbitrarily controlled.

Abstract translation: 本发明提供了具有螺旋飞行路径的飞行时间质谱仪，其质量分辨率可以相对于分析对象或其他因素适当地改变，而没有任何复杂的改变或添加机械结构。 在本发明的具体形式中，质谱仪包括位于半圆柱形电极11和12之间的偏转电极20-23，用于使离子沿着螺旋路径飞行。 偏转电极20-23产生用于使离子在半圆柱形电极11和12的轴向上移动的偏转电场。 施加到偏转电极20-23的电压根据所需的质量分辨率而改变。 随着电压的变化产生或去除偏转电场，这使得离子沿着螺旋路径或相同的环轨道飞行。 通过调节电压可以根据需要控制离子的飞行距离，使得离子在环轨道中飞行适当次数。 因此，质量分辨率可以任意控制。

公开(公告)号：US20050045817A1

公开(公告)日：2005-03-03

申请号：US10929770

申请日：2004-08-31

Applicant: Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda ,  Daisuke Okumura

Inventor： Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda ,  Daisuke Okumura

IPC: G01N27/62 ,  B01D59/44 ,  G01N27/64 ,  H01J49/00 ,  H01J49/40

CPC classification number: H01J49/408 ,  H01J49/027

Abstract: In a time of flight mass spectrometer (TOF-MS) of the present invention, a flight controller makes ions fly a loop orbit a predetermined number of turns, and an ion detector detects the ions at each turn of the flight. A flight time measurer measures the length of flight time of ions of a same mass to charge ratio at every turn, and a data processor constructs a spectrum of flight time. The data processor further computes the Fourier transformation of the spectrum, and determines the mass to charge ratio of the ions based on a frequency peak appearing in the Fourier transformation.

Abstract translation: 在本发明的飞行时间质谱仪（TOF-MS）中，飞行控制器使离子飞行预定匝数的环路轨道，并且离子检测器在飞行的每一回合处检测离子。 飞行时间测量器可以测量每一回合具有相同质荷比的离子的飞行时间长度，并且数据处理器构建飞行时间谱。 数据处理器进一步计算光谱的傅立叶变换，并且基于在傅里叶变换中出现的频率峰值来确定离子的质荷比。

公开(公告)号：US20050017169A1

公开(公告)日：2005-01-27

申请号：US10896064

申请日：2004-07-22

Applicant: Shinichi Yamaguchi

Inventor： Shinichi Yamaguchi

IPC: G01N27/62 ,  H01J49/00 ,  H01J49/40

CPC classification number: H01J49/408

Abstract: In a TOF-MS according to the present invention, ions fly a round orbit or a reciprocal path once or more than once to be separated by their mass to charge ratios before they are detected by a detector, The detector is movable at least in two positions, where the effective distances from the exit of the round orbit or the reciprocal path to the detector are different. The length of time of flight of ions in each position of detector is measured, and the mass to charge ratio of an ion is calculated based on the difference of the lengths of time of flight in at least two positions. Similarly, the ion source may be movable at least in two positions, and a similar method can be used to calculate or estimate the mass to charge ratio of ions.

公开(公告)号：US12131895B2

公开(公告)日：2024-10-29

申请号：US17717505

申请日：2022-04-11

Applicant: Micromass UK Limited

Inventor： John Brian Hoyes ,  Boris Kozlov

IPC: H01J49/40 ,  H01J49/06 ,  H01J49/42

CPC classification number: H01J49/401 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: A Time of Flight mass analyser is disclosed comprising: at least one ion mirror 34 for reflecting ions; an ion detector 36 arranged for detecting the reflected ions; a first pulsed ion accelerator 30 for accelerating an ion packet in a first dimension (Y-dimension) towards the ion detector 36 so that the ion packet spatially converges in the first dimension as it travels to the detector 36; and a pulsed orthogonal accelerator 32 for orthogonally accelerating the ion packet in a second, orthogonal dimension (X-dimension) into one of said at least one ion mirrors 34.

公开(公告)号：US11990328B2

公开(公告)日：2024-05-21

申请号：US17723652

申请日：2022-04-19

Applicant: SHIMADZU CORPORATION

Inventor： Hiroyuki Miura ,  Hideaki Izumi

IPC: H01J49/40 ,  H01J49/24

CPC classification number: H01J49/408 ,  H01J49/24

Abstract: A mass spectrometer 1 includes a vacuum container 5 divided into a first chamber 51 containing an ion trap 3 and a second chamber 52 containing a time-of-flight mass spectrometer 4. The ion trap 3 is held within an ion-trap-holding space 610 surrounded by a wall 61. In this wall 61, a cooling-gas discharge port 64 is formed in addition to an introduction-side ion passage port 62 and an ejection-side ion passage port 63. A cooling gas supplied into an ion-capturing space 315 of the ion trap 3 is discharged from the ion-trap-holding space 610 through the three ports. The provision of the cooling-gas discharge port 64 reduces the amount of cooling gas flowing into the ejection-side ion passage port 63 and interfering with the ejection of ions from the ion trap 3 into the time-of-flight mass spectrometer 4. Consequently, the detection intensity of the ions is improved.

公开(公告)号：US20160104609A1

公开(公告)日：2016-04-14

申请号：US14877593

申请日：2015-10-07

Applicant: SHIMADZU CORPORATION

Inventor： Li DING ,  Mikhail SUDAKOV ,  Sumio KUMASHIRO

IPC: H01J49/02 ,  H01J49/06 ,  H01J49/42

CPC classification number: H01J49/027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.

Abstract translation: 用于质量分析的静电离子阱包括第一电极阵列和与第一电极阵列间隔开的第二电极阵列。 第一和第二电极阵列可以是由平行条形电极或同心圆形或部分圆形导电环形成的平面阵列。 阵列的电极被提供有基本上相同的电压模式，由此阵列之间的空间中的电位分布使得在飞行方向上等离子地反射离子，使得它们在空间中经历周期性的振荡运动 基本上位于阵列之间。 放大器电路用于检测具有与经历周期性振荡运动的离子的质荷比相关的频率分量的图像电流。