MULTI-DISPERSIVE SPECTROMETER
    61.
    发明公开

    公开(公告)号:US20230251132A1

    公开(公告)日:2023-08-10

    申请号:US17943056

    申请日:2022-09-12

    Abstract: A multi-dispersive spectrometer is provided in which the spectrometer comprises an optical system configured to direct an excitation signal from an excitation light source toward a sample, receive a spectroscopy signal from the sample, and direct the spectroscopy signal toward the detector. The optical system comprises a movable optical component adapted to move the spectroscopy signal relative to at least one sensor of the detector and the detector is adapted to detect a plurality of discrete shifted spectroscopy signals. A method of obtaining a Raman spectrum from a sample is also provided. The method comprises directing an excitation signal from an excitation light source toward a sample; receiving a spectroscopy signal from the sample; and directing the spectroscopy signal toward a detector, wherein the spectroscopy signal is moved relative to at least one sensor of the detector to provide a plurality of discrete shifted spectroscopy signals.

    DETECTING PLANT PRODUCT PROPERTIES
    62.
    发明公开

    公开(公告)号:US20230236117A1

    公开(公告)日:2023-07-27

    申请号:US18011992

    申请日:2021-06-24

    Abstract: A method for detecting at least one property of a plant product, the method including: directing source light including ultraviolet (UV) light at UV wavelengths and polarized visible and/or near-infrared (VIS/NIR) light at VIS/NIR wavelengths onto a region of the plant product; blocking the polarized VIS/NIR light of the source light, and blocking polarized specular reflection from the region of the plant product, from being transmitted to a visible and/or near-infrared (VIS/NIR) spectrometer; and transmitting a portion of emitted light caused by fluorescence and/or diffuse reflection from the region of the plant product to the visible and/or near-infrared (VIS/NIR) spectrometer.

    SURFACE-ENHANCED RAMAN SCATTERING BIOSENSOR
    63.
    发明公开

    公开(公告)号:US20230221258A1

    公开(公告)日:2023-07-13

    申请号:US17983136

    申请日:2022-11-08

    CPC classification number: G01N21/658 G02B1/005 G01J3/44

    Abstract: A general purpose sensor architecture integrating a surface enhanced Raman spectroscopy (SERS) substrate, a diffractive laser beam delivery substrate and a diffractive infrared detection substrate is provided that can be used to implement a low-cost, compact lab-on-a-chip biosensor that can meet the needs of large-scale infectious disease testing. The sensor architecture can also be used in any other application in which molecules present in the liquid, gaseous or solid phases need to be characterized reliably, cost-effectively and with minimal intervention by highly skilled personnel.

    SPECTRAL ANALYSIS OF A SAMPLE
    64.
    发明公开

    公开(公告)号:US20230218174A1

    公开(公告)日:2023-07-13

    申请号:US17925272

    申请日:2021-03-02

    CPC classification number: A61B5/0075 G01J3/4412 G01J3/0208 G01N21/65

    Abstract: Apparatus and methods for spectral analysis of a sample are described, for example for carrying out Raman or other optical or spectroscopic analysis of samples such as pharmaceutical dosage forms, including oral solid dosage forms such as tablets or capsules. Such apparatus may comprise delivery optics arranged to direct probe light to a delivery region of the sample, collection optics arranged to collect probe light scattered from a collection region of the sample, and a spectrometer having an entrance port, the spectrometer being arranged to receive the collected probe light from the collection optics at the entrance port of the spectrometer, and to detect spectral features in the received probe light. In particular, the collection optics may comprise Koehler integration optics arranged to process the collected probe light such that the collected light from each point of the collection region is distributed across the entrance port of the spectrometer.

    USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM

    公开(公告)号:US20230175967A1

    公开(公告)日:2023-06-08

    申请号:US17885167

    申请日:2022-08-10

    Applicant: Biogen MA Inc.

    CPC classification number: G01N21/65 G01J3/44 G01N2201/0446 G01N2201/06113

    Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.

    SEMI-TRANSPARENT DETECTOR ARRAY FOR UV/NEAR-UV DETECTION

    公开(公告)号:US20230139708A1

    公开(公告)日:2023-05-04

    申请号:US17514884

    申请日:2021-10-29

    Abstract: An apparatus and method are provided for a night vision system that integrates functions of detecting an intensified image and transmitting the intensified image superimposed with a heads-up display. The night vision system includes an optical device having a transparent display configured with pixels emitting display light (i.e., the heads-up display), and the transparent display has transmission regions arranged among the pixels for transmitting light representing an intensified image (e.g., luminescent light from a phosphor screen). Light rays passing through the transmission regions also pass through detectors, which detect light outside of the visible spectrum (e.g., UV light). By detecting light outside of the visible spectrum, the detectors detect the intensified image without degrading the image in the visible spectrum that is provided to users.

    System and Method for Drug Detection in Exhaled Breath

    公开(公告)号:US20230125894A1

    公开(公告)日:2023-04-27

    申请号:US18088439

    申请日:2022-12-23

    Applicant: Sensa Bues AB

    Abstract: A portable system is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit and a housing arranged to hold the sampling unit, the sampling unit is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing has at least one inlet for the subject to exhale into the housing to the sampling unit and at least one outlet for the exhaled breath to exit through.

    Microspectroscope having position correction function

    公开(公告)号:US11635605B2

    公开(公告)日:2023-04-25

    申请号:US16782716

    申请日:2020-02-05

    Abstract: The present invention relates to improvement in accuracy of an automatic sample detection technique in spectrometry of a microspectroscope.
    A microspectroscope 10 comprises: a light source 12 that emits an excitation light to a sample 20; a condensing lens 16 that emits the excitation light to a predetermined position of the sample 20 and condenses a reflected light or a transmitted light from the sample 20; a spectrometer 24 that detects a condensed light; and an analysis control unit 30 for analyzing a signal from the spectrometer 24; the microspectroscope 10 that uses an observation image of the sample 20 to perform spectrometry, wherein the analysis control unit 30 comprises: an image storage part 32 that converts the observation image to an all-in-focus image to store the all-in-focus image; and a control part 34 that makes the microspectroscope 10 to perform measurement, and the control part 34 uses the all-in-focus image and performs a template matching as a matching action of the image to perform position correction to a position deviation of a sample point that is a target of spectrometry in the sample.

    SEMICONDUCTOR DEVICE MEASURING DEVICE AND METHOD FOR MEASURING SEMICONDUCTOR DEVICE

    公开(公告)号:US20230101968A1

    公开(公告)日:2023-03-30

    申请号:US17827231

    申请日:2022-05-27

    Abstract: A semiconductor device measuring device includes: a light generator which generates light; a polarizer which polarizes the light; a wafer stage including a first load port on which an undoped reference wafer is loaded, and a second load port on which a doped sample wafer is loaded, the wafer stage being movable to first and second positions at which the polarized light is incident on the reference wafer and the sample wafer, respectively; a spectroscope which collects first and second Raman spectral information of light reflected from the reference and sample wafers, respectively; a photodetector which detects first and second Raman scattering signals based on the first and second Raman spectral information, respectively; a spectrum corrector which corrects the second Raman scattering signal using the first Raman scattering signal; and a controller which calculates a concentration of the dopant of the sample wafer using the corrected scattering signal.

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