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    Method and apparatus for coating of substrates
    72.
    发明授权
    Method and apparatus for coating of substrates 有权
    用于涂布基材的方法和装置

    公开(公告)号：US07669548B2

    公开(公告)日：2010-03-02

    申请号：US11539443

    申请日：2006-10-06

    Applicant: Ralph A. Chappa

    Inventor： Ralph A. Chappa

    IPC: B05B15/04 ,  B05C5/00

    CPC classification number: B05D1/02 ,  B05B7/0807 ,  B05B7/0861 ,  B05B7/0869 ,  B05B13/0207 ,  B05B13/0228 ,  B05B13/0436 ,  B05B13/0442 ,  B05C13/025 ,  B05D1/002 ,  Y10S118/11

    Abstract: The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an embodiment, the invention includes a method with a bi-directional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.

    Abstract translation: 本发明涉及减少装置涂覆期间遇到的问题的方法和装置，例如具有圆柱形形状的医疗装置。 在一个实施例中，本发明包括一种包括双向旋转构件的装置。 在一个实施例中，本发明包括具有双向分度运动的方法。 在一个实施方案中，本发明包括具有平行于涂覆设备上的辊之间的间隙定向的长轴的涂布溶液供应构件。 在一个实施例中，本发明包括装置保持构件。 在一个实施例中，本发明包括空气喷嘴或气刀。 在一个实施例中，本发明包括一种包括从小直径医疗装置中去除静电荷的方法。

    METHODS AND MATERIALS FOR INCREASING THE ADHESION OF ELUTION CONTROL MATRICES TO SUBSTRATES
    74.
    发明申请
    METHODS AND MATERIALS FOR INCREASING THE ADHESION OF ELUTION CONTROL MATRICES TO SUBSTRATES 审中-公开
    扩展控制矩阵到基板的方法和材料

    公开(公告)号：US20080171087A1

    公开(公告)日：2008-07-17

    申请号：US11839905

    申请日：2007-08-16

    Applicant: Ralph A. Chappa ,  Michael J. Finley

    Inventor： Ralph A. Chappa ,  Michael J. Finley

    IPC: A61K9/00 ,  A61L33/06

    CPC classification number: A61L29/085 ,  A61L29/06 ,  A61L29/16 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/08 ,  C08L83/04 ,  C08L65/04

    Abstract: The present invention relates to methods and components for increasing adhesion of an elution control matrix to a polymeric substrate, and medical devices including such components. In an embodiment, the invention includes a medical device including a substrate having a surface, the substrate comprising a polysiloxane, a parylene layer contacting the surface of the substrate, and an elution control matrix contacting the parylene layer, the elution control matrix comprising a polymeric matrix and an active agent dispersed within the polymeric matrix. Other embodiments are included herein.

    Abstract translation: 本发明涉及用于增加洗脱控制基质与聚合物基质的粘附性的方法和组分，以及包括这些组分的医疗装置。 在一个实施方案中，本发明包括医疗装置，其包括具有表面的基底，所述基底包含聚硅氧烷，接触基底表面的聚对二甲苯层和接触聚对二甲苯层的洗脱控制基质，洗脱控制基质包含聚合物 基质和分散在聚合物基质内的活性剂。 本文还包括其它实施例。

    MULTI-LAYERED COATINGS AND METHODS FOR CONTROLLING ELUTION OF ACTIVE AGENTS
    75.
    发明申请
    MULTI-LAYERED COATINGS AND METHODS FOR CONTROLLING ELUTION OF ACTIVE AGENTS 审中-公开
    多层涂料和控制活性剂溶液的方法

    公开(公告)号：US20080075753A1

    公开(公告)日：2008-03-27

    申请号：US11860856

    申请日：2007-09-25

    Applicant: Ralph A. Chappa

    Inventor： Ralph A. Chappa

    IPC: A61F2/00 ,  A61L27/34

    CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L2300/608 ,  A61L2420/08 ,  C08L65/04

    Abstract: Embodiments of the invention include multi-layered coatings for controlling the elution rates of active agents and methods. In an embodiment, the invention includes a method of applying an elution control coating to a substrate. The method can include depositing a coating solution onto the substrate to form a base layer. The method can also include selecting a desired concentration of the solvent based on a desired elution rate. The method can further include removing solvent from the base layer to reach a desired concentration of the solvent and depositing a layer of parylene on the base layer. In an embodiment, the invention can include a medical device including a substrate, a base layer, and a porous layer. The base layer can include a polymeric matrix and an active agent dispersed within the polymeric matrix. The porous layer can include parylene. Other embodiments are also included herein.

    Abstract translation: 本发明的实施方案包括用于控制活性剂的洗脱速率的多层涂层和方法。 在一个实施方案中，本发明包括将洗脱控制涂层施加到基底上的方法。 该方法可以包括将涂布溶液沉积到基底上以形成基底层。 该方法还可以包括基于所需的洗脱速率来选择所需浓度的溶剂。 该方法还可以包括从基层去除溶剂以达到所需浓度的溶剂并在基层上沉积聚对二甲苯层。 在一个实施例中，本发明可以包括包括基底，基底层和多孔层的医疗装置。 基层可以包括分散在聚合物基质内的聚合物基质和活性剂。 多孔层可以包括聚对二甲苯。 本文还包括其它实施例。

    Coating method
    79.
    发明授权
    Coating method 有权
    涂布方法

    公开(公告)号：US06709712B2

    公开(公告)日：2004-03-23

    申请号：US10429019

    申请日：2003-05-01

    Applicant: Ralph A. Chappa ,  Steven J. Porter

    Inventor： Ralph A. Chappa ,  Steven J. Porter

    IPC: B05D102

    CPC classification number: B05B13/0442 ,  B05B7/0416 ,  B05B13/0242 ,  B05B13/0405 ,  B05B15/70

    Abstract: The invention provides a device for holding a substrate during deposition processes that includes a rotation member rotatable about a first, central axis, and a plurality of substrate holders positioned on the rotation member, the substrate holders being rotatable about second axes. In another aspect, the invention provides a method of applying a substantially uniform coating on a substrate including the steps of providing a device of the invention; mounting a substrate onto the substrate mounts; providing at least one substrate coating station in spaced relation to the substrate mounts; rotating the rotation member about a central axis to position one or more of the substrate mounts at the substrate coating station; supplying the coating through the nozzle; moving the nozzle of the coating station in a direction parallel to the substrate at a predetermined rate to apply a uniform coating on the substrate; and rotating the substrate mounts about the second axes during the coating process.

    Abstract translation: 本发明提供了一种用于在沉积过程期间保持基板的装置，其包括可围绕第一中心轴线旋转的旋转构件和位于旋转构件上的多个基板保持器，所述基板保持器可围绕第二轴线旋转。 另一方面，本发明提供了一种在基材上施加基本均匀的涂层的方法，包括提供本发明的装置的步骤; 将衬底安装到衬底安装件上; 提供与衬底安装件间隔开的至少一个衬底涂覆站; 使所述旋转构件围绕中心轴旋转以将所述衬底安装件中的一个或多个位于所述衬底涂覆站处; 通过喷嘴供应涂层; 以预定的速率沿着平行于基板的方向移动涂布站的喷嘴以在基板上施加均匀的涂层; 并且在涂覆过程中围绕第二轴旋转衬底安装件。

    Coating process and apparatus
    80.
    发明授权
    Coating process and apparatus 有权
    涂装工艺及装置

    公开(公告)号：US06254921B1

    公开(公告)日：2001-07-03

    申请号：US09456925

    申请日：1999-12-08

    Applicant: Ralph A. Chappa ,  Steven J. Porter

    Inventor： Ralph A. Chappa ,  Steven J. Porter

    IPC: A61L2700

    CPC classification number: B05C3/09 ,  B05D1/18 ,  B05D1/32 ,  B05D7/20

    Abstract: A process and apparatus for dip-coating intermediate and/or discrete discontinuous portions of longitudinal devices, including medical devices such as catheters and guidewires. The apparatus provides a chamber in which both the desired portion(s) of the device and the coating solution can be controllably contacted. A controlled coating can be achieved within the chamber by providing and controlling one or more of the following relationships: a) the manner in which a chamber (containing solution) is itself moved with respect to a static device, b) the manner in which the device is moved with respect to a fixed chamber position containing a fixed volume of solution, and/or c) the manner in which both the chamber and device are fixed in position, and the coating is achieved by adding and removing a volume of solution from the chamber. The resultant movement of solution and device is intended to mimic or replicate the relative movements involved in a conventional dip-coating procedure, at least along the length of device to be coated.

    Abstract translation: 用于浸涂纵向装置的中间和/或离散不连续部分的方法和装置，包括诸如导管和导丝的医疗装置。 该设备提供了一个室，其中装置的期望部分和涂覆溶液都可以可控制地接触。 通过提供和控制一个或多个以下关系，可以在室内实现受控涂层：a）室（含有溶液）本身相对于静态装置自身移动的方式，b） 装置相对于包含固定体积溶液的固定室位移动，和/或c）室和装置两者都固定就位的方式，涂层通过将一定体积的溶液从 房间。 所得到的溶液和装置的运动旨在模拟或复制常规浸涂过程中涉及的相对运动，至少沿待涂覆的装置的长度。

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