公开(公告)号：US08029863B2

公开(公告)日：2011-10-04

申请号：US12230924

申请日：2008-09-08

Applicant: Agnès Fonverne ,  Jean Dijon ,  Florence Ricoul ,  Emmanuelle Rouviere

Inventor： Agnès Fonverne ,  Jean Dijon ,  Florence Ricoul ,  Emmanuelle Rouviere

IPC: B32B38/00 ,  C23C16/00

CPC classification number: B81C1/00206 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00835 ,  B01J2219/00846 ,  B01J2219/00862 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/12 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C2201/019 ,  B81C2203/038

Abstract: A microfluidic component comprises at least one closed microchannel filled with nanostructures. The microchannel is produced by previously forming an opening delineating a bottom wall and two opposite side walls of the microchannel in a surface of a substrate. The nanostructures filling said microchannel are formed by in situ growth to constitute a layer of metallic catalyst deposited on said side walls and on said wall bottom. The microchannel is closed, before the nanostructures are formed, by sealing a protective cover onto said surface of the substrate. Sealing is obtained by formation of an eutectic compound between a material of the cover and the metal of the catalyst used for in situ growth of the nanostructures and deposited on the surface of the substrate designed to come into contact with the cover.

Abstract translation: 微流体组分包括填充有纳米结构的至少一个闭合微通道。 微通道预先形成在衬底的表面中描绘微通道的底壁和两个相对的侧壁的开口。 填充所述微通道的纳米结构通过原位生长形成，以构成沉积在所述侧壁上和所述壁底上的金属催化剂层。 在形成纳米结构之前，通过将保护盖密封在基材的所述表面上来封闭微通道。 通过在盖的材料和用于纳米结构的原位生长的催化剂的金属之间形成共晶化合物并沉积在设计成与盖接触的基板的表面上来获得密封。

公开(公告)号：US07977122B2

公开(公告)日：2011-07-12

申请号：US11669351

申请日：2007-01-31

Applicant: Roger Sandoz ,  Carlo Effenhauser

Inventor： Roger Sandoz ,  Carlo Effenhauser

IPC: H01L21/00 ,  B27N3/18 ,  G02B5/18 ,  C12N11/08

CPC classification number: B01F5/061 ,  B01F13/0059 ,  B01F2005/0621 ,  B01F2005/0636 ,  B01J2219/00511 ,  B01J2219/00889 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/086 ,  B81B1/00 ,  B81B2201/058 ,  B81C2201/019

Abstract: A micro fluidic device comprises a laminate structure, comprising a plurality of individual layers. At least one layer comprises a micro fluidic channel structure and at least on one side of said layer a further layer is arranged comprising a three-dimensional (3D) micro structure such that the 3D micro structure is influencing a flow characteristic of a fluid within the micro fluidic channel structure.

Abstract translation: 微流体装置包括层压结构，其包括多个单独的层。 至少一层包括微流体通道结构，并且至少在所述层的一侧上布置另外的层，其包括三维（3D）微结构，使得3D微结构影响流体的流动特性 微流体通道结构。

公开(公告)号：US20110136932A1

公开(公告)日：2011-06-09

申请号：US12913807

申请日：2010-10-28

Applicant: Paul A. Kohl ,  Sue Ann Bidstrup-Allen ,  Clifford Lee Henderson

Inventor： Paul A. Kohl ,  Sue Ann Bidstrup-Allen ,  Clifford Lee Henderson

IPC: C08F10/14

CPC classification number: G03F7/004 ,  B81B2201/058 ,  B81B2203/0338 ,  B81B2203/0384 ,  B81C1/00103 ,  B81C2201/0108 ,  C08J3/28 ,  C08K5/0041 ,  G03F7/40 ,  Y10T428/24479

Abstract: Polymers, methods of use thereof, and methods of decomposition thereof, are provided. One exemplary polymer, among others, includes, a photodefinable polymer having a sacrificial polymer and a photoinitiator.

Abstract translation: 提供聚合物，其使用方法及其分解方法。 一个示例性聚合物，其中包括具有牺牲聚合物和光引发剂的光可定义聚合物。

公开(公告)号：US07957155B2

公开(公告)日：2011-06-07

申请号：US11377818

申请日：2006-03-15

Applicant: Harold B. Kent ,  Steven T. Kent

Inventor： Harold B. Kent ,  Steven T. Kent

IPC: H05K7/06

CPC classification number: H05K7/06 ,  A61M25/0021 ,  A61M25/0023 ,  A61M25/0043 ,  A61M25/0045 ,  A61M25/005 ,  A61M2025/0037 ,  A61M2025/004 ,  B01L3/5027 ,  B81B2201/058 ,  B81C3/008 ,  H05K1/0272 ,  H05K1/182 ,  H05K1/183 ,  H05K3/341 ,  H05K3/3447 ,  H05K3/368 ,  H05K3/4046 ,  H05K2201/10265 ,  Y02P70/613 ,  Y10T29/4902 ,  Y10T29/49117 ,  Y10T137/0318 ,  Y10T137/8593

Abstract: A method and system for transporting a fluid, gas, semi-solid, cryogen, or particulate matter, or combination thereof, between a three-dimensional structure and a substantially two-dimensional structure is disclosed. A system and method for electrically coupling a three-dimensional structure to a substantially two dimensional structure is also disclosed.

Abstract translation: 公开了一种用于在三维结构和基本上二维结构之间输送流体，气体，半固体，低温或颗粒物质或其组合的方法和系统。 还公开了一种将三维结构电耦合到基本二维结构的系统和方法。

公开(公告)号：US07923379B2

公开(公告)日：2011-04-12

申请号：US12347250

申请日：2008-12-31

Applicant: Jiou-Kang Lee ,  Ting-Hau Wu ,  Shang-Ying Tsai ,  Jung-Huei Peng ,  Chun-Ren Cheng

Inventor： Jiou-Kang Lee ,  Ting-Hau Wu ,  Shang-Ying Tsai ,  Jung-Huei Peng ,  Chun-Ren Cheng

IPC: H01L21/31

CPC classification number: B81C1/00071 ,  B81B2201/052 ,  B81B2201/058 ,  H01L21/76898

Abstract: A method of forming an integrated circuit structure includes forming an opening in a substrate, with the opening extending from a top surface of the substrate into the substrate. The opening is filled with a filling material until a top surface of the filling material is substantially level with the top surface of the substrate. A device is formed over the top surface of the substrate, wherein the device includes a storage opening adjoining the filling material. A backside of the substrate is grinded until the filling material is exposed. The filling material is removed from the channel until the storage opening of the device is exposed.

Abstract translation: 形成集成电路结构的方法包括在衬底中形成开口，其中开口从衬底的顶表面延伸到衬底中。 开口填充有填充材料，直到填充材料的顶表面基本上与基板的顶表面平齐。 在衬底的顶表面上形成器件，其中该器件包括与填充材料相邻的存储开口。 研磨衬底的背面，直到填充材料暴露。 将填充材料从通道中取出直到设备的存储开口露出。

公开(公告)号：US20110038767A1

公开(公告)日：2011-02-17

申请号：US12846692

申请日：2010-07-29

Applicant: Daniel J. Baril

Inventor： Daniel J. Baril

IPC: B01L3/00 ,  B32B38/14 ,  B32B38/00

CPC classification number: B01L3/5027 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406 ,  B29C65/482 ,  B29C65/4825 ,  B29C65/483 ,  B29C65/4835 ,  B29C65/4845 ,  B29C65/522 ,  B29C65/526 ,  B29C66/1122 ,  B29C66/45 ,  B29C66/71 ,  B29C66/73171 ,  B29C66/73175 ,  B29L2031/737 ,  B29L2031/756 ,  B81B2201/058 ,  B81C99/0095 ,  B81C2201/019 ,  Y10T156/10 ,  Y10T428/24843 ,  Y10T428/24851 ,  B29K2067/00

Abstract: A method of making a microfluidic diagnostic device for use in the assaying of biological fluids, whereby a layer of adhesive in a channel pattern is printed onto a surface of a base sheet and a cover sheet is adhered to the base sheet with the adhesive. The layer of adhesive defines at least one channel, wherein the channel passes through the thickness of the adhesive layer.

Abstract translation: 一种制造用于生物流体测定的微流体诊断装置的方法，其中将通道图案中的粘合剂层印刷到基片的表面上，并且覆盖片用粘合剂粘附到基片上。 粘合剂层限定至少一个通道，其中通道穿过粘合剂层的厚度。

公开(公告)号：US20110033887A1

公开(公告)日：2011-02-10

申请号：US12679497

申请日：2008-09-24

Applicant: Nicholas X. Fang ,  Chunguang Xia ,  Andrew Cox

Inventor： Nicholas X. Fang ,  Chunguang Xia ,  Andrew Cox

IPC: C12M3/00 ,  G03F7/20 ,  C12P1/00 ,  G01D18/00

CPC classification number: C12M23/16 ,  B01L3/502707 ,  B33Y10/00 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00119 ,  B81C99/0095

Abstract: In an aspect, the present invention uses projection micro stereolithography to generate three-dimensional microvessel networks that are capable of supporting and fostering growth of a cell population. For example, provided is a method of making a microvascularized bioreactor via layer-by-layer polymerization of a photocurable liquid composition with repeated patterns of illumination, wherein each layer corresponds to a layer of the desired microvessel network. The plurality of layers are assembled to make a microvascular network. Support structures having different etch rates than the structures that make up the network provides access to manufacturing arbitrary geometries that cannot be made by conventional methods. A cell population is introduced to the external wall of the network to obtain a microvascularized bioreactor. Provided are various methods and related bioreactors, wherein the network wall has a permeability to a biological material that varies within and along the network.

Abstract translation: 在一方面，本发明使用投影微立体光刻术来产生能够支持和促进细胞群体生长的三维微血管网络。 例如，提供了通过具有重复照明模式的光固化液体组合物的逐层聚合制备微血管化生物反应器的方法，其中每层对应于所需微血管网络的层。 组合多个层以形成微血管网络。 具有与组成网络的结构不同的蚀刻速率的支撑结构提供了对通过常规方法不能制造的任意几何形状的访问。 将细胞群引入网络的外壁以获得微血管生物反应器。 提供了各种方法和相关的生物反应器，其中网络壁具有在网络内和沿网络变化的生物材料的渗透性。

公开(公告)号：US20110033338A1

公开(公告)日：2011-02-10

申请号：US12936839

申请日：2009-04-10

Applicant: Sin Kil Cho ,  Seok Chung

Inventor： Sin Kil Cho ,  Seok Chung

IPC: G01N33/48 ,  B29C65/08 ,  B29C65/14

CPC classification number: B29C66/3022 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2200/0689 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  B29C65/02 ,  B29C65/08 ,  B29C65/1635 ,  B29C65/168 ,  B29C65/48 ,  B29C65/4895 ,  B29C65/8253 ,  B29C66/1122 ,  B29C66/30223 ,  B29C66/53461 ,  B29C66/71 ,  B29C66/8322 ,  B29K2033/08 ,  B29K2033/12 ,  B29K2069/00 ,  B29L2031/756 ,  B81B3/0094 ,  B81B2201/0214 ,  B81B2201/051 ,  B81B2201/058 ,  B81B2203/0338 ,  B81B2203/0392 ,  B81C1/00103 ,  B81C2201/019 ,  B29K2083/00

Abstract: A microfluidic circuit element comprising a microfluidic channel, in which the microfluidic channel has nano interstices formed at both sides thereof and having a height less than that of the center of the channel, gives more driving force of the microfluidic channel and provides stable flow of a fluid.

Abstract translation: 一种微流体电路元件，包括微流体通道，其中微流体通道在其两侧形成有具有低于通道中心的高度的纳米空隙，给予更多的微流体通道的驱动力并提供稳定的流动 流体。

公开(公告)号：US20100310437A1

公开(公告)日：2010-12-09

申请号：US12867242

申请日：2009-01-21

Applicant: Hiroshi Hirayama ,  Takuji Hatano

Inventor： Hiroshi Hirayama ,  Takuji Hatano

IPC: B81B1/00 ,  B01L3/00 ,  B32B37/00

CPC classification number: B81C1/00071 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0887 ,  B29C65/1406 ,  B29C65/1612 ,  B29C65/1648 ,  B29C65/1683 ,  B29C65/18 ,  B29C65/48 ,  B29C65/4845 ,  B29C65/8223 ,  B29C65/8246 ,  B29C66/112 ,  B29C66/1122 ,  B29C66/3452 ,  B29C66/53461 ,  B29C66/71 ,  B29C66/919 ,  B29C66/929 ,  B29L2031/756 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C2201/019 ,  B29K2009/00 ,  B29K2023/06 ,  B29K2023/12 ,  B29K2023/38 ,  B29K2025/06 ,  B29K2027/06 ,  B29K2027/08 ,  B29K2031/04 ,  B29K2033/12 ,  B29K2033/20 ,  B29K2067/003 ,  B29K2069/00 ,  B29K2077/00 ,  B29K2083/00

Abstract: Provided are a microchip formed by joining a resinous film onto a resinous substrate, which enables the prevention of a leak due to peeling of a peripheral portion and prevention of deformation and clogging of a microchannel, and a method for manufacturing the same. The microchip comprises a resinous substrate including a first surface in which a channel groove is formed and a second surface on the side opposite to the first surface, and a resinous film joined to the first surface of the resinous substrate. A joint plane between the resinous substrate and the resinous film is composed of a central area including an area in which the channel groove is formed and a peripheral area corresponding to the outer periphery of the central area, the joint strength between the resinous substrate and the resinous film in the central area is larger than 0.098 N/cm, and the joint strength in at least part of the peripheral area of the joint plane is larger than the joint strength in the central area.

Abstract translation: 提供一种通过将树脂膜接合到树脂基板上而形成的微芯片，其能够防止由于周边部分的剥离而导致的泄漏，并且防止微通道的变形和堵塞及其制造方法。 微芯片包括树脂基板，其包括形成沟槽的第一表面和与第一表面相对的一侧上的第二表面，以及与树脂基板的第一表面接合的树脂膜。 树脂基材和树脂膜之间的接合面由包括形成沟槽的区域和与中心区域的外周对应的周边区域的中心区域构成，树脂基板与树脂基板的接合强度 中心区域的树脂膜大于0.098N / cm，接合面的周边区域的至少一部分的接合强度大于中心区域的接合强度。

公开(公告)号：US20100277722A1

公开(公告)日：2010-11-04

申请号：US12237398

申请日：2008-09-25

Applicant: Karsten KRAICZEK ,  Beno MUELLER ,  Timothy BEERLING

Inventor： Karsten KRAICZEK ,  Beno MUELLER ,  Timothy BEERLING

IPC: G01N21/01 ,  G01N30/74 ,  G01N21/05 ,  G01N27/26 ,  H01L21/02

CPC classification number: G01N30/74 ,  B81B2201/058 ,  B81B2203/0338 ,  B81B2203/0392 ,  B81C1/00071 ,  H01L31/101

Abstract: An integrated flow cell, the flow cell comprising a semiconductor substrate, and a fluidic conduit having an at least partially transparent semiconductor oxide tubing, wherein the semiconductor oxide tubing is formed with the semiconductor substrate.

Abstract translation: 集成流通池，所述流动池包括半导体衬底和具有至少部分透明的半导体氧化物管的流体导管，其中所述半导体氧化物管与所述半导体衬底形成。