公开(公告)号：US20130302212A1

公开(公告)日：2013-11-14

申请号：US13979858

申请日：2012-01-19

Applicant: Akihito Wakui ,  Hajime Yamazaki

Inventor： Akihito Wakui ,  Hajime Yamazaki

IPC: G01N21/47

CPC classification number: G01N21/47 ,  G01N21/253 ,  G01N21/51 ,  G01N33/49 ,  G01N33/493 ,  G01N35/025 ,  G01N2021/0325 ,  G01N2021/513 ,  G01N2021/825 ,  G01N2035/0444 ,  G01N2201/0415

Abstract: The invention provides an automatic analyzer having a scattered-light detecting optical system in which a light source is disposed at an angle with respect to a plane of a reaction vessel. This reduces the amount of a sample-reagent mix required for an analysis, thereby reducing the running cost of reagents as well, and also allows relatively free design of reaction vessels in terms of their sizes and shapes. The automatic analyzer includes: a reaction vessel in which a sample is caused to react with a reagent; a reaction disk on which to place reaction vessels in the form of a circle; a reaction disk rotating mechanism for rotating the reaction disk; a light source for radiating light to be measured onto one of the reaction vessels; and a photodetector for detecting transmissive light radiated from the light source and passing through a sample-reagent mix in the one of the reaction vessels. The automatic analyzer further includes an optical system for causing the light source to radiate light onto one of the reaction vessels at an angle with respect to a plane of the one of the reaction vessels.

Abstract translation: 本发明提供了一种具有散射光检测光学系统的自动分析仪，其中光源相对于反应容器的平面以一定角度设置。 这减少了分析所需的样品 - 试剂混合物的量，从而降低了试剂的运行成本，并且还允许反应容器在其尺寸和形状方面相对自由地设计。 自动分析装置包括：使试样与试剂反应的反应容器; 将反应容器置于圆形的反应盘上; 用于旋转反作用盘的反作用盘旋转机构; 用于将待测量的光照射到其中一个反应容器上的光源; 以及光检测器，用于检测从光源辐射并穿过反应容器之一中的样品 - 试剂混合物的透射光。 自动分析仪还包括一个光学系统，用于使光源相对于一个反应容器的平面以一定角度将光辐射到一个反应容器中。

公开(公告)号：US08501461B2

公开(公告)日：2013-08-06

申请号：US12630302

申请日：2009-12-03

Applicant: Byron J. Knight ,  Haitao Li

Inventor： Byron J. Knight ,  Haitao Li

IPC: C12M1/34 ,  C12M3/00

CPC classification number: G01N21/6428 ,  B01L7/52 ,  C12Q1/6813 ,  C12Q1/6851 ,  G01N21/6454 ,  G01N21/76 ,  G01N35/00693 ,  G01N35/0092 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/028 ,  G01N35/04 ,  G01N35/1002 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2035/00346 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0097 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0455 ,  G01N2035/0491 ,  G01N2035/103 ,  G01N2201/0415 ,  Y10S435/808 ,  Y10S435/809 ,  Y10T436/113332 ,  Y10T436/25 ,  C12Q2537/165

Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.

Abstract translation: 用于同时执行多个诊断测定的自动分析器包括多个站，其中在样品容器中包含的流体样品上执行测定的离散方面。 分析仪包括用于自动准备样品，孵育样品，预先分析分析程序，确定目标分析物的存在以及分析目标分析物的量的站。 自动化容器输送系统将样品容器从一个站移动到另一个站。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程，并且在一个实施方案中，用于实时监测扩增过程的方法。

公开(公告)号：US20120282137A1

公开(公告)日：2012-11-08

申请号：US13516006

申请日：2011-01-21

Applicant: Goro Yoshida

Inventor： Goro Yoshida

IPC: G01N21/75

CPC classification number: G01N21/90 ,  G01N21/253 ,  G01N21/9018 ,  G01N35/00623 ,  G01N35/025 ,  G01N2021/0325 ,  G01N2201/0415

Abstract: Reaction vessels and a reaction vessel detecting mechanism are disposed on the outer circumference of a reaction disk. A positional detector for detecting the position of a reaction vessel is placed on the track of the reaction vessels. A light source and a spectrophotometer are also disposed so as to sandwich one of the reaction vessels, thereby measuring the light intensity of the reaction vessels. With this arrangement, the steps of: repetitively starting and stopping the rotation of the reaction disk with high resolution; conducting photometric measurement while the reaction disk is being halted; and acquiring an absorbance distribution of the reaction vessels are performed. This makes it possible for an automatic analyzer, which examines particular constituents of a biological sample (e.g., blood and urine), to detect contaminants and scars on the reaction vessels in a separate manner, thereby ensuring the high quality of the reaction vessels.

Abstract translation: 反应容器和反应容器检测机构设置在反应盘的外周。 用于检测反应容器位置的位置检测器被放置在反应容器的轨道上。 还设置光源和分光光度计，以夹住反应容器中的一个，从而测量反应容器的光强度。 采用这种布置方式，重复地以高分辨率反复启动和停止反作用盘的旋转; 在反应盘停止时进行光度测量; 并获得反应容器的吸光度分布。 这使得检测生物样品（例如血液和尿液）的特定组分的自动分析仪可以以分离的方式检测反应容器上的污染物和疤痕，从而确保反应容器的高品质。

公开(公告)号：US20120088265A1

公开(公告)日：2012-04-12

申请号：US12899910

申请日：2010-10-07

Applicant: Rajesh Guntupalli ,  Nilmini Viswaprakash

Inventor： Rajesh Guntupalli ,  Nilmini Viswaprakash

IPC: C12Q1/04 ,  C12M1/34

CPC classification number: G01N21/59 ,  C12Q1/04 ,  G01N2201/022 ,  G01N2201/0415 ,  G01N2201/0646

Abstract: The present invention is a mold pathogen detection apparatus in which an agar strip is exposed to the environment being tested for a period of time and then exposed to a non-UV light to determine the amount of light passing through the agar strip.

Abstract translation: 本发明是一种霉菌病原体检测装置，其中将琼脂条暴露于被测试的环境一段时间，然后暴露于非UV光以确定通过琼脂条的光量。

公开(公告)号：US20110110822A1

公开(公告)日：2011-05-12

申请号：US13002664

申请日：2009-07-30

Applicant: Sakuichiro Adachi ,  Kunio Harada ,  Isao Yamazaki ,  Masaharu Kiyama ,  Takeshi Fujita

Inventor： Sakuichiro Adachi ,  Kunio Harada ,  Isao Yamazaki ,  Masaharu Kiyama ,  Takeshi Fujita

IPC: G01N21/59

CPC classification number: G01N21/253 ,  G01N21/0332 ,  G01N21/255 ,  G01N35/025 ,  G01N2035/00386 ,  G01N2035/0455 ,  G01N2201/0231 ,  G01N2201/0415 ,  G01N2201/0453 ,  G01N2201/0624 ,  G01N2201/0627

Abstract: Using an LED element as a light source, a photometric unit including the light source, a light receiving element and other components therebetween is reduced in size. A holder 30 detachable from the device as a unit holds a light emission unit 15 formed of an LED and a light receiving element 21, and the holder is placed inside a thermostatic chamber 18 which holds a constant temperature fluid 17. Thus, the photometric unit is reduced in size.

Abstract translation: 使用LED元件作为光源，包括光源，光接收元件和其间的其它部件的光度单元的尺寸减小。 从装置作为一个单元可拆卸的保持器30保持由LED和光接收元件21形成的发光单元15，并且保持器放置在保持恒温流体17的恒温室18内部。因此，测光单元 尺寸减小。

公开(公告)号：US20110008825A1

公开(公告)日：2011-01-13

申请号：US12682402

申请日：2008-10-10

Applicant: Gal Ingber ,  William G. Atterbury ,  Russell H. Barnes ,  Douglas E. Boyd ,  Joseph D. Dennis ,  Jonathan Gurfinkel ,  Dave Holley ,  Steven E. Huckaby ,  Thomas A. Klausing ,  John S. Laudo ,  Kevin Sadeski ,  Jason A. Schaefer ,  K. Bryan Scott ,  Carol Stillman ,  Sherwood Talbert ,  John Tallarico

Inventor： Gal Ingber ,  William G. Atterbury ,  Russell H. Barnes ,  Douglas E. Boyd ,  Joseph D. Dennis ,  Jonathan Gurfinkel ,  Dave Holley ,  Steven E. Huckaby ,  Thomas A. Klausing ,  John S. Laudo ,  Kevin Sadeski ,  Jason A. Schaefer ,  K. Bryan Scott ,  Carol Stillman ,  Sherwood Talbert ,  John Tallarico

IPC: C12Q1/06 ,  C12M1/34

CPC classification number: G01N33/493 ,  C12Q1/04 ,  G01N21/0303 ,  G01N35/025 ,  G01N35/04 ,  G01N2021/6482 ,  G01N2035/0436 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0458 ,  G01N2201/0415

Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.

Abstract translation: 用于进行微生物识别和定量的系统，例如尿样中的细菌，其包括：1）几个用于保持四个一次性组件的一次性盒，包括离心管，具有1ml体积的移液管尖端，第二移液管尖 具有0.5ml体积，以及光学杯或比色皿; 2）用于接收一次性盒并且处理尿液样品的样品处理器，包括将经处理的尿样转移到光学杯; 以及3）用于接收一次性盒并用于分析尿样中的微生物的类型和数量的光学分析仪。 在样品处理器中使用具有包括光学杯或比色皿的组件的一次性盒，并且在光学分析仪中使用含有经处理的尿液样品的光学杯或比色杯，用于鉴定和定量存在于加工过程中的微生物的类型 尿样。

公开(公告)号：US07794659B2

公开(公告)日：2010-09-14

申请号：US11372223

申请日：2006-03-10

Applicant: Gary D. Lair ,  Thanh N. Nguyen ,  Haitao Li ,  Florence F. Li ,  Byron J. Knight ,  Robert E. Heinz ,  Jerzy A. Macioszek ,  Christopher B. Davis ,  Robert F. Scalese

Inventor： Gary D. Lair ,  Thanh N. Nguyen ,  Haitao Li ,  Florence F. Li ,  Byron J. Knight ,  Robert E. Heinz ,  Jerzy A. Macioszek ,  Christopher B. Davis ,  Robert F. Scalese

IPC: G01N33/00

CPC classification number: G01N21/6428 ,  B01L7/52 ,  C12Q1/6813 ,  C12Q1/6851 ,  G01N21/6454 ,  G01N21/76 ,  G01N35/00693 ,  G01N35/0092 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/028 ,  G01N35/04 ,  G01N35/1002 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2035/00346 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0097 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0455 ,  G01N2035/0491 ,  G01N2035/103 ,  G01N2201/0415 ,  Y10S435/808 ,  Y10S435/809 ,  Y10T436/113332 ,  Y10T436/25 ,  C12Q2537/165

Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.

Abstract translation: 用于同时执行多个诊断测定的自动化分析仪包括多个站，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备样品，孵育样品，预先分析分析程序，确定目标分析物的存在以及分析目标分析物的量的站。 自动插座输送系统将反应容器从一个站移动到另一个站。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程，并且在一个实施方案中，用于实时监测扩增过程的方法。

公开(公告)号：US20100045994A1

公开(公告)日：2010-02-25

申请号：US12613422

申请日：2009-11-05

Applicant: Yuji Ogawa

Inventor： Yuji Ogawa

IPC: G01N21/00

CPC classification number: G01N21/253 ,  G01N35/025 ,  G01N2021/3181 ,  G01N2201/0415 ,  G01N2201/0627

Abstract: A photometric apparatus and an automatic analyzer in which liquid samples contained in vessels are measured with light of different wavelengths while the vessels are transferred are provided. A photometric apparatus includes light sources that are arranged in the movement direction of a vessel and emit light of different wavelengths, light-receiving devices that are located opposing the light sources with the vessels interposed inbetween and receive light of different wavelengths emitted from the light sources. The arrangement length of light sources along the movement direction of the vessels is shorter than the arrangement pitch of the vessels.

Abstract translation: 提供了一种测量装置和自动分析器，其中容纳在容器中的液体样品在容器转移时用不同波长的光测量。 一种测光装置包括沿容器的移动方向布置并发射不同波长的光的光源;与容器相对设置的光接收装置，其间插入有容器，并接收从光源发射的不同波长的光 。 沿着船舶移动方向的光源的布置长度比船舶的排列间距短。

公开(公告)号：US20080285025A1

公开(公告)日：2008-11-20

申请号：US12121120

申请日：2008-05-15

Applicant: Sakuichiro ADACHI

Inventor： Sakuichiro ADACHI

IPC: G01J3/00

CPC classification number: G01N21/253 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/04 ,  G01J3/36 ,  G01J3/42 ,  G01N21/13 ,  G01N21/255 ,  G01N2021/0325 ,  G01N2021/115 ,  G01N2021/3155 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0618

Abstract: A light amount is increased and an analyzing accuracy can be kept in accordance with an enlargement of a load angle, however, a scattered light tends to be loaded in an analysis accompanying the scattered light and a dynamic range of a concentration which can be measured becomes narrow. A light is dispersed by a light dispersing portion, a load angle of the received light is changed per wavelength, the load angle is made larger in the light of a wavelength having a small light amount, and the load angle is made smaller in the light a wavelength having a large light amount and used for an analysis accompanying a scattered light. Accordingly, it is possible to gain a dynamic range of a concentration which can be measured in the analysis accompanying the scattered light, while increasing the light amount and maintaining the analyzing accuracy.

Abstract translation: 光量增加，并且可以根据负载角的放大来保持分析精度，然而，伴随散射光的分析倾向于加载散射光，并且可测量的浓度的动态范围变为 狭窄。 通过光分散部分散射光，每波长改变接收光的负载角度，在具有小光量的波长的光中使负载角变大，并且使光的负载角变小 具有大光量的波长并用于伴随散射光的分析。 因此，在增加光量并保持分析精度的同时，可以获得在伴随散射光的分析中可以测量的浓度的动态范围。

公开(公告)号：US20080273205A1

公开(公告)日：2008-11-06

申请号：US11936117

申请日：2007-11-07

Applicant: Jeong-gun Lee ,  Jung-nam Lee ,  Yoon-kyoung Cho ,  Jung-suk Yoo

Inventor： Jeong-gun Lee ,  Jung-nam Lee ,  Yoon-kyoung Cho ,  Jung-suk Yoo

IPC: G01N21/00

CPC classification number: G01N35/00069 ,  G01N21/07 ,  G01N21/253 ,  G01N21/64 ,  G01N21/6452 ,  G01N2201/0415 ,  G01N2201/0696

Abstract: An optical detection apparatus and method using a phase sensitive detection method for a disk-type microfluidic device are provided. The optical detection apparatus includes: a rotation driving unit stopping rotation of the microfluidic device when a detection area of the disk-type microfluidic device reaches a predetermined position; at least one light source turned on and off at a corresponding frequency to emit light to the detection area held at the predetermined position; an optical sensor disposed to face the detection area and generating an electrical signal according to intensity of incident light; and a signal processing unit receiving the electrical signal generated by the optical sensor and outputting only a signal having a same frequency as an on/off frequency of one of the at least one light source.

Abstract translation: 提供了一种使用盘式微流体装置的相敏检测方法的光学检测装置和方法。 光学检测装置包括：当盘式微流体装置的检测区域到达预定位置时，旋转驱动单元停止微流体装置的旋转; 至少一个光源以相应的频率开启和关闭以向保持在预定位置的检测区域发光; 光传感器，其设置成面对检测区域并根据入射光的强度产生电信号; 以及信号处理单元，其接收由所述光学传感器产生的电信号，并且仅输出与所述至少一个光源中的一个光源的开/关频率具有相同频率的信号。