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    Enhanced instrumentation and method for optical measurement of samples
    3.
    发明授权
    Enhanced instrumentation and method for optical measurement of samples 有权
    增强了样品光学测量仪器和方法

    公开(公告)号：US07843568B2

    公开(公告)日：2010-11-30

    申请号：US12692758

    申请日：2010-01-25

    Applicant: Petri Kivela

    Inventor： Petri Kivela

    IPC: G01N21/25

    CPC classification number: G01N21/253 ,  G01N21/13 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0826 ,  G01N2201/103

    Abstract: The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrumentation wherein a sample (281-285) is activated (212AS, 218AS) and the emission is detected (291, 292), wherein between the activation and detection phases of measuring the sample, a shift is made in the relative position between the sample and means (218) directing the activation radiation to the sample as well as in the relative position between the sample and the means (293) receiving the emission radiation from the sample. This can be implemented e.g. by moving (299) the sample assay plate and/or a measuring head between the activation and emission phases of a sample. The invention allows a simultaneous activation of a first sample and detecting emission from a second sample thus enhancing efficiency of the measurement.

    Abstract translation: 本发明一般涉及生物化学实验室仪器的领域，用于不同应用样品的测量性质。 微量滴定板和相应的样品支架。 本发明的目的是通过提供一种光学测量仪器实现的，其中样品（281-285）被激活（212AS，218AS）并且检测到发射（291,292），其中在测量样品的激活和检测阶段之间 在样品和将激活辐射指向样品的装置（218）之间的相对位置以及样品和接收来自样品的发射辐射的装置（293）之间的相对位置进行位移。 这可以被实现。 通过在样品的活化和发射阶段之间移动（299）样品测定板和/或测量头。 本发明允许同时激活第一样品并检测来自第二样品的发射，从而提高测量的效率。

    SPECTROPHOTOMETRIC OPTICAL SYSTEM OF MICROPLATE READER AND FILTER WHEEL THEREOF
    4.
    发明申请
    SPECTROPHOTOMETRIC OPTICAL SYSTEM OF MICROPLATE READER AND FILTER WHEEL THEREOF 有权
    微波读数器和滤光片的光谱光学系统

    公开(公告)号：US20080062421A1

    公开(公告)日：2008-03-13

    申请号：US11564446

    申请日：2006-11-29

    Applicant: Lihua ZHOU ,  Jinhong QIU

    Inventor： Lihua ZHOU ,  Jinhong QIU

    IPC: G01N21/25 ,  G01N21/51

    CPC classification number: G01J3/51 ,  G01J3/0243 ,  G01J3/12 ,  G01J2003/1217 ,  G01N2201/0453

    Abstract: A spectrophotometric optical system of a microplate reader and a filter wheel thereof are disclosed. The filter wheel comprises a pivotable wheel body, at least one narrow-band filter with a relatively long central wavelength mounted to the wheel body, and at least one narrow-band filter with a relatively short central wavelength mounted to the wheel body. The narrow-band filter with a relatively long central wavelength is provided with a diaphragm on a front surface thereof The diaphragm is formed with a plurality of apertures. A ratio of a total effective area of the plurality of apertures to an effective area of the narrow-band filter with a relatively short central wavelength is equivalent to a ratio of energy amounts of shorter wavelength light passed through the narrow-band filter with a relatively short central wavelength to energy amounts of longer wavelength light passed through the narrow-band filter with a relatively long central wavelength when the diaphragm is not disposed. By the diaphragm attached to the front surface of the narrow-band filter with a relatively long central wavelength, an energy matching between light of longer wavelength and light of shorter wavelength may be achieved. Further, due to the uniformly distributed apertures in the diaphragm, an even light spot may be obtained.

    Abstract translation: 公开了微板读数器及其滤光轮的分光光度学系统。 所述滤光轮包括可枢转的轮体，至少一个安装在所述车轮主体上的具有较长的中心波长的窄带过滤器以及至少一个具有相对短的中心波长的窄带过滤器，安装在所述车轮主体上。 具有相对长的中心波长的窄带滤光片在其前表面上设置有隔膜。隔膜形成有多个孔。 多个孔的总有效面积与具有相对短的中心波长的窄带滤光器的有效面积的比率等于通过窄带滤光器的较短波长光的能量比与相对 当不设置隔膜时，较长的中心波长与较长波长的光的能量通过具有较长的中心波长的窄带滤光器。 通过附着在具有较长中心波长的窄带滤光片的前表面的光阑，可以实现较长波长的光与较短波长的光之间的能量匹配。 此外，由于隔膜中均匀分布的孔，可以获得均匀的光点。

    Instrumentation and Method Adapted For Optical Measurement of an Amplified Luminescent Proximity Homogeneous Assay
    5.
    发明申请
    Instrumentation and Method Adapted For Optical Measurement of an Amplified Luminescent Proximity Homogeneous Assay 审中-公开
    适用于放大发光近距均匀测定的光学测量的仪器和方法

    公开(公告)号：US20070247628A1

    公开(公告)日：2007-10-25

    申请号：US11662468

    申请日：2004-09-10

    Applicant: Petri Kivelä

    Inventor： Petri Kivelä

    IPC: G01N21/00

    CPC classification number: G01N21/253 ,  G01N21/13 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0826 ,  G01N2201/103

    Abstract: The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on microtitration plates and corresponding sample supports. An optical measurement instrumentation is provided, a sample is activated and the emission is detected, wherein between the activation and detection phases of measuring the sample, a shift is made in the relative position between the sample and elements directing the activation radiation to the sample as well as in the relative position between the sample and the elements receiving the emission radiation from the sample. This can be implemented e.g. by moving the sample assay plate and/or a measuring head between the activation and emission phases of a sample. The invention allows a simultaneous activation of a first sample and detecting emission from a second sample thus enhancing efficiency of the measurement.

    Abstract translation: 本发明一般涉及生物化学实验室仪器领域，用于不同应用样品在微量滴定板和相应样品载体上的测量性质。 提供光学测量仪器，激活样品并检测发射，其中在测量样品的激活和检测阶段之间，在将样品和将激活辐射指向样品的元件之间的相对位置进行偏移，作为 以及在样品和接收来自样品的发射辐射的元件之间的相对位置。 这可以被实现。 通过在样品的活化和发射阶段之间移动样品测定板和/或测量头。 本发明允许同时激活第一样品并检测来自第二样品的发射，从而提高测量的效率。

    LED densitometer for microtiter plate
    6.
    发明授权
    LED densitometer for microtiter plate 有权
    用于微量滴定板的LED光密度计

    公开(公告)号：US09243996B2

    公开(公告)日：2016-01-26

    申请号：US13383986

    申请日：2010-07-16

    Applicant: Peter Van Praet

    Inventor： Peter Van Praet

    IPC: G01N21/00 ,  G01N21/25

    CPC classification number: G01N21/00 ,  G01N21/253 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0627 ,  G01N2201/10

    Abstract: Light emitting diodes (LEDs) are mounted in an array to an upper structure overlying a lower structure with a plurality of light detectors thereon. Each LED is configured to overlie a separate detector. Each LED emits light at a frequency relevant for measuring optical density of a specimen. LEDs having different frequencies are included within the LED array. A corresponding array of detectors is also provided, mounted to the lower structure. Spacing between adjacent LEDs and between adjacent detectors match a spacing between wells in a microtiter plate. Spacing between the lower structure and the upper structure supporting the LEDs is sufficient for the microtiter plate to fit between. Circuitry sequentially fires individual LEDs and gathers optical density data through the detectors for specimens in the wells of the microtiter plate. The structures are then moved to a next adjacent well position on the microtiter plate and the process repeated.

    Abstract translation: 发光二极管（LED）以阵列的形式安装在覆盖下部结构的上部结构上，其上具有多个光检测器。 每个LED被配置为覆盖单独的检测器。 每个LED以与测量样品的光密度相关的频率发光。 具有不同频率的LED包括在LED阵列内。 还提供了相应的检测器阵列，安装到下部结构。 相邻LED之间和相邻检测器之间的间距与微量滴定板中的孔之间的间距相匹配。 支撑LED的下部结构和上部结构之间的间距足以使微量滴定板相适应。 电路依次点火各个LED，并通过微量滴定板孔中的标本的检测器收集光密度数据。 然后将结构移动到微量滴定板上的下一个相邻的孔位置，并重复该过程。

    Biochemical analyzer
    8.
    发明授权
    Biochemical analyzer 有权
    生化分析仪

    公开(公告)号：US07978325B2

    公开(公告)日：2011-07-12

    申请号：US12121120

    申请日：2008-05-15

    Applicant: Sakuichiro Adachi

    Inventor： Sakuichiro Adachi

    IPC: G01J3/04 ,  G01J3/28

    CPC classification number: G01N21/253 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/04 ,  G01J3/36 ,  G01J3/42 ,  G01N21/13 ,  G01N21/255 ,  G01N2021/0325 ,  G01N2021/115 ,  G01N2021/3155 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0618

    Abstract: A light amount is increased and an analyzing accuracy can be kept in accordance with an enlargement of a load angle, however, a scattered light tends to be loaded in an analysis accompanying the scattered light and a dynamic range of a concentration which can be measured becomes narrow. A light is dispersed by a light dispersing portion, a load angle of the received light is changed per wavelength, the load angle is made larger in the light of a wavelength having a small light amount, and the load angle is made smaller in the light a wavelength having a large light amount and used for an analysis accompanying a scattered light. Accordingly, it is possible to gain a dynamic range of a concentration which can be measured in the analysis accompanying the scattered light, while increasing the light amount and maintaining the analyzing accuracy.

    Abstract translation: 光量增加，并且可以根据负载角的放大来保持分析精度，然而，伴随散射光的分析倾向于加载散射光，并且可测量的浓度的动态范围变为 狭窄。 通过光分散部分散射光，每波长改变接收光的负载角度，在具有小光量的波长的光中使负载角变大，并且使光的负载角变小 具有大光量的波长并用于伴随散射光的分析。 因此，在增加光量并保持分析精度的同时，可以获得在伴随散射光的分析中可以测量的浓度的动态范围。

    Multiphoton excitation microscope for biochip fluorescence assay
    9.
    发明申请
    Multiphoton excitation microscope for biochip fluorescence assay 有权
    用于生物芯片荧光测定的多光子激发显微镜

    公开(公告)号：US20030222222A1

    公开(公告)日：2003-12-04

    申请号：US10160251

    申请日：2002-06-04

    Applicant: National Taiwan University

    Inventor： Chen-Yuan Dong ,  Peter T.C. So ,  Sunney I. Chan

    IPC: G01N021/64

    CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0446 ,  G01N2201/0453

    Abstract: This invention provides a multiphoton excitaion microscope for simultaneously detecting differently colored fluorescence materials on biochips, which includes a multiphoton excitation source, objectives, and a plurality of detection channels. The biochip is hybridized and labeled with fluorescence materials for expressing hybridized biological signals. The multiphoton excitation source is focused to a light spot on the biochip to excite the fluorescence materials bound thereon. After that, the fluorescence emission at different wavelengths from the different fluorescent materials can be detected by the plural detection channels.

    Abstract translation: 本发明提供了一种多光子激发显微镜，用于同时检测生物芯片上的不同颜色的荧光材料，其包括多光子激发源，物镜和多个检测通道。 将生物芯片杂交并用用于表达杂交的生物信号的荧光材料标记。 多光子激发源被聚焦到生物芯片上的光点以激发结合在其上的荧光材料。 之后，可以通过多个检测通道检测来自不同荧光材料的不同波长的荧光发射。

    OPTICAL DETECTION APPARATUS AND OPTICAL MEASUREMENT SYSTEM
    10.
    发明申请
    OPTICAL DETECTION APPARATUS AND OPTICAL MEASUREMENT SYSTEM 有权
    光学检测装置和光学测量系统

    公开(公告)号：US20130100434A1

    公开(公告)日：2013-04-25

    申请号：US13307004

    申请日：2011-11-30

    Applicant: Chao-Ming Chen

    Inventor： Chao-Ming Chen

    IPC: G01N33/48 ,  G01N21/17

    CPC classification number: G01N33/49 ,  G01N21/253 ,  G01N2201/0423 ,  G01N2201/0453 ,  G01N2201/0627

    Abstract: An optical detection apparatus which is capable of measuring a sample is provided. The optical detection apparatus includes a plurality of light emission units, a light receiving unit, a driving unit, and an analyzing unit. Each of the light emission units is capable of emitting a light beam. The light receiving unit is capable of receiving the light beam passing through the sample and is capable of converting the received light beam to an electrical signal. The driving unit is capable of changing the relative position of the light emission units and the sample. The analyzing unit is electrically connected to the light receiving unit and is capable of measuring a property of the sample by using the electrical signal. A number of the light receiving unit is less than a number of the light emission units. An optical measurement system including the optical detection apparatus is also provided.

    Abstract translation: 提供了能够测量样品的光学检测装置。 光检测装置包括多个发光单元，光接收单元，驱动单元和分析单元。 每个发光单元能够发射光束。 光接收单元能够接收通过样本的光束，并且能够将接收到的光束转换成电信号。 驱动单元能够改变发光单元和样品的相对位置。 分析单元电连接到光接收单元，并且能够通过使用电信号来测量样品的性质。 光接收单元的数量少于多个发光单元。 还提供了一种包括光学检测装置的光学测量系统。

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