公开(公告)号：US12133991B2

公开(公告)日：2024-11-05

申请号：US17907543

申请日：2021-03-22

Applicant: RAYSEARCH LABORATORIES AB

Inventor： Bjorn Andersson ,  Erik Engwall ,  Albin Fredriksson ,  Kjell Eriksson

IPC: A61N5/10

Abstract: A computer-based method of optimizing a radiotherapy treatment plan for a patient is proposed, wherein a treatment plan to be provided by one radiation set is optimized taking into account a previously delivered dose delivered by a different radiation set. One of the radiation sets is external beam radiotherapy and the other is brachytherapy.

公开(公告)号：US12076586B2

公开(公告)日：2024-09-03

申请号：US17618088

申请日：2020-06-02

Applicant: RaySearch Laboratories AB

Inventor： Minna Wedenberg ,  Jakob Ödén ,  Albin Fredriksson ,  Erik Traneus

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1038 ,  A61N2005/1041

Abstract: A method for generating a robust radiotherapy treatment plan for a treatment volume of a subject, the treatment volume being defined using a plurality of voxels, the method comprising the steps of defining (S100) an optimization problem using at least one optimization function for a biological endpoint related to the radiotherapy treatment; defining (S102) a set of scenarios comprising at least a first scenario and a second scenario, wherein at least two of the scenarios in the set of scenarios represent different biological models to quantify the same biological endpoint; calculating (S104) an optimization function value for each scenario in the set of scenarios; generating (S106) a radiotherapy treatment plan by robustly optimizing the optimization function value evaluated over the set of scenarios.

公开(公告)号：US12053647B2

公开(公告)日：2024-08-06

申请号：US17056477

申请日：2019-05-24

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz

IPC: A61N5/10

CPC classification number: A61N5/1036 ,  A61N5/1047

Abstract: Automatic radiation therapy treatment planning for generating a plan to be delivered from at least one beam angle, using a collimator having a variable collimator angle. Delivery times are determined for a number of possible collimator angles, and the optimization problem is defined to take the delivery times into account when selecting the collimator angles to be used when delivering the radiation.

公开(公告)号：US11969608B2

公开(公告)日：2024-04-30

申请号：US17415019

申请日：2019-12-12

Applicant: RaySearch Laboratories AB

Inventor： Albin Fredriksson ,  Erik Engwall ,  Kjell Eriksson ,  Erik Traneus

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1078 ,  A61N2005/1087

Abstract: A method of generating a radiotherapy plan for ion therapy, wherein the beam (6) is shaped by means of passive devices is arranged to allow variation in settings of at least one of the passive devices and/or the MU during the delivery of the beam and to control the movement of the patient and/or the beam in such a way as to create an arc. The arc is preferably a continuous arc or includes at least one continuous sub-arc. The method may include forward planning or optimization. In the latter case, the optimization uses an optimization problem set up to allow variation in settings of at least one of the range modulating device (9), the aperture element (11) and the MU during the delivery of the arc. Computer programs control the planning and the delivery.

公开(公告)号：US20240033539A1

公开(公告)日：2024-02-01

申请号：US18256427

申请日：2021-11-29

Applicant: RAYSEARCH LABORATORIES AB

Inventor： Mats HOLMSTROM ,  David ANDERSSON ,  Gabriel CARRIZO ,  Adnan HOSSAIN

IPC: A61N5/10 ,  G16H20/40

CPC classification number: A61N5/1038 ,  A61N5/1039 ,  G16H20/40

Abstract: An estimated or predicted dose for radiotherapy treatment may be generated based on a partial dose map including dose information only for one or more regions of interest within a treatment site, by use of a properly trained machine learning system such as a U-Net or a V-Net. Said partial dose map typically set to fulfil clinical goals. A method of training such a machine learning system is also disclosed.

公开(公告)号：US11607559B2

公开(公告)日：2023-03-21

申请号：US16646267

申请日：2018-09-07

Applicant: RaySearch Laboratories AB

Inventor： Kjell Eriksson ,  Albin Fredriksson ,  Henrik Olsson

IPC: A61N5/10

Abstract: It is provided a method for determining arc costs. The method comprises the steps of: determining a plurality of beam orientations; evaluating a set of at least one cost function comprising an intermediate exposure cost function that is evaluated by performing the substeps of: projecting the at least one target volumes on a beam plane; determining an alignment angle based on a collimator angle value; finding any intermediate area in the beam plane along the alignment angle between areas of the at least one target volume projection; determining a value of the intermediate exposure cost function. The method further comprises the steps of: finding a plurality of arcs, wherein each arc comprises a sequence of a plurality of beam orientations; and calculating, for each arc in the plurality of arcs, at least one arc cost based on the cost function values of the beam orientations of the arc.

公开(公告)号：US11602645B2

公开(公告)日：2023-03-14

申请号：US16668234

申请日：2019-10-30

Applicant: RaySearch Laboratories AB

Inventor： Oscar Stål ,  Erik Engwall ,  Martin Janson ,  Lars Glimelius ,  Erik Traneus ,  Kjell Eriksson

IPC: A61N5/10

Abstract: A method of optimizing a radiation treatment plan of ion treatment, in which the optimization procedure is interrupted, some but not all low-weight spots are discarded and the optimization procedure is resumed with a reduced set of spots. The weight of one or more remaining spots may be increased before resuming the optimization procedure, for example by adding the spot weight of one or more of the discarded spots to one or more of the remaining spots.

公开(公告)号：US11554270B2

公开(公告)日：2023-01-17

申请号：US16645169

申请日：2018-06-12

Applicant: RaySearch Laboratories AB

Inventor： Björn Andersson ,  Björn Hårdemark ,  Rasmus Bokrantz

IPC: A61N5/10 ,  G16H20/40

Abstract: It is provided a method for optimizing a treatment plan for use in radiation therapy. The method is performed in a treatment planning system and comprises the steps of: obtaining a first quality function of the treatment plan, the first quality function yielding an output value based on an input treatment plan; obtaining a first pair of input values and a slope indicator, the input values associating a value of the first quality function to a value of a score; constructing a score function that maps values of the first quality function to values of the score by fitting a curve to the first pair of input values and the slope indicator; and optimizing the treatment plan with respect to the score function, by varying the treatment plan such that the value of the score function is either improved or constrained to a feasible range of score values.

公开(公告)号：US11446517B2

公开(公告)日：2022-09-20

申请号：US16625988

申请日：2018-06-28

Applicant: RaySearch Laboratories AB

Inventor： Erik Engwall ,  Martin Janson ,  Lars Glimelius

IPC: A61N5/10

Abstract: It is provided a method for determining ripple filter settings for an ion therapy beam being capable of providing ions of different energy levels to a target volume. The method is performed in a treatment planning system and comprises the steps of: determining at least one beam direction to use to cover a target volume; and assigning a ripple filter setting to each one of a plurality of sub-beams of each one of the at least one beam direction such that each sub-beam is assigned a different ripple filter setting, wherein each ripple filter setting results in a different effect on a Bragg-peak width in a direction along the ion therapy beam, and each energy level is assigned to one of the plurality of sub-beams. The step of assigning a ripple filter setting comprises optimising based on different filter settings for different sub-beams for each beam direction.

公开(公告)号：US11426606B2

公开(公告)日：2022-08-30

申请号：US17424195

申请日：2020-01-29

Applicant: RaySearch Laboratories AB

Inventor： Erik Traneus

IPC: A61N5/10

Abstract: A method of evaluating a radiation therapy (RT) treatment plan for a treatment volume, divided into sub-volumes and having a target volume and one or more organs at risk, OAR. It includes obtaining a RT treatment plan; calculating the linear energy transfer, LET, in each sub-volume; dividing the dose distribution into doses of a first category and a second category in each sub-volume, wherein the first category comprises doses with energy depositions with an LET below a first LET threshold and the second category comprises doses with energy depositions with an LET above a second LET threshold; determining amounts of doses of the first and of the second category in each sub-volume; and performing an analysis of the quality of the RT treatment plan by metrics based on the obtained distribution of doses of the first and of the second category in the target volume and in the OAR.