公开(公告)号：US12179038B2

公开(公告)日：2024-12-31

申请号：US17415768

申请日：2019-12-12

Applicant: RaySearch Laboratories AB

Inventor： Albin Fredriksson ,  Rasmus Bokrantz ,  Erik Engwall ,  Kjell Eriksson ,  Lars Glimelius

IPC: A61N5/10

Abstract: A method of optimizing the use of resources in treatment planning involving more than one radiation set delivered to one or more patients, the radiation sets requiring different resources, respectively, wherein the optimization is performed using an optimization problem comprising an optimization function related to the first and second sets of resources. The method may be used for optimizing one plan for one patient, or a number of plans for different patients, in such a way that the available resources are used in the best possible way.

公开(公告)号：US11865363B2

公开(公告)日：2024-01-09

申请号：US17057170

申请日：2019-05-27

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz ,  Albin Fredriksson ,  Kjell Eriksson ,  Erik Engwall ,  Erik Traneus

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N2005/1089 ,  A61N2005/1091

Abstract: The present disclosure generally relates to the field of radiation treatment. More specifically, the present disclosure generally relates to methods and radiation treatment systems for facilitating a multimodal radiation therapy treatment plan, in particular a multimodal radiation therapy plan employing a combined photon beam and electron beam radiation treatment. According to one example embodiment described in the disclosure, a method may comprise obtaining information related to a set of candidate beam types for the combined photon beam and electron beam radiation treatment; comparing the set of candidate beam types against a selection criterion to establish a subset of beam types from the candidate beam types; and generating the combined photon beam and electron beam radiation treatment plan utilizing the thus established subset of beam types.

公开(公告)号：US12023517B2

公开(公告)日：2024-07-02

申请号：US18552670

申请日：2022-02-17

Applicant: RaySearch Laboratories AB (Publ)

Inventor： Lars Glimelius ,  Erik Engwall ,  Otte Marthin

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1043 ,  A61N2005/1087

Abstract: A computer-based method of providing a set of selected spots for use in ion radiotherapy optimization is proposed, the method comprising the steps of defining a number of positions in the volume, each position corresponding to a possible Bragg peak location, the positions being defined to provide coverage of the volume, for each position, for at least one beam direction, performing a ray trace to determine characteristics of a potential spot in the beam that will place its Bragg peak in the position and for each position, selecting zero, one or more of the potential spots, based on the characteristics, and including the one or more selected spots in the set of selected spots. The set of selected spots may be used in treatment planning. The invention also relates to computer program products and a computer system for performing the methods.

公开(公告)号：US11565127B2

公开(公告)日：2023-01-31

申请号：US16471055

申请日：2017-12-20

Applicant: RaySearch Laboratories AB

Inventor： Erik Engwall ,  Martin Janson ,  Erik Traneus

IPC: A61N5/10 ,  G16H20/40

Abstract: A system for determining a treatment plan in active ion beam treatment, to minimize unwanted dose, while maintaining or improving target dose coverage, whereby a beam is split into at least two sub-beams and where each sub-beam has a range shifter of different settings.

公开(公告)号：US12296189B2

公开(公告)日：2025-05-13

申请号：US17907546

申请日：2021-03-22

Applicant: RaySearch Laboratories AB (Publ)

Inventor： Bjorn Andersson ,  Erik Engwall ,  Albin Fredriksson ,  Kjell Eriksson

IPC: A61N5/10

Abstract: A computer-based method of optimizing a radiotherapy treatment plan for a patient is proposed, wherein a complete treatment comprising both external beam therapy and brachytherapy is optimized in one procedure using an optimization problem comprising an objective function designed to optimize the total dose distribution as a combination of a first dose distribution to be provided by a first radiation set and a second dose distribution to be provided by a second radiation set. One of the radiation sets is external beam radiotherapy and the other is brachytherapy. The optimization is based on a total desired dose for the whole treatment, images of the patient before the treatment starts and an estimated image of the patient after the first radiation set has been delivered.

公开(公告)号：US11602644B2

公开(公告)日：2023-03-14

申请号：US16625895

申请日：2018-06-26

Applicant: RaySearch Laboratories AB

Inventor： Erik Engwall ,  Lars Glimelius ,  Martin Janson

IPC: A61N5/10

Abstract: It is provided a method for determining a distribution of spots for use with ion beam therapy for providing the spots in a target volume, wherein each spot represents a collection of ions of a specific energy level and of a specific size at a specific lateral location. The method is performed in a treatment planning system and comprises the steps of: dividing the target volume in a plurality of target sections based on a user configuration comprising at least one spot size strategy defining a maximum spot size at the location of a Bragg peak; assigning a spot size strategy to each one of the target sections based on the location of the respective target section; and determining, within each target section, spots in accordance with its spot size strategy.

公开(公告)号：US11020616B2

公开(公告)日：2021-06-01

申请号：US16625871

申请日：2018-06-26

Applicant: RaySearch Laboratories AB

Inventor： Erik Engwall ,  Lars Glimelius ,  Martin Janson

IPC: A61N5/10

Abstract: According to a first aspect, it is presented a method for determining a treatment plan comprising a distribution of spots for use with ion beam therapy for providing the spots in a target volume. The method comprises the steps of: selecting energy layers to be used in the treatment plan; determining a number of spot sizes to use; generating, for each energy layer, one copy of the energy layer for each spot size to use and populating each copy with spots of the spot size for that copy; optimizing spots of all copies of all energy layers, by repeatedly varying a weight of at least a subset of the spots and calculating an effect on a performance measurement, wherein the performance measurement is calculated by combining a plurality of evaluation criteria, comprising a first criterion related to total treatment time and a second criterion related to a desired dose distribution.

公开(公告)号：US10888712B2

公开(公告)日：2021-01-12

申请号：US15567400

申请日：2016-04-11

Applicant: RaySearch Laboratories AB

Inventor： Albin Fredriksson ,  Erik Engwall

IPC: A61N5/10

Abstract: An optimization method for a radiotherapy plan using robust optimization to handle different scenarios that may occur during one treatment session because of patient movement. The optimization is based on the period and amplitude of the movement, the starting point of the treatment session within a period and the delivery time structure.

公开(公告)号：US20250161714A1

公开(公告)日：2025-05-22

申请号：US18840949

申请日：2022-12-20

Applicant: RaySearch Laboratories AB (Publ)

Inventor： Erik Engwall ,  Otte MARTHIN ,  Rasmus BOKRANTZ ,  Lars GLIMELIUS ,  Albin FREDRIKSSON ,  Bjorn ANDERSSON ,  Viktor WASE

IPC: A61N5/10

Abstract: A method of creating an ion-based radiotherapy treatment plan includes a spot-weight optimization procedure arranged to create the plan involving an arc as a combination of one or more sub-arcs and possibly a static beam wherein the one or more sub-arcs either overlap or have different directions. The method includes selecting the first and second sets of energy levels together.

公开(公告)号：US12133991B2

公开(公告)日：2024-11-05

申请号：US17907543

申请日：2021-03-22

Applicant: RAYSEARCH LABORATORIES AB

Inventor： Bjorn Andersson ,  Erik Engwall ,  Albin Fredriksson ,  Kjell Eriksson

IPC: A61N5/10

Abstract: A computer-based method of optimizing a radiotherapy treatment plan for a patient is proposed, wherein a treatment plan to be provided by one radiation set is optimized taking into account a previously delivered dose delivered by a different radiation set. One of the radiation sets is external beam radiotherapy and the other is brachytherapy.