公开(公告)号：US11701504B2

公开(公告)日：2023-07-18

申请号：US17150986

申请日：2021-01-15

Applicant: California Institute of Technology ,  The Regents of the University of California

Inventor： Yu-Chong Tai ,  Aubrey M. Shapero ,  Shane S. Shahrestani ,  Azita Emami ,  Abhinav Agarwal ,  Kuang-Ming Shang ,  Sunghoon Kim ,  Olajire Idowu ,  Kurtis I. Auguste

IPC: A61M27/00

CPC classification number: A61M27/006 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2207/00

Abstract: A long-lasting, wireless, biocompatible pressure sensor device is integrated within a hydrocephalus shunt, either within the shunt's reservoir/anchor or as an inline or pigtailed connector. When integrated within a typical reservoir, the device can sit within the reservoir's hollow frustum area covered by the resilient silicone dome of the reservoir. When integrated as an inline connector, the device can sit at any point on the peritoneal catheter or ventricular catheter, including between the VP shut's valve and reservoir. The pressure sensor device includes electronics that can be powered wirelessly by a reader held to a patient's scalp, and so no battery may be required. The reader can transmit an ambient, atmospheric pressure reading from outside the skull to the implanted device so that its electronics can calculate a calibrated gauge pressure internally and then relay it to a patient's smart phone.

公开(公告)号：US20230069775A1

公开(公告)日：2023-03-02

申请号：US17984046

申请日：2022-11-09

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Aubrey M. Shapero ,  Nicholas E. Scianmarello ,  Mark S. Humayun

IPC: A61F9/00 ,  A61K9/00 ,  A61M31/00

Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

公开(公告)号：US20210402186A1

公开(公告)日：2021-12-30

申请号：US17473406

申请日：2021-09-13

Applicant: California Institute of Technology ,  University of Louisville Research Foundation, Inc. ,  The Regents of the University of California

Inventor： Victor Reggie Edgerton ,  Roland R. Roy ,  Yury Gerasimenko ,  Joel W. Burdick ,  Susan J. Harkema ,  Jonathan Hodes ,  Yu-Chong Tai ,  Mandheerej S. Nandra ,  Claudia A. Angeli ,  Thomas Anthony Desautels

IPC: A61N1/36 ,  A61N1/05 ,  A63B21/00 ,  A61H1/02

Abstract: Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having a spinal cord injury, a brain injury, or a neurological neuromotor disease are described.

公开(公告)号：US20210283308A1

公开(公告)日：2021-09-16

申请号：US17199844

申请日：2021-03-12

Applicant: City of Hope ,  California Institute of Technology

Inventor： Hirotake Komatsu ,  Colin Andrew Cook ,  Yu-Chong Tai ,  Kuang-Ming Shang

IPC: A61L27/38 ,  A61L27/18 ,  A61B17/34 ,  A61K35/39 ,  A61L27/54 ,  A61L27/56

Abstract: An oxygen transporter device configured to transport O2 from an ambient air location into or toward a subcutaneous site. The device includes an absorption component, a cannula, and a discharge component configured to be implanted in a subcutaneous location while the absorption component is not subcutaneous. The cannula can extend through or across the skin of a patient. The discharge component can includes one or more multi-layered, flexible mesh sheets, which are coupled to cells.

公开(公告)号：US11116976B2

公开(公告)日：2021-09-14

申请号：US15878325

申请日：2018-01-23

Applicant: The Regents of the University of California ,  California Institute of Technology ,  University of Louisville Research Foundation, Inc.

Inventor： Victor Reggie Edgerton ,  Roland R. Roy ,  Yury Gerasimenko ,  Joel W. Burdick ,  Susan J. Harkema ,  Jonathan Hodes ,  Yu-Chong Tai ,  Mandheerej S. Nandra ,  Claudia A. Angeli ,  Thomas Anthony Desautels

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A63B21/00 ,  A61H1/02 ,  A63B69/00 ,  A63B22/02

Abstract: Methods comprising applying electrical stimulation to patients in conjunction with physical training are described.

公开(公告)号：US11077462B2

公开(公告)日：2021-08-03

申请号：US15331544

申请日：2016-10-21

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Wei Wang ,  Dongyang Kang

IPC: B05D1/00 ,  B05D3/04 ,  B81C1/00 ,  C23C16/455

Abstract: Apparatus, system, and method of depositing thin and ultra-thin parylene are described. In an example, a core deposition chamber is used. The core deposition chamber includes a base and a rigid, removable cover configured to mate and seal with the base to create the core deposition chamber and to define an inside and an outside of the core deposition chamber. The core deposition chamber also includes a conduit through a top of the cover. The conduit has a lumen connecting the inside to the outside of the core deposition chamber. The lumen has a length and a cross-section. The cross-section has a width between 50 μm and 6000 μm. The length is less than 140 times the cross-section width. The core deposition chamber can be placed in an outer deposition chamber and can achieve parylene deposition less than 1 μm thick inside the core deposition chamber.

公开(公告)号：US20210220627A1

公开(公告)日：2021-07-22

申请号：US17150986

申请日：2021-01-15

Applicant: California Institute of Technology ,  The Regents of the University of California

Inventor： Yu-Chong Tai ,  Aubrey M. Shapero ,  Shane S. Shahrestani ,  Azita Emami ,  Abhinav Agarwal ,  Kuang-Ming Shang ,  Sunghoon Kim ,  Olajire Idowu ,  Kurtis I. Auguste

IPC: A61M27/00

Abstract: A long-lasting, wireless, biocompatible pressure sensor device is integrated within a hydrocephalus shunt, either within the shunt's reservoir/anchor or as an inline or pigtailed connector. When integrated within a typical reservoir, the device can sit within the reservoir's hollow frustum area covered by the resilient silicone dome of the reservoir. When integrated as an inline connector, the device can sit at any point on the peritoneal catheter or ventricular catheter, including between the VP shut's valve and reservoir. The pressure sensor device includes electronics that can be powered wirelessly by a reader held to a patient's scalp, and so no battery may be required. The reader can transmit an ambient, atmospheric pressure reading from outside the skull to the implanted device so that its electronics can calculate a calibrated gauge pressure internally and then relay it to a patient's smart phone.

公开(公告)号：US11051977B2

公开(公告)日：2021-07-06

申请号：US16437388

申请日：2019-06-11

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Colin A. Cook ,  Mark S. Humayun

IPC: A61F9/00 ,  A61K9/00 ,  G02C7/04 ,  A61M31/00 ,  B29D11/00 ,  A61P27/02

Abstract: An eye treatment apparatus is described. The apparatus includes an annular body that has a hollow optical zone in its center. An inner perimeter of the annular body surrounds the optical zone. The inner perimeter has a diameter that corresponds to a diameter of the eye's cornea. An outer perimeter of the annular body has a diameter such that the annular body can extend to underneath the eye lid in an open eye position when the eye treatment apparatus is in operation. In this way, the apparatus can be worn on the eye, where the hollow optical zone substantially corresponds to the cornea and does not interfere with the field of vision. The annular body also includes a storage chamber that stores therapeutic liquid for an eye. An outlet is coupled with the storage chamber such that, in operation, the therapeutic liquid can be dispensed to the eye.

公开(公告)号：US10737095B2

公开(公告)日：2020-08-11

申请号：US15940473

申请日：2018-03-29

Applicant: California Institute of Technology ,  University of Louisville Research Foundation, Inc. ,  The Regents of the University of California

Inventor： Joel W. Burdick ,  Yu-Chong Tai ,  John F. Naber ,  Robert S. Keynton ,  Victor Reggie Edgerton ,  Roland R Roy ,  Yury Gerasimenko ,  Susan J. Harkema ,  Jonathan Hodes ,  Claudia A. Angeli ,  Mandheerej S. Nandra ,  Thomas Anthony Desautels ,  Steven L. Upchurch ,  Douglas J. Jackson ,  Nicholas A. Terrafranca, Jr. ,  Yangsheng Chen

IPC: A61N1/36 ,  A61N1/05 ,  A61B5/00 ,  A61B5/0492 ,  A61B5/11

Abstract: Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.

公开(公告)号：US10512534B2

公开(公告)日：2019-12-24

申请号：US15722751

申请日：2017-10-02

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Colin A Cook

IPC: A61B5/06 ,  A61F2/16 ,  A61K9/00 ,  A61K51/12 ,  A61N5/06 ,  A61N5/04 ,  A61K49/00 ,  A61L27/54 ,  A61N5/10

Abstract: Embodiments of the present disclosure are directed to a phototherapy eye device. In an example, the phototherapy eye device includes a number of radioluminescent light sources and an anchor. Each radioluminescent light source includes an interior chamber coated with phosphor material, such as zinc sulfide, and containing a radioisotope material, such as gaseous tritium. The volume, shape, phosphor material, and radioisotope material are selected for emission of light at a particular wavelength and delivering a particular irradiance on the retina (when implanted in an eyeball). The wavelength is in the range of 400 to 600 nm and the irradiance is substantially 109 to 1011 photons per second per cm2.