公开(公告)号：US20210277418A1

公开(公告)日：2021-09-09

申请号：US17265749

申请日：2019-08-02

Applicant: VOYAGER THERAPEUTICS, INC. ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dinah Wen-Yee Sah ,  Jinzhao Hou ,  Kei Adachi ,  Wei Wang ,  Qingmin Chen ,  Jenna Carroll Soper ,  Amy Ren ,  Xiao-Qin Ren ,  Benjamin E. Deverman ,  Viviana Gradinaru ,  Qin Huang

IPC: C12N15/86 ,  C12N15/113 ,  A61K45/06

Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.

公开(公告)号：US11077462B2

公开(公告)日：2021-08-03

申请号：US15331544

申请日：2016-10-21

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Wei Wang ,  Dongyang Kang

IPC: B05D1/00 ,  B05D3/04 ,  B81C1/00 ,  C23C16/455

Abstract: Apparatus, system, and method of depositing thin and ultra-thin parylene are described. In an example, a core deposition chamber is used. The core deposition chamber includes a base and a rigid, removable cover configured to mate and seal with the base to create the core deposition chamber and to define an inside and an outside of the core deposition chamber. The core deposition chamber also includes a conduit through a top of the cover. The conduit has a lumen connecting the inside to the outside of the core deposition chamber. The lumen has a length and a cross-section. The cross-section has a width between 50 μm and 6000 μm. The length is less than 140 times the cross-section width. The core deposition chamber can be placed in an outer deposition chamber and can achieve parylene deposition less than 1 μm thick inside the core deposition chamber.

公开(公告)号：US20170113246A1

公开(公告)日：2017-04-27

申请号：US15331544

申请日：2016-10-21

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Wei Wang ,  Dongyang Kang

IPC: B05D1/00 ,  B05D3/04 ,  B81C1/00

CPC classification number: B05D1/60 ,  B05D3/0486 ,  B05D3/0493 ,  B81C1/00674 ,  C23C16/45559

Abstract: Apparatus, system, and method of depositing thin and ultra-thin parylene are described. In an example, a core deposition chamber is used. The core deposition chamber includes a base and a rigid, removable cover configured to mate and seal with the base to create the core deposition chamber and to define an inside and an outside of the core deposition chamber. The core deposition chamber also includes a conduit through a top of the cover. The conduit has a lumen connecting the inside to the outside of the core deposition chamber. The lumen has a length and a cross-section. The cross-section has a width between 50 μm and 6000 μm. The length is less than 140 times the cross-section width. The core deposition chamber can be placed in an outer deposition chamber and can achieve parylene deposition less than 1 μm thick inside the core deposition chamber.

公开(公告)号：US20240218526A1

公开(公告)日：2024-07-04

申请号：US18542516

申请日：2023-12-15

Applicant: California Institute of Technology ,  Battelle Memorial Institute

Inventor： Harry A. Atwater ,  Chengxiang Xiang ,  Zhiyuan Qi ,  Monica Hwang ,  Richard F. Zheng ,  Wei Wang ,  Soowhan Kim ,  Ryan Benavides ,  Daniel R. Bottenus

IPC: C25B1/04 ,  C25B9/15 ,  C25B9/23 ,  C25B11/032 ,  C25B11/052 ,  C25B11/063 ,  C25B11/065 ,  C25B11/075 ,  C25B11/081 ,  C25B11/085 ,  C25B15/08

CPC classification number: C25B1/04 ,  C25B9/15 ,  C25B9/23 ,  C25B11/032 ,  C25B11/052 ,  C25B11/063 ,  C25B11/065 ,  C25B11/075 ,  C25B11/081 ,  C25B11/085 ,  C25B15/08

Abstract: Systems and methods for generating high-pressure hydrogen are described. The hydrogen generation systems include hybrid electrolyzer systems and catalytic compression systems. The systems can directly generate gaseous hydrogen at a pressure of at least 700 bar.