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    Charge detection mass spectrometry
    81.
    发明授权
    Charge detection mass spectrometry 有权

    公开(公告)号：US11367602B2

    公开(公告)日：2022-06-21

    申请号：US16971958

    申请日：2019-02-22

    Applicant: Micromass UK Limited

    Inventor： Keith Richardson ,  Jeffery Mark Brown ,  David J. Langridge

    IPC: H01J49/00 ,  H01J49/06 ,  H01J49/42

    Abstract: Disclosed herein are various methods and apparatus for performing charge detection mass spectrometry (CDMS). In particular, techniques are disclosed for monitoring a detector signal from a CDMS device to determine how many ions are present in the ion trap (10) of the CDMS device. For example, if no ions are present the measurement can then be terminated early. Similarly, if more than one ion is present, the measurement can be terminated early, or ions can be removed from the trap (10) until only a single ion remains. Techniques are also provided for increasing the probability of there being a single ion in the trap (10). A technique for attenuating an ion beam is also provided.

    TWO DIMENSIONAL MSMS
    82.
    发明申请
    TWO DIMENSIONAL MSMS 有权

    公开(公告)号：US20210319993A1

    公开(公告)日：2021-10-14

    申请号：US17356793

    申请日：2021-06-24

    Applicant: Micromass UK Limited

    Inventor： Keith Richardson ,  Jason Lee Wildgoose

    IPC: H01J49/00 ,  H01J49/02

    Abstract: A method of mass spectrometry is disclosed comprising: performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses transmitted therefrom is varied with time; and mass analysing ions.

    Ion trap mass spectrometers with space charge control
    84.
    发明授权
    Ion trap mass spectrometers with space charge control 有权

    公开(公告)号：US11049709B2

    公开(公告)日：2021-06-29

    申请号：US15035952

    申请日：2014-11-11

    Applicant: Micromass UK Limited

    Inventor： Kevin Giles ,  Martin Raymond Green ,  Keith Richardson ,  Jason Lee Wildgoose

    IPC: H01J49/06 ,  H01J49/00 ,  G01N27/622

    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region; selecting a target maximum charge desired to be stored within the ion storage region at any given time; and reducing the ion current passing to the ion storage region such that the ions entering the ion storage region do not cause the total charge within the storage region to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region comprises: temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter. Said steps of separating and mass filtering the ions result in substantially only target ions having selected combinations of ion mobility and mass to charge ratio being transmitted towards the ion storage region. The method further comprises accumulating the target ions within the ion storage region during an ion accumulation period.

    MASS FILTER HAVING EXTENDED OPERATIONAL LIFETIME
    86.
    发明申请
    MASS FILTER HAVING EXTENDED OPERATIONAL LIFETIME 审中-公开

    公开(公告)号：US20200075308A1

    公开(公告)日：2020-03-05

    申请号：US16563203

    申请日：2019-09-06

    Applicant: Micromass UK Limited

    Inventor： Martin Green ,  Jason Wildgoose ,  Keith Richardson ,  Kevin Giles ,  Daniel Kenny ,  David Langridge ,  Richard Moulds

    IPC: H01J49/42 ,  H01J49/06

    Abstract: A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.

    Confirmation using multiple collision cross section (“CCS”) measurements
    89.
    发明授权
    Confirmation using multiple collision cross section (“CCS”) measurements 有权

    公开(公告)号：US10388499B2

    公开(公告)日：2019-08-20

    申请号：US15125363

    申请日：2015-03-10

    Applicant: Micromass UK Limited

    Inventor： Kevin Giles ,  Martin Raymond Green ,  Keith Richardson ,  Jason Lee Wildgoose

    IPC: H01J49/36 ,  H01J49/00 ,  G01N27/62

    Abstract: A method of identifying ions or confirming the identity of ions is disclosed comprising determining a physico-chemical or other property of first ions under first conditions, determining the physico-chemical or other property of the first ions or second ions derived from the first ions under second different conditions, and identifying or confirming the identity of the first ions or determining a class of the first or the second ions on the basis of the physico-chemical or other property of the first ions as determined under the first conditions and on the basis of the physico-chemical or other property of the first ions or second ions derived from the first ions as determined under the second conditions.

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