公开(公告)号：US20150036135A1

公开(公告)日：2015-02-05

申请号：US14516772

申请日：2014-10-17

Applicant: Thermo Scientific Portable Analytical Instruments Inc.

Inventor： Kevin J. KNOPP ,  Robert L. GREEN ,  Brendon D. TOWER ,  Christopher D. BROWN ,  Gregory H. VANDER RHODES

IPC: G01N21/17 ,  G01N21/55 ,  G01N21/47 ,  G01N21/59 ,  G01J3/44 ,  G01J3/42

CPC classification number: G01N21/17 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/42 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/47 ,  G01N21/4738 ,  G01N21/55 ,  G01N21/59 ,  G01N21/65 ,  G01N2021/3595 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/105 ,  G01N2201/125

Abstract: Disclosed are apparatus, kits, methods, and systems that include a radiation source configured to direct radiation to a sample; a detector configured to measure radiation from the sample; an electronic processor configured to determine information about the sample based on the measured radiation; a housing enclosing the source, the detector, and the electronic processor, the housing having a hand-held form factor; an arm configured to maintain a separation between the sample and the housing, the arm including a first end configured to connect to the housing and a second end configured to contact the sample; and a layer positioned on the second end of the arm, the layer being configured to contact the sample and to transmit at least a portion of the radiation from the sample to the detector.

Abstract translation: 公开了包括被配置为将辐射引导到样品的辐射源的装置，试剂盒，方法和系统; 检测器，被配置为测量来自样品的辐射; 电子处理器，被配置为基于所测量的辐射来确定关于样本的信息; 包围所述源，所述检测器和所述电子处理器的外壳，所述外壳具有手持外形尺寸; 臂被配置为保持样品和壳体之间的分离，所述臂包括构造成连接到壳体的第一端和被配置为接触样品的第二端; 以及位于所述臂的第二端上的层，所述层被配置为接触所述样品并将所述辐射的至少一部分从所述样品透射到所述检测器。

公开(公告)号：US20150028876A1

公开(公告)日：2015-01-29

申请号：US14340440

申请日：2014-07-24

Applicant: Nathan McLaughlin ,  Benjamin Smith ,  Norbert Puetz

Inventor： Nathan McLaughlin ,  Benjamin Smith ,  Norbert Puetz

IPC: G01R31/44 ,  G01N21/21 ,  G01N21/25

CPC classification number: G01R31/44 ,  G01N21/21 ,  G01N21/255 ,  G01N2201/125 ,  G01R31/2635

Abstract: An apparatus to measure and collect data relating to properties of light for a plurality of light-producing devices comprises a rail having a longitudinal axis along which the plurality of light-producing devices is aligned. A measurement tool is mounted on the rail and moved under motor control to measure the data for each of the plurality of light-producing devices.

Abstract translation: 用于测量和收集关于多个发光装置的光的属性的数据的装置包括具有纵向轴线的轨道，多个发光装置沿着该纵向轴对准。 测量工具安装在导轨上并在电动机控制下移动以测量多个发光装置中的每一个的数据。

公开(公告)号：US20150008346A1

公开(公告)日：2015-01-08

申请号：US14368882

申请日：2012-12-21

Applicant: METSO AUTOMATION OY

Inventor： Markku Mäntylä ,  Jussi Graeffe ,  Karri Niemelä ,  Heimo Keränen ,  Pekka Suopajärvi ,  Lauri Kurki

IPC: G01N21/84 ,  G01N21/86 ,  G01B11/06

CPC classification number: G01N21/84 ,  D21B1/327 ,  D21F7/06 ,  G01B11/026 ,  G01B11/06 ,  G01B11/26 ,  G01N21/8422 ,  G01N21/86 ,  G01N21/89 ,  G01N2021/8427 ,  G01N2021/8663 ,  G01N2201/125 ,  Y02W30/646

Abstract: A measuring device includes a first optical sensor row and a second optical sensor row between which a planar object to be measured is placed. The direction of the first sensor row and the direction of the second sensor row differ from one another. Each sensor of the first sensor row forms data representing a distance between the object to be measured and the sensor. Each sensor of the second sensor row forms data representing a distance between the object to be measured and the sensor in order to determine at least one property of the object to be measured on the basis of the data.

Abstract translation: 测量装置包括第一光学传感器行和第二光学传感器行，在该第二光学传感器行之间放置待测量的平面物体。 第一传感器行的方向和第二传感器行的方向彼此不同。 第一传感器行的每个传感器形成表示被测量物体与传感器之间的距离的数据。 第二传感器行的每个传感器形成表示待测量对象与传感器之间的距离的数据，以便基于该数据来确定待测量对象的至少一个属性。

公开(公告)号：US20130300848A1

公开(公告)日：2013-11-14

申请号：US13760193

申请日：2013-02-06

Applicant: Cambridge Research & Instrumentation, Inc.

Inventor： Richard Levenson ,  Paul J. Cronin

IPC: G01N21/64

CPC classification number: G01N33/4833 ,  A61B5/0059 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/255 ,  G01N21/6486 ,  G01N2201/062 ,  G01N2201/125

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

Abstract translation: 提供了设备和方法，用于使用光谱成像提供高度敏感的检测来生物样本中深层组织中的结构成像。 通过获取提供具有不同光谱加权的样本的多个图像的数据和随后的光谱分析，来自目标化合物的光发射与样品中的自发荧光分离。 随着自发荧光降低或消除，获得目标化合物的改进的测量。

公开(公告)号：US08391961B2

公开(公告)日：2013-03-05

申请号：US11522745

申请日：2006-09-18

Applicant: Richard Levenson ,  Paul J. Cronin

Inventor： Richard Levenson ,  Paul J. Cronin

IPC: A61B6/00 ,  A61B1/00 ,  G01J3/00

CPC classification number: G01N33/4833 ,  A61B5/0059 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/255 ,  G01N21/6486 ,  G01N2201/062 ,  G01N2201/125

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

Abstract translation: 提供了设备和方法，用于使用光谱成像提供高度敏感的检测来生物样本中深层组织中的结构成像。 通过获取提供具有不同光谱加权的样本的多个图像的数据和随后的光谱分析，来自目标化合物的光发射与样品中的自发荧光分离。 随着自发荧光降低或消除，获得目标化合物的改进的测量。

公开(公告)号：US08011133B2

公开(公告)日：2011-09-06

申请号：US11823140

申请日：2007-06-27

Applicant: Adda Sayers ,  Dean M. Tranel ,  Travis A. Hanselman ,  Stephen D. Strachan

Inventor： Adda Sayers ,  Dean M. Tranel ,  Travis A. Hanselman ,  Stephen D. Strachan

IPC: A01B79/00 ,  A01B79/02 ,  A01C1/00 ,  A01G1/00 ,  A01H3/00

CPC classification number: G01N21/17 ,  A01G7/00 ,  G01N1/4077 ,  G01N15/06 ,  G01N15/10 ,  G01N15/1463 ,  G01N33/0098 ,  G01N2021/1765 ,  G01N2201/02 ,  G01N2201/125 ,  G06K9/00134 ,  G06Q99/00

Abstract: An apparatus and method of quantitatively obtaining a measurement of pollen of a plant. One method of counting comprises imaging the sample with the pollen well-distributed in the focal plane of the imager. Image evaluation software can identify and count objects in the image that are consistent with pollen. Total pollen count for the plant can be derived from the count of pollen of the sample, proportionality of the sample volume to the starting volume, and proportionality of area of sample imaged to total area of sample. Pollen quantification can be used for research or commercial production decisions relative to the plant or its seed.

Abstract translation: 一种定量获得植物花粉测量的装置和方法。 一种计数方法包括用分布在成像器的焦平面中的花粉成像样品。 图像评估软件可以识别和计数与花粉一致的图像中的对象。 植物的总花粉计数可以从样品的花粉计数，样品体积与起始体积的比例以及样品的面积与样品总面积的比例来得出。 花粉量化可用于相对于植物或其种子的研究或商业生产决策。

公开(公告)号：US20090245605A1

公开(公告)日：2009-10-01

申请号：US12390690

申请日：2009-02-23

Applicant: Richard Levenson ,  Paul J. Cronin ,  Kirk William Gossage ,  Clifford C. Hoyt

Inventor： Richard Levenson ,  Paul J. Cronin ,  Kirk William Gossage ,  Clifford C. Hoyt

IPC: G06K9/00

CPC classification number: G01N33/4833 ,  A61B5/0059 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/255 ,  G01N21/6486 ,  G01N2201/062 ,  G01N2201/125

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract translation: 本发明的特征在于一种方法，包括：（i）响应于样品的照明，提供关于来自包含深层组织的样品中的不同空间位置的光的光谱解析信息，其中所述光包括来自样品中不同组分的贡献; （ii）将所述不同空间位置中的至少一些中的每一个的所述光谱解析信息分解为与所述样本中的至少一些组件相关联的频谱估计的贡献; 和（iii）基于分解构建样品的深层组织图像，以优先显示所选择的组分之一。

公开(公告)号：US5117119A

公开(公告)日：1992-05-26

申请号：US668490

申请日：1991-03-13

Applicant: Paul C. Schubert ,  Richard R. Lemberger

Inventor： Paul C. Schubert ,  Richard R. Lemberger

IPC: G01J1/44 ,  G01N21/27 ,  G01N21/59 ,  G03B27/80 ,  G03D15/00

CPC classification number: G01N21/27 ,  G01J2001/4406 ,  G01N2021/5946 ,  G01N2201/125

Abstract: A film densitometer for generating digital density values as a function of analog transmittance signals received at an input. A comparator coupled to the input compares the transmittance signals to one or more range references characterizing a plurality of ranges of transmittance signal magnitudes, and provides digital transmittance range signals as a function of the comparison. An amplifier amplifies the transmittance signals to provide amplified transmittance base signals. A gain control circuit coupled to the amplifier and the comparator controls the gain factor of the amplifier as a function of the magnitudes of the transmittance signals. The amplified transmittance base signals are converted to digital transmittance base values by an analog-to-digital converter. A lookup table of data characterizing the logarithmic relationship between transmittance base values and density base values is stored in base memory. A lookup table of data characterizing the relationship between the transmittance range signals and range gain values is stored in range memory. A digital processor accesses the memory as a function of the transmittance base values and transmittance range signals, and generates the digital density values as a function of a sum of the density base values and range gain values.