公开(公告)号：US20240377319A1

公开(公告)日：2024-11-14

申请号：US18196946

申请日：2023-05-12

Applicant: RedShift BioAnalytics, Inc.

Inventor： Jinhong Kim ,  Dennis Merrill

IPC: G01N21/3577 ,  G01N21/01 ,  G01N33/18

Abstract: In illustrative embodiments, matched optical filters, and methods and systems for using matched optical filters for acquiring infra-red transmission spectra of liquid analytes in very highly absorbing reference solutions are disclosed herein. The matched optical filters compensate for the very high absorbance of the reference solution by filtering out at least a portion of coherent light from a tunable infra-red optical laser to a substantially inverse manner to the absorbance of the reference solution. The matched optical filter may be adjusted to compensate for differences in laser gain across a spectral region of interest where the differential transmission at each wavelength may vary by more than 150 times across the operating range. Thus, the matched optical filters make it possible to obtain spectra of the liquid analyte that may have several orders of magnitude lower absorbance than the reference solution.

公开(公告)号：US11169084B2

公开(公告)日：2021-11-09

申请号：US16257112

申请日：2019-01-25

Applicant: Redshift Bioanalytics, Inc.

Inventor： Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N21/17 ,  G01N21/35 ,  G01N21/85 ,  B01L3/00 ,  G01N21/05 ,  G01N21/27 ,  G01N21/3577 ,  G01N21/45 ,  G01N21/39 ,  G01N21/552 ,  G01N21/01

Abstract: A fluid analyzer includes an optical source and an optical detector defining an optical beam path through an interrogation region of a fluid flow cell. Flow-control devices conduct analyte and reference fluids through a channel and the interrogation region, and manipulate fluid flow in response to control signals to move a fluid boundary separating the analyte and reference fluids across the interrogation region. A controller generates control signals to (1) cause the fluid boundary to be moved across the interrogation region accordingly, (2) sample an output signal from the optical detector at a first interval during which the interrogation region contains more analyte fluid than reference fluid and at a second interval during which the interrogation region contains more reference fluid than analyte fluid, and (3) determine from samples of the output signal a measurement value indicative of an optically measured characteristic of the analyte fluid.

公开(公告)号：US10746646B2

公开(公告)日：2020-08-18

申请号：US16218875

申请日：2018-12-13

Applicant: Redshift Bioanalytics, Inc.

Inventor： Matthias Wagner ,  Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N21/00 ,  G01N15/14 ,  G01N21/39 ,  G01N21/05 ,  G01N21/03 ,  G01N21/3577 ,  G01N21/85 ,  G01N15/02 ,  G01N21/53

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.

公开(公告)号：US20190226983A1

公开(公告)日：2019-07-25

申请号：US16257112

申请日：2019-01-25

Applicant: Redshift Bioanalytics, Inc.

Inventor： Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N21/17 ,  G01N21/39 ,  G01N21/85 ,  G01N21/05 ,  G01N21/27 ,  G01N21/3577 ,  B01L3/00 ,  G01N21/35 ,  G01N21/45

Abstract: A fluid analyzer includes an optical source and an optical detector defining an optical beam path through an interrogation region of a fluid flow cell. Flow-control devices conduct analyte and reference fluids through a channel and the interrogation region, and manipulate fluid flow in response to control signals to move a fluid boundary separating the analyte and reference fluids across the interrogation region. A controller generates control signals to (1) cause the fluid boundary to be moved across the interrogation region accordingly, (2) sample an output signal from the optical detector at a first interval during which the interrogation region contains more analyte fluid than reference fluid and at a second interval during which the interrogation region contains more reference fluid than analyte fluid, and (3) determine from samples of the output signal a measurement value indicative of an optically measured characteristic of the analyte fluid.

公开(公告)号：US20190113436A1

公开(公告)日：2019-04-18

申请号：US16218875

申请日：2018-12-13

Applicant: Redshift Bioanalytics, Inc.

Inventor： Matthias Wagner ,  Charles McAllister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N15/14 ,  G01N21/85 ,  G01N21/05 ,  G01N21/03 ,  G01N15/02 ,  G01N21/53 ,  G01N21/39 ,  G01N21/3577

CPC classification number: G01N15/1436 ,  G01N15/0205 ,  G01N15/1404 ,  G01N15/1484 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/3577 ,  G01N21/39 ,  G01N21/532 ,  G01N21/85 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/10

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.

公开(公告)号：US11874288B1

公开(公告)日：2024-01-16

申请号：US16247925

申请日：2019-01-15

Applicant: Redshift Bioanalytics, Inc.

Inventor： Charles McAlister Marshall ,  Richard C. Sharp ,  Frederick Milton Blodgett, Jr. ,  Vlorent Morina ,  Jerry E. Hurst, Jr.

IPC: B01L3/00 ,  G01N35/00 ,  B01L7/00 ,  B01L5/00 ,  B01L1/02

CPC classification number: G01N35/00732 ,  B01L1/02 ,  B01L3/50851 ,  B01L3/50853 ,  B01L3/565 ,  B01L5/00 ,  B01L7/54 ,  B01L2200/146 ,  B01L2300/048 ,  B01L2300/0663 ,  B01L2300/0829 ,  B01L2300/0861 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/1805 ,  B01L2300/1833

Abstract: A well plate includes a frame section that defines a plane, and a plurality of well structures. Each well structure extends in a direction away from the plane defined by the frame section, and each well structure defines a well for holding a fluid. The well plate further includes an artifact connected to at least one well structure. The artifact uniquely identifies a type of the well plate among other types of well plates. Along these lines, a result of a well plate type identification operation, which indicates whether the well plate includes the artifact, may determine whether a predefined pressure is applied to the well plate to facilitate fluid sampling in response to the result, whether fluid level sensing can be performed to gauge amounts of fluids drawn from the wells and/or identify how much fluid is left in the wells, etc.

公开(公告)号：US11454584B2

公开(公告)日：2022-09-27

申请号：US16992266

申请日：2020-08-13

Applicant: Redshift Bioanalytics, Inc.

Inventor： Matthias Wagner ,  Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N15/14 ,  G01N21/39 ,  G01N21/05 ,  G01N21/03 ,  G01N21/3577 ,  G01N21/85 ,  G01N15/02 ,  G01N21/53

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.

公开(公告)号：US10720754B2

公开(公告)日：2020-07-21

申请号：US16458327

申请日：2019-07-01

Applicant: Redshift Bioanalytics, Inc.

Inventor： Eugene Yi-Shan Ma ,  Charles McAlister Marshall

IPC: H01S5/068 ,  B82Y20/00 ,  G02B5/28 ,  H01S5/14 ,  H01S3/106 ,  H01S5/024 ,  H01S5/028 ,  H01S5/34

Abstract: A tunable laser has a solid state laser medium with optical gain region and generates coherent radiation through a facet. A lens collects the coherent radiation and generates a collimated light beam. An external cavity includes a reflective surface and an optical filter, the reflective surface reflecting the collimated beam back to the lens and laser medium, the optical filter positioned between the reflective surface and the lens and having two surfaces and a thermally tunable optical transmission band within the optical gain region of the laser medium. The optical filter (1) transmits a predominant portion of the collimated beam at a desired wavelength of operation, and (2) specularly reflects a remaining portion of the collimated beam from each surface, the collimated beam being incident on the optical filter such that the reflected collimated beams propagate at a non-zero angle with respect to the incident collimated beam.

公开(公告)号：US10190969B2

公开(公告)日：2019-01-29

申请号：US15454033

申请日：2017-03-09

Applicant: Redshift Bioanalytics, Inc.

Inventor： Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N21/17 ,  G01N21/35 ,  G01N21/39 ,  G01N21/85 ,  B01L3/00 ,  G01N21/05 ,  G01N21/27 ,  G01N21/3577 ,  G01N21/45 ,  G01N21/01 ,  G01N21/552

Abstract: A fluid analyzer includes an optical source and an optical detector defining an optical beam path through an interrogation region of a fluid flow cell. Flow-control devices conduct analyte and reference fluids through a channel and the interrogation region, and manipulate fluid flow in response to control signals to move a fluid boundary separating the analyte and reference fluids across the interrogation region. A controller generates control signals to (1) cause the fluid boundary to be moved across the interrogation region accordingly, (2) sample an output signal from the optical detector at a first interval during which the interrogation region contains more analyte fluid than reference fluid and at a second interval during which the interrogation region contains more reference fluid than analyte fluid, and (3) determine from samples of the output signal a measurement value indicative of an optically measured characteristic of the analyte fluid.

公开(公告)号：US10348053B2

公开(公告)日：2019-07-09

申请号：US15647839

申请日：2017-07-12

Applicant: Redshift Bioanalytics, Inc.

Inventor： Eugene Yi-Shan Ma ,  Charles M. Marshall

IPC: H01S5/068 ,  G02B5/28 ,  H01S5/14 ,  B82Y20/00 ,  H01S3/106 ,  H01S5/024 ,  H01S5/028 ,  H01S5/34

Abstract: A tunable laser has a solid state laser medium having an optical gain region and generates coherent radiation through a facet. A lens collects the coherent radiation and generates a collimated light beam. Components of an external cavity include a reflective surface and an optical filter, the reflective surface reflecting the collimated beam back to the lens and the laser medium, the optical filter positioned between the reflective surface and the lens and having two surfaces with a thermally tunable optical transmission band within the optical gain region of the laser medium. The optical filter (1) transmits a predominant portion of the collimated beam at a desired wavelength of operation, and (2) specularly reflects a remaining portion of the collimated beam from each surface, the collimated beam being incident on the optical filter such that the reflected collimated beams propagate at a non-zero angle with respect to the incident collimated beam.