公开(公告)号：US3681436A

公开(公告)日：1972-08-01

申请号：US3681436D

申请日：1970-08-20

Applicant: ABBOTT LAB

Inventor： LYNCH DON MURL ,  COLE JOHN WAYNE

IPC: C07C39/17 ,  C07C39/23 ,  C07C69/16 ,  C07C39/12 ,  C07C43/22

CPC classification number: C07C39/17 ,  C07C39/23 ,  C07C2602/08 ,  Y10S514/843

Abstract: The present invention is directed to 1-(4-substituted benzyl)indans and simple analogs thereof; they have been found to inhibit the metabolic function of reproductive organs when administered to female, warm-blooded animals in very small doses.

Abstract translation: 本发明涉及1-（4-取代苄基）茚满及其简单类似物; 当以非常小的剂量施用于雌性，温血动物时，已经发现它们抑制生殖器官的代谢功能。

公开(公告)号：US3691176A

公开(公告)日：1972-09-12

申请号：US3691176D

申请日：1970-05-25

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  COLE JOHN WAYNE

IPC: C07D211/58 ,  C07D211/72 ,  C07D29/28

CPC classification number: C07D211/58 ,  C07D211/72

Abstract: A new series of piperidine derivatives has been discovered; they are the N-(3-(p-fluorophenoxy)propyl)piperidines carrying in the 4-position of the piperidine ring a substituted anilino group. These new compounds and their non-toxic acid addition salts are highly effective analgesics of low toxicity.

公开(公告)号：US3189606A

公开(公告)日：1965-06-15

申请号：US29845963

申请日：1963-07-29

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN ,  COLE JOHN WAYNE

IPC: C07J53/00 ,  C07J75/00

CPC classification number: C07J53/00 ,  C07J75/00

公开(公告)号：US3686187A

公开(公告)日：1972-08-22

申请号：US3686187D

申请日：1970-05-25

Applicant: ABBOTT LAB

Inventor： COLE JOHN WAYNE ,  HALLAS ROBERT

IPC: C07D211/58 ,  C07D211/72 ,  C07D29/28

CPC classification number: C07D211/58 ,  C07D211/72

Abstract: A NEW SERIES OF PIPERDINE DERIVATIVES HAS BEEN DISCOVERED; THEY ARE COMPOUNDS CARRYING, IN THE 4-POSITION OF THE PIPERIDINE RING, A SUBSTITUTED ANILINO GROUP AND IN THE 1-POSITION, A P-FLUOROPHENYL RING SEPARATED FROM THE PIPERIDINE RING BY A CARBON CHAIN OF 4. THESE NEW COMPOUNDS AND THEIR NON-TOXIC ACID ADDITION SALTS ARE HIGHLY EFFECTIVE ANALGEICES OF LOW TOXICITY.

公开(公告)号：US3487065A

公开(公告)日：1969-12-30

申请号：US3487065D

申请日：1968-01-02

Applicant: ABBOTT LAB

Inventor： FLOURET GEORGE ROGELIO ,  COLE JOHN WAYNE

IPC: C07J41/00 ,  A61K27/00 ,  C07C169/24

CPC classification number: C07J41/0005 ,  Y10S930/28

公开(公告)号：US3468880A

公开(公告)日：1969-09-23

申请号：US3468880D

申请日：1966-09-09

Applicant: ABBOTT LAB

Inventor： COLE JOHN WAYNE ,  LEX CHARLES GEORGE

IPC: A61K31/568 ,  A61K31/569 ,  A61K31/58 ,  C07J31/00 ,  C07J75/00 ,  C07C169/08 ,  A61K17/00 ,  C07C173/00

CPC classification number: A61K31/58 ,  A61K31/568 ,  A61K31/569 ,  C07J31/00 ,  C07J75/00