公开(公告)号：US09383312B2

公开(公告)日：2016-07-05

申请号：US14534511

申请日：2014-11-06

Applicant: Ciencia, Inc.

Inventor： William Page ,  George N. Gibson ,  Ernest F. Guignon

IPC: G01N21/55 ,  G01N21/552 ,  G02F1/061 ,  G02F1/19

CPC classification number: G01N21/553 ,  G01N21/7743 ,  G01N2201/067 ,  G02F1/061 ,  G02F1/195

Abstract: An instrument for measuring and analyzing surface plasmon resonance (SPR) and/or surface plasmon coupled emission on an electro-optic grating-coupled sensor surface is described herein. The sensor chip achieves SPR through a grating-coupled approach, with variations in the local dielectric constant at regions of interest (ROI) at the sensor surface detected as a function of the intensity of light reflecting from these ROI. Unlike other grating-based approaches, the metal surface is sufficiently thin that resonant conditions are sensitive to dielectric constant changes both above and below the metal surface (like the Kretschmann configuration). Dielectric constant shifts that occur as mass accumulates on the surface can be returned to reference intensities by applying voltage across the underlying electro-optic polymer. Approaches to the development of the sensor surfaces are described, as are software and hardware features facilitating sample handling, data gathering, and data analysis by this solid-state approach.

Abstract translation: 本文描述了用于测量和分析电光栅耦合传感器表面上的表面等离子体共振（SPR）和/或表面等离子体激元耦合发射的仪器。 传感器芯片通过光栅耦合方法实现SPR，传感器表面处的感兴趣区域（ROI）处的局部介电常数的变化作为从这些ROI反射的光的强度的函数被检测。 与其他基于光栅的方法不同，金属表面足够薄，使得谐振条件对金属表面上方和下方的介电常数变化敏感（如Kretschmann结构）。 通过在下面的电光聚合物上施加电压，可以将质量在表面上积累的介电常数偏移返回到参考强度。 描述了开发传感器表面的方法，以及通过该固态方法促进样品处理，数据采集和数据分析的软件和硬件特征。

公开(公告)号：US09535005B2

公开(公告)日：2017-01-03

申请号：US15200217

申请日：2016-07-01

Applicant: Ciencia, Inc.

Inventor： William Page ,  George N. Gibson ,  Ernest F. Guignon

IPC: G01N21/00 ,  G01N21/552 ,  G02F1/19

CPC classification number: G01N21/553 ,  G01N21/7743 ,  G01N2201/067 ,  G02F1/061 ,  G02F1/195

Abstract: An instrument for measuring and analyzing surface plasmon resonance (SPR) and/or surface plasmon coupled emission on an electro-optic grating-coupled sensor surface is described herein. The sensor chip achieves SPR through a grating-coupled approach, with variations in the local dielectric constant at regions of interest (ROI) at the sensor surface detected as a function of the intensity of light reflecting from these ROI. Unlike other grating-based approaches, the metal surface is sufficiently thin that resonant conditions are sensitive to dielectric constant changes both above and below the metal surface (like the Kretschmann configuration). Dielectric constant shifts that occur as mass accumulates on the surface can be returned to reference intensities by applying voltage across the underlying electro-optic polymer. Approaches to the development of the sensor surfaces are described, as are software and hardware features facilitating sample handling, data gathering, and data analysis by this solid-state approach.

Abstract translation: 本文描述了用于测量和分析电光栅耦合传感器表面上的表面等离子体共振（SPR）和/或表面等离子体激元耦合发射的仪器。 传感器芯片通过光栅耦合方法实现SPR，传感器表面处的感兴趣区域（ROI）处的局部介电常数的变化作为从这些ROI反射的光的强度的函数被检测。 与其他基于光栅的方法不同，金属表面足够薄，使得谐振条件对金属表面上方和下方的介电常数变化敏感（如Kretschmann结构）。 通过在下面的电光聚合物上施加电压，可以将质量在表面上积累的介电常数偏移返回到参考强度。 描述了开发传感器表面的方法，以及通过该固态方法促进样品处理，数据采集和数据分析的软件和硬件特征。

公开(公告)号：US20160313247A1

公开(公告)日：2016-10-27

申请号：US15200217

申请日：2016-07-01

Applicant: Ciencia, Inc.

Inventor： William Page ,  George N. Gibson ,  Ernest F. Guignon

IPC: G01N21/552

CPC classification number: G01N21/553 ,  G01N21/7743 ,  G01N2201/067 ,  G02F1/061 ,  G02F1/195

Abstract: An instrument for measuring and analyzing surface plasmon resonance (SPR) and/or surface plasmon coupled emission on an electro-optic grating-coupled sensor surface is described herein. The sensor chip achieves SPR through a grating-coupled approach, with variations in the local dielectric constant at regions of interest (ROI) at the sensor surface detected as a function of the intensity of light reflecting from these ROI. Unlike other grating-based approaches, the metal surface is sufficiently thin that resonant conditions are sensitive to dielectric constant changes both above and below the metal surface (like the Kretschmann configuration). Dielectric constant shifts that occur as mass accumulates on the surface can be returned to reference intensities by applying voltage across the underlying electro-optic polymer. Approaches to the development of the sensor surfaces are described, as are software and hardware features facilitating sample handling, data gathering, and data analysis by this solid-state approach.

公开(公告)号：US11845070B2

公开(公告)日：2023-12-19

申请号：US16625466

申请日：2018-06-23

Applicant: Ciencia, Inc.

Inventor： William D. Page ,  George N. Gibson ,  Stephen B. Cronin ,  Arturo O. Pilar ,  Ernest F. Guignon

IPC: B01J19/12 ,  B01J35/00 ,  C01B3/04 ,  C01B13/02 ,  G01N21/25 ,  G01N21/63 ,  G02B5/18 ,  G01N21/64

CPC classification number: B01J35/004 ,  C01B3/042 ,  C01B13/0207 ,  G01N21/25 ,  G01N21/63 ,  G02B5/18 ,  C01B2203/0277 ,  C01B2203/06 ,  G01N2021/258 ,  G01N2021/6478 ,  Y02E60/36

Abstract: Plasmonically-enhanced catalytic surfaces and accompanying optics are described herein. These elements facilitate efficient coupling of light energy into a photocatalytic system by way of a surface plasmon. Various compatible optical configurations are presented, with an emphasis on the broadband coupling of light into a single plasmon mode. In an example embodiment, dispersive optics are used to direct polychromatic light onto a grating-embossed SPR-active surface. Dispersive optics allow resonance to be achieved at a wide range of incident wavelengths. Energy then transfers from the excited plasmon to an adjacent photocatalyst. The plasmon mode thus acts as a “funnel” of broadband light energy to the catalytic materials. High-efficiency incoupling and outcoupling from the plasmon mode suggest overall enhancement of catalytic activity, and broad applicability is anticipated due to the inherent flexibility of the system. The catalytic surfaces and optical components can be fabricated as sheets or 3D arrays, justifying industrial-scale manufacturing.

公开(公告)号：US20210146347A1

公开(公告)日：2021-05-20

申请号：US16625466

申请日：2018-06-23

Applicant: Ciencia, Inc.

Inventor： William D. Page ,  George N. Gibson ,  Stephen B. Cronin ,  Arturo O. Pilar ,  Ernest F. Guignon

IPC: B01J35/00 ,  C01B3/04 ,  C01B13/02 ,  G01N21/25 ,  G01N21/63

Abstract: Plasmonically-enhanced catalytic surfaces and accompanying optics are described herein. These elements facilitate efficient coupling of light energy into a photocatalytic system by way of a surface plasmon. Various compatible optical configurations are presented, with an emphasis on the broadband coupling of light into a single plasmon mode. In an example embodiment, dispersive optics are used to direct polychromatic light onto a grating-embossed SPR-active surface. Dispersive optics allow resonance to be achieved at a wide range of incident wavelengths. Energy then transfers from the excited plasmon to an adjacent photocatalyst. The plasmon mode thus acts as a “funnel” of broadband light energy to the catalytic materials. High-efficiency incoupling and outcoupling from the plasmon mode suggest overall enhancement of catalytic activity, and broad applicability is anticipated due to the inherent flexibility of the system. The catalytic surfaces and optical components can be fabricated as sheets or 3D arrays, justifying industrial-scale manufacturing.

公开(公告)号：US20130169954A1

公开(公告)日：2013-07-04

申请号：US13751181

申请日：2013-01-28

Applicant: CIENCIA, INC.

Inventor： George N. Gibson ,  Ernest F. Guignon ,  Michael T. Reilly

IPC: G01N21/55

CPC classification number: G01N21/55 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/553 ,  G01N21/648 ,  G01N21/7743

Abstract: An instrument for measuring and analyzing surface plasmon resonance on a sensor surface has a polarized light source optically connected to the sensor surface by a plurality of optical elements, including in one embodiment an optical telescope that transfers light from a rotatable reflecting surface to the sensor surface. Selective positioning of a cylindrical lens into a first position within the path of light transforms collimated light to a rectangular wedge that is incident upon the sensor surface at numerous angles. In another embodiment, the light source is operated as a laser to excite fluorescence on the sensor surface and the fluorescence is selectively directed to a detector by appropriate optical elements positioned in specific configurations.

Abstract translation: 用于测量和分析传感器表面上的表面等离子体共振的仪器具有通过多个光学元件光学连接到传感器表面的偏振光源，在一个实施例中包括将光从可旋转反射表面传输到传感器表面的光学望远镜 。 将柱面透镜选择性地定位在光路内的第一位置将准直光转换成以多个角度入射在传感器表面上的矩形楔形物。 在另一个实施例中，光源作为激光器操作以在传感器表面上激发荧光，并且通过以特定配置定位的适当的光学元件将荧光选择性地导向检测器。

公开(公告)号：US20150124254A1

公开(公告)日：2015-05-07

申请号：US14534511

申请日：2014-11-06

Applicant: Ciencia, Inc.

Inventor： William Page ,  George N. Gibson ,  Ernest F. Guignon

IPC: G01N21/552 ,  G02F1/01

CPC classification number: G01N21/553 ,  G01N21/7743 ,  G01N2201/067 ,  G02F1/061 ,  G02F1/195

Abstract: An instrument for measuring and analyzing surface plasmon resonance (SPR) and/or surface plasmon coupled emission on an electro-optic grating-coupled sensor surface is described herein. The sensor chip achieves SPR through a grating-coupled approach, with variations in the local dielectric constant at regions of interest (ROI) at the sensor surface detected as a function of the intensity of light reflecting from these ROI. Unlike other grating-based approaches, the metal surface is sufficiently thin that resonant conditions are sensitive to dielectric constant changes both above and below the metal surface (like the Kretschmann configuration). Dielectric constant shifts that occur as mass accumulates on the surface can be returned to reference intensities by applying voltage across the underlying electro-optic polymer. Approaches to the development of the sensor surfaces are described, as are software and hardware features facilitating sample handling, data gathering, and data analysis by this solid-state approach.

Abstract translation: 本文描述了用于测量和分析电光栅耦合传感器表面上的表面等离子体共振（SPR）和/或表面等离子体激元耦合发射的仪器。 传感器芯片通过光栅耦合方法实现SPR，传感器表面处的感兴趣区域（ROI）处的局部介电常数的变化作为从这些ROI反射的光的强度的函数被检测。 与其他基于光栅的方法不同，金属表面足够薄，使得谐振条件对金属表面上方和下方的介电常数变化敏感（如Kretschmann结构）。 通过在下面的电光聚合物上施加电压，可以将质量在表面上积累的介电常数偏移返回到参考强度。 描述了开发传感器表面的方法，以及通过该固态方法促进样品处理，数据采集和数据分析的软件和硬件特征。

公开(公告)号：US08526001B2

公开(公告)日：2013-09-03

申请号：US13751181

申请日：2013-01-28

Applicant: Ciencia, Inc.

Inventor： George N. Gibson ,  Ernest F. Guignon ,  Michael T. Reilly

IPC: G01N21/55

CPC classification number: G01N21/55 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/553 ,  G01N21/648 ,  G01N21/7743

Abstract: An instrument for measuring and analyzing surface plasmon resonance on a sensor surface has a polarized light source optically connected to the sensor surface by a plurality of optical elements, including in one embodiment an optical telescope that transfers light from a rotatable reflecting surface to the sensor surface. Selective positioning of a cylindrical lens into a first position within the path of light transforms collimated light to a rectangular wedge that is incident upon the sensor surface at numerous angles. In another embodiment, the light source is operated as a laser to excite fluorescence on the sensor surface and the fluorescence is selectively directed to a detector by appropriate optical elements positioned in specific configurations.