公开(公告)号：US5822060A

公开(公告)日：1998-10-13

申请号：US783157

申请日：1997-01-14

Applicant: Clemens Linowski ,  Thomas Doerr

Inventor： Clemens Linowski ,  Thomas Doerr

IPC: G01J3/44 ,  G01N27/447 ,  G01N30/74 ,  G01N30/86 ,  G01J3/30 ,  G01J3/28

CPC classification number: G01J3/4406 ,  G01N27/44721 ,  G01N30/74 ,  G01N30/8617

Abstract: A method of detecting sample substances separated by an analytical separation technique, for example liquid chromatography or capillary electrophoresis, using electromagnetic radiation, and a corresponding fluorescence spectrometer are disclosed. The spectrometer comprises: a flashlamp for emitting pulses of light, an adjustable diffraction element for adjusting selectable measuring wavelengths, a sample cuvette through which sample substances to be detected flow, detection means for receiving fluorescence light emitted from said sample substances flowing through said sample cuvette, and control means for adjusting different measuring wavelengths by corresponding control of said adjustable diffraction element, and for synchronizing the emission of light pulses from said flashlamp with said adjusting of different measuring wavelengths.

Abstract translation: 公开了通过分析分离技术分离的样品物质的方法，例如使用电磁辐射的液相色谱或毛细管电泳，以及相应的荧光光谱仪。 光谱仪包括：用于发射光脉冲的闪光灯，用于调节可选择的测量波长的可调节衍射元件，待检测样品物质流过的样品比色皿，用于接收从流过所述样品比色皿的所述样品物质发射的荧光的检测装置 以及用于通过所述可调节衍射元件的相应控制来调节不同测量波长的控制装置，以及用于使来自所述闪光灯的光脉冲的发射与所述不同测量波长的调节同步。

公开(公告)号：US5721613A

公开(公告)日：1998-02-24

申请号：US755931

申请日：1996-11-25

Applicant: Clemens Linowski ,  Thomas Doerr

Inventor： Clemens Linowski ,  Thomas Doerr

IPC: G01J3/44 ,  G01N30/74 ,  G01J3/443 ,  G01N21/64

CPC classification number: G01J3/4406 ,  G01N30/74

Abstract: A fluorescence spectrometer comprises a light source with a flashlamp (2), means (9) for selecting an excitation wavelength, a sample cuvette (11), means (16) for spectrally separating the radiation emitted from the sample cuvette (11), and detector means (18) for detecting the spectrally separated radiation. The detector means (18) comprise an avalanche photodiode, preferably an array of avalanche photodiodes. The use of a flashlamp in combination with avalanche photodiodes ensures high sensitivity in the determination of low sample concentrations, in particular when the sample composition changes over time as in liquid chromatography.

Abstract translation: 荧光光谱仪包括具有闪光灯（2）的光源，用于选择激发波长的装置（9），样品比色杯（11），用于光谱分离从样品比色皿（11）发射的辐射的装置（16），以及 用于检测光谱分离的辐射的检测器装置（18）。 检测器装置（18）包括雪崩光电二极管，优选地是雪崩光电二极管阵列。 使用闪光灯与雪崩光电二极管组合确保了在测定低样品浓度时的高灵敏度，特别是当样品组成随时间而变化时，如在液相色谱中。

公开(公告)号：US09339644B2

公开(公告)日：2016-05-17

申请号：US13004165

申请日：2011-01-11

Applicant: Thomas Doerr ,  Ingo Weiss

Inventor： Thomas Doerr ,  Ingo Weiss

IPC: A61N1/05 ,  A61N1/08 ,  G01R33/28

CPC classification number: A61N1/05 ,  A61N1/086 ,  G01R33/288

Abstract: The present invention relates to an apparatus for medical applications. The apparatus includes an oblong conductive element having a distal end. A resistance element is disposed in the vicinity of the distal end. The resistance element changes the resistance thereof as a function of a temperature and/or an electromagnetic field. To this end, the resistance element is designed to reduce a temperature rise of the distal end caused by energy absorption from, for example, an electromagnetic field.

Abstract translation: 本发明涉及一种用于医疗应用的装置。 该装置包括具有远端的长方形导电元件。 电阻元件设置在远端附近。 电阻元件根据温度和/或电磁场改变其电阻。 为此，电阻元件被设计成减少由例如电磁场的能量吸收引起的远端的温度升高。

公开(公告)号：US09278227B2

公开(公告)日：2016-03-08

申请号：US13539412

申请日：2012-06-30

Applicant: Thomas Doerr

Inventor： Thomas Doerr

IPC: A61N1/362 ,  A61N1/39 ,  A61N1/05

CPC classification number: A61N1/3918 ,  A61N1/0563 ,  A61N1/3962

Abstract: An implantable defibrillation arrangement comprising a defibrillation device having a sensing component and a defibrillation component, and an electrode lead comprising a lead body, a plug, a sensing electrode for sensing cardiac action potentials with a first electrode supply lead, and a defibrillation electrode for transmitting shock pulses to cardiac tissue with a second electrode supply lead, wherein a switching unit is provided to switch the sensing electrode to the potential of the defibrillation electrode in response to the output of a defibrillation shock by the defibrillation component.

Abstract translation: 一种可植入除颤装置，包括具有感测部件和除颤部件的除颤装置，以及包括引线体，插塞，用于利用第一电​​极供给引线感测心脏动作电位的感测电极的电极引线，以及用于发送的除颤电极 用第二电极供应引线对心脏组织进行冲击脉冲，其中提供切换单元以响应于除颤组件的除颤电击的输出将感测电极切换到除颤电极的电位。

公开(公告)号：US09238143B2

公开(公告)日：2016-01-19

申请号：US13446158

申请日：2012-04-13

Applicant: Thomas Doerr

Inventor： Thomas Doerr

IPC: A61N1/08 ,  A61N1/372

CPC classification number: A61N1/37241 ,  A61N2001/083

Abstract: An exemplary implantable medical device includes an electrode lead connector having at least one electrical contact for connection of an electrode lead, and an analyzing unit which is connected to the electrode lead connector and is designed to detect and evaluate a response signal present at the at least one electrical connector in response to known electromagnetic irradiation. The analyzing unit may compare a signal modulation resulting from an electromagnetic irradiation of the electrode lead with a reference signal modulation. The electrode lead may be classified as defective if the deviation exceeds a threshold deviation. If a second antenna is available, the analyzing unit may compare response signals resulting from electromagnetic irradiation of the electrode lead and the second antenna. If the ratio of response signals exceeds a threshold, the electrode lead may be classified as defective.

Abstract translation: 示例性可植入医疗装置包括具有用于连接电极引线的至少一个电触头的电极引线连接器和连接到电极引线连接器的分析单元，其被设计成检测和评估至少存在的响应信号 一个电连接器响应于已知的电磁辐射。 分析单元可以将由电极引线的电磁辐射产生的信号调制与参考信号调制进行比较。 如果偏差超过阈值偏差，则电极引线可能被分类为有缺陷的。 如果第二天线可用，则分析单元可以比较由电极引线和第二天线的电磁辐射产生的响应信号。 如果响应信号的比例超过阈值，则电极引线可能被分类为有缺陷的。

公开(公告)号：US09220914B2

公开(公告)日：2015-12-29

申请号：US13084624

申请日：2011-04-12

Applicant: Thomas Doerr ,  Volker Lang

Inventor： Thomas Doerr ,  Volker Lang

IPC: A61N1/37 ,  A61N1/39 ,  A61N1/378

CPC classification number: A61N1/3975 ,  A61N1/3708 ,  A61N1/378 ,  A61N1/3937

Abstract: An energy accumulator arrangement for an electromedical implant includes a battery, a capacitor, and a charging device which is designed to supply an electric charge from the battery to the capacitor according to a charging program. A maintenance system for maintaining the energy accumulator arrangement includes a monitoring device contained in the implant which captures a physical parameter value of the energy accumulator arrangement; an evaluation unit for evaluating the captured physical parameter value and generating a resulting evaluation result signal; a transceiver contained in the implant which sends the captured physical parameter value to the evaluation unit, and receive the evaluation result signal generated by the evaluation unit; and additionally a control unit contained in the implant which controls the charging device and the monitoring device, and adapts the charging program as a function of the evaluation result signal.

Abstract translation: 用于电动植入物的蓄能器装置包括电池，电容器和充电装置，其被设计成根据充电程序从电池向电容器提供电荷。 用于维持蓄能器装置的维护系统包括：包含在植入物中的监测装置，其捕获蓄能器装置的物理参数值; 评估单元，用于评估所捕获的物理参数值并产生所得到的评估结果信号; 包含在所述植入物中的收发器，其将所捕获的物理参数值发送到所述评估单元，并且接收由所述评估单元生成的评估结果信号; 以及附加地包含在植入物中的控制单元，其控制充电装置和监视装置，并且根据评估结果信号调整充电程序。

公开(公告)号：US09072618B2

公开(公告)日：2015-07-07

申请号：US13085718

申请日：2011-04-13

Applicant: Thomas Doerr ,  Alexander Borck

Inventor： Thomas Doerr ,  Alexander Borck

IPC: A61F2/82 ,  A61L27/52 ,  A61L27/04 ,  A61L27/28 ,  A61L27/50 ,  A61L27/58 ,  A61L31/02 ,  A61L31/08 ,  A61L31/14

CPC classification number: A61F2/82 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61F2210/0066 ,  A61F2210/009 ,  A61F2250/0001 ,  A61F2250/003 ,  A61L27/04 ,  A61L27/28 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/022 ,  A61L31/08 ,  A61L31/14 ,  A61L31/148

Abstract: The present invention relates to a biocorrodable implant in which corrosion may be triggered or accelerated after implantation by applying an external stimulus, the implant having a base body which is completely or partially composed of a biocorrodable metallic material, and the base body having a coating with a protective layer which is not biocorrodable. According to the invention, the implant has control elements which are configured in such a way that the protective layer, optionally in combination with the control elements, completely or partially encloses the base body so as to be impermeable to bodily medium, and the protective layer being convertible to a form which is permeable to bodily medium as the result of a change in shape of the control elements which may be regulated and/or controlled by an external stimulus.

Abstract translation: 本发明涉及一种生物可蚀刻植入物，其中可以通过施加外部刺激在植入后触发或加速腐蚀，所述植入物具有完全或部分由生物可腐蚀金属材料组成的基体，并且所述基体具有涂层 不能生物保护的保护层。 根据本发明，植入物具有控制元件，其配置成使得保护层任选地与控制元件组合，完全或部分地包围基体以便不能渗透到身体介质上，并且保护层 可转换为可由外部刺激调节和/或控制的控制元件的形状变化的结果导致的体内可渗透的形式。

公开(公告)号：US09050456B2

公开(公告)日：2015-06-09

申请号：US13539422

申请日：2012-06-30

Applicant: Thomas Doerr

Inventor： Thomas Doerr

IPC: A61N1/05 ,  A61N1/39

CPC classification number: A61N1/0563 ,  A61N1/3962

Abstract: A unipolar multipurpose electrode line, comprising a line body, a unipolar plug, a defibrillation electrode attached to the line body, and a stimulation and sensing electrode, which are connected by way of a common feed line to the unipolar plug, wherein the defibrillation electrode is connected by means of at least one voltage-dependent component to the electrode feed line so that the connection has low impedance only in response to the application of a defibrillation voltage at the plug.

Abstract translation: 一种单极多用途电极线，包括线体，单极插塞，附着于线体的除颤电极以及通过公共馈电线连接到单极插头的刺激感测电极，其中除颤电极 通过至少一个电压依赖组件连接到电极馈电线，使得连接仅响应于在插塞处施加除颤电压而具有低阻抗。

公开(公告)号：US08965495B2

公开(公告)日：2015-02-24

申请号：US13195560

申请日：2011-08-01

Applicant: Thomas Doerr

Inventor： Thomas Doerr

IPC: A61B5/04 ,  A61N1/362

CPC classification number: A61N1/3621

Abstract: An implantable electronic therapy device, having a therapy unit, a heart rate capturing unit, a contractility determination unit, and an evaluation and control unit. The therapy unit delivers an antitachycardiac therapy. The heart rate capturing unit determines a ventricular heart rate from an input signal, and the contractility determination unit generates from an input signal, a contraction signal reflecting a contractility of a ventricle. The evaluation and control unit is connected to the therapy unit, the heart rate capturing unit, and the contractility determination unit actuates the therapy unit to administer an antitachycardiac therapy when the heart rate capturing unit detects an increase in the heart rate above a specified threshold value and the contractility determination unit supplies a contraction signal which is not physiologically adequate for the increase in the heart rate.

Abstract translation: 一种可植入电子治疗装置，具有治疗单元，心率捕获单元，收缩力确定单元和评估和控制单元。 治疗单位提供抗心律失常疗法。 心率捕获单元从输入信号确定心室心率，并且收缩力确定单元从输入信号产生反映心室收缩力的收缩信号。 评估和控制单元连接到治疗单元，心率捕获单元和收缩力确定单元致动治疗单元以在心率捕获单元检测到心率增加高于指定阈值时进行抗心律失调治疗 并且收缩性判定单元提供在生理上不足以增加心率的收缩信号。

公开(公告)号：US08886305B2

公开(公告)日：2014-11-11

申请号：US12407703

申请日：2009-03-19

Applicant: Thomas Doerr ,  Frank Tscherch ,  Ulrich Tietze

Inventor： Thomas Doerr ,  Frank Tscherch ,  Ulrich Tietze

IPC: A61N1/05 ,  A61N1/39 ,  A61N1/362 ,  A61N1/368 ,  A61N1/37

CPC classification number: A61N1/3925 ,  A61N1/3622 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3704 ,  A61N1/3962

Abstract: The invention relates to an implantable ventricular heart stimulator (10), comprising an at least partially electrically conductive housing (12), an electrode line terminal for connection of a ventricular defibrillation electrode line (20) and a terminal for a defibrillation electrode (26). According to the invention, the heart stimulator has a far-field electrocardiogram detection unit (70) which has a first input connected to the terminal for the ventricular defibrillation electrode and has a second input connected to the electrically conductive housing and designed or configured to generate a far-field electrocardiogram on the basis of the electric potentials applied to the two inputs during operation. The inventive heart stimulator also has a far-field electrocardiogram evaluation unit (72) which is connected to the far-field electrocardiogram detection unit and is designed to detect signal features characteristic of atrial depolarizations in a far-field electrocardiogram generated by the far-field electrocardiogram detection unit.

Abstract translation: 本发明涉及可植入心室心脏刺激器（10），其包括至少部分导电的壳体（12），用于连接心室除颤电极线（20）和用于除颤电极（26）的端子的电极线端子， 。 根据本发明，心脏刺激器具有远场心电图检测单元（70），其具有连接到心室除颤电极的端子的第一输入端，并且具有连接到导电壳体的第二输入端，并被设计或构造成产生 基于在操作期间施加到两个输入端的电位的远场心电图。 本发明的心脏刺激器还具有远场心电图评估单元（72），其连接到远场心电图检测单元，并被设计成检测由远场产生的远场心电图中心房去极化特征的信号特征 心电图检测单元。