公开(公告)号：US10784098B2

公开(公告)日：2020-09-22

申请号：US16490400

申请日：2018-03-01

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Igor Chernushevich ,  Nic G. Bloomfield

IPC: H01J49/40 ,  H01J49/02 ,  H01J49/00 ,  H01J49/06

Abstract: Two-channel electrical and photo-electrical TOF ion detection systems are provided. These systems maintain the resolution and dynamic range advantages of four-channel systems but at a lower cost. Electrodes or light pipes are configured to direct electrons or photons produced by ion impacts into two separate channels. The first channel receives electrons or photons resulting from the inner or central part of the rectangular pattern of each ion impact. The second channel receives electrons or photons resulting from the two outer ends of the rectangular pattern of each ion impact. In a two-channel digitizer, the first channel and the second channel are independently calibrated to align the first digital value and the second digital value in time and account for the convex shape of the ion impacts of each ion packet and/or the curvature of a microchannel plate.

公开(公告)号：US20140357502A1

公开(公告)日：2014-12-04

申请号：US14365983

申请日：2012-11-28

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD

Inventor： John Lawrence Campbell ,  Yves Le Blanc ,  Alexandre V. Loboda ,  Igor Chernushevich

IPC: G06F19/00

CPC classification number: G06F19/703 ,  H01J49/0031 ,  H01J49/004

Abstract: In a first location of a mass spectrometer, a plurality of ionized molecules of an ion source are selected that have mass-to-charge ratios within a mass-to-charge ratio window width. The plurality of selected ionized molecules are transmitted from a first to a second location. Reagent ions are transmitted to the second location to reduce a charge state of one or more of the plurality of selected ionized molecules. A mass analyzer is used to analyze the plurality of reduced ionized molecules and produce a mass spectrum. A compound is identified from a peak of the spectrum that has a mass-to-charge ratio less than or equal to the highest mass-to-charge ratio in the window width if the noise is multiply charged and greater than the highest mass-to-charge ratio in the window width if the noise is singly charged.

Abstract translation: 在质谱仪的第一位置，选择离子源的多个离子化分子，其具有在质荷比窗口宽度之内的质荷比。 多个选择的电离分子从第一位置传递到第二位置。 试剂离子被传递到第二位置以减少多个选定的电离分子中的一个或多个的电荷状态。 质量分析器用于分析多个还原离子化分子并产生质谱。 如果噪声是多次充电并且大于最高质量 - 到达的质量 - 荷电比，如果光谱的峰值具有小于或等于窗口宽度中的最高质荷比的化合物， 如果噪声被单独充电，则窗口宽度的充电比例。

公开(公告)号：US12283474B2

公开(公告)日：2025-04-22

申请号：US16980956

申请日：2019-04-10

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Nicholas G. Bloomfield ,  Igor Chernushevich ,  Robert Haufler

IPC: H01J49/40 ,  H01J49/00 ,  H01J49/06 ,  H01J49/42

Abstract: Systems and methods are disclosed for dynamically switching an ion guide and a TOF mass analyzer between concentrating or not concentrating ions in a targeted acquisition. Product ions are ejected from the ion guide into the TOF mass analyzer and the intensity of a known product ion is measured at two or more time steps. The ion guide initially ejects product ions using a sequential or Zeno pulsing mode that concentrates product ions with different m/z values within the TOF mass analyzer at the same time. If the intensity of the product ion is increasing and greater than a threshold intensity, the ion guide switches to a continuous or normal pulsing mode that does not concentrate ions with different m/z values in the TOF mass analyzer at the same time. Similarly, if the intensity decreases below a threshold in continuous mode, the ion guide switches back to sequential mode.

公开(公告)号：US20240242958A1

公开(公告)日：2024-07-18

申请号：US18559108

申请日：2022-05-03

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Igor Chernushevich ,  Pavel Ryumin ,  Takashi Baba

IPC: H01J49/42 ,  H01J49/38

CPC classification number: H01J49/4225 ,  H01J49/38 ,  H01J49/4245

Abstract: During an accumulation time period of each time cycle of an ion guide and before a ramped AC voltage is applied to at least one set of axial rods to eject ions according to m/z value, a number of steps are performed. Ions are received from outside of the ion guide through an entrance aperture and into a first cell. A low DC voltage is applied to a barrier electrode to receive ions from the first cell into a second cell. And, a high DC voltage is applied to an exit electrode to prevent ions from exiting the ion guide. During a cooling time period before the AC time period, a high DC voltage is applied to the barrier electrode to trap and cool ions in the second cell and to continue to receive ions into the first cell without being affected by the ramped AC voltage.

公开(公告)号：US20200020517A1

公开(公告)日：2020-01-16

申请号：US16490400

申请日：2018-03-01

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Igor Chernushevich ,  Nic G. Bloomfield

IPC: H01J49/40 ,  H01J49/02 ,  H01J49/00 ,  H01J49/06

Abstract: Two-channel electrical and photo-electrical TOF ion detection systems are provided. These systems maintain the resolution and dynamic range advantages of four-channel systems but at a lower cost. Electrodes or light pipes are configured to direct electrons or photons produced by ion impacts into two separate channels. The first channel receives electrons or photons resulting from the inner or central part of the rectangular pattern of each ion impact. The second channel receives electrons or photons resulting from the two outer ends of the rectangular pattern of each ion impact. In a two-channel digitizer, the first channel and the second channel are independently calibrated to align the first digital value and the second digital value in time and account for the convex shape of the ion impacts of each ion packet and/or the curvature of a microchannel plate.

公开(公告)号：US20160209361A1

公开(公告)日：2016-07-21

申请号：US14907450

申请日：2014-08-07

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Nic G. Bloomfield ,  Alexandre V. Loboda ,  Igor Chernushevich

IPC: G01N27/62 ,  H01J49/40 ,  H01J49/42

CPC classification number: G01N27/62 ,  G16C20/20 ,  H01J49/0036 ,  H01J49/40 ,  H01J49/4225

Abstract: Systems and methods are provided for calculating and storing an average amplitude response for each peak of a mass spectrum during data acquisition. A mass analyzer is instructed to analyze N extractions of an ion beam, producing N sub-spectra. For each sub-spectrum of the N sub-spectra, a nonzero amplitude from an ADC detector subsystem is counted as one ion, producing a count of one for each ion. The ADC amplitudes and counts of the N sub-spectra are summed, producing a spectrum that includes a summed ADC amplitude and a total count for each ion. For each ion of the spectrum, an estimated ion count is calculated from a Poisson distribution of the total count of each ion for the N sub-spectra. For each ion of the spectrum, an average amplitude response is calculated by dividing the summed amplitude by the estimated ion count and stored.

Abstract translation: 提供了用于在数据采集期间计算和存储质谱的每个峰值的平均振幅响应的系统和方法。 指示质量分析仪分析离子束的N次提取，产生N个子光谱。 对于N个子光谱的每个子光谱，来自ADC检测器子系统的非零幅度被计为一个离子，为每个离子产生一个计数。 将N个子谱的ADC幅度和计数相加，产生包括ADC的幅度和每个离子的总计数的谱。 对于光谱的每个离子，从N个子光谱的每个离子的总计数的泊松分布计算估计的离子计数。 对于频谱的每个离子，通过将总和振幅除以估计的离子计数并存储来计算平均振幅响应。

公开(公告)号：US09390238B2

公开(公告)日：2016-07-12

申请号：US14365983

申请日：2012-11-28

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： John Lawrence Campbell ,  Yves Le Blanc ,  Alexandre V. Loboda ,  Igor Chernushevich

IPC: H01J49/00 ,  G06F19/00

CPC classification number: G06F19/703 ,  H01J49/0031 ,  H01J49/004

Abstract: In a first location of a mass spectrometer, a plurality of ionized molecules of an ion source are selected that have mass-to-charge ratios within a mass-to-charge ratio window width. The plurality of selected ionized molecules are transmitted from a first to a second location. Reagent ions are transmitted to the second location to reduce a charge state of one or more of the plurality of selected ionized molecules. A mass analyzer is used to analyze the plurality of reduced ionized molecules and produce a mass spectrum. A compound is identified from a peak of the spectrum that has a mass-to-charge ratio less than or equal to the highest mass-to-charge ratio in the window width if the noise is multiply charged and greater than the highest mass-to-charge ratio in the window width if the noise is singly charged.

Abstract translation: 在质谱仪的第一位置，选择离子源的多个离子化分子，其具有在质荷比窗口宽度之内的质荷比。 多个选择的电离分子从第一位置传递到第二位置。 试剂离子被传递到第二位置以减少多个选定的电离分子中的一个或多个的电荷状态。 质量分析器用于分析多个还原离子化分子并产生质谱。 如果噪声是多次充电并且大于最高质量 - 到达的质量 - 荷电比，如果光谱的峰值具有小于或等于窗口宽度中的最高质荷比的化合物， 如果噪声被单独充电，则窗口宽度的充电比例。