公开(公告)号：US20160233077A1

公开(公告)日：2016-08-11

申请号：US15026236

申请日：2014-10-07

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： James Walter Hager ,  Frank Londry ,  Nic G. Bloomfield

IPC: H01J49/42 ,  H01J49/04 ,  H01J49/00

CPC classification number: H01J49/4215 ,  H01J49/0027 ,  H01J49/004 ,  H01J49/04 ,  H01J49/427

Abstract: Systems and methods are provided for shaping an effective transmission window used to select precursor ions for a precursor mass range of a sequential windowed acquisition experiment. For at least one precursor mass range, an ion transfer function is selected that is a function of mass using a processor. A quadrupole mass filter that transmits ions from a sample is instructed to produce two or more transmission windows over time using the processor. The two or more transmission windows are produced to cumulatively create an effective transmission window for the at least one precursor mass range with a shape described by the ion transfer function.

Abstract translation: 提供了系统和方法，用于形成用于选择前体离子的有效传输窗口用于顺序窗口采集实验的前体质量范围。 对于至少一个前体质量范围，选择使用处理器作为质量的函数的离子传递函数。 指示从样品传输离子的四极质量过滤器使用处理器随时间产生两个或更多个传输窗口。 产生两个或更多个传输窗口以累积地产生具有由离子传递函数描述的形状的至少一个前体质量范围的有效传播窗口。

公开(公告)号：US09768009B2

公开(公告)日：2017-09-19

申请号：US15026236

申请日：2014-10-07

Applicant: DH Technologies Development Pte. Ltd.

Inventor： James Walter Hager ,  Frank Londry ,  Nic G. Bloomfield

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/4215 ,  H01J49/0027 ,  H01J49/004 ,  H01J49/04 ,  H01J49/427

Abstract: Systems and methods are provided for shaping an effective transmission window used to select precursor ions for a precursor mass range of a sequential windowed acquisition experiment. For at least one precursor mass range, an ion transfer function is selected that is a function of mass using a processor. A quadrupole mass filter that transmits ions from a sample is instructed to produce two or more transmission windows over time using the processor. The two or more transmission windows are produced to cumulatively create an effective transmission window for the at least one precursor mass range with a shape described by the ion transfer function.

公开(公告)号：US10446384B2

公开(公告)日：2019-10-15

申请号：US15567474

申请日：2016-04-19

Applicant: DH Technologies Development Pte. Ltd.

Inventor： James Walter Hager

IPC: H01J49/00 ,  H01J49/38 ,  H01J49/42 ,  H01J49/08

Abstract: A quadrupole is filled with ions and the ions are cooled by applying a pressure and gas flow within the quadrupole. Ions are trapped in the quadrupole by applying a DC voltage and an RF voltage to quadrupole rods of the quadrupole, one or more DC voltages to a plurality of auxiliary electrodes of the quadrupole, and a DC voltage and an RF voltage to an exit lens at the end of the quadrupole. The ions are coherently oscillated after the filling and cooling by applying a coherent excitation between at least two rods of the quadrupole rods. The coherently oscillating ions are axially ejected through the exit lens and to a destructive detector for detection by changing one or more voltages of the one or more DC voltages of the plurality of auxiliary electrodes and changing the DC voltage of the exit lens.

公开(公告)号：US20180114685A1

公开(公告)日：2018-04-26

申请号：US15567474

申请日：2016-04-19

Applicant: DH Technologies Development Pte. Ltd.

Inventor： James Walter Hager

IPC: H01J49/38 ,  H01J49/42 ,  H01J49/08

CPC classification number: H01J49/38 ,  H01J49/08 ,  H01J49/4205

Abstract: A quadrupole is filled with ions and the ions are cooled by applying a pressure and gas flow within the quadrupole. Ions are trapped in the quadrupole by applying a DC voltage and an RF voltage to quadrupole rods of the quadrupole, one or more DC voltages to a plurality of auxiliary electrodes of the quadrupole, and a DC voltage and an RF voltage to an exit lens at the end of the quadrupole. The ions are coherently oscillated after the filling and cooling by applying a coherent excitation between at least two rods of the quadrupole rods. The coherently oscillating ions are axially ejected through the exit lens and to a destructive detector for detection by changing one or more voltages of the one or more DC voltages of the plurality of auxiliary electrodes and changing the DC voltage of the exit lens.