公开(公告)号：US20240297028A1

公开(公告)日：2024-09-05

申请号：US18589559

申请日：2024-02-28

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Scott DANIELS ,  Aaron STELLA ,  Michal WEINSTOCK

IPC: H01J49/00 ,  G06F3/0484

CPC classification number: H01J49/0009 ,  G06F3/0484

Abstract: A method for calibrating a mass spectrometry (MS) system includes: receiving at least one input through a corresponding to a calibrator in a sample, wherein the sample includes an analyte, and wherein the sample is analyzed by the MS system; automatically determining a plurality of transitions in the sample corresponding to the calibrator according to natural abundances of isotopes; automatically determining concentrations of the plurality of transitions according to a concentration of the calibrator in the sample; identifying a plurality of transitions as calibrator transitions and for identifying a different one of the plurality of transitions as an internal standard; detecting a concentration of each of the plurality of transitions and the calibrator in the sample; automatically calibrating the MS system based in part on the detected concentrations of the plurality of calibrator transitions and the internal standard; and detecting the concentration of the analyte in response to execution of the calibration instructions.

公开(公告)号：US20230258652A1

公开(公告)日：2023-08-17

申请号：US18020690

申请日：2021-08-11

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Scott DANIELS ,  Subhakar Dey ,  Subhasish PURKAYASTHA

IPC: G01N33/68 ,  G01N33/58 ,  G01N33/74

CPC classification number: G01N33/6848 ,  G01N33/58 ,  G01N33/743 ,  G01N2560/00 ,  G01N2458/15

Abstract: A derivatizing reagent, set of derivatizing reagents, and derivatizing techniques are provided herein for the relative quantitation, absolute quantitation, or both, of analytes containing carboxyl and/or phenolic functional groups including those analytes that may be difficult to analyze via mass spectrometry using traditional techniques of ionization. By way of non-limiting examples, such analytes can include fatty acids, carnitines, eicosanoids, and estrogens. Methods for producing the derivatizing reagent are also disclosed.

公开(公告)号：US20250157803A1

公开(公告)日：2025-05-15

申请号：US18722148

申请日：2022-12-14

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Scott DANIELS ,  Yongquan LAI ,  Subhasish PURKAYASTHA

IPC: H01J49/00 ,  G01N30/62 ,  G01N30/72 ,  G01N30/88

Abstract: In one aspect, a calibration mass standard for use in mass spectrometry is disclosed, which includes a plurality of natural isotopologues of a compound, where the natural isotopologues are present in the mass standard at relative concentrations corresponding to their natural atomic abundances.