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    Systems and Methods for Detecting Leaks from Liquid Flow into an Ion Source of a Mass Spectrometry System
    1.
    发明申请
    Systems and Methods for Detecting Leaks from Liquid Flow into an Ion Source of a Mass Spectrometry System 有权

    公开(公告)号：US20250067617A1

    公开(公告)日：2025-02-27

    申请号：US18718916

    申请日：2022-12-13

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Amit PATEL ,  Aaron STELLA

    IPC: G01M3/20

    Abstract: Leak detection systems and methods in accordance with various aspects of the present teachings can, in various embodiments, sequester fluid leaking from the interface between a sample source and the inlet of the ion source, alert an operator as to a leak condition, and/or automatically terminate the experiment. In various aspects, a liquid leak detection system is accordance with the present teachings comprises a collection basin configured to couple to a proximal end of a conduit in fluid communication with a discharge end of an ion source of a mass spectrometer such that the proximal end of the conduit extends through the internal volume of the basin. The system may also comprise a drainage tube having an inlet end opening into an internal volume of the collection basin and configured to drain liquid therefrom, a sensor disposed within the basin or the drainage tube and configured to generate a signal indicative of liquid therewithin, and a processor that is configured to cause a user to be alerted and/or cause an experiment to be terminated upon receiving from the sensor a signal indicative of a leak.

    CALIBRATION TECHNIQUES FOR MASS SPECTROMETRY SYSTEM
    2.
    发明公开
    CALIBRATION TECHNIQUES FOR MASS SPECTROMETRY SYSTEM 审中-公开

    公开(公告)号：US20240297028A1

    公开(公告)日：2024-09-05

    申请号：US18589559

    申请日：2024-02-28

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Scott DANIELS ,  Aaron STELLA ,  Michal WEINSTOCK

    IPC: H01J49/00 ,  G06F3/0484

    CPC classification number: H01J49/0009 ,  G06F3/0484

    Abstract: A method for calibrating a mass spectrometry (MS) system includes: receiving at least one input through a corresponding to a calibrator in a sample, wherein the sample includes an analyte, and wherein the sample is analyzed by the MS system; automatically determining a plurality of transitions in the sample corresponding to the calibrator according to natural abundances of isotopes; automatically determining concentrations of the plurality of transitions according to a concentration of the calibrator in the sample; identifying a plurality of transitions as calibrator transitions and for identifying a different one of the plurality of transitions as an internal standard; detecting a concentration of each of the plurality of transitions and the calibrator in the sample; automatically calibrating the MS system based in part on the detected concentrations of the plurality of calibrator transitions and the internal standard; and detecting the concentration of the analyte in response to execution of the calibration instructions.

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