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    INTEGRATED SAMPLE PROCESSING SYSTEM WITH VARIABLE WORKFLOWS
    3.
    发明公开
    INTEGRATED SAMPLE PROCESSING SYSTEM WITH VARIABLE WORKFLOWS 审中-公开

    公开(公告)号：US20230417731A1

    公开(公告)日：2023-12-28

    申请号：US18190438

    申请日：2023-03-27

    Applicant: Beckman Coulter, Inc. ,  DH Technologies Development Pte. Ltd.

    Inventor： Aaron HUDSON ,  Takayuki MIZUTANI ,  Subhasish PURKAYASTHA ,  Thomas ROSCOE

    IPC: G01N33/487 ,  G01N35/00

    CPC classification number: G01N33/48792 ,  G01N35/1095 ,  G01N35/00871

    Abstract: One embodiment of the invention is directed to a sample processing system for analyzing a biological sample from a patient. The sample processing system comprises: a plurality of analyzers comprising at least one mass spectrometer, wherein each analyzer in the plurality of analyzers is configured to acquire at least one measurement value corresponding to at least one characteristic of the biological sample; at least one data storage component which stores (i) a list of parameters for the plurality of analyzers, and (ii) at least two condition sets, which contain data associated with completing one or more test orders. The condition sets contain data which differ by at least one variable; and a control system operatively coupled to the plurality of analyzers, and the at least one data storage component. The control system is configured to (i) determine which condition set of the at least two condition sets to use based on the determined condition set, (ii) determine which analyzer or analyzers of the plurality of analyzers to use to process each test order based on the determined condition set and one or more parameters from the list of parameters, and (iii) cause the determined analyzer or analyzers to acquire one or more measurement values for the biological sample.

    METHODS AND SYSTEMS FOR DETECTION OF VITAMIN D METABOLITES
    5.
    发明申请
    METHODS AND SYSTEMS FOR DETECTION OF VITAMIN D METABOLITES 有权

    公开(公告)号：US20210088486A1

    公开(公告)日：2021-03-25

    申请号：US16976751

    申请日：2019-01-29

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Jason Joshua COURNOYER ,  Scott B. DANIELS ,  Aaron James HUDSON ,  Subhasish PURKAYASTHA

    IPC: G01N30/86 ,  G01N30/14 ,  G01N30/72 ,  G01N30/88 ,  G01N30/60 ,  G01N1/40

    Abstract: A method and kit for detecting at least two vitamin D metabolites in a biological sample is disclosed, which comprises processing the biological sample to prepare the sample for LC-MS/MS analysis, passing the prepared sample through a liquid chromatography column having an outlet connected to an inlet port of a tandem mass spectrometer to separate said two vitamin D metabolites, if present in the sample, and introduce the two vitamin D metabolites into the tandem mass spectrometer. The method further comprises generating [M+H]+ ions of each of the two vitamin D metabolites in said tandem mass spectrometer, and generating two fragment ions of said [M+H]+ ions associated with said vitamin D metabolites, wherein said fragment ions are not due to water losses from the [M+H]+ ions; and detecting the fragment ions to identify presence of the two metabolites in the biological sample.

    Methods For Detection Of Isomeric Steroids Using Differential Mobility Spectrometry
    7.
    发明公开
    Methods For Detection Of Isomeric Steroids Using Differential Mobility Spectrometry 审中-公开

    公开(公告)号：US20240003846A1

    公开(公告)日：2024-01-04

    申请号：US18036098

    申请日：2021-11-09

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： John Lawrence Campbell ,  Subhasish PURKAYASTHA

    IPC: G01N27/624

    CPC classification number: G01N27/624

    Abstract: Method for separating, detecting, and/or quantifying steroid isomers using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicant's teachings, the method can provide for the separation of racemic or non-racemic mixtures of steroid isomers that may be difficult to separate with conventional techniques, such as mass spectrometry (MS), including both steroid stereoisomers and constitutional steroid isomers. The method may further comprise detecting the ionized derivatized steroids transported from the differential mobility spectrometer at a first combination of compensation voltage and separation voltage and at a second combination of compensation voltage and separation voltage applied to the differential mobility spectrometer, wherein the first combination is configured to optimize transmission of a first ionized derivatized steroid corresponding to a first steroid of an isomeric steroid pair and the second combination is configured to optimize transmission of a second ionized derivatized steroid corresponding to a second steroid of the isomeric steroid pair.

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