公开(公告)号：US20130213154A1

公开(公告)日：2013-08-22

申请号：US13880402

申请日：2011-11-09

Applicant: Timothy M. Crowder ,  Jason E. Dickens ,  Kevin J. Ely ,  Dwight Sherod Walker

Inventor： Timothy M. Crowder ,  Jason E. Dickens ,  Kevin J. Ely ,  Dwight Sherod Walker

IPC: G01N21/64 ,  G01N21/25 ,  G01N21/65 ,  G01N33/00

CPC classification number: G01N21/64 ,  B08B1/00 ,  G01N21/25 ,  G01N21/65 ,  G01N21/76 ,  G01N33/00 ,  G01N2001/028 ,  G01N2201/0221

Abstract: A method of determining cleanliness of a manufacturing area is disclosed. The method of determining cleanliness of a manufacturing area comprising swabbing at least one target area within the manufacturing area, placing the swab in a testing apparatus, analyzing for the presence of the at least one substance with the testing apparatus and determining in real time the cleanliness of the manufacturing area.

Abstract translation: 公开了一种确定制造区域的清洁度的方法。 确定制造区域的清洁度的方法，包括在制造区域内擦拭至少一个目标区域，将拭子放置在测试装置中，用测试装置分析至少一种物质的存在并实时确定清洁度 的制造区域。

公开(公告)号：US20100148091A1

公开(公告)日：2010-06-17

申请号：US12442972

申请日：2007-09-12

Applicant: Dwight Sherod Walker

Inventor： Dwight Sherod Walker

IPC: G01J1/58 ,  G01N21/64

CPC classification number: G01N21/6408 ,  G01N21/85 ,  G01N2201/0221 ,  G01N2201/062 ,  G01N2201/0625 ,  G01N2201/0696 ,  G01N2201/129

Abstract: A system for use in analyzing a pharmaceutical composition having multiple constituents comprising a luminescence sensor, the sensor being adapted to direct a plurality of radiation pulses to the pharmaceutical composition and detect luminescence emitted from each composition constituent as a function of time, the sensor being further adapted to provide at least one luminescence signal corresponding to the detected luminescence of each constituent, and control means in communication with the sensor for controlling the sensor and analyzing the luminescence signal.

Abstract translation: 一种用于分析具有多个成分的药物组合物的系统，所述组合物包含发光传感器，所述传感器适于将多个辐射脉冲引导到所述药物组合物并检测作为时间的函数从每个组成成分发出的发光，所述传感器进一步 适于提供对应于每个构件的检测到的发光的至少一个发光信号，以及与传感器通信的控制装置，用于控制传感器并分析发光信号。

公开(公告)号：US07034933B2

公开(公告)日：2006-04-25

申请号：US10451868

申请日：2002-01-25

Applicant: Dwight Sherod Walker ,  Mark Austin Patrick

Inventor： Dwight Sherod Walker ,  Mark Austin Patrick

IPC: G01N1/10

CPC classification number: G01N21/05 ,  G01N21/31

Abstract: A system and method for in vitro analysis of therapeutic agents comprising a reservoir adapted to hold a therapeutic agent, a first flow cell having a first cell chamber adapted to receive at least a first sample of the therapeutic agent, a second flow cell having a second cell chamber adapted to receive at least a second sample of the therapeutic agent, the first flow cell having a first path length (be′) and the second flow cell having a second path length (be″), the first path length being substantially equal to a sensitivity factor (f)×be″, a membrane chamber having a biological cell membrane therein adapted to receive at least a third sample of the therapeutic agent, the membrane chamber being further adapted to detect the membrane potential of the biological cell membrane; and spectroscopic detection means for detecting the spectral characteristics of the first and second therapeutic agent samples.

Abstract translation: 一种用于体外分析治疗剂的系统和方法，所述治疗剂包括适于保持治疗剂的贮存器，具有适于接收所述治疗剂的至少第一样品的第一细胞室的第一流动池，具有第二流体池 细胞室，其适于接收至少第二样品的治疗剂，所述第一流动池具有第一路径长度（b），所述第二流动池具有第二路径长度（b

公开(公告)号：US20110026010A1

公开(公告)日：2011-02-03

申请号：US12672625

申请日：2008-08-07

Applicant: Dwight Sherod Walker

Inventor： Dwight Sherod Walker

IPC: G01J3/00 ,  G01B11/02

CPC classification number: G01N21/4795 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/9508

Abstract: An optical coherence tomographic analysis system for analyzing a pharmaceutical delivery system comprising manufacturing means for manufacturing the pharmaceutical delivery system, the manufacturing means including at least one manufacturing process, and an optical coherence tomographic system having a light source that is adapted to direct a radiation beam to the pharmaceutical delivery system, whereby the radiation beam interacts with the pharmaceutical delivery system, the interaction including the emission of emitted light by the pharmaceutical delivery system, the interferometer being adapted to receive the emitted light from the pharmaceutical delivery system and construct an optical image of the pharmaceutical delivery system from the emitted light in real-time during manufacturing of the pharmaceutical delivery system.

Abstract translation: 一种用于分析药物递送系统的光学相干断层分析系统，包括用于制造药物递送系统的制造装置，所述制造装置包括至少一个制造过程，以及具有光源的光学相干断层摄影系统，所述光学相干断层摄影系统适于引导辐射束 由此辐射束与药物递送系统相互作用，所述相互作用包括由药物递送系统发射的发射光，干涉仪适于接收来自药物递送系统的发射光并构建光学图像 的药物递送系统在药物递送系统的制造期间实时发射。

公开(公告)号：US20100172839A1

公开(公告)日：2010-07-08

申请号：US12514472

申请日：2007-11-12

Applicant: Dwight Sherod Walker

Inventor： Dwight Sherod Walker

IPC: A61K49/00 ,  A61B7/00

CPC classification number: A61B7/008 ,  A61B5/42 ,  A61B5/6805 ,  A61B7/04

Abstract: A system and method for evaluating gastrointestinal motility that can be effectively employed to acquire one or more signals associated with acoustic energy (i.e. sound) emanating from an abdominal region of a body and determine at least one gastrointestinal parameter based on the acoustic energy signal(s) is described. The gastrointestinal parameter can include a gastrointestinal event, including gastrointestinal mixing, emptying, contraction and propulsion, and gastrointestinal transit time.

Abstract translation: 一种用于评估胃肠运动性的系统和方法，其可以有效地用于获取与从身体的腹部区域发出的声能（即声音）相关联的一个或多个信号，并基于声能信号确定至少一个胃肠参数 ）。 胃肠道参数可以包括胃肠道事件，包括胃肠混合，排空，收缩和推进，以及胃肠通过时间。

公开(公告)号：US20080306355A1

公开(公告)日：2008-12-11

申请号：US12117161

申请日：2008-05-08

Applicant: Dwight Sherod Walker

Inventor： Dwight Sherod Walker

IPC: A61B5/02 ,  A61B7/00 ,  A61B5/11

CPC classification number: A61B7/008 ,  A61B5/42 ,  A61B5/6805

Abstract: A system and method for evaluating gastrointestinal motility and, optionally, other physiological characteristics (e.g., pulse rate) that can be effectively employed to acquire one or more signals associated with acoustic energy (i.e. sound) emanating from an abdominal region of a body and determine at least one gastrointestinal parameter or event based on the acoustic energy signal(s) is described. The gastrointestinal parameter can include a gastrointestinal event, including gastrointestinal mixing, emptying, contraction and propulsion, and gastrointestinal transit time, or a gastrointestinal system disorder, including reflux disease, irritable bowel disease, ulcerative colitis, constipation, diarrhea, and a migrating motor complex disorder.

Abstract translation: 一种用于评估胃肠运动性和任选的其他生理特征（例如，脉搏率）的系统和方法，其可以有效地用于获取与从身体的腹部区域发出的声能（即声音）相关联的一个或多个信号，并且确定 描述了基于声能信号的至少一个胃肠参数或事件。 胃肠道参数可以包括胃肠道事件，包括胃肠混合，排空，收缩和推进，以及胃肠道通过时间，或胃肠系统疾病，包括反流疾病，肠易激肠，溃疡性结肠炎，便秘，腹泻和迁移运动综合征 紊乱。

公开(公告)号：US07089786B2

公开(公告)日：2006-08-15

申请号：US10513841

申请日：2003-05-12

Applicant: Dwight Sherod Walker

Inventor： Dwight Sherod Walker

IPC: G01B23/00

CPC classification number: G01K1/022 ,  B65D79/02 ,  G01K1/026 ,  G01K5/486 ,  G01N35/00009

Abstract: A sensor system for determining at least one environmental condition within pharmaceutical packaging comprising a base sheet with at least one pocket formed therein, a lid sheet having a pocket portion, the pocket portion being disposed proximate the pocket when the lid sheet is bonded to the base sheet; and a microelectromechanical (MEMS) sensor disposed proximate the pocket portion.

Abstract translation: 一种用于确定药物包装内的至少一种环境状况的传感器系统，包括：具有形成在其中的至少一个口袋的基片;具有袋部的盖片;当所述盖片接合到所述底座上时， 片; 以及设置在口袋部分附近的微机电（MEMS）传感器。

公开(公告)号：US20110101242A1

公开(公告)日：2011-05-05

申请号：US12999338

申请日：2009-07-02

Applicant: Jason Dickens ,  Dwight Sherod Walker

Inventor： Jason Dickens ,  Dwight Sherod Walker

IPC: G01N21/64

CPC classification number: G01J3/10 ,  G01N21/31 ,  G01N21/33 ,  G01N21/41 ,  G01N21/6402 ,  G01N21/6428 ,  G01N21/76 ,  G01N21/8507 ,  G01N2021/6417 ,  G01N2021/8411

Abstract: An apparatus for analyzing a composition includes an excitation source adapted to transmit incident energy, the excitation source comprising an array of energy emitting sources, and a plurality of photometric detectors adapted to receive radiation emitted from the composition when the incident radiation is transmitted thereto.

Abstract translation: 用于分析组合物的装置包括适于透射入射能量的激发源，所述激发源包括能量发射源阵列，以及多个测光检测器，适于在入射辐射传输时接收从组合物发射的辐射。

公开(公告)号：US07456952B2

公开(公告)日：2008-11-25

申请号：US11531469

申请日：2006-09-13

Applicant: Dwight Sherod Walker

Inventor： Dwight Sherod Walker

IPC: G01J3/30

CPC classification number: G01N21/64 ,  G01N21/03 ,  G01N21/9508 ,  G01N23/043 ,  G01N2021/0339 ,  G01N2021/6417 ,  G01N2021/845

Abstract: A system for use in in-situ analysis of pharmaceutical samples, said system comprising means for holding a plurality of said samples, wherein said samples are present in the form of a powder formulation; means for moving said plurality of samples along a sample path; means for generating a plurality of incident radiation pulses of different wavelength; means for illuminating at least a respective one of said samples with at least a respective one of said radiation pulses during said movement of said samples, said radiation pulse having a suitable range of radiation wavelengths capable of inducing a fluorescent response; means for detecting a first resultant fluorescence emitted from each of said samples; first control means in communication with said moving means and said incident radiation generating means for synchronizing said means for illuminating each of said samples with said moving means.

Abstract translation: 一种用于药物样品的原位分析的系统，所述系统包括用于保持多个所述样品的装置，其中所述样品以粉末制剂的形式存在; 用于沿着采样路径移动所述多个样本的装置; 用于产生不同波长的多个入射辐射脉冲的装置; 用于在所述样品运动期间用至少一个所述辐射脉冲照射至少一个所述样品的装置，所述辐射脉冲具有能够诱导荧光响应的适当范围的辐射波长; 用于检测从每个所述样品发射的第一合成荧光的装置; 与所述移动装置和所述入射辐射发生装置通信的第一控制装置，用于使所述用于照亮每个所述样本的装置与所述移动装置同步。

公开(公告)号：US07429127B2

公开(公告)日：2008-09-30

申请号：US10512268

申请日：2003-04-23

Applicant: Dwight Sherod Walker ,  Michael Bernard James

Inventor： Dwight Sherod Walker ,  Michael Bernard James

IPC: G01N25/02 ,  G01K7/00

CPC classification number: G01K7/32 ,  G01K7/36 ,  G01K11/26 ,  G01N5/025 ,  G01N29/036 ,  G01N29/2412 ,  G01N33/15 ,  G01N2291/02845 ,  G01N2291/02881 ,  G01N2291/0423

Abstract: A remote sensor system (60) and method for passively sensing environmental conditions, such as temperature and humidity, uses a magnetic impulse from an AC interrogation coil (68) to stimulate a magnetoelastic sensor (62) to generate an acoustic signal (AE) at the resonant frequency of the magnetoelastic sensor (62). The acoustic signal (AE) is received by amplifier (74), detected and displayed (76). The systems and methods are particularly suited for detecting environmental conditions in commercial pharmaceutical packaging, such as blister packs.

Abstract translation: 用于被动地感测诸如温度和湿度的环境条件的远程传感器系统（60）和方法使用来自AC询问线圈（68）的磁脉冲来刺激磁弹性传感器（62）以产生声信号（AE） 磁弹性传感器（62）的共振频率。 声信号（AE）由放大器（74）接收，检测并显示（76）。 这些系统和方法特别适用于检测商业药品包装中的环境条件，例如泡罩包装。