Using convolution neural networks for on-the-fly single particle reconstruction

    公开(公告)号:US11151356B2

    公开(公告)日:2021-10-19

    申请号:US16287982

    申请日:2019-02-27

    Applicant: FEI Company

    Abstract: Convolutional neural networks (CNNs) of a set of CNNs are evaluated using a test set of images (electron micrographs) associated with a selected particle type. A preferred CNN is selected based on the evaluation and used for processing electron micrographs of test samples. The test set of images can be obtained by manual selection or generated using a model of the selected particle type. Upon selection of images using the preferred CNN in processing additional electron micrographs, the selected images can be added to a training set or used as an additional training set to retrain the preferred CNN. In some examples, only selected layers of the preferred CNN are retrained. In other examples, two dimensional projections of based on particles of similar structure are used for CNN training or retraining.

    DEEP LEARNING TECHNIQUES FOR ANALYSES OF EXPERIMENTAL DATA GENERATED BY TWO OR MORE DETECTORS

    公开(公告)号:US20240281650A1

    公开(公告)日:2024-08-22

    申请号:US18171543

    申请日:2023-02-20

    Applicant: FEI Company

    CPC classification number: G06N3/08

    Abstract: Disclosed herein are scientific instrument support systems, as well as related methods, apparatus, computing devices, and computer-readable media. Some embodiments provide a scientific instrument including detectors supporting two or more spectroscopic modalities and an imaging modality and further including an electronic controller configured to process streams of measurements received from the detectors. The electronic controller operates to generate a base image of the sample based on the measurements corresponding to the imaging modality and further operates to generate a cluster-mapped image of the sample based on the base image and further based on mappings of the measured spectra corresponding to different pixels of the base image to various clusters in the latent space of a variational autoencoder. In at least some instances, the cluster-mapped image can beneficially be used to identify, within seconds, chemically similar areas within the sample even when the measured spectra have relatively low signal-to-noise-ratio values.

    USING CONVOLUTION NEURAL NETWORKS FOR ON-THE-FLY SINGLE PARTICLE RECONSTRUCTION

    公开(公告)号:US20200272805A1

    公开(公告)日:2020-08-27

    申请号:US16287982

    申请日:2019-02-27

    Applicant: FEI Company

    Abstract: Convolutional neural networks (CNNs) of a set of CNNs are evaluated using a test set of images (electron micrographs) associated with a selected particle type. A preferred CNN is selected based on the evaluation and used for processing electron micrographs of test samples. The test set of images can be obtained by manual selection or generated using a model of the selected particle type. Upon selection of images using the preferred CNN in processing additional electron micrographs, the selected images can be added to a training set or used as an additional training set to retrain the preferred CNN. In some examples, only selected layers of the preferred CNN are retrained. In other examples, two dimensional projections of based on particles of similar structure are used for CNN training or retraining.

    MICROSCOPE ABERRATION CORRECTION
    9.
    发明申请

    公开(公告)号:US20250006457A1

    公开(公告)日:2025-01-02

    申请号:US18345675

    申请日:2023-06-30

    Applicant: FEI Company

    Abstract: Disclosed herein are scientific-instrument support systems, as well as related methods, apparatus, computing devices, and computer-readable media. In some embodiments, a support apparatus for a scientific instrument includes an interface device and a processing device. The interface device receives Ronchigrams acquired with the scientific instrument and transmits control signals for the electron-beam optics thereof. The processing device converts a measured Ronchigram into an input token for a transformer, produces an output token based on a tokenized sentence ending with the input token, and determines adjustments to the control signals based on the input and output tokens. The input and output tokens belong to a plurality of tokens representing reference Ronchigrams sampling an alignment parameter space of the electron-beam optics. The transformer implements an autoregressive masked language model trained on a corpus of reference sentences representing paths through the alignment parameter space to a target alignment state of the electron-beam optics.

    SPARSE IMAGE RECONSTRUCTION FROM NEIGHBORING TOMOGRAPHY TILT IMAGES

    公开(公告)号:US20220373481A1

    公开(公告)日:2022-11-24

    申请号:US17329081

    申请日:2021-05-24

    Applicant: FEI Company

    Abstract: Tomographic images are obtained by processing a tilt series of 2D images by aligning and combining images withing a group of neighbor images. The tilt series generally includes sparsely sampled images. Images of the tilt series at tilt angles associated with the sparsely sample images are selected as reference frames, grouped with neighbor images, and the group of images aligned. The aligned images are combined to produce replacement frames and a replacement frame tilt series that can be used for tomographic reconstruction.

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