公开(公告)号：US11776801B2

公开(公告)日：2023-10-03

申请号：US17470769

申请日：2021-09-09

Applicant: Fluidigm Canada Inc.

Inventor： Alexander Loboda ,  Raymond Jong ,  Michael Sullivan ,  Serguei Vorobiev ,  Robert Rotenberg ,  Emil D. Stratulativ ,  Maxim Voronov ,  Mark Armstrong

IPC: H01J49/00 ,  H01J49/10 ,  H05H1/30 ,  H05H1/24 ,  H01J49/04

CPC classification number: H01J49/105 ,  H01J49/0027 ,  H01J49/0463 ,  H05H1/2406 ,  H05H1/30

Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.

公开(公告)号：US09431227B2

公开(公告)日：2016-08-30

申请号：US14594319

申请日：2015-01-12

Applicant: FLUIDIGM CANADA INC.

Inventor： Raymond Jong

IPC: H01J49/10 ,  H01J49/04 ,  G01N35/10 ,  G01N15/00 ,  G01N15/06

CPC classification number: H01J49/0445 ,  G01N15/06 ,  G01N15/10 ,  G01N35/10 ,  G01N2015/0065 ,  G01N2015/1006 ,  H01J49/045 ,  H01J49/105

Abstract: In a mass cytometer or mass spectrometer, a sample of elemental tagged particles is transferred from a dispersion to a gas flow through a carrier aerosol spray for atomization and ionization by inductively coupled plasma (ICP) source. The configuration of the sample transfer apparatus allow for total consumption of the sample by passing the sample spray through a deceleration stage to decelerate the spray of particles from its high velocity expansion. Following the deceleration stage, the decelerated sample of particles can be accelerated and focused through an acceleration stage for transferring into the ICP. This effectively improves the particle transfer between the sample spray and the ICP.

公开(公告)号：US20220093382A1

公开(公告)日：2022-03-24

申请号：US17470769

申请日：2021-09-09

Applicant: Fluidigm Canada Inc.

Inventor： Alexander Loboda ,  Raymond Jong ,  Michael Sullivan ,  Serguei Vorobiev ,  Robert Rotenberg ,  Emil D. Stratulativ ,  Maxim Voronov ,  Mark Armstrong

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/04 ,  H05H1/24 ,  H05H1/30

Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.