中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

16 records (took 0.015 seconds)

    SAMPLE SUPPORT BODY AND PRODUCTION METHOD FOR SAMPLE SUPPORT BODY
    1.
    发明申请
    SAMPLE SUPPORT BODY AND PRODUCTION METHOD FOR SAMPLE SUPPORT BODY 有权

    公开(公告)号：US20210033564A1

    公开(公告)日：2021-02-04

    申请号：US16967046

    申请日：2019-01-08

    Applicant: Hamamatsu Photonics K.K.

    Inventor： Yasuhide NAITO ,  Takayuki OHMURA ,  Masahiro KOTANI

    IPC: G01N27/62

    Abstract: A sample support body includes: a substrate having a first surface and a second surface opposite to each other; and a conductive layer provided on at least the first surface. A plurality of through-holes, which open to the second surface and to a third surface of the conductive layer which is locate at a side opposite to the substrate, are provided in the substrate and the conductive layer. A protective film having a higher affinity with water than the substrate is provided on the second surface, the third surface, and each inner surface of the plurality of through-holes.

    LASER DESORPTION/IONIZATION METHOD, MASS SPECTROMETRY METHOD, SAMPLE SUPPORT BODY, AND MANUFACTURING METHOD OF SAMPLE SUPPORT BODY
    2.
    发明申请
    LASER DESORPTION/IONIZATION METHOD, MASS SPECTROMETRY METHOD, SAMPLE SUPPORT BODY, AND MANUFACTURING METHOD OF SAMPLE SUPPORT BODY 审中-公开

    公开(公告)号：US20200279729A1

    公开(公告)日：2020-09-03

    申请号：US16762517

    申请日：2018-10-05

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Yasuhide NAITO ,  Takayuki OHMURA ,  Masahiro KOTANI

    IPC: H01J49/16 ,  H01J49/00 ,  H01J49/04 ,  B01L3/00

    Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, a conductive layer provided on at least the first surface, and a solvent provided in the plurality of through holes with refractoriness in a vacuum; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; and a third step of ionizing a component of the sample that is mixed with the solvent and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser beam while applying a voltage to the conductive layer.

    MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD
    3.
    发明申请
    MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD 有权

    公开(公告)号：US20230042476A1

    公开(公告)日：2023-02-09

    申请号：US17792770

    申请日：2020-04-07

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Yasuhide NAITO ,  Tsuyoshi HIRAO ,  Minoru KONDO

    IPC: G01N27/623 ,  G01N27/64 ,  H01J49/16 ,  H01J49/40

    Abstract: A mass spectrometry device includes a sample stage, an irradiator, a MCP, a fluorescent body, an imager, and a controller. The irradiator irradiates a sample with an energy beam to ionize a plurality of components of the sample while maintaining position information of the plurality of components. The MCP emits electrons in accordance with an ionized sample. The fluorescent body emits fluorescent light in accordance with the electrons. The imager has a shutter mechanism configured to be capable of switching an open state and a close state. The controller controls an opening and closing operation of the shutter mechanism. The controller allows the imager to image the fluorescent light corresponding to each of the plurality of components by performing the opening and closing of the shutter mechanism at a timing for each of the components.

    LASER DESORPTION/IONIZATION METHOD AND MASS SPECTROMETRY METHOD
    4.
    发明申请
    LASER DESORPTION/IONIZATION METHOD AND MASS SPECTROMETRY METHOD 审中-公开

    公开(公告)号：US20200266043A1

    公开(公告)日：2020-08-20

    申请号：US16647261

    申请日：2018-08-06

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Yasuhide NAITO ,  Masahiro KOTANI ,  Takayuki OHMURA

    IPC: H01J49/04 ,  H01J49/00 ,  H01J49/16

    Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; a third step of introducing a matrix solution into the plurality of through holes; and a fourth step of ionizing a component of the sample that is mixed with the matrix solution and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser light while a voltage is applied to the conductive layer.

    IMAGING UNIT, MASS SPECTROMETER, AND MASS SPECTROMETRY METHOD
    5.
    发明申请
    IMAGING UNIT, MASS SPECTROMETER, AND MASS SPECTROMETRY METHOD 有权

    公开(公告)号：US20230042588A1

    公开(公告)日：2023-02-09

    申请号：US17792786

    申请日：2020-04-07

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Yasuhide NAITO ,  Tsuyoshi HIRAO ,  Minoru KONDO

    IPC: H01J49/16 ,  H01J49/04

    Abstract: An imaging unit includes a MCP, a fluorescent body, and an imager. The MCP is provided on a flight route of an ionized sample that is a component of a sample ionized and emits electrons in accordance with the ionized sample. The fluorescent body is disposed in a subsequent stage of the MCP and emits fluorescent light in accordance with the electrons emitted from the MCP. The imager is disposed in a subsequent stage of the fluorescent body and has a shutter mechanism configured to be capable of switching an open state in which the fluorescent light is imaged by allowing the fluorescent light from the fluorescent body to pass through and a close state in which the fluorescent light is not imaged by blocking the fluorescent light from the fluorescent body. An afterglow time of the fluorescent body is 12 ns or shorter.

    MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD
    6.
    发明申请
    MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD 审中-公开

    公开(公告)号：US20200013608A1

    公开(公告)日：2020-01-09

    申请号：US16489753

    申请日：2018-03-01

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Yasuhide NAITO ,  Masahiro KOTANI ,  Takayuki OHMURA

    IPC: H01J49/26 ,  H01J49/16 ,  G01N1/28

    Abstract: A mass spectrometry device according to one aspect of the invention includes: a sample stage on which a sample is placed and on which a sample support having a substrate, in which a plurality of through-holes passing from one surface thereof to the other surface thereof are provided, and a conductive layer, which covers at least a portion of the one surface which is not provided with the through-holes, is placed such that the other surface faces the sample; a laser beam application unit that controls application of a laser beam such that the laser beam is applied to an imaging target region on the one surface; and a detector that detects the sample ionized by the application of the laser beam in a state where a positional relation of the sample in the imaging target region is maintained.

    LASER DESORPTION/IONIZATION METHOD AND MASS SPECTROMETRY METHOD
    9.
    发明申请
    LASER DESORPTION/IONIZATION METHOD AND MASS SPECTROMETRY METHOD 审中-公开

    公开(公告)号：US20200273689A1

    公开(公告)日：2020-08-27

    申请号：US16647493

    申请日：2018-08-03

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Yasuhide NAITO ,  Takayuki OHMURA ,  Masahiro KOTANI

    IPC: H01J49/04 ,  H01J49/02 ,  H01J49/16

    Abstract: A laser desorption/ionization method includes a first process of preparing a sample support body. The sample support body includes a substrate, an ionization substrate, and a support that supports the ionization substrate with respect to the substrate such that a first surface of the ionization substrate is separated from the substrate. A plurality of through-holes are formed at least in measurement regions of the ionization substrate. A conductive layer is provided on peripheral edges of the through-holes at least on the second surface. Further, the laser desorption/ionization method includes a second process of dropping the sample on the measurement regions of the ionization substrate, and a third process of, after the sample has infiltrated into the ionization substrate, ionizing components of the sample by applying a laser beam to the second surface while applying a voltage to the conductive layer.

Patent Agency Ranking