-
1.发明申请公开(公告)号：US20190172206A1
公开(公告)日：2019-06-06
申请号：US16323808
申请日：2017-08-28
Applicant: Hitachi High-Technologies Corporation
Inventor： Yasuki KAKISHITA , Hideharu HATTORI , Kenko UCHIDA , Sadamitsu ASO , Toshinari SAKURAI
Abstract: Reaction values indicating based on which areas in an input image a plurality of identification results representing the states of cells or tissues are judged are calculated, and differences between a plurality of reaction values are obtained to thereby calculate the degree to which cells or tissues in an area of interest likely are in each state. Thereby, each state of cells or tissues can be visualized at an accurate position in an area of interest; therefore, diagnostic assistance to pathologist becomes possible.
-
2.发明申请公开(公告)号：US20200151877A1
公开(公告)日：2020-05-14
申请号：US16603445
申请日：2018-02-26
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Hideharu HATTORI , Yasuki KAKISHITA , Kenko UCHIDA , Sadamitsu ASO , Toshinari SAKURAI
Abstract: An image diagnosis assisting apparatus according to the present invention executes: processing of inputting an image of a tissue or cell; processing of extracting a feature amount of a tissue or cell from a processing target image; processing of extracting a feature amount of a tissue or cell from an image having a component different from that of the target image; and processing of determining presence or absence of a lesion and lesion probability for each of the target images by using a plurality of the feature amounts.
-
公开(公告)号：US20180053296A1
公开(公告)日：2018-02-22
申请号：US15556546
申请日：2016-01-28
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Hideharu HATTORI , Yasuki KAKISHITA , Kenko UCHIDA , Sadamitsu ASO , Fumiaki HAMAZATO
IPC: G06T7/00 , G01N33/483 , G06K9/46 , G06K9/62
Abstract: The present invention realizes determination of tissues and cells from an image by calculating feature values of a deformed degree of the cells even in a case where the tissues or the cells have various shapes. An image diagnosis support apparatus according to the present invention executes processing of inputting an image of cells, processing of extracting the feature values of a plurality of direction components from a target image of the processing, processing of determining whether or not the image corresponds to one-classification by using the plurality of feature values, and processing of determining whether or not the determination processing is finished with respect to all of the classifications set in advance (FIG. 1).
-
公开(公告)号：US20170159003A1
公开(公告)日：2017-06-08
申请号：US15327208
申请日：2015-07-08
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Akihiro SHIMASE , Kazumichi IMAI , Sadamitsu ASO , Eiichiro TAKADA , Masako KAWARAI , Toshinari SAKURAI
CPC classification number: C12M41/40 , C12M23/58 , C12M27/00 , C12M29/14 , C12M29/18 , C12M31/10 , C12M41/06 , C12M41/36 , C12M41/48 , C12Q1/06
Abstract: A device which automatically performs a step in which expanded and cultured cells are diluted to a desired cell concentration and re-inoculated using a cell-concentration adjustment device having an inlet for taking in a cell suspension; an outlet for discharging a diluted cell suspension; and a flow path which is provided between the inlet and the outlet and is capable of holding a cell suspension, the flow path being provided with: a liquid delivery pump for causing a cell suspension inside to flow; a cell-concentration measurement instrument for collecting data related to a cell concentration per unit amount of the cell suspension; and a dilution-liquid container for holding a dilution liquid which is supplied to the flow path to dilute the cell suspension. The device further includes a control unit for controlling at least the liquid delivery pump on the basis of the data obtained by the cell-concentration measurement instrument, wherein the control unit determines, on the basis of the data obtained by the cell-concentration measurement instrument, an amount of the dilution liquid required to bring the cell concentration to the desired concentration, and drives the liquid delivery pump so as to take in the required amount of the dilution liquid into the flow path and mix the cell suspension and the dilution liquid.
-
公开(公告)号：US20170191019A1
公开(公告)日：2017-07-06
申请号：US15320369
申请日：2015-07-08
Applicant: Hitachi High-Technologies Corporation
Inventor： Masako KAWARAI , Akihiro SHIMASE , Sadamitsu ASO , Toshinari SAKURAI , Eiichiro TAKADA , Kazumichi IMAI
CPC classification number: C12M33/00 , C12M29/00 , C12M41/00 , C12M41/36 , C12M41/48 , C12Q1/02 , G01N15/06 , G01N21/47 , G01N21/51 , G01N21/53 , G01N21/59 , G01N2015/0053 , G01N2015/0065 , G01N2015/0693 , G01N2201/12
Abstract: The present invention addresses the problem of providing: a cell dispersion measurement mechanism whereby it becomes possible to fully disperse cells regardless of the experiences of operators skilled in cell culture and it also becomes possible to determine the number or concentration of cells accurately; a cell culture apparatus equipped with the cell dispersion measurement mechanism; and a cell dispersion measurement method. The problem can be solved by circulating a cell suspension in a flow path to disperse cell masses contained in the cell suspension, and then determining over time the number or concentration of cells and/or the degree of dispersion of cells in the cell suspension that is flowing in the circulation flow path.
-
Patent Agency Ranking
6.发明申请Charged Particle Beam Device, Sample Observation Method, Sample Platform, Observation System, and Light Emitting Member 审中-公开带电粒子束装置，样品观察方法，样品平台，观察系统和发光元件公开(公告)号：US20160025659A1
公开(公告)日：2016-01-28
申请号：US14774367
申请日：2014-01-22
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Yusuke OMINAMI , Mitsugu SATO , Kenko UCHIDA , Sadamitsu ASO , Taku SAKAZUME , Hideo MORISHITA , Sukehiro ITO , Takashi OHSHIMA
IPC: G01N23/225 , G01N23/22
CPC classification number: G01N23/2251 , G01N23/2204 , H01J37/20 , H01J37/244 , H01J37/28 , H01J2237/2003 , H01J2237/2443 , H01J2237/2445 , H01J2237/24455 , H01J2237/2605
Abstract: The purpose of the present invention is to eliminate the effort in placement and extraction of samples in observations using transmitted charged particles. A charged particle beam device (601) is characterized by having: a charged particle optical lens tube that irradiates a sample (6) with a primary charged particle beam; a sample stage on which a light emitting member (500) that emits light because of charged particles that have come by transmission internally in the sample (6) or scattering therefrom or a sample platform (600) having the light emitting member (500) is attachably and detachably disposed; and a detector (503) that detects the light emitted by the light emitting member.
Abstract translation: 本发明的目的是消除在使用透射带电粒子的观察中放置和提取样品的努力。 带电粒子束装置（601）的特征在于，具有：带有原色带电粒子束照射样品（6）的带电粒子光学透镜管; 具有发光元件（500）的样品台，其上由于在样品（6）内部传播或散射的带电粒子或具有发光元件（500）的样品台（600）而发光的发光元件 可拆卸地设置; 以及检测由发光部件发出的光的检测器（503）。
-
7.发明申请公开(公告)号：US20190236779A1
公开(公告)日：2019-08-01
申请号：US16340401
申请日：2017-10-26
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Hideharu HATTORI , Kenko UCHIDA , Sadamitsu ASO , Toshinari SAKURAI , Yasuki KAKISHITA
CPC classification number: G06T7/0012 , G01N15/00 , G01N33/48 , G06K9/00147 , G06T1/0007 , G06T2207/10056 , G06T2207/20081 , G06T2207/30024 , G06T2207/30096 , G16H30/40 , G16H50/20
Abstract: A diagnostic imaging assistance apparatus according to the present invention performs a process of inputting images of a tissue and a cell, a process of extracting feature amounts of a wide view and a narrow view from a target image to be processed, a process of classifying whether the target images having different views are normal or abnormal from the feature amounts, and a process of classifying a lesion likelihood using a classification result.
-
公开(公告)号：US20180080002A1
公开(公告)日：2018-03-22
申请号：US15326938
申请日：2015-07-08
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Akihiro SHIMASE , Kazumichi IMAI , Sadamitsu ASO , Eiichiro TAKADA , Masako KAWARAI , Toshinari SAKURAI
CPC classification number: C12M41/48 , C12M1/00 , C12M1/02 , C12M1/34 , C12M29/00 , C12M41/00 , C12M41/36 , C12M45/02 , C12M47/04
Abstract: The purpose of the present invention is to provide a means for dispersing cell aggregates without damaging the cells, such that a sufficient multiplication rate can be obtained in a subculture. According to the present invention, provided is a cell-suspension processing device which disperses cell aggregates included in a cell suspension. The device is provided with: an inlet for taking in the cell suspension; an outlet for discharging the processed cell suspension; and a flow path which is provided between the inlet and the outlet, and which is capable of holding the cell suspension. The flow path has, provided thereto, a liquid delivery pump for causing the cell suspension inside to flow, a cell-dispersion-degree measurement instrument for measuring the dispersion degree of cells in the cell suspension, and a narrow part for imparting shearing force to the cell suspension flowing inside. The cell-suspension processing device is further provided with a control unit for controlling at least the liquid delivery pump on the basis of data obtained by the cell-dispersion-degree measurement instrument. The control unit determines whether the cells have attained a prescribed dispersion degree on the basis of the data obtained by the cell-dispersion-degree measurement instrument, and, in cases when the cells have not attained the prescribed dispersion degree, drives the liquid delivery pump such that the cell suspension is passed through the narrow part.
-
公开(公告)号：US20170037351A1
公开(公告)日：2017-02-09
申请号：US15106945
申请日：2014-12-24
Applicant: Hitachi High-Technologies Corporation
Inventor： Akihiro SHIMASE , Kazumichi IMAI , Eiichiro TAKADA , Sadamitsu ASO
IPC: C12M1/00
Abstract: According to the present invention, a simple structure can be used to achieve reliable liquid delivery with no residual air, and simple attachment/detachment of a culture vessel, and thus a closed-system cell culture device exhibiting high reliability can be constructed at low cost. In the present invention, a liquid is supplied or discharged while a culture vessel is in an inclined state. The culture vessel is provided with two flow paths, namely an intake flow path and a discharge flow path, which connect a culture chamber and a connection member. Points where the flow paths join with the culture chamber are respectively configured as an intake port and a discharge port. The discharge port is provided in the position nearest to the axis of inclination of the culture vessel. The intake port is provided in a plane projected from a vertical plane including the aforementioned axis of inclination.
Abstract translation: 根据本发明，可以使用简单的结构来实现无残留空气的可靠的液体输送，以及培养容器的简单的附着/分离，从而可以以低成本构建出具有高可靠性的封闭系统的细胞培养装置 。 在本发明中，在培养容器处于倾斜状态时供给或排出液体。 培养容器具有连接培养室和连接部件的两个流路，即进气流路和排出流路。 流路与培养室连接的点分别构成进气口和排出口。 排出口设置在最靠近培养容器倾斜轴线的位置。 进气口设置在从包括上述倾斜轴线的垂直平面投影的平面中。
-
公开(公告)号：US20160319233A1
公开(公告)日：2016-11-03
申请号：US15107548
申请日：2014-12-24
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Akihiro SHIMASE , Kazumichi IMAI , Eiichiro TAKADA , Sadamitsu ASO
CPC classification number: C12M23/40 , B01L3/502738 , B01L3/567 , B01L2200/025 , B01L2200/0668 , B01L2300/0816 , B01L2300/0838 , B01L2300/0861 , B01L2400/0487 , B01L2400/0622 , B01L2400/0655 , C12M23/14 , C12M23/58 , C12M29/00 , F16K7/045
Abstract: According to the present invention, a problem of closed systems, namely minimizing the number of electromagnetic valves required to control a plurality of flow paths, can be addressed, and thus a low-cost cell culture device can be achieved. In this flow-path control method for X number of flow paths satisfying X≦2N, the X number of flow paths are selected by using N number of valves to simultaneously and selectively control the opening and closing of the plurality of flow paths.
Abstract translation: 根据本发明，可以解决封闭系统的问题，即最小化控制多个流路所需的电磁阀的数量，从而可以实现低成本的细胞培养装置。 在该X-2N流路的流路控制方法中，通过使用N个阀来选择X个流路，以同时选择性地控制多个流路的开闭。
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.016 seconds)
