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公开(公告)号：US12203839B2
公开(公告)日：2025-01-21
申请号：US18418401
申请日：2024-01-22
Applicant: IDEXX Laboratories Inc.
IPC: G01N15/01 , G01N15/1434
Abstract: A flow cytometer of a blood analyzer including a transverse-electric (TE) laser diode, a flow cell, a quarter wave plate (QWP), a plurality of lenses, and a side scatter detector. The TE laser diode is configured to output a laser beam along an optical axis and has a fast axis full width at half maximum (FWHM) divergence of from about 16 degrees to about 25 degrees. The QWP is disposed along the optical axis between the TE laser diode and the flow cell and configured to circularly polarize the laser beam. The plurality of lenses is disposed between the TE laser diode and the flow cell and configured to focus the laser beam at the flow cell.
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公开(公告)号：US11543342B2
公开(公告)日：2023-01-03
申请号：US17348298
申请日：2021-06-15
Applicant: IDEXX Laboratories Inc.
Abstract: A flow cytometer of a blood analyzer including a transverse-electric (TE) laser diode, a flow cell, a quarter wave plate (QWP), a plurality of lenses, and a side scatter detector. The TE laser diode is configured to output a laser beam along an optical axis and has a fast axis full width at half maximum (FWHM) divergence of from about 16 degrees to about 25 degrees. The QWP is disposed along the optical axis between the TE laser diode and the flow cell and configured to circularly polarize the laser beam. The plurality of lenses is disposed between the TE laser diode and the flow cell and configured to focus the laser beam at the flow cell.
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公开(公告)号：US11141725B2
公开(公告)日：2021-10-12
申请号：US15769665
申请日：2016-10-21
Applicant: IDEXX Laboratories, Inc.
Inventor： Garland Christian Misener , Richard Ellis Holt , Keith Nassif
IPC: B01L3/00 , G01N33/487 , G02B21/34 , B01L9/00
Abstract: A hematology test slide has the same or similar dimensions as a chemical reagent test slide and an immunoassay test slide so that it may be used with these other slides on a single clinical instrument. The hematology slide includes, in order from top to bottom, a slide housing having a top housing member, a top cover slip, a U-shaped, transfer tape spacer, a bottom cover slip, a base gasket and a base plate. The U-shaped spacer has a curved end portion which defines a sample deposit area, where a blood sample is pipetted thereon, and a pair of straight, parallel, spaced apart legs extending from the curved end portion. The legs define a read area. A blood sample deposited on the hematology slide at the sample deposit area will flow by capillary action to the read area, where optical measurements are made on the sample.
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公开(公告)号：US20250116594A1
公开(公告)日：2025-04-10
申请号：US18985324
申请日：2024-12-18
Applicant: IDEXX Laboratories Inc.
IPC: G01N15/1434 , G01N15/01
Abstract: A flow cytometer of a blood analyzer including a transverse-electric (TE) laser diode, a flow cell, a quarter wave plate (QWP), a plurality of lenses, and a side scatter detector. The TE laser diode is configured to output a laser beam along an optical axis and has a fast axis full width at half maximum (FWHM) divergence of from about 16 degrees to about 25 degrees. The QWP is disposed along the optical axis between the TE laser diode and the flow cell and configured to circularly polarize the laser beam. The plurality of lenses is disposed between the TE laser diode and the flow cell and configured to focus the laser beam at the flow cell.
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公开(公告)号：US10914913B2
公开(公告)日：2021-02-09
申请号：US16367816
申请日：2019-03-28
Applicant: IDEXX Laboratories Inc.
Abstract: A flow cytometer, laser optics assembly thereof, and methods of assembling the same are provided. The flow cytometer is capable of yielding consistent and accurate results despite exposure to adverse environmental conditions such as, for example, temperature changes within a relatively wide temperature range and/or a relatively large amount of random-axis mechanical vibration. The flow cytometer of the present disclosure is additionally or alternatively relatively insensitive to real or apparent core stream shifts, employs a slowly converging beam along the axis perpendicular to core stream flow, and provides the ability to precisely measure time-of-flight.
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Patent Agency Ranking
公开(公告)号：US20180304257A1
公开(公告)日：2018-10-25
申请号：US15769665
申请日：2016-10-21
Applicant: IDEXX Laboratories, Inc.
Inventor： Garland Christian Misener , Richard Ellis Holt , Keith Nassif
CPC classification number: B01L3/502715 , B01L3/502707 , B01L9/52 , B01L2300/0609 , B01L2300/0822 , B01L2300/168 , B01L2400/0406 , G01N33/4875 , G02B21/34
Abstract: A hematology test slide has the same or similar dimensions as a chemical reagent test slide and an immunoassay test slide so that it may be used with these other slides on a single clinical instrument. The hematology slide includes, in order from top to bottom, a slide housing having a top housing member, a top cover slip, a U-shaped, transfer tape spacer, a bottom cover slip, a base gasket and a base plate. The U-shaped spacer has a curved end portion which defines a sample deposit area, where a blood sample is pipetted thereon, and a pair of straight, parallel, spaced apart legs extending from the curved end portion. The legs define a read area. A blood sample deposited on the hematology slide at the sample deposit area will flow by capillary action to the read area, where optical measurements are made on the sample.
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公开(公告)号：US20230305262A1
公开(公告)日：2023-09-28
申请号：US18203169
申请日：2023-05-30
Applicant: IDEXX Laboratories Inc.
CPC classification number: G02B7/021 , G01N15/0205 , G01N15/1434 , G02B27/30 , G02B19/0052 , G02B27/0966
Abstract: A flow cytometer, laser optics assembly thereof, and methods of assembling the same are provided. The flow cytometer is capable of yielding consistent and accurate results despite exposure to adverse environmental conditions such as, for example, temperature changes within a relatively wide temperature range and/or a relatively large amount of random-axis mechanical vibration. The flow cytometer of the present disclosure is additionally or alternatively relatively insensitive to real or apparent core stream shifts, employs a slowly converging beam along the axis perpendicular to core stream flow, and provides the ability to precisely measure time-of-flight.
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公开(公告)号：US09797916B2
公开(公告)日：2017-10-24
申请号：US14592282
申请日：2015-01-08
Applicant: IDEXX Laboratories, Inc.
Inventor： David Lance Connolly , Mark Raymond Dumont , Justin Jay Griffin , John Harvey McGibbon , Garland Christian Misener , Jeffrey Eric Phelps , Carl Russell Rich , Kenneth Eugene Smith , Dragan Vidacic
CPC classification number: G01N35/0099 , B25J9/1697 , B25J19/021 , G01N1/312 , G01N35/00029 , G01N35/00732 , G01N35/025 , G01N35/04 , G01N35/109 , G01N2035/00039 , G01N2035/00079 , G01N2035/00138 , G01N2035/00356 , G01N2035/0405 , G01N2035/0449 , G01N2035/103 , Y10S901/09 , Y10S901/41
Abstract: A medical apparatus for analyzing fluid samples includes an outer casing, a slide loading mechanism disposed within the outer casing for loading fluid analysis slides, a slide ejecting mechanism disposed within the outer casing for ejecting fluid analysis slides, an evaporation cap opening mechanism disposed within the outer casing for opening an evaporation cap, an evaporation cap closing mechanism disposed within the outer casing for closing an evaporation cap, a drawer locking mechanism disposed within the outer casing for locking a drawer associated with the outer casing, a camera disposed within the outer casing, and a robot disposed within the outer casing. The robot is movable in three dimensions and has means for conducting three or more of the following operations: slide loading; slide ejecting; evaporation cap opening; evaporation cap closing; drawer locking; and camera manipulation.
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公开(公告)号：US20150226759A1
公开(公告)日：2015-08-13
申请号：US14592282
申请日：2015-01-08
Applicant: IDEXX Laboratories, Inc.
Inventor： David Lance Connolly , Mark Raymond Dumont , Justin Jay Griffin , John Harvey McGibbon , Garland Christian Misener , Jeffrey Eric Phelps , Carl Russell Rich , Kenneth Eugene Smith , Dragan Vidacic
CPC classification number: G01N35/0099 , B25J9/1697 , B25J19/021 , G01N1/312 , G01N35/00029 , G01N35/00732 , G01N35/025 , G01N35/04 , G01N35/109 , G01N2035/00039 , G01N2035/00079 , G01N2035/00138 , G01N2035/00356 , G01N2035/0405 , G01N2035/0449 , G01N2035/103 , Y10S901/09 , Y10S901/41
Abstract: A medical apparatus for analyzing fluid samples includes an outer casing, a slide loading mechanism disposed within the outer casing for loading fluid analysis slides, a slide ejecting mechanism disposed within the outer casing for ejecting fluid analysis slides, an evaporation cap opening mechanism disposed within the outer casing for opening an evaporation cap, an evaporation cap closing mechanism disposed within the outer casing for closing an evaporation cap, a drawer locking mechanism disposed within the outer casing for locking a drawer associated with the outer casing, a camera disposed within the outer casing, and a robot disposed within the outer casing. The robot is movable in three dimensions and has means for conducting three or more of the following operations: slide loading; slide ejecting; evaporation cap opening; evaporation cap closing; drawer locking; and camera manipulation.
Abstract translation: 用于分析流体样品的医疗装置包括外壳，设置在用于装载流体分析滑块的外壳内的滑动装载机构，设置在外壳内用于喷射流体分析滑块的滑动弹出机构，设置在内壳内的蒸发盖开启机构 用于打开蒸发盖的外壳，设置在外壳内用于封闭蒸发盖的蒸发盖关闭机构，设置在外壳内的用于锁定与外壳相关联的抽屉的抽屉锁定机构，设置在外壳内的照相机 以及设置在外壳内的机器人。 机器人可以三维移动，并且具有用于进行三个或更多个以下操作的装置：滑动装载; 幻灯片弹出; 蒸发盖开口; 蒸发盖关闭; 抽屉锁; 和相机操纵。
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公开(公告)号：US12050171B2
公开(公告)日：2024-07-30
申请号：US17831458
申请日：2022-06-03
Applicant: IDEXX Laboratories Inc.
Inventor： Garland Christian Misener , Bailey R. Auspland
CPC classification number: G01N21/274 , G01J3/027 , G01J3/42 , G01J3/427 , G01N33/721 , G01J2003/2879
Abstract: A method for calibrating sensitivity of a photometer includes measuring, by a double-beam spectrophotometer, an absorbance spectrum of a control solution, which has been diluted and includes a control substance. The method further includes linearly regressing the absorbance spectrum of the control solution over a predetermined range of wavelengths and determining whether a first slope of the linearly regressed absorbance spectrum of the control solution falls within a range of slopes of lines obtained from linearly regressing absorbance spectra of a plurality of reference solutions over the predetermined range of wavelengths. A concentration of chromophore in each reference solution is known and the absorbance spectra of the plurality of reference solutions have been obtained by the double-beam spectrophotometer.
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