公开(公告)号：US20160370298A1

公开(公告)日：2016-12-22

申请号：US15122170

申请日：2015-02-13

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva UMAPATHY ,  Sanchita SIL ,  Gagan DHAL ,  Freek ARIESE

IPC: G01N21/65 ,  G01J3/44 ,  G01B11/00 ,  G01J3/02

CPC classification number: G01N21/65 ,  G01B11/00 ,  G01J3/0221 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/4795 ,  G01N2201/0221 ,  G01N2201/06113 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: The invention provides a method for chemical signature resolved detection of a concealed object within a system. The method includes irradiating the system at a plurality of positions with aplurality of electromagnetic radiation of specific wavelength; capturing a certain component of the scattered electromagnetic radiation from the object at a plurality of locations along various 3D planes around the system; obtaining a plurality of profiles from the captured component of the scattered electromagnetic radiation; filtering the profiles to obtain a chemical signature specific to the object; and resolving the chemical signatures to detect the concealed object, wherein, the step of detection includes determination of the shape, size and location of the object.

Abstract translation: 本发明提供了一种用于系统内隐蔽物体的化学特征解析检测的方法。 该方法包括在多个具有特定波长的电磁辐射的位置照射系统; 在围绕系统的各种3D平面的多个位置处捕获来自物体的散射电磁辐射的某一分量; 从所述散射电磁辐射的拍摄成分获得多个轮廓; 过滤轮廓以获得特定于物体的化学特征; 以及解析所述化学特征以检测所述隐藏对象，其中，所述检测步骤包括确定所述物体的形状，大小和位置。

公开(公告)号：US20240003921A1

公开(公告)日：2024-01-04

申请号：US18032196

申请日：2021-12-15

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva UMAPATHY ,  Venkatesh KALIAPERUMAL ,  Ria MUKHERJEE

IPC: G01N33/92 ,  G01N21/65 ,  G01N21/3577

CPC classification number: G01N33/92 ,  G01N21/65 ,  G01N21/3577 ,  G01N2800/32

Abstract: The invention provides a method for rapid detection of the viability of microorganisms. The method includes capturing a first unique signature with respect to a first lipid component, capturing a second unique signature with respect to a second lipid component, transforming each of the first lipid signatures and second lipid signatures to obtain amplified signatures, comparing the amplified signatures to obtain a first ratio and repeating the abovementioned steps at least one more time to obtain a second ratio. The alteration in the first ratio and the second ratio provides the indication for cardiovascular disorder.

公开(公告)号：US20160178525A1

公开(公告)日：2016-06-23

申请号：US14374928

申请日：2013-09-02

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva UMAPATHY ,  Sanchita SIL ,  John KIRAN

IPC: G01N21/65 ,  G01N33/22 ,  G01N21/51

CPC classification number: G01N21/65 ,  G01N21/51 ,  G01N33/227 ,  G01N2201/06113 ,  G01N2201/063

Abstract: The invention provides a method for detection of hazardous chemicals in a non-metallic container. The method comprises of irradiating the sample at a predefined location with an electromagnetic radiation of specific wavelength; selectively capturing a certain component of the scattered electromagnetic radiation to obtain a plurality of profiles; and filtering the profiles to obtain a signature specific to at least one hazardous chemical present in the container. The invention provides a system for obtaining a signature specific to the hazardous chemicals in the container.

Abstract translation: 本发明提供了一种用于在非金属容器中检测危险化学品的方法。 该方法包括在预定位置用特定波长的电磁辐射照射样品; 选择性地捕获散射电磁辐射的某一部分以获得多个轮廓; 并过滤轮廓以获得特定于容器中存在的至少一种危险化学品的特征。 本发明提供一种用于获得特定于容器中的危险化学品的签名的系统。

公开(公告)号：US20240068947A1

公开(公告)日：2024-02-29

申请号：US18269557

申请日：2021-12-22

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva UMAPATHY ,  Sanchita SIL ,  Dipak KUMBHAR ,  Srividya KUMAR

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01N2201/06113 ,  G01N2201/0631

Abstract: The invention provides a method for homogenized coherent excitation of a sample for determining molecular structure. The method includes selecting a monochromatic coherent light, homogenizing the monochromatic coherent light; irradiating the sample with the homogenized monochromatic light; collecting the Raman scattered light to obtain a profile and analyzing the profile to obtain chemical specific signature of the sample. The invention also provides a method for obtaining two dimensional imaging of a sample using irradiation of large sample area by homogenized monochromatic light without compromise in spatial resolution. A system for homogenized coherent excitation of a sample for determining molecular structure is also provided.

公开(公告)号：US20240060900A1

公开(公告)日：2024-02-22

申请号：US18269558

申请日：2021-12-22

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva UMAPATHY ,  Sanchita SIL ,  Dipak KUMBHAR ,  R Vishnu KUMAR

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/4412 ,  G01N2201/06113 ,  G01N2201/0631

Abstract: The method includes homogenizing a monochromatic coherent light source, irradiating the sample at plurality of points along all planes with the homogenized monochromatic light, collecting the molecular scattered light from all angles and planes to obtain a plurality of profile, resolving the plurality of profiles to obtain a molecular intensity maps, and reconstituting the intensity maps to obtain a three dimensional image of the sample. The system described is capable of obtaining molecular specific 3D morphology and profile of samples. The system described is capable of differentiating different chemicals or sample distribution throughout the 3D volume.

公开(公告)号：US20230393116A1

公开(公告)日：2023-12-07

申请号：US18032832

申请日：2021-12-16

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva UMAPATHY ,  Dipankar NANDI ,  Ravindran BALACHANDRAN ,  Taru VERMA

IPC: G01N33/483 ,  G01N21/65

CPC classification number: G01N33/483 ,  G01N21/65

Abstract: The invention provides a method of obtaining a biomarker for blood anomaly using Raman scattering. The method includes the first step of capturing at least two unique Raman signatures with respect to the biomarker. The Raman signatures are obtained at regular interval. Second step is comparing the obtained unique Raman signatures to detect the change in the signature. Change in the Raman signature provides the indication for blood anomaly.

公开(公告)号：US20180372643A1

公开(公告)日：2018-12-27

申请号：US15781150

申请日：2016-01-27

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva UMAPATHY ,  Deepak Kumar SAINI ,  Srividya KUMAR

IPC: G01N21/65 ,  G01N1/34

Abstract: The invention provides a method for rapid detection of a specific bacterial species. The method includes preparing a sample, irradiating the prepared sample with an electromagnetic radiation of specific wavelength, capturing the electromagnetic radiation scattered by the sample to obtain a Raman spectra and analyzing the Raman spectra to obtain a unique biochemical signature. The unique biochemical signature identifies a single bacterium within the sample. The method also provides for rapid detection of a group of bacterial species within the sample. The method takes about 1 minute to about 1 hour for the detection of specific bacterial species.

公开(公告)号：US20160103069A1

公开(公告)日：2016-04-14

申请号：US14374933

申请日：2013-09-02

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva UMAPATHY ,  Sanchita SIL ,  John KIRAN

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/4412 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/129

Abstract: The invention provides a method for obtaining sample specific signatures. The method comprises of irradiating the sample at a predefined location with an electromagnetic radiation of specific wavelength; selectively capturing a certain component of the scattered electromagnetic radiation to obtain a plurality of profiles; and filtering the profiles to obtain a sample specific signature. The invention provides an apparatus for obtaining sample specific signatures.

Abstract translation: 本发明提供了一种获取样本特定签名的方法。 该方法包括在预定位置用特定波长的电磁辐射照射样品; 选择性地捕获散射电磁辐射的某一部分以获得多个轮廓; 并过滤配置文件以获得样本特定签名。 本发明提供一种用于获取样本特定签名的装置。