公开(公告)号：US06828328B1

公开(公告)日：2004-12-07

申请号：US10087283

申请日：2002-03-01

Applicant: James Ellis ,  Fangming Zou

Inventor： James Ellis ,  Fangming Zou

IPC: A61K3144

CPC classification number: A61K31/34 ,  A61K31/16 ,  A61K31/19 ,  A61K31/415 ,  A61K31/44 ,  A61K2300/00

Abstract: This invention relates to the combination of muscarinic agonists with narcotic analgesics, non-steroidal anti-inflammatory drugs or other analgesic drugs and to their use as antinociception (pain relief) agents. In particular, the invention relates to a combination of a specific class of M4 selective muscarinic agonists with narcotic analgesics, non-steroidal anti-inflammatory drugs or other analgesic drugs.

Abstract translation: 本发明涉及毒蕈碱激动剂与麻醉止痛剂，非甾体抗炎药或其它镇痛药的组合，以及它们作为抗感冒药（止痛剂）的用途。 特别地，本发明涉及特定类型的M4选择性毒蕈碱激动剂与麻醉止痛剂，非甾体抗炎药或其它止痛药的组合。

公开(公告)号：US06524851B1

公开(公告)日：2003-02-25

申请号：US09411449

申请日：1999-10-01

Applicant: James Ellis

Inventor： James Ellis

IPC: C12N1500

CPC classification number: C07K14/805 ,  A61K48/00 ,  C07K2319/00

Abstract: The invention relates to hybrid nucleic acid molecules for gene therapy in cells of the erythroid lineage, and in particular &agr;-, &bgr;-, &dgr;-, &egr;, &ggr;-, or &zgr;-globin nucleotide sequences operably linked to &bgr;-globin regulatory elements. The hybrid nucleic acid molecules, at single copy, are capable of producing a polypeptide. The hybrid nucleic acid molecules are useful for treatment of hemoglobinopathies such as sickle cell anemia or &bgr;-thalassemia. The hybrid nucleic acid molecules are useful at single copy for erythroid expression at single copy of RNA and polypeptides in transgenic animals.

Abstract translation: 本发明涉及用于在红细胞谱系的细胞中进行基因治疗的杂交核酸分子，特别是与β珠蛋白调节元件可操作地连接的α，β，δ-，εi，γ或zeta珠蛋白核苷酸序列。 单拷贝的杂交核酸分子能够产生多肽。 杂交核酸分子可用于治疗血红蛋白病，例如镰状细胞性贫血或β-地中海贫血。杂交核酸分子在单拷贝中可用于转基因动物中单核苷酸和多肽的单拷贝。

公开(公告)号：US20110053166A1

公开(公告)日：2011-03-03

申请号：US12920059

申请日：2009-02-27

Applicant: James Ellis ,  Akitsu Hotta

Inventor： James Ellis ,  Akitsu Hotta

IPC: C12Q1/68 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  C12N15/85 ,  C12N15/06 ,  C12Q1/04

CPC classification number: C12N15/85 ,  C12N2740/13043 ,  C12N2740/15043 ,  C12N2830/008 ,  C12N2830/30 ,  C12N2830/60

Abstract: A stem cell expression cassette, comprising a nucleic acid comprising a pluripotent stem cell specific promoter, and a tag sequence, wherein the pluripotent stem cell specific promoter and tag sequences are operatively linked, is provided. Also provided are methods of identifying and methods of selecting a pluripotent cell, using the stem cell expression cassette.

Abstract translation: 提供了包含多能干细胞特异性启动子的核酸和其中多能干细胞特异性启动子和标签序列可操作地连接的标签序列的干细胞表达盒。 还提供了使用干细胞表达盒鉴定和选择多能细胞的方法的方法。

公开(公告)号：US20090107153A1

公开(公告)日：2009-04-30

申请号：US12260570

申请日：2008-10-29

Applicant: James Ellis ,  Patronella Van Emde Boas ,  Hein Wille

Inventor： James Ellis ,  Patronella Van Emde Boas ,  Hein Wille

IPC: F16L55/045 ,  F17C6/00 ,  F17C13/00 ,  F16L55/05 ,  F17C13/04

CPC classification number: B63B27/24 ,  Y10T137/2605

Abstract: An offshore hydrocarbon transfer system (10) wherein a conduit (24) connects a floating structure (12) to a second structure (22) to carry hydrocarbons between them, and one of the structures has a shutoff valve (30) that produces a pressure surge in the conduit if the shut-off valve closes too fast. The invention provides a surge protection apparatus (40) with an overflow container (50) that receives hydrocarbons in the event of a pressure surge. The overflow container lies adjacent to the conduit and is connected to the conduit by a pressure relief valve (60). In one apparatus (40), the overflow container lies coaxial with a relief conduit section (42), and includes an elastic outer wall (44) that surrounds the conduit section. In another apparatus, the overflow container (72) lies completely outside the conduit section (42), and can be removed after it has filled with hydrocarbons.

Abstract translation: 一种近海烃转移系统（10），其中导管（24）将浮动结构（12）连接到第二结构（22）以在它们之间承载烃，并且所述结构之一具有产生压力的截止阀（30） 如果关闭阀关闭得太快，则导管中的电涌。 本发明提供具有溢流容器（50）的浪涌保护装置（40），该溢流容器在压力波动的情况下接收碳氢化合物。 溢流容器位于导管附近，并通过一个泄压阀（60）与导管连接。 在一个装置（40）中，溢流容器与释放导管部分（42）同轴，并且包括围绕导管部分的弹性外壁（44）。 在另一装置中，溢流容器（72）完全位于导管部分（42）的外部，并且可以在填充有碳氢化合物之后被移除。

公开(公告)号：US20050241659A1

公开(公告)日：2005-11-03

申请号：US11176720

申请日：2005-07-07

Applicant: Charles Ashcraft ,  James Ellis ,  James Hutchens ,  Gregory Pierce ,  John Tomel ,  Don White ,  Sara Williard ,  Pau Chapman ,  Mark Powell

Inventor： Charles Ashcraft ,  James Ellis ,  James Hutchens ,  Gregory Pierce ,  John Tomel ,  Don White ,  Sara Williard ,  Pau Chapman ,  Mark Powell

IPC: A24D1/02

CPC classification number: A24D1/025

Abstract: Smokable rods of cigarettes are manufactured using wrapping materials that incorporate at least one fibrous material (e.g., flax fibers, hardwood pulp fibers and/or softwood pulp fibers) at least one filler material (e.g., calcium carbonate in particulate form). The wrapping materials possess multi-layer coatings. The wrapping materials possess coatings in the form of series of spaced apart bands, each band possessing a series of layers. At least one of the coating layers can have a filler material dispersed or suspended within a film-forming material of that layer.

公开(公告)号：US06797713B2

公开(公告)日：2004-09-28

申请号：US10242346

申请日：2002-09-12

Applicant: Ralph Scannell ,  Pierre Chatelain ,  Anna Toy-Palmer ,  Edmond Differding ,  James Ellis ,  Marie-Agnes Lassoie ,  Michelle Young ,  Xiong Cai ,  Sajjat Hussoin ,  Gurmit Grewal ,  Timothy Lewis

Inventor： Ralph Scannell ,  Pierre Chatelain ,  Anna Toy-Palmer ,  Edmond Differding ,  James Ellis ,  Marie-Agnes Lassoie ,  Michelle Young ,  Xiong Cai ,  Sajjat Hussoin ,  Gurmit Grewal ,  Timothy Lewis

IPC: A61K31495

CPC classification number: C07D295/096 ,  C07D295/084 ,  C07D295/088 ,  C07D295/125 ,  C07D295/13 ,  C07D295/135 ,  C07D295/15 ,  C07D307/14 ,  C07D307/52 ,  C07D401/04

Abstract: The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

Abstract translation: 本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。 本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。 本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。 这些病症优选包括哮喘，季节性和常年性过敏性鼻炎，鼻窦炎，结膜炎，食物过敏症，偶发性中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性阻塞性肺病，血栓性疾病和中耳炎。 还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

公开(公告)号：US08668646B2

公开(公告)日：2014-03-11

申请号：US12825770

申请日：2010-06-29

Applicant: Marc Stein ,  James Ellis

Inventor： Marc Stein ,  James Ellis

IPC: A61B8/00

CPC classification number: A61B5/6878 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6846 ,  A61B5/7239 ,  A61B8/15 ,  Y10T307/615

Abstract: A sensing assemblage (1) for capturing a transit time, phase, or frequency of energy waves propagating through a medium is disclosed to measure a parameter of the muscular-skeletal system. The sensing assemblage (1) comprises a transducer (2) and a waveguide (3). The transducer (2) is coupled to the waveguide (3) at a first location. A second transducer (11) can be coupled to the waveguide (3) at a second location. An interface material that is transmissive to acoustic energy waves can be placed between transducers (402, 404) and a waveguide (414) to improve transfer. The interface material (408, 410) can affix the transducers (402, 404) to the waveguide (414). Alternatively, a reflecting feature (5) can be placed at a second location of the waveguide (3) to reflect acoustic waves back to the transducer (2) where transducer (2) emits energy waves into the medium and detects propagated energy waves.

Abstract translation: 公开了用于捕获通过介质传播的能量波的传播时间，相位或频率的感测组件（1），以测量肌肉 - 骨骼系统的参数。 感测组件（1）包括换能器（2）和波导（3）。 换能器（2）在第一位置处耦合到波导（3）。 第二传感器（11）可以在第二位置处耦合到波导（3）。 对声能波透射的界面材料可以放置在换能器（402,404）和波导（414）之间，以改善转移。 界面材料（408,410）可以将换能器（402,404）固定到波导（414）上。 或者，反射特征（5）可以放置在波导（3）的第二位置处，以将声波反射回到换能器（2），其中换能器（2）将能量波发射到介质中并检测传播的能量波。

公开(公告)号：US20100331738A1

公开(公告)日：2010-12-30

申请号：US12825883

申请日：2010-06-29

Applicant: Marc Stein ,  James Ellis

Inventor： Marc Stein ,  James Ellis

IPC: A61B5/103 ,  H05K1/14

CPC classification number: A61B5/4528 ,  A61B5/103 ,  A61B5/4509 ,  A61B5/6846 ,  A61B2562/0219 ,  H05K1/147 ,  H05K1/148

Abstract: A sensing insert device (100) is disclosed for measuring a parameter of the muscular-skeletal system. The sensing insert device (100) can be temporary or permanent. Used intra-operatively, the sensing insert device (100) comprises an insert dock (202) and a sensing module (200). The sensing module (200) is a self-contained encapsulated measurement device having at least one contacting surface that couples to the muscular-skeletal system. The sensing module (200) comprises one or more sensing assemblages (1802), electronic circuitry (307), and communication circuitry (320). An interconnect stack within the sensing module (1700) couples at least one circuit board (1612 and 1616) to one or more sensing assemblages (1802). The interconnect stack includes at least one flexible interconnect (1506) that couples to the circuit board (1612 and 1616). The flexible interconnect (1506) can be in a path for conducting an energy wave through the sensing assemblage (1802).

Abstract translation: 公开了一种用于测量肌肉 - 骨骼系统的参数的感测插入装置（100）。 感测插入装置（100）可以是暂时的或永久的。 在操作中使用的感测插入装置（100）包括插入坞（202）和感测模块（200）。 感测模块​​（200）是独立的封装测量装置，其具有耦合到肌肉 - 骨骼系统的至少一个接触表面。 感测模块​​（200）包括一个或多个感测组件（1802），电子电路（307）和通信电路（320）。 感测模块​​（1700）内的互连堆叠将至少一个电路板（1612和1616）耦合到一个或多个感测组件（1802）。 互连堆叠包括耦合到电路板（1612和1616）的至少一个柔性互连（1506）。 柔性互连（1506）可以在用于通过感测组件（1802）传导能量波的路径中。

公开(公告)号：US20100331737A1

公开(公告)日：2010-12-30

申请号：US12825736

申请日：2010-06-29

Applicant: Marc Stein ,  James Ellis

Inventor： Marc Stein ,  James Ellis

IPC: A61B5/103

CPC classification number: A61B5/6878 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6846 ,  A61B5/7239 ,  A61B8/15 ,  Y10T307/615

Abstract: A sensing insert device (100) is disclosed for measuring a parameter of the muscular-skeletal system. The sensing insert device (100) can be temporary or permanent. Used intra-operatively, the sensing insert device (100) comprises an insert dock (202) and a sensing module (200). The sensing module (200) is a self-contained encapsulated measurement device having at least one contacting surface that couples to the muscular-skeletal system. The insert dock (202) is a passive component made for different prosthetic component manufacturers as well as for different size prosthetic components. The sensing module (200) fits in an opening or cavity of the insert dock (202). The intra-operative insert device is substantially equal in dimension to an implanted final insert. The sensing insert device (100) is also a permanent prosthetic component. The sensing module (200) residing within the sensing insert device and coupling to a bearing surface of the insert.

Abstract translation: 公开了一种用于测量肌肉 - 骨骼系统的参数的感测插入装置（100）。 感测插入装置（100）可以是暂时的或永久的。 在操作中使用的感测插入装置（100）包括插入坞（202）和感测模块（200）。 感测模块​​（200）是独立的封装测量装置，其具有耦合到肌肉 - 骨骼系统的至少一个接触表面。 插入坞（202）是为不同的假肢部件制造商以及用于不同尺寸的假体部件制成的被动部件。 感测模块​​（200）装配在插入坞（202）的开口或空腔中。 术中插入装置在尺寸上基本上等于植入的最终插入物。 感测插入装置（100）也是永久性假体部件。 感测模块​​（200）位于感测插入装置内并且联接到插入件的支承表面。

公开(公告)号：US20050088655A1

公开(公告)日：2005-04-28

申请号：US10976902

申请日：2004-11-01

Applicant: James Ellis ,  Mike Sasges ,  Peter Van Doodewaard ,  Alex Verdun

Inventor： James Ellis ,  Mike Sasges ,  Peter Van Doodewaard ,  Alex Verdun

IPC: G01N21/59 ,  A61L2/10 ,  C02F1/00 ,  C02F1/32 ,  G01J1/02 ,  G01J1/42 ,  G01N21/53 ,  G01N21/00

CPC classification number: G01J1/429 ,  A61L2/10 ,  C02F1/325 ,  C02F2201/326 ,  G01N21/534

Abstract: An optical radiation sensor device for detecting radiation in a radiation field having a thickness. A preferred embodiment of the device includes a radiation source and a radiation sensor element positioned to receive radiation from the radiation source. A motor (or other motive means) is provided to alter the thickness of the radiation field from a first thickness to a second thickness. The sensor element is capable of detecting and responding to incident radiation from radiation source at the first thickness and at the second thickness. The optical radiation sensor device allows for determination of radiation (preferably ultraviolet radiation) transmittance of a fluid of interest.

Abstract translation: 一种用于检测具有厚度的辐射场中的辐射的光辐射传感器装置。 设备的优选实施例包括辐射源和放射线传感器元件，其被定位成接收来自辐射源的辐射。 提供电动机（或其他动力装置）以将辐射场的厚度从第一厚度改变到第二厚度。 传感器元件能够检测并响应来自第一厚度和第二厚度处的辐射源的入射辐射。 光学辐射传感器装置允许确定感兴趣的流体的辐射（优选紫外线辐射）透射率。