公开(公告)号：US20150144781A1

公开(公告)日：2015-05-28

申请号：US14409735

申请日：2013-06-17

Applicant: Micromass UK Limited

Inventor： Kevin R. Howes ,  Simon Meffan-Main ,  Richard B. Moulds

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/10 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/16

Abstract: A method for controlling the supply of ions from a liquid chromatograph through an ion source into a mass spectrometer. The ion source is foreseen to be either an electrospray ionization sources or an impaction spraying ion sources. The ion source can be operated in two modes: a mode in which ions are supplied into the mass spectrometer and a mode in which ions are prevented to be supplied into the mass spectrometer. In this latter mode, the supply of ions into the mass spectrometer is prevented by reducing the potential applied to the ionization source, reducing the nebulizer gas flow and/or increasing the cone gas flow.

Abstract translation: 用于控制从液相色谱仪通过离子源将离子供给到质谱仪中的方法。 离子源可预见为电喷雾离子源或冲击喷射离子源。 离子源可以以两种模式操作：将离子供给到质谱仪中的模式以及防止将离子供给到质谱仪中的模式。 在后一种模式中，通过降低施加到电离源的电位，减少雾化器气体流量和/或增加锥形气体流量来防止向质谱仪中提供离子。