公开(公告)号：US20210202226A1

公开(公告)日：2021-07-01

申请号：US17177892

申请日：2021-02-17

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Kevin R. Howes

IPC: H01J49/02 ,  H01J49/42 ,  H01J49/00

Abstract: A method of mass and/or ion mobility spectrometry is disclosed that comprises accumulating ions for a first period of time (T1) one or more times so as to form one or more first groups of ions, accumulating ions for a second period of time (T2) one or more times so as to form one or more second groups of ions, wherein the second period of time (T2) is less that the first period of time (T1), analysing the one or more first groups of ions to generate one or more first data sets, analysing the one or more second groups of ions to generate one or more second data sets, and determining whether the one or more first data sets comprise saturated and/or distorted data. If it is determined that the one or more first data sets comprise saturated and/or distorted data, then the method further comprises replacing the saturated and/or distorted data from the one or more first data sets with corresponding data from the one or more second data sets.

公开(公告)号：US10522336B2

公开(公告)日：2019-12-31

申请号：US15574116

申请日：2016-05-13

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Kevin R. Howes

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/42

Abstract: A method of mass and/or ion mobility spectrometry is disclosed that comprises accumulating ions for a first period of time (T1) one or more times so as to form one or more first groups of ions, accumulating ions for a second period of time (T2) one or more times so as to form one or more second groups of ions, wherein the second period of time (T2) is less that the first period of time (T1), analysing the one or more first groups of ions to generate one or more first data sets, analysing the one or more second groups of ions to generate one or more second data sets, and determining whether the one or more first data sets comprise saturated and/or distorted data. If it is determined that the one or more first data sets comprise saturated and/or distorted data, then the method further comprises replacing the saturated and/or distorted data from the one or more first data sets with corresponding data from the one or more second data sets.

公开(公告)号：US11488815B2

公开(公告)日：2022-11-01

申请号：US17177892

申请日：2021-02-17

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Kevin R. Howes

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/42

Abstract: A method of mass and/or ion mobility spectrometry is disclosed that comprises accumulating ions for a first period of time (T1) one or more times so as to form one or more first groups of ions, accumulating ions for a second period of time (T2) one or more times so as to form one or more second groups of ions, wherein the second period of time (T2) is less that the first period of time (T1), analysing the one or more first groups of ions to generate one or more first data sets, analysing the one or more second groups of ions to generate one or more second data sets, and determining whether the one or more first data sets comprise saturated and/or distorted data. If it is determined that the one or more first data sets comprise saturated and/or distorted data, then the method further comprises replacing the saturated and/or distorted data from the one or more first data sets with corresponding data from the one or more second data sets.

公开(公告)号：US10957525B2

公开(公告)日：2021-03-23

申请号：US16726519

申请日：2019-12-24

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Kevin R. Howes

IPC: H01J49/02 ,  H01J49/42 ,  H01J49/00

Abstract: A method of mass and/or ion mobility spectrometry is disclosed that comprises accumulating ions for a first period of time (T1) one or more times so as to form one or more first groups of ions, accumulating ions for a second period of time (T2) one or more times so as to form one or more second groups of ions, wherein the second period of time (T2) is less that the first period of time (T1), analysing the one or more first groups of ions to generate one or more first data sets, analysing the one or more second groups of ions to generate one or more second data sets, and determining whether the one or more first data sets comprise saturated and/or distorted data. If it is determined that the one or more first data sets comprise saturated and/or distorted data, then the method further comprises replacing the saturated and/or distorted data from the one or more first data sets with corresponding data from the one or more second data sets.

公开(公告)号：US20180350580A1

公开(公告)日：2018-12-06

申请号：US15574116

申请日：2016-05-13

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Kevin R. Howes

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/42

CPC classification number: H01J49/025 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/4265

Abstract: A method of mass and/or ion mobility spectrometry is disclosed that comprises accumulating ions for a first period of time (T1) one or more times so as to form one or more first groups of ions, accumulating ions for a second period of time (T2) one or more times so as to form one or more second groups of ions, wherein the second period of time (T2) is less that the first period of time (T1), analysing the one or more first groups of ions to generate one or more first data sets, analysing the one or more second groups of ions to generate one or more second data sets, and determining whether the one or more first data sets comprise saturated and/or distorted data. If it is determined that the one or more first data sets comprise saturated and/or distorted data, then the method further comprises replacing the saturated and/or distorted data from the one or more first data sets with corresponding data from the one or more second data sets.

公开(公告)号：US20150144781A1

公开(公告)日：2015-05-28

申请号：US14409735

申请日：2013-06-17

Applicant: Micromass UK Limited

Inventor： Kevin R. Howes ,  Simon Meffan-Main ,  Richard B. Moulds

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/10 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/16

Abstract: A method for controlling the supply of ions from a liquid chromatograph through an ion source into a mass spectrometer. The ion source is foreseen to be either an electrospray ionization sources or an impaction spraying ion sources. The ion source can be operated in two modes: a mode in which ions are supplied into the mass spectrometer and a mode in which ions are prevented to be supplied into the mass spectrometer. In this latter mode, the supply of ions into the mass spectrometer is prevented by reducing the potential applied to the ionization source, reducing the nebulizer gas flow and/or increasing the cone gas flow.

Abstract translation: 用于控制从液相色谱仪通过离子源将离子供给到质谱仪中的方法。 离子源可预见为电喷雾离子源或冲击喷射离子源。 离子源可以以两种模式操作：将离子供给到质谱仪中的模式以及防止将离子供给到质谱仪中的模式。 在后一种模式中，通过降低施加到电离源的电位，减少雾化器气体流量和/或增加锥形气体流量来防止向质谱仪中提供离子。