公开(公告)号：US10436685B2

公开(公告)日：2019-10-08

申请号：US15417858

申请日：2017-01-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Martin Kopp ,  Nenad Milicevic ,  Daniel Mueller ,  Emad Sarofim ,  Goran Savatic

IPC: G01N1/40 ,  G01N15/04 ,  G01N35/00 ,  G01N35/10 ,  B01L3/00 ,  B04B11/04 ,  B04B13/00 ,  B04B5/04 ,  B04B7/08 ,  C12M1/00

Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

公开(公告)号：US20180010990A1

公开(公告)日：2018-01-11

申请号：US15417858

申请日：2017-01-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Martin Kopp ,  Nenad Milicevic ,  Daniel Mueller ,  Emad Sarofim ,  Goran Savatic

IPC: G01N1/40 ,  B04B5/04 ,  B04B7/08 ,  B01L3/00 ,  G01N35/10 ,  G01N35/00 ,  G01N15/04 ,  B04B13/00 ,  B04B11/04

CPC classification number: G01N1/4077 ,  B01L3/5021 ,  B01L2300/0848 ,  B01L2300/0858 ,  B01L2300/168 ,  B01L2400/086 ,  B04B5/0407 ,  B04B7/08 ,  B04B11/04 ,  B04B13/00 ,  C12M47/02 ,  G01N1/405 ,  G01N15/042 ,  G01N35/00584 ,  G01N35/10 ,  G01N2001/4083 ,  G01N2015/045 ,  Y10T436/111666 ,  Y10T436/25375

Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion comprising a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion comprising a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion comprising a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

公开(公告)号：US09606140B2

公开(公告)日：2017-03-28

申请号：US14286194

申请日：2014-05-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Geza Burghardt ,  Michael Glauser ,  Oliver Gutmann ,  Daniel Mueller ,  Edwin Oosterbroek ,  Roger Sandoz ,  Emad Sarofim ,  Goran Savatic

IPC: G01N21/75 ,  G01P15/02 ,  B01L3/00

CPC classification number: G01P15/02 ,  B01L3/5021 ,  B01L3/5453 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/025 ,  B01L2300/0663 ,  B01L2400/0409

Abstract: An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.

公开(公告)号：US20160303556A1

公开(公告)日：2016-10-20

申请号：US15099644

申请日：2016-04-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Kopp ,  Emad Sarofim

IPC: B01L3/02

CPC classification number: B01L3/0217 ,  B01L3/021 ,  B01L2200/0684 ,  B01L2200/14 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/163 ,  G01N35/1016 ,  G01N2035/1025

Abstract: A pressure transmission liquid for a cellular analyzer, a cellular analyzer, and a method for analyzing a liquid cellular sample using such a cellular analyzer are disclosed. The pressure transmission liquid comprises an aqueous solution of at least one substance, wherein the solution has isotonic and substantially non-conductive characteristics. The cellular analyzer comprises a pipetting module having a pipetting tip, an automated positioning device for positioning the pipetting module, a capacitive liquid level sensor for detecting a liquid level of a liquid cellular sample to be analyzed, a pressure transmission liquid reservoir comprising such a pressure transmission liquid, and a pressure transmission liquid conduit connected to the pipetting tip and the pressure transmission liquid reservoir.

Abstract translation: 公开了一种用于细胞分析仪的压力传递液体，细胞分析仪和使用这种细胞分析仪分析液体细胞样品的方法。 压力传递液体包含至少一种物质的水溶液，其中该溶液具有等渗且基本上不导电的特性。 细胞分析仪包括具有移液末端的移液模块，用于定位移液模块的自动定位装置，用于检测要分析的液体细胞样品的液位的电容式液位传感器，包括这种压力 传输液体和连接到移液头和压力传输液体储存器的压力传递液体导管。

公开(公告)号：US20200033240A1

公开(公告)日：2020-01-30

申请号：US16542786

申请日：2019-08-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Martin Kopp ,  Nenad Milicevic ,  Daniel Mueller ,  Emad Sarofim ,  Goran Savatic

IPC: G01N1/40 ,  B01L3/00 ,  C12M1/00 ,  B04B5/04 ,  B04B7/08 ,  B04B11/04 ,  B04B13/00 ,  G01N15/04 ,  G01N35/00 ,  G01N35/10

Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

公开(公告)号：US20210287370A1

公开(公告)日：2021-09-16

申请号：US17197655

申请日：2021-03-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Emad Sarofim

IPC: G06T7/00 ,  G06T7/11

Abstract: A method for determining sample container characteristics is presented. The method comprises providing first image data representing a first image of a sample container in a first scenario, wherein in the first scenario, a first illumination condition comprising a sample container background illumination is applied to the sample container; providing second image data representing a second image of the sample container in a second scenario, wherein in the second scenario, a second illumination condition different from the first is applied to the sample container; determining a mask from the first image that indicates a sub-image section of the first image comprising a sample container representation in the first image; determining sub-image data from the second image containing a sample container representation in the second image by applying the mask to the second image; and determining the sample container characteristics from an image data analysis comprising image sub-image data data analysis.

公开(公告)号：US09063038B2

公开(公告)日：2015-06-23

申请号：US13800795

申请日：2013-03-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Carlo Effenhauser ,  Patrick Griss ,  Stephan Korner ,  Emad Sarofim

IPC: G01N33/00 ,  G01N1/20 ,  B01L3/02 ,  B01L3/00

CPC classification number: G01N1/20 ,  B01L3/0244 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2400/025 ,  B01L2400/0406 ,  Y10T29/49826 ,  Y10T436/110833 ,  Y10T436/2575

Abstract: A device for sampling, transporting and/or disposal of fluid media in the nl and μl-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.

Abstract translation: 用于在nl和μl范围内采样，运输和/或处理流体介质的装置包括分别具有开放或封闭的毛细管状凹槽或通道的基底，分别具有开放或封闭的凹槽或毛细管的基底弯曲或 至少在一个位置弧形。 衬底包括至少一个端部，开放或封闭的毛细管状沟槽或沟槽分别延伸到其中，该端部根据其应用或用途被成形为例如形状。 针状，直线切割，尖端状，至少半圆形，圆形等

公开(公告)号：US20240371479A1

公开(公告)日：2024-11-07

申请号：US18636375

申请日：2024-04-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Glauser ,  Oliver Gutmann ,  Gabriele Piero Janner ,  Emad Sarofim ,  Stephan Schweighauser ,  Marcel Thomann ,  Urs Vollenweider

IPC: G16H10/40

Abstract: A computer-implemented method for optimising an assignment of one or more medical samples to one or more analytical tests to be conducted on those medical samples. The method comprises the steps of: obtaining an initial assignment of the one or more medical samples to the one or more analytical tests; determining a compliance status for the or each medical sample, the compliance status indicating: (i) whether a sample quality metric of the or each medical sample violates an analytical test specification of the medical sample's assigned analytical test(s) in the initial assignment and/or (ii) whether the or each medical sample is unprocessable; and performing a mitigation action if one or more compliance status indicate: (i) that the sample quality metric of a given medical sample violates the analytical test specification and/or (ii) a given medical sample is unprocessable.

公开(公告)号：US11645755B2

公开(公告)日：2023-05-09

申请号：US17197655

申请日：2021-03-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Emad Sarofim

IPC: G06T7/00 ,  G06T7/11

CPC classification number: G06T7/0014 ,  G06T7/11 ,  G06T2207/10152 ,  G06T2207/30024

Abstract: A method for determining sample container characteristics is presented. The method comprises providing first image data representing a first image of a sample container in a first scenario, wherein in the first scenario, a first illumination condition comprising a sample container background illumination is applied to the sample container; providing second image data representing a second image of the sample container in a second scenario, wherein in the second scenario, a second illumination condition different from the first is applied to the sample container; determining a mask from the first image that indicates a sub-image section of the first image comprising a sample container representation in the first image; determining sub-image data from the second image containing a sample container representation in the second image by applying the mask to the second image; and determining the sample container characteristics from an image data analysis comprising image sub-image data data analysis.

公开(公告)号：US11169061B2

公开(公告)日：2021-11-09

申请号：US16542786

申请日：2019-08-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Martin Kopp ,  Nenad Milicevic ,  Daniel Mueller ,  Emad Sarofim ,  Goran Savatic

IPC: G01N1/40 ,  G01N15/04 ,  G01N35/00 ,  G01N35/10 ,  B01L3/00 ,  C12M1/00 ,  B04B5/04 ,  B04B7/08 ,  B04B11/04 ,  B04B13/00

Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid containing the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.