公开(公告)号：US10436685B2

公开(公告)日：2019-10-08

申请号：US15417858

申请日：2017-01-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Martin Kopp ,  Nenad Milicevic ,  Daniel Mueller ,  Emad Sarofim ,  Goran Savatic

IPC: G01N1/40 ,  G01N15/04 ,  G01N35/00 ,  G01N35/10 ,  B01L3/00 ,  B04B11/04 ,  B04B13/00 ,  B04B5/04 ,  B04B7/08 ,  C12M1/00

Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

公开(公告)号：US20190285660A1

公开(公告)日：2019-09-19

申请号：US16291562

申请日：2019-03-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Kopp ,  Oliver Gutmann ,  Norbert Schmitt

IPC: G01N35/00 ,  G01R33/00

Abstract: A laboratory system for a laboratory automation system is presented. The laboratory system comprises a sample container carrier. The sample container carrier is configured to carry a laboratory sample container and comprises a removal detector. The removal detector is configured to interact with the laboratory sample container to detect a removal of the carried laboratory sample container from the sample container carrier. Furthermore, the laboratory system is configured to determine based on the detected removal that a before valid logic assignment of the sample container carrier to the carried laboratory sample container is invalid.

公开(公告)号：US20180010990A1

公开(公告)日：2018-01-11

申请号：US15417858

申请日：2017-01-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Martin Kopp ,  Nenad Milicevic ,  Daniel Mueller ,  Emad Sarofim ,  Goran Savatic

IPC: G01N1/40 ,  B04B5/04 ,  B04B7/08 ,  B01L3/00 ,  G01N35/10 ,  G01N35/00 ,  G01N15/04 ,  B04B13/00 ,  B04B11/04

CPC classification number: G01N1/4077 ,  B01L3/5021 ,  B01L2300/0848 ,  B01L2300/0858 ,  B01L2300/168 ,  B01L2400/086 ,  B04B5/0407 ,  B04B7/08 ,  B04B11/04 ,  B04B13/00 ,  C12M47/02 ,  G01N1/405 ,  G01N15/042 ,  G01N35/00584 ,  G01N35/10 ,  G01N2001/4083 ,  G01N2015/045 ,  Y10T436/111666 ,  Y10T436/25375

Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion comprising a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion comprising a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion comprising a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

公开(公告)号：US20160303556A1

公开(公告)日：2016-10-20

申请号：US15099644

申请日：2016-04-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Kopp ,  Emad Sarofim

IPC: B01L3/02

CPC classification number: B01L3/0217 ,  B01L3/021 ,  B01L2200/0684 ,  B01L2200/14 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/163 ,  G01N35/1016 ,  G01N2035/1025

Abstract: A pressure transmission liquid for a cellular analyzer, a cellular analyzer, and a method for analyzing a liquid cellular sample using such a cellular analyzer are disclosed. The pressure transmission liquid comprises an aqueous solution of at least one substance, wherein the solution has isotonic and substantially non-conductive characteristics. The cellular analyzer comprises a pipetting module having a pipetting tip, an automated positioning device for positioning the pipetting module, a capacitive liquid level sensor for detecting a liquid level of a liquid cellular sample to be analyzed, a pressure transmission liquid reservoir comprising such a pressure transmission liquid, and a pressure transmission liquid conduit connected to the pipetting tip and the pressure transmission liquid reservoir.

Abstract translation: 公开了一种用于细胞分析仪的压力传递液体，细胞分析仪和使用这种细胞分析仪分析液体细胞样品的方法。 压力传递液体包含至少一种物质的水溶液，其中该溶液具有等渗且基本上不导电的特性。 细胞分析仪包括具有移液末端的移液模块，用于定位移液模块的自动定位装置，用于检测要分析的液体细胞样品的液位的电容式液位传感器，包括这种压力 传输液体和连接到移液头和压力传输液体储存器的压力传递液体导管。

公开(公告)号：US11709171B2

公开(公告)日：2023-07-25

申请号：US16291562

申请日：2019-03-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Kopp ,  Oliver Gutmann ,  Norbert Schmitt

IPC: G01N35/00 ,  G01N35/04 ,  G01R33/00

CPC classification number: G01N35/00732 ,  G01N35/04 ,  G01R33/0035 ,  G01N2035/00633 ,  G01N2035/00643 ,  G01N2035/00762 ,  G01N2035/00801 ,  G01N2035/0401 ,  G01N2035/0477

Abstract: A laboratory system for a laboratory automation system is presented. The laboratory system comprises a sample container carrier. The sample container carrier is configured to carry a laboratory sample container and comprises a removal detector. The removal detector is configured to interact with the laboratory sample container to detect a removal of the carried laboratory sample container from the sample container carrier. Furthermore, the laboratory system is configured to determine based on the detected removal that a before valid logic assignment of the sample container carrier to the carried laboratory sample container is invalid.

公开(公告)号：US20200033240A1

公开(公告)日：2020-01-30

申请号：US16542786

申请日：2019-08-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Martin Kopp ,  Nenad Milicevic ,  Daniel Mueller ,  Emad Sarofim ,  Goran Savatic

IPC: G01N1/40 ,  B01L3/00 ,  C12M1/00 ,  B04B5/04 ,  B04B7/08 ,  B04B11/04 ,  B04B13/00 ,  G01N15/04 ,  G01N35/00 ,  G01N35/10

Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

公开(公告)号：US11169061B2

公开(公告)日：2021-11-09

申请号：US16542786

申请日：2019-08-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Martin Kopp ,  Nenad Milicevic ,  Daniel Mueller ,  Emad Sarofim ,  Goran Savatic

IPC: G01N1/40 ,  G01N15/04 ,  G01N35/00 ,  G01N35/10 ,  B01L3/00 ,  C12M1/00 ,  B04B5/04 ,  B04B7/08 ,  B04B11/04 ,  B04B13/00

Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid containing the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

公开(公告)号：US10456777B2

公开(公告)日：2019-10-29

申请号：US15099644

申请日：2016-04-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Kopp ,  Emad Sarofim

IPC: B01L3/02 ,  G01N35/10

Abstract: A pressure transmission liquid for a cellular analyzer, a system for transferring a liquid cellular sample for analysis by a cellular analyzer, and a method for transferring a liquid cellar sample for analysis are disclosed. The pressure transmission liquid includes an aqueous solution which is isotonic and substantially non-conductive characteristics. The cellular analyzer includes a pipetting module having a pipetting tip, a device for positioning the pipetting module, a sensor for detecting a liquid level of a liquid cellular sample to be analyzed, a pressure transmission liquid, and a pressure transmission liquid conduit connected to the pipetting tip and the pressure transmission liquid reservoir.