公开(公告)号：US20180021219A1

公开(公告)日：2018-01-25

申请号：US15653816

申请日：2017-07-19

Applicant: Sysmex Corporation

Inventor： Ayato TAGAWA ,  Junko KOJIMA ,  Nobuyasu HORI ,  Kenji AKAMA ,  Masaya OKADA ,  Kunpeng CAI ,  Samiko HOSOYA ,  Shigeki IWANAGA

IPC: A61J1/14 ,  A61J1/16 ,  A61J1/05

CPC classification number: A61J1/1475 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150748 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/15105 ,  A61B5/155 ,  A61J1/05 ,  A61J1/165 ,  B01L3/502715 ,  B01L3/5082 ,  B01L2200/0684 ,  B01L2300/024 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2300/1822 ,  B01L2300/1894

Abstract: A blood collection device including a flow path to flow blood by capillary action capable of collecting a large amount of blood is provided. The blood collection device includes an introduction inlet 23 for introducing the blood of the subject M, a substrate 20 connected to the introduction inlet 23 and including a flow path 25 to flow the blood by capillary action, and a cooling body 30 for cooling the flow path 25.

公开(公告)号：US20180149574A1

公开(公告)日：2018-05-31

申请号：US15825965

申请日：2017-11-29

Applicant: SYSMEX CORPORATION

Inventor： Yasuko KAWAMOTO ,  Ayato TAGAWA

IPC: G01N15/14 ,  B03C1/28

CPC classification number: G01N15/1404 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2400/0487 ,  B03C1/288 ,  B03C2201/18 ,  G01N15/1459 ,  G01N15/1484 ,  G01N33/54326 ,  G01N35/00069 ,  G01N35/0098 ,  G01N35/085 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1415 ,  G01N2015/1486 ,  G01N2035/00158 ,  G01N2035/00237 ,  G01N2035/1034

Abstract: Disclosed is a method of processing a specimen in which a target component in a specimen is processed using a specimen processing chip provided with a flow-path, the method including: introducing a fluid into a flow-path to form an interface that divides the fluid from a process liquid used for the processing of the target component with a rim of the interface on an inner wall of the flow-path, the process liquid containing particles including the target component; and moving the formed interface along the flow-path with the rim of the interface on the inner wall so as to force out the particles retained in the process liquid by the fluid.

公开(公告)号：US20240142789A1

公开(公告)日：2024-05-02

申请号：US18495946

申请日：2023-10-27

Applicant: SYSMEX CORPORATION

Inventor： Takuya KUWANA ,  Takeshi SUGIYAMA ,  Kazuhiro YAMADA ,  Ayato TAGAWA

IPC: G02B27/42 ,  G01N15/14

CPC classification number: G02B27/4205 ,  G01N15/1436 ,  G01N15/1459 ,  G01N2015/0065

Abstract: Disclosed is an optical system including: a light source configured to emit light; an irradiation optical system including a diffractive optical element on which the light is incident, the irradiation optical system being configured to apply illumination light in which a plurality of diffracted lights generated by the diffractive optical element are distributed; a flow cell in which a sample containing cells is caused to flow to a position at which the illumination light is applied by the irradiation optical system; and a light receiver configured to receive light generated from each cell flowing in the flow cell, upon application of the illumination light by the irradiation optical system. The illumination light includes zero-order diffracted light whose relative intensity relative to another diffracted light is not greater than 10 times. The irradiation optical system applies the illumination light to a position through which the cell in the flow cell passes.

公开(公告)号：US20180221878A1

公开(公告)日：2018-08-09

申请号：US15947006

申请日：2018-04-06

Applicant: SYSMEX CORPORATION

Inventor： Ayato TAGAWA ,  Tsuyoshi NAKANO ,  Yasuko KAWAMOTO ,  Koya YAMAWAKI ,  Hiroaki TOBIMATSU

IPC: B01L3/00 ,  B01L9/00 ,  C12Q1/6851

CPC classification number: B01L3/502715 ,  B01J19/0046 ,  B01J2219/00813 ,  B01L3/502784 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0487 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/6851 ,  G01N35/08 ,  G01N37/00

Abstract: This specimen treatment chip includes: a first fluid module having a first flow channel for performing a first treatment step on an object component in a specimen; a second fluid module having a second flow channel for performing a second treatment step on the object component subjected to the first treatment step; a substrate; and a connection flow channel for connecting the first fluid module and the second fluid module disposed on the substrate.

公开(公告)号：US20170259266A1

公开(公告)日：2017-09-14

申请号：US15454397

申请日：2017-03-09

Applicant: Sysmex Corporation

Inventor： Koya YAMAWAKI ,  Ayato TAGAWA ,  Tsuyoshi NAKANO

IPC: B01L3/00 ,  G01N1/44 ,  B01L7/00 ,  G01N1/38

CPC classification number: B01L3/502784 ,  B01F3/0807 ,  B01F5/0647 ,  B01F13/0062 ,  B01F13/0079 ,  B01F13/0081 ,  B01L7/00 ,  B01L2200/16 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/18 ,  B01L2300/185 ,  B01L2400/0445 ,  B01L2400/0487 ,  G01N1/31 ,  G01N1/38 ,  G01N1/44

Abstract: Disclosed is a sample processing method for processing a target component in a sample by use of a sample processing chip having a storage portion and a droplet forming flow path, the sample processing method including: storing, in the storage portion, a mixture of the target component and a predetermined amount of a diluent for causing the target component to be encapsulated by one molecule or by one particle into a droplet; heating the mixture in the storage portion to cause thermal convection in the storage portion thereby to mix the target component and the diluent together; and in the droplet forming flow path, forming droplets in a dispersion medium, each droplet containing the diluted target component and a reagent that reacts with the target component.

公开(公告)号：US20190285520A1

公开(公告)日：2019-09-19

申请号：US16352140

申请日：2019-03-13

Applicant: SYSMEX CORPORATION

Inventor： Koya YAMAWAKI ,  Kichitarou NAKAJIMA ,  Katsumi NAKANISHI ,  Yasuko KAWAMOTO ,  Ayato TAGAWA

IPC: G01N1/38

Abstract: A sample processing method comprises storing a processing liquid (11) containing a target component (10) and a diluent (12) for diluting the processing liquid (11) in a reservoir (110) of a sample processing chip (100), and agitating the processing liquid (11) and the diluent (12) in the reservoir (110) by introducing a gas into the reservoir (110). The processing liquid (11) is diluted in order to prepare a droplet forming sample (13) for forming droplets (14) individually encapsulating the target component (10).

公开(公告)号：US20180243744A1

公开(公告)日：2018-08-30

申请号：US15905034

申请日：2018-02-26

Applicant: SYSMEX CORPORATION

Inventor： Kunpeng CAI ,  Koya YAMAWAKI ,  Yasuko KAWAMOTO ,  Katsumi NAKANISHI ,  Ayato TAGAWA

IPC: B01L3/00 ,  C12Q1/6806 ,  G01N33/53

CPC classification number: B01L3/56 ,  B01L3/0293 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2300/0663 ,  B01L2400/0487 ,  B01L2400/082 ,  C12Q1/6806 ,  G01N33/5302

Abstract: Disclosed is a liquid sending method for sending liquid to a sample processing chip having a flow path formed therein, the method including: measuring a flow of a second liquid which is different from a first liquid which is introduced into the flow path in the sample processing chip; controlling the flow of the second liquid on the basis of the measured flow; and introducing the first liquid into the flow path in the sample processing chip by means of the second liquid of which flow is controlled.

公开(公告)号：US20180221881A1

公开(公告)日：2018-08-09

申请号：US15947218

申请日：2018-04-06

Applicant: SYSMEX CORPORATION

Inventor： Ayato TAGAWA ,  Tsuyoshi NAKANO ,  Yasuko KAWAMOTO ,  Koya YAMAWAKI ,  Hiroaki TOBIMATSU

IPC: B01L3/00 ,  B01F11/00 ,  B01F3/08 ,  B01L7/00 ,  G01N35/00 ,  C12Q1/6844

CPC classification number: B01L3/502784 ,  B01F3/0819 ,  B01F11/0005 ,  B01L7/52 ,  B01L2300/0816 ,  B01L2400/06 ,  B01L2400/082 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12Q1/68 ,  C12Q1/6844 ,  G01N35/0098 ,  G01N37/00 ,  G01N2035/00366 ,  G01N2035/00475 ,  G01N2035/00524

Abstract: The present specimen treatment chip includes: a first flow channel for forming a droplet containing a mixed liquid of a nucleic acid, a reagent for an amplification reaction of the nucleic acid, and a carrier to which a primer for binding to the nucleic acid is added, in a dispersion medium; a second flow channel for amplifying the nucleic acid in the droplet; and a third flow channel for mixing the droplet containing the carrier with the primer having bound to an amplification product of the nucleic acid, and a reagent for breaking down the droplet, to break down the droplet.

公开(公告)号：US20180149566A1

公开(公告)日：2018-05-31

申请号：US15826136

申请日：2017-11-29

Applicant: SYSMEX CORPORATION

Inventor： Tsuyoshi NAKANO ,  Koya YAMAWAKI ,  Ayato TAGAWA

IPC: G01N1/44 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/68

CPC classification number: G01N1/44 ,  B01L3/502715 ,  B01L3/563 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/027 ,  B01L2300/041 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2300/1805 ,  B01L2400/0487 ,  C12Q1/6806 ,  G01N35/00029 ,  G01N2035/00158 ,  G01N2035/00366 ,  G01N2035/00376

Abstract: Disclosed is a specimen treatment apparatus that treats a specimen by using a specimen treatment chip including a flow channel and a connecting port communicating with the flow channel, the specimen treatment apparatus including: a placement part in which the specimen treatment chip is placed; a connector provided to be engaged with the connecting port to allow a sample containing a specimen to be injected into the flow channel through the connector; and a heating unit that is pressed on the specimen treatment chip and heats the specimen treatment chip while the connector is connected to the connecting port of the specimen treatment chip placed in the placement part.

公开(公告)号：US20160061730A1

公开(公告)日：2016-03-03

申请号：US14837043

申请日：2015-08-27

Applicant: SYSMEX CORPORATION

Inventor： Ayato TAGAWA

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6471

Abstract: Disclosed is an embodiment of a fluorescence detection apparatus comprises a photodetector that detects a plurality of colors of light; a light filter member on or above the photodetector that transmits light at or above a predefined wavelength and that cuts off light with a wavelength included in a wavelength band below the predefined wavelength, the predefined wavelength being included in a wavelength band being a sensitivity range of the photodetector; an irradiator that irradiates a fluorescent substance on the light filter member, with excitation light with a peak wavelength included in the wavelength band below the predefined wavelength; and a first correction unit that compensates for a signal of light cut off by the light filter member out of fluorescence emitted from the fluorescent substance in response to irradiation from the excitation light.

Abstract translation: 公开了一种荧光检测装置的实施例，其包括：光电检测器，其检测多种颜色的光; 所述光检测器上方或上方的光过滤器部件透射预定波长以上或以上的光，并且将所述波长带中包含的波长的光截止在所述预定波长以下，所述预定波长包括在波长带内， 光电检测器; 照射器，其具有包含在所述预定波长以下的波长带内的峰值波长的激发光，对所述滤光器部件照射荧光物质; 以及第一校正单元，其响应于来自激发光的照射，从由荧光物质发出的荧光中补偿由光过滤器构件切断的光的信号。