公开(公告)号：US20180221878A1

公开(公告)日：2018-08-09

申请号：US15947006

申请日：2018-04-06

Applicant: SYSMEX CORPORATION

Inventor： Ayato TAGAWA ,  Tsuyoshi NAKANO ,  Yasuko KAWAMOTO ,  Koya YAMAWAKI ,  Hiroaki TOBIMATSU

IPC: B01L3/00 ,  B01L9/00 ,  C12Q1/6851

CPC classification number: B01L3/502715 ,  B01J19/0046 ,  B01J2219/00813 ,  B01L3/502784 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0487 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/6851 ,  G01N35/08 ,  G01N37/00

Abstract: This specimen treatment chip includes: a first fluid module having a first flow channel for performing a first treatment step on an object component in a specimen; a second fluid module having a second flow channel for performing a second treatment step on the object component subjected to the first treatment step; a substrate; and a connection flow channel for connecting the first fluid module and the second fluid module disposed on the substrate.

公开(公告)号：US20180149574A1

公开(公告)日：2018-05-31

申请号：US15825965

申请日：2017-11-29

Applicant: SYSMEX CORPORATION

Inventor： Yasuko KAWAMOTO ,  Ayato TAGAWA

IPC: G01N15/14 ,  B03C1/28

CPC classification number: G01N15/1404 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2400/0487 ,  B03C1/288 ,  B03C2201/18 ,  G01N15/1459 ,  G01N15/1484 ,  G01N33/54326 ,  G01N35/00069 ,  G01N35/0098 ,  G01N35/085 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1415 ,  G01N2015/1486 ,  G01N2035/00158 ,  G01N2035/00237 ,  G01N2035/1034

Abstract: Disclosed is a method of processing a specimen in which a target component in a specimen is processed using a specimen processing chip provided with a flow-path, the method including: introducing a fluid into a flow-path to form an interface that divides the fluid from a process liquid used for the processing of the target component with a rim of the interface on an inner wall of the flow-path, the process liquid containing particles including the target component; and moving the formed interface along the flow-path with the rim of the interface on the inner wall so as to force out the particles retained in the process liquid by the fluid.

公开(公告)号：US20190285520A1

公开(公告)日：2019-09-19

申请号：US16352140

申请日：2019-03-13

Applicant: SYSMEX CORPORATION

Inventor： Koya YAMAWAKI ,  Kichitarou NAKAJIMA ,  Katsumi NAKANISHI ,  Yasuko KAWAMOTO ,  Ayato TAGAWA

IPC: G01N1/38

Abstract: A sample processing method comprises storing a processing liquid (11) containing a target component (10) and a diluent (12) for diluting the processing liquid (11) in a reservoir (110) of a sample processing chip (100), and agitating the processing liquid (11) and the diluent (12) in the reservoir (110) by introducing a gas into the reservoir (110). The processing liquid (11) is diluted in order to prepare a droplet forming sample (13) for forming droplets (14) individually encapsulating the target component (10).

公开(公告)号：US20180243744A1

公开(公告)日：2018-08-30

申请号：US15905034

申请日：2018-02-26

Applicant: SYSMEX CORPORATION

Inventor： Kunpeng CAI ,  Koya YAMAWAKI ,  Yasuko KAWAMOTO ,  Katsumi NAKANISHI ,  Ayato TAGAWA

IPC: B01L3/00 ,  C12Q1/6806 ,  G01N33/53

CPC classification number: B01L3/56 ,  B01L3/0293 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2300/0663 ,  B01L2400/0487 ,  B01L2400/082 ,  C12Q1/6806 ,  G01N33/5302

Abstract: Disclosed is a liquid sending method for sending liquid to a sample processing chip having a flow path formed therein, the method including: measuring a flow of a second liquid which is different from a first liquid which is introduced into the flow path in the sample processing chip; controlling the flow of the second liquid on the basis of the measured flow; and introducing the first liquid into the flow path in the sample processing chip by means of the second liquid of which flow is controlled.

公开(公告)号：US20180221881A1

公开(公告)日：2018-08-09

申请号：US15947218

申请日：2018-04-06

Applicant: SYSMEX CORPORATION

Inventor： Ayato TAGAWA ,  Tsuyoshi NAKANO ,  Yasuko KAWAMOTO ,  Koya YAMAWAKI ,  Hiroaki TOBIMATSU

IPC: B01L3/00 ,  B01F11/00 ,  B01F3/08 ,  B01L7/00 ,  G01N35/00 ,  C12Q1/6844

CPC classification number: B01L3/502784 ,  B01F3/0819 ,  B01F11/0005 ,  B01L7/52 ,  B01L2300/0816 ,  B01L2400/06 ,  B01L2400/082 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12Q1/68 ,  C12Q1/6844 ,  G01N35/0098 ,  G01N37/00 ,  G01N2035/00366 ,  G01N2035/00475 ,  G01N2035/00524

Abstract: The present specimen treatment chip includes: a first flow channel for forming a droplet containing a mixed liquid of a nucleic acid, a reagent for an amplification reaction of the nucleic acid, and a carrier to which a primer for binding to the nucleic acid is added, in a dispersion medium; a second flow channel for amplifying the nucleic acid in the droplet; and a third flow channel for mixing the droplet containing the carrier with the primer having bound to an amplification product of the nucleic acid, and a reagent for breaking down the droplet, to break down the droplet.