公开(公告)号：US20180221878A1

公开(公告)日：2018-08-09

申请号：US15947006

申请日：2018-04-06

Applicant: SYSMEX CORPORATION

Inventor： Ayato TAGAWA ,  Tsuyoshi NAKANO ,  Yasuko KAWAMOTO ,  Koya YAMAWAKI ,  Hiroaki TOBIMATSU

IPC: B01L3/00 ,  B01L9/00 ,  C12Q1/6851

CPC classification number: B01L3/502715 ,  B01J19/0046 ,  B01J2219/00813 ,  B01L3/502784 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0487 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/6851 ,  G01N35/08 ,  G01N37/00

Abstract: This specimen treatment chip includes: a first fluid module having a first flow channel for performing a first treatment step on an object component in a specimen; a second fluid module having a second flow channel for performing a second treatment step on the object component subjected to the first treatment step; a substrate; and a connection flow channel for connecting the first fluid module and the second fluid module disposed on the substrate.

公开(公告)号：US20170247682A1

公开(公告)日：2017-08-31

申请号：US15443837

申请日：2017-02-27

Applicant: Sysmex Corporation

Inventor： Yasuhiro SAKAI ,  Hiroaki TOBIMATSU ,  Takeo SAITOU ,  Tomoko OHYAMA ,  Takanori MAEKAWA

IPC: C12N15/10

CPC classification number: C12N15/1013 ,  G01N35/0098

Abstract: Disclosed is a specimen pretreatment apparatus comprising: a specimen container holder configured to hold a specimen container for containing a plasma specimen; a reagent container holder configured to hold a first reagent container for containing a first reagent including magnetic particles on which a nucleic acid in the plasma specimen is adsorbed; a reaction unit in which a plurality of reaction containers are disposed, the reaction unit being configured to accelerate, in each reaction container, reaction of the plasma specimen and the first reagent; a washing unit in which a washing container is disposed, the washing unit including a magnetic force applying portion configured to apply magnetic force to the washing container; a dispensing unit; and a controller programmed to control the dispensing unit to: dispense the plasma specimen contained in the specimen container and the first reagent into the plurality of reaction containers in the reaction unit; dispense a mix liquid of the plasma specimen and the first reagent from each of the plurality of reaction containers into the washing container; and remove a liquid component from the washing container while the magnetic particles contained in the discharged mix liquid is attracted by the magnetic force applying portion.

公开(公告)号：US20180180638A1

公开(公告)日：2018-06-28

申请号：US15854999

申请日：2017-12-27

Applicant: SYSMEX CORPORATION

Inventor： Toru MIZUHASHI ,  Hiroaki TOBIMATSU ,  Tomoya HAYASHI

IPC: G01N35/10 ,  G01N15/14

CPC classification number: G01N35/1009 ,  G01N15/1404 ,  G01N15/1425 ,  G01N35/1002 ,  G01N35/1004 ,  G01N35/1095 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00465

Abstract: A specimen measurement apparatus may include: an aspirator via which a specimen is aspirated. A flow path may be connected to the aspirator. A first pump may be connected to the flow path. A second pump may be connected to the flow path. A controller may select and cause either the first pump or the second pump to aspirate the specimen via the aspirator.

公开(公告)号：US20180149667A1

公开(公告)日：2018-05-31

申请号：US15823652

申请日：2017-11-28

Applicant: SYSMEX CORPORATION

Inventor： Yuto SASAKI ,  Kazuki ASAO ,  Kazuyuki IGUCHI ,  Keiichiro SHOHMI ,  Shoichiro ASADA ,  Hiroaki TOBIMATSU ,  Ryutaro SHINYA

IPC: G01N35/02 ,  B01L9/00 ,  G01N35/04

CPC classification number: G01N35/026 ,  B01L9/00 ,  B01L9/523 ,  B01L2200/025 ,  B01L2300/0829 ,  G01N35/04 ,  G01N2035/0415 ,  G01N2035/042 ,  G01N2035/0465

Abstract: A specimen transport apparatus according to an embodiment includes: a holder including first and second trenches and configured to hold a specimen; a first transporter including a first protrusion to engage with the first trench and configured to transport the holder by transferring the first protrusion engaged with the first trench in an extension direction of the second trench; a second transporter including a second protrusion to engage with the second trench and configured to transport the holder by transferring the second protrusion engaged with the second trench in an extension direction of the first trench. The first trench is formed in at least one of an upper surface and a lower surface of the holder. The second trench is formed in at least one of the upper surface and the lower surface of the holder, and is formed to extend to a lateral surface of the holder.

公开(公告)号：US20180221881A1

公开(公告)日：2018-08-09

申请号：US15947218

申请日：2018-04-06

Applicant: SYSMEX CORPORATION

Inventor： Ayato TAGAWA ,  Tsuyoshi NAKANO ,  Yasuko KAWAMOTO ,  Koya YAMAWAKI ,  Hiroaki TOBIMATSU

IPC: B01L3/00 ,  B01F11/00 ,  B01F3/08 ,  B01L7/00 ,  G01N35/00 ,  C12Q1/6844

CPC classification number: B01L3/502784 ,  B01F3/0819 ,  B01F11/0005 ,  B01L7/52 ,  B01L2300/0816 ,  B01L2400/06 ,  B01L2400/082 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12Q1/68 ,  C12Q1/6844 ,  G01N35/0098 ,  G01N37/00 ,  G01N2035/00366 ,  G01N2035/00475 ,  G01N2035/00524

Abstract: The present specimen treatment chip includes: a first flow channel for forming a droplet containing a mixed liquid of a nucleic acid, a reagent for an amplification reaction of the nucleic acid, and a carrier to which a primer for binding to the nucleic acid is added, in a dispersion medium; a second flow channel for amplifying the nucleic acid in the droplet; and a third flow channel for mixing the droplet containing the carrier with the primer having bound to an amplification product of the nucleic acid, and a reagent for breaking down the droplet, to break down the droplet.

公开(公告)号：US20180149564A1

公开(公告)日：2018-05-31

申请号：US15825992

申请日：2017-11-29

Applicant: SYSMEX CORPORATION

Inventor： Hiroaki TOBIMATSU ,  Toshimi SATO

IPC: G01N1/38 ,  C12Q1/68

CPC classification number: G01N1/38 ,  B01F1/0022 ,  B01F5/0237 ,  B01F5/025 ,  B01L7/52 ,  C12N15/1013 ,  C12Q1/6806 ,  C12Q1/6844 ,  G01N35/0098 ,  G01N35/1011 ,  G01N35/109 ,  G01N2035/00544 ,  G01N2035/00574 ,  G01N2035/106 ,  C12Q2563/143 ,  C12Q2563/149

Abstract: A particle dispersion method for dispersing particles (500) fixed on the inner surface of a container (12) into a liquid. The particle dispersion method includes a discharge step of discharging a liquid into the container (12). The container (12) has a cylindrical main body part (310), and an inclined part (311) having an inner diameter that decreases from the main body part (310) side to the bottom part side and having a constant angle relative to the central axis of the container. In the discharge step, the liquid is discharged from above the inclined part (311) toward the inclined part (311) on the side opposite the particles (500) fixed to the inner surface of the container (12) across the central axis (300) of the container (12).