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公开(公告)号：US09624289B2
公开(公告)日：2017-04-18
申请号：US14539884
申请日：2014-11-12
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：US11766437B2
公开(公告)日：2023-09-26
申请号：US16635320
申请日：2018-08-01
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Mark Robert Bray , Jacqueline M. Mason , Tak W. Mak , Graham Fletcher
IPC: A61K31/519 , A61P35/00 , A61K39/395
CPC classification number: A61K31/519 , A61K39/3955 , A61P35/00
Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
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公开(公告)号：US20200230144A1
公开(公告)日：2020-07-23
申请号：US16635320
申请日：2018-08-01
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Mark Robert Bray , Jacqueline M. Mason , Tak W. Mak , Graham Fletcher
IPC: A61K31/519 , A61K39/395 , A61P35/00
Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
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4.发明申请METHODS AND COMPOSITIONS FOR DETECTION OF TARGETS INVOLVED IN CANCER METASTASIS 审中-公开用于检测癌症参与的靶标的方法和组合物公开(公告)号：US20150252434A1
公开(公告)日：2015-09-10
申请号：US14641023
申请日：2015-03-06
Applicant: University Health Network
Inventor： Heiko Blaser , Tak W. Mak
Abstract: The present invention is further directed to methods and compositions for identifying target nucleic acids that are involved in cancer metastasis.
Abstract translation: 本发明还涉及用于鉴定参与癌症转移的靶核酸的方法和组合物。
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公开(公告)号：US20150250853A1
公开(公告)日：2015-09-10
申请号：US14640318
申请日：2015-03-06
Applicant: University Health Network
Inventor： Tak W. Mak
IPC: A61K38/17 , C12N15/113 , A61K39/395
Abstract: The present invention is directed to methods and compositions for modulating proteins involved in the immune response. The present invention further provides methods and compositions for treatment of autoimmune disease and cancer by modulating the expression and activity of such proteins.
Abstract translation: 本发明涉及用于调节参与免疫应答的蛋白质的方法和组合物。 本发明还提供了通过调节这些蛋白质的表达和活性来治疗自身免疫疾病和癌症的方法和组合物。
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Patent Agency Ranking
公开(公告)号：US20150139995A1
公开(公告)日：2015-05-21
申请号：US14539879
申请日：2014-11-12
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：US10533222B2
公开(公告)日：2020-01-14
申请号：US14641358
申请日：2015-03-07
Applicant: University Health Network
Inventor： Brian Hershenfield , Tak W. Mak
IPC: C12N15/113 , A61K38/17 , A61K39/00 , C12Q1/68 , C12Q1/6883 , A61K49/00 , C12Q1/6886 , G01N33/50
Abstract: The present invention is directed to methods and compositions for identifying targets for induction of self-tolerance and treatment of autoimmune disease.
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公开(公告)号：US20180016320A1
公开(公告)日：2018-01-18
申请号：US15583788
申请日：2017-05-01
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：US09493561B2
公开(公告)日：2016-11-15
申请号：US14322551
申请日：2014-07-02
Applicant: University Health Network
Inventor： Tak W. Mak , Xiuqiu Lai , Michael W. Tusche
CPC classification number: C07K16/2803 , C07K2317/622
Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
Abstract translation: 本发明提供了用于调节Toso活性并治疗涉及Toso的疾病和病症的方法和组合物。 这样的方法和组合物包括使用结合Toso蛋白质或Toso蛋白质配体的一种或多种抗体。
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公开(公告)号：US20150197551A1
公开(公告)日：2015-07-16
申请号：US14539884
申请日：2014-11-12
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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