公开(公告)号：US10891730B1

公开(公告)日：2021-01-12

申请号：US16206958

申请日：2018-11-30

Applicant: University of Southern California

Inventor： Pu Wang ,  Francesco Cutrale ,  Scott E. Fraser

IPC: G06T7/00 ,  G06T5/00 ,  A61B1/00

Abstract: Implementations of the present disclosure include methods, systems, and computer-readable storage mediums for image reconstruction. Actions include receiving an image acquired by an endoscopic system including an optical fiber bundle with multiple optical fibers, each optical fiber being surrounded by cladding, determining in the image fiber core locations corresponding to the optical fibers, reconstructing missing information from the image using interpolation performed in accordance with the fiber core locations, the missing information corresponding to artifacts in the acquired image that result from the cladding, and providing a fiber-pattern removed image, in which the artifacts in the acquired image are removed using the missing information.

公开(公告)号：US20190287222A1

公开(公告)日：2019-09-19

申请号：US16348102

申请日：2017-11-07

Applicant: University of Southern California

Inventor： Francesco Cutrale ,  Scott E. Fraser

IPC: G06T5/00 ,  H04N5/33 ,  H04N9/68 ,  G06T5/10 ,  G01J3/28 ,  G01J3/44 ,  G01N21/64 ,  G02B21/16 ,  G02B21/36 ,  G02B21/08

Abstract: This invention relates to a hyperspectral imaging system for denoising and/or color unmixing multiple overlapping spectra in a low signal-to-noise regime with a fast analysis time. This system may be configured to carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze hyper-spectral time-lapse data. For example, this system may be configured to carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze five-dimensional (5D) hyper-spectral time-lapse data. Advantages of this imaging system may include: (a) fast computational speed, (b) the ease of phasor analysis, and (c) a denoising algorithm to obtain the minimally-acceptable signal-to-noise ratio (SNR). An unmixed color image of a target may be generated. These images may be used in diagnosis of a health condition, which may enhance a patient's clinical outcome and evolution of the patient's health.

公开(公告)号：US11869176B2

公开(公告)日：2024-01-09

申请号：US17427890

申请日：2020-01-31

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Wen Shi ,  Eun Sang Koo ,  Scott E. Fraser ,  Francesco Cutrale

IPC: G06T5/10 ,  G01J3/28 ,  G06T5/00 ,  A61B5/00

CPC classification number: G06T5/10 ,  G01J3/2823 ,  G06T5/002 ,  A61B5/0075 ,  A61B5/441 ,  G06T2207/10024 ,  G06T2207/20056

Abstract: This invention relates to a hyperspectral imaging system for denoising and/or color unmixing multiple overlapping spectra in a low signal-to-noise regime with a fast analysis time. This system may carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze hyper-spectral time-lapse data. For example, this system may carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze five-dimensional (5D) hyper-spectral time-lapse data. Advantages of this imaging system may include: (a) fast computational speed, (b) the ease of phasor analysis, and (c) a denoising algorithm to obtain the minimally-acceptable signal-to-noise ratio (SNR). An unmixed color image of a target may be generated. These images may be used in diagnosis of a health condition, which may enhance a patient's clinical outcome and evolution of the patient's health.

公开(公告)号：US10803558B2

公开(公告)日：2020-10-13

申请号：US16348102

申请日：2017-11-07

Applicant: University of Southern California

Inventor： Francesco Cutrale ,  Scott E. Fraser

IPC: G06K9/00 ,  G06T5/00 ,  G01J3/28 ,  G01J3/44 ,  G01N21/64 ,  G02B21/08 ,  G02B21/16 ,  G02B21/36 ,  G06T5/10 ,  H04N5/33 ,  H04N9/68 ,  G01J3/00 ,  A61B5/00 ,  G02B21/00

Abstract: This invention relates to a hyperspectral imaging system for denoising and/or color unmixing multiple overlapping spectra in a low signal-to-noise regime with a fast analysis time. This system may be configured to carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze hyper-spectral time-lapse data. For example, this system may be configured to carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze five-dimensional (5D) hyper-spectral time-lapse data. Advantages of this imaging system may include: (a) fast computational speed, (b) the ease of phasor analysis, and (c) a denoising algorithm to obtain the minimally-acceptable signal-to-noise ratio (SNR). An unmixed color image of a target may be generated. These images may be used in diagnosis of a health condition, which may enhance a patient's clinical outcome and evolution of the patient's health.

公开(公告)号：US12196679B2

公开(公告)日：2025-01-14

申请号：US17911006

申请日：2021-03-12

Applicant: University of Southern California

Inventor： Francesco Cutrale ,  Pu Wang ,  Scott E. Fraser

IPC: G01N21/64 ,  G02B21/16 ,  G02B21/36

Abstract: Systems and methods are provided for multi-spectral or hyper-spectral fluorescence imaging. In one example, a spectral encoding device may be positioned in a detection light path between a detection objective and an imaging sensor of a microscope. In one example, the spectral encoding device includes a first dichroic mirror having a sine transmittance profile and a second dichroic mirror having a cosine transmittance profile. In addition to collecting transmitted light, reflected light from each dichroic mirror is collected and used for total intensity normalization and image analysis.

公开(公告)号：US20230092749A1

公开(公告)日：2023-03-23

申请号：US17911006

申请日：2021-03-12

Applicant: University of Southern California

Inventor： Francesco Cutrale ,  Pu Wang ,  Scott E. Fraser

IPC: G01N21/64 ,  G02B21/36 ,  G02B21/16

Abstract: Systems and methods are provided for multi-spectral or hyper-spectral fluorescence imaging. In one example, a spectral encoding device may be positioned in a detection light path between a detection objective and an imaging sensor of a microscope. In one example, the spectral encoding device includes a first dichroic mirror having a sine transmittance profile and a second dichroic mirror having a cosine transmittance profile. In addition to collecting transmitted light, reflected light from each dichroic mirror is collected and used for total intensity normalization and image analysis.