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公开(公告)号：US11869176B2
公开(公告)日：2024-01-09
申请号：US17427890
申请日：2020-01-31
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Wen Shi , Eun Sang Koo , Scott E. Fraser , Francesco Cutrale
CPC classification number: G06T5/10 , G01J3/2823 , G06T5/002 , A61B5/0075 , A61B5/441 , G06T2207/10024 , G06T2207/20056
Abstract: This invention relates to a hyperspectral imaging system for denoising and/or color unmixing multiple overlapping spectra in a low signal-to-noise regime with a fast analysis time. This system may carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze hyper-spectral time-lapse data. For example, this system may carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze five-dimensional (5D) hyper-spectral time-lapse data. Advantages of this imaging system may include: (a) fast computational speed, (b) the ease of phasor analysis, and (c) a denoising algorithm to obtain the minimally-acceptable signal-to-noise ratio (SNR). An unmixed color image of a target may be generated. These images may be used in diagnosis of a health condition, which may enhance a patient's clinical outcome and evolution of the patient's health.
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公开(公告)号：US10803558B2
公开(公告)日：2020-10-13
申请号：US16348102
申请日：2017-11-07
Applicant: University of Southern California
Inventor： Francesco Cutrale , Scott E. Fraser
IPC: G06K9/00 , G06T5/00 , G01J3/28 , G01J3/44 , G01N21/64 , G02B21/08 , G02B21/16 , G02B21/36 , G06T5/10 , H04N5/33 , H04N9/68 , G01J3/00 , A61B5/00 , G02B21/00
Abstract: This invention relates to a hyperspectral imaging system for denoising and/or color unmixing multiple overlapping spectra in a low signal-to-noise regime with a fast analysis time. This system may be configured to carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze hyper-spectral time-lapse data. For example, this system may be configured to carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze five-dimensional (5D) hyper-spectral time-lapse data. Advantages of this imaging system may include: (a) fast computational speed, (b) the ease of phasor analysis, and (c) a denoising algorithm to obtain the minimally-acceptable signal-to-noise ratio (SNR). An unmixed color image of a target may be generated. These images may be used in diagnosis of a health condition, which may enhance a patient's clinical outcome and evolution of the patient's health.
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3.发明申请公开(公告)号：US20170000327A1
公开(公告)日：2017-01-05
申请号：US15104491
申请日：2015-02-04
Inventor： Jeffrey P. Fingler , Scott E. Fraser
CPC classification number: A61B3/0025 , A61B3/0041 , A61B3/102 , A61B3/1233 , A61B5/7203 , G01B9/02076 , G01B9/02091 , G01B2290/65
Abstract: This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system with improved motion contrast. This disclosure particularly relates to motion contrast methods for such OCT systems. The OCT system of this disclosure may have a configuration that scans a physical object, which has a surface and a depth, with a beam of light that has a beam width and a direction; acquires OCT signals from the scan; forms at least one A-scan using the acquired OCT signals; forms at least one B-scan cluster set using the acquired OCT signals that includes at least two B-scan clusters that each include at least two B-scans. The B-scans within each B-scan cluster set are parallel to one another and parallel to the direction of the beam of light. The OCT system may have a configuration that calculates OCT motion contrast using the at least one B-scan cluster set. This OCT system may form and display an image of the physical object.
Abstract translation: 本公开涉及光学相干断层扫描（OCT）领域。 本公开特别涉及具有改善的运动对比度的OCT系统。 本公开特别涉及这种OCT系统的运动对比方法。 本公开的OCT系统可以具有使具有波束宽度和方向的光束扫描具有表面和深度的物理对象的配置; 从扫描获取OCT信号; 使用获取的OCT信号形成至少一个A扫描; 使用所获取的OCT信号形成至少一个B扫描簇组，所述OCT信号包括至少两个B扫描簇，每个B扫描簇包括至少两个B扫描。 每个B扫描群集中的B扫描彼此平行并平行于光束的方向。 OCT系统可以具有使用至少一个B扫描簇集计算OCT运动对比度的配置。 该OCT系统可以形成并显示物理对象的图像。
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公开(公告)号：US20220145387A1
公开(公告)日：2022-05-12
申请号：US17415586
申请日：2019-12-20
Applicant: University of Southern California
Inventor： Scott E. Fraser , Simon Restrepo , Joseph P. Dunham
IPC: C12Q1/6876 , C12Q1/6841 , C12Q1/6855
Abstract: Described herein is a method to create dendritic biocompatible polymers from pairs of complementary dendritic nucleic acid monomers in a controlled manner, using polymerization triggers. The dendritic monomers are constituted of nucleic acids and an organic polymer capable of self-assembly. A variety of additional improvements are described herein, including processes not requiring snap cooling, “wobble clamp” designs to confer a transitory measure of hairpin stability prior to branch migration, and multiple assemblies of amplifying systems. Depending on the context this technology could be used to reveal the presence of a large variety of analytes such as specific nucleic acid molecules, small molecules, proteins, and peptides.
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公开(公告)号：US10891730B1
公开(公告)日：2021-01-12
申请号：US16206958
申请日：2018-11-30
Applicant: University of Southern California
Inventor： Pu Wang , Francesco Cutrale , Scott E. Fraser
Abstract: Implementations of the present disclosure include methods, systems, and computer-readable storage mediums for image reconstruction. Actions include receiving an image acquired by an endoscopic system including an optical fiber bundle with multiple optical fibers, each optical fiber being surrounded by cladding, determining in the image fiber core locations corresponding to the optical fibers, reconstructing missing information from the image using interpolation performed in accordance with the fiber core locations, the missing information corresponding to artifacts in the acquired image that result from the cladding, and providing a fiber-pattern removed image, in which the artifacts in the acquired image are removed using the missing information.
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Patent Agency Ranking
公开(公告)号：US20190287222A1
公开(公告)日：2019-09-19
申请号：US16348102
申请日：2017-11-07
Applicant: University of Southern California
Inventor： Francesco Cutrale , Scott E. Fraser
IPC: G06T5/00 , H04N5/33 , H04N9/68 , G06T5/10 , G01J3/28 , G01J3/44 , G01N21/64 , G02B21/16 , G02B21/36 , G02B21/08
Abstract: This invention relates to a hyperspectral imaging system for denoising and/or color unmixing multiple overlapping spectra in a low signal-to-noise regime with a fast analysis time. This system may be configured to carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze hyper-spectral time-lapse data. For example, this system may be configured to carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze five-dimensional (5D) hyper-spectral time-lapse data. Advantages of this imaging system may include: (a) fast computational speed, (b) the ease of phasor analysis, and (c) a denoising algorithm to obtain the minimally-acceptable signal-to-noise ratio (SNR). An unmixed color image of a target may be generated. These images may be used in diagnosis of a health condition, which may enhance a patient's clinical outcome and evolution of the patient's health.
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公开(公告)号：US09763570B2
公开(公告)日：2017-09-19
申请号：US15106910
申请日：2015-02-04
Inventor： Jeffrey P. Fingler , Scott E. Fraser
CPC classification number: A61B3/102 , A61B3/0025 , A61B3/10 , A61B3/1233 , G01B9/02091 , G01N21/4795 , G02B6/0005
Abstract: This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system having a configuration that uses a phase sensitive B-scan registration method. In this disclosure, an OCT system may have a configuration that scans a physical object, acquires OCT signals to form B-scans, uses these B-scans to determine an optimal shift in an axial direction by using total phase error between B-scans, and align B-scans, thereby minimizing effects of motion that may occur during scanning of the physical object.
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8.发明申请公开(公告)号：US20160317026A1
公开(公告)日：2016-11-03
申请号：US15106966
申请日：2015-03-04
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Jeffrey P. Fingler , Scott E. Fraser
CPC classification number: A61B3/102 , A61B3/0025 , A61B3/1005 , A61B3/1241
Abstract: This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to methods and systems for providing larger field of view OCT images. This disclosure also particularly relates to methods and systems for OCT angiography. This disclosure further relates to systems for health characterization of an eye by OCT angiography. This OCT angiography system may determine a feature of a vasculature within an eye tissue and thereby identify a vascular anomaly and a spatial location of the vascular anomaly within the eye tissue.
Abstract translation: 本公开涉及光学相干断层扫描（OCT）领域。 本公开特别涉及用于提供更大视场OCT图像的方法和系统。 本公开还特别涉及用于OCT血管造影术的方法和系统。 本公开还涉及通过OCT血管造影术对眼睛的健康表征的系统。 该OCT血管造影系统可以确定眼组织内的脉管系统的特征，从而识别眼组织内血管异常的血管异常和空间位置。
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公开(公告)号：US20230193363A1
公开(公告)日：2023-06-22
申请号：US18047215
申请日：2022-10-17
Applicant: University of Southern California
Inventor： Scott E. Fraser , Simon Restrepo , Joseph P. Dunham
IPC: C12Q1/682 , C12Q1/6841 , C12N15/11 , C12Q1/6834 , G01N21/64
CPC classification number: C12Q1/682 , C12Q1/6841 , C12N15/11 , C12Q1/6834 , G01N21/6428 , C12N2310/531 , G01N2021/6439
Abstract: Described herein is a method to create dendritic biocompatible polymers from pairs of complementary dendritic nucleic acid monomers in a controlled manner, using polymerization triggers. The dendritic monomers are constituted of nucleic acids and an organic polymer capable of self-assembly. Each polymer contains approximately 200 dendrites that can be used to attach labels and constitute a biologically compatible signal amplification technology. Depending on the context this technology could be used to reveal the presence of a large variety of analytes such as specific nucleic acid molecules, small molecules, proteins, and peptides.
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公开(公告)号：US20230175019A1
公开(公告)日：2023-06-08
申请号：US17927454
申请日：2021-05-28
Applicant: University of Southern California
Inventor： Scott E. Fraser , Le Trinh
IPC: C12N15/90 , A01K67/027 , C12N15/113 , C12N15/65 , C12N15/79
CPC classification number: C12N15/902 , A01K67/0275 , C12N15/113 , C12N15/65 , C12N15/79 , A01K2217/072 , A01K2227/40 , A01K2267/03 , C12N2310/20 , C12N9/22
Abstract: A new DNA knock-in approach is provided based on the usage of three single guide RNA (sgRNA) to increase the integration efficiency of donor DNA based on the CRISRP-Cas system. The approach uses a pair of universal sgRNAs complementary to the donor DNA and a single sgRNA that targets the locus of interest. In various embodiments, targeting is achieved by pre-forming a DNA:RNA:protein (DNA:RNP) complex in vitro and introducing the complex into the embryo or cells of interest either by microinjection or transfection.
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