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    라세믹 시스-1,3-디옥소란 유도체의 광학분할 방법
    1.
    发明公开
    라세믹 시스-1,3-디옥소란 유도체의 광학분할 방법 失效
    种类CIS-1,3-二氧化物衍生物的催化分解方法

    公开(公告)号：KR1020040056592A

    公开(公告)日：2004-07-01

    申请号：KR1020020083097

    申请日：2002-12-24

    Applicant: 한국과학기술연구원

    Inventor： 정찬성 ,  이소하 ,  김영희 ,  채한국 ,  조현성

    IPC: C12P41/00

    Abstract: PURPOSE: A catalyzed resolution method of racemic cis-1,3-dioxolane derivatives is provided, thereby effectively separating racemic cis-1,3-dioxolane derivatives which is useful as an intermediate used for preparing itraconazole and ketoconazole. CONSTITUTION: The catalyzed resolution method of racemic cis-1,3-dioxolane derivatives represented by formula (1) comprises hydrolysis of racemic cis-1,3-dioxolane derivatives using enzyme in a phosphate buffer solution at pH 6 to 9 and 20 to 60 deg. C to prepare pure cis-1,3-dioxolane derivatives of formulas (1a) and (1b), wherein R is CH2OH, COOH, COOR' or CH2OCOR'; R' is C1-C10 alkyl; the enzyme is Pseudomonas cepacia(PCL) or Candida antartica(CAL).

    Abstract translation: 目的：提供外消旋顺式-1,3-二氧戊环衍生物的催化拆分方法，有效分离外消旋顺式-1,3-二氧戊环衍生物，其用作制备伊曲康唑和酮康唑的中间体。 构成：由式（1）表示的外消旋顺式-1,3-二氧戊环衍生物的催化分解方法包括使用酶在pH6至9和20至60的磷酸盐缓冲溶液中水解外消旋的顺式-1,3-二氧戊环衍生物 度。 制备式（1a）和（1b）的纯的顺式-1,3-二氧戊环衍生物，其中R是CH 2 OH，COOH，COOR'或CH 2 OCOR'; R'是C 1 -C 10烷基; 该酶是洋葱假单胞菌（PCL）或假丝酵母（CAL）。

    세라시아 마르세센스 균주의 배양액으로 부터 분리한 면역억제제용 프로디지오신
    2.
    发明授权
    세라시아 마르세센스 균주의 배양액으로 부터 분리한 면역억제제용 프로디지오신 有权
    空值

    公开(公告)号：KR100252197B1

    公开(公告)日：2000-04-15

    申请号：KR1019970047869

    申请日：1997-09-20

    Applicant: 한국과학기술연구원

    Inventor： 김환묵 ,  이창우 ,  김영희 ,  김성욱 ,  유성락 ,  김환묵 ,  김영국 ,  한상배 ,  손광희

    IPC: C12N1/20 ,  A61K39/00

    CPC classification number: C12R1/43 ,  C12P17/165

    Abstract: PURPOSE: Provided is prodigiosin isolated from culture broth of Serratia marcescens. The prodigiosin inhibits specifically immunogenecity of T cell and is used in immunosuppresive drug. CONSTITUTION: A Prodigiosin isolated from culture broth of Serratia marcescens B-1231 (KCTC 0386BP) is represented by the formula (I). The Prodigiosin is prepared by the following steps of: (a) cultivating Serratia marcescens B-1231 (KCTC 0386BP) in a medium comprised of soluble starch of 1%, glucose of 0.25, ammonium sulfate of 0.1%, potassium phosphate of 0.1%, magnesium sulfate- septuple crystal solution of 0.05%, calcium chloride of 0.1 %, sodium chloride of 0.3% at pH value of 7 and temperature of 28 deg.C for 62 hours; (b) mixing them with adding ethyl acetate in a same amount, thereto for 30 minutes, to obtain organic solvent layer; (c) concentrating the mixture under reduced pressure, to obtain a red material; (d) isolating and purifying an active material therefrom; and (e) purifying it by silicagel thin layer chromatography.

    Abstract translation: 目的：提供从粘质沙雷氏菌的培养液中分离的天蛾素。 胎牛血清抑制T细胞的特异性免疫原性，并用于免疫抑制药物。 构成：从粘质沙雷氏菌B-1231（KCTC 0386BP）的培养肉汤中分离出的地高辛分子由式（I）表示。 Prodigiosin通过以下步骤制备：（a）在由1％的可溶性淀粉，0.25的硫酸铵，0.1％的磷酸钾，0.1％的磷酸钾组成的培养基中培养粘质沙雷氏菌B-1231（KCTC 0386BP） 0.5％硫酸镁 - 六分体晶体溶液，氯化钙0.1％，氯化钠0.3％，pH值7，温度28℃62小时; （b）将其与相同量的乙酸乙酯混合30分钟，得到有机溶剂层; （c）在减压下浓缩混合物，得到红色材料; （d）从其中分离和纯化活性物质; 和（e）通过硅胶薄层色谱纯化。

    라세믹 시스-1,3-디옥소란 유도체의 광학분할 방법
    4.
    发明授权
    라세믹 시스-1,3-디옥소란 유도체의 광학분할 방법 失效
    라세믹시스-1,3디옥소란유도체의광학분할방

    公开(公告)号：KR100453212B1

    公开(公告)日：2004-10-15

    申请号：KR1020020083097

    申请日：2002-12-24

    Applicant: 한국과학기술연구원

    Inventor： 정찬성 ,  이소하 ,  김영희 ,  채한국 ,  조현성

    IPC: C12P41/00

    Abstract: PURPOSE: A catalyzed resolution method of racemic cis-1,3-dioxolane derivatives is provided, thereby effectively separating racemic cis-1,3-dioxolane derivatives which is useful as an intermediate used for preparing itraconazole and ketoconazole. CONSTITUTION: The catalyzed resolution method of racemic cis-1,3-dioxolane derivatives represented by formula (1) comprises hydrolysis of racemic cis-1,3-dioxolane derivatives using enzyme in a phosphate buffer solution at pH 6 to 9 and 20 to 60 deg. C to prepare pure cis-1,3-dioxolane derivatives of formulas (1a) and (1b), wherein R is CH2OH, COOH, COOR' or CH2OCOR'; R' is C1-C10 alkyl; the enzyme is Pseudomonas cepacia(PCL) or Candida antartica(CAL).

    Abstract translation: 目的：提供外消旋顺式-1,3-二氧戊环衍生物的催化拆分方法，由此有效地分离用作制备伊曲康唑和酮康唑中间体的外消旋顺式-1,3-二氧戊环衍生物。 构成：由式（1）表示的外消旋顺式-1,3-二氧戊环衍生物的催化拆分方法包括使用酶在pH 6至9和20至60的磷酸盐缓冲溶液中水解外消旋顺式-1,3-二氧戊环衍生物 度。 制备式（1a）和（1b）的纯顺式-1,3-二氧戊环衍生物，其中R为CH 2 OH，COOH，COOR'或CH 2 OCOR'; R'是C 1 -C 10烷基; 该酶是洋葱假单胞菌（Pseudomonas cepacia）（PCL）或南极假丝酵母（Candida antartica）（CAL）。

    라세미체의 케토로락을 단일이성체로 분리하는 방법
    5.
    发明公开
    라세미체의 케토로락을 단일이성체로 분리하는 방법 有权
    来自居民身体的KETOROLAC的单一异构体的分离方法

    公开(公告)号：KR1020030008805A

    公开(公告)日：2003-01-29

    申请号：KR1020010043741

    申请日：2001-07-20

    Applicant: 경동제약 주식회사 ,  한국과학기술연구원

    Inventor： 이병석 ,  정찬성 ,  이소하 ,  김영희

    IPC: C07D487/04

    Abstract: PURPOSE: A separating method of a single isomer from the ketorolac of the racemic body is provided, thereby separating the high purity of a single isomer form ketorolac. CONSTITUTION: The separating method of a single isomer from the ketorolac of the racemic body comprises the steps of: reaction of the ketorolac of the racemic body represented by formula(1) with alcohol compounds in the presence of Candida antartica lipase B; and separation of (-)-isomer from the reaction mixture by absorption, wherein the alcohol compounds are C3 to C20 alcohols; the amount of the Candida antartica lipase B is 10 to 150 wt.%; and the reaction temperature is 20 to 70 deg. C.

    Abstract translation: 目的：提供单体异构体与外消旋体的酮咯酸的分离方法，从而分离高纯度的单一异构体酮咯酸。 构成：单体异构体与外消旋体的酮咯酸的分离方法包括以下步骤：在假丝酵母脂肪酶B存在下，将由式（1）表示的外消旋体的酮咯酸与醇化合物反应; 和通过吸收从反应混合物中分离（ - ） - 异构体，其中醇化合物是C3至C20醇; 念珠菌antartica脂肪酶B的量为10〜150重量％。 反应温度为20〜70℃。 C。

    층상 실리카와 금속산화물로 이루어진 세공성 촉매 및 이를 이용한 ε-카프로락탐의 제조방법
    9.
    发明公开
    층상 실리카와 금속산화물로 이루어진 세공성 촉매 및 이를 이용한 ε-카프로락탐의 제조방법 失效
    支柱二氧化硅和金属氧化物催化剂及其制备方法

    公开(公告)号：KR1020010028430A

    公开(公告)日：2001-04-06

    申请号：KR1019990040680

    申请日：1999-09-21

    Applicant: 한국과학기술연구원

    Inventor： 어용선 ,  김영희 ,  김명훈 ,  김선진

    IPC: B01J23/20 ,  B01J35/10 ,  C07D223/10 ,  C07B61/00

    CPC classification number: B01J29/049 ,  C07D201/04 ,  Y02P20/52

    Abstract: PURPOSE: Disclosed are a porous catalyst composed of pillard silica and metal oxide and a preparation method of ε-caprolactam from cyclohexanone oxime. CONSTITUTION: The porous catalyst is mainly composed of a pillard silica and a metal oxide. The sodium ion (Na+) on pillard silica is substituted with hydrogen ion (H+) of inorganic acid solution and a spacing width of pillard silica expands to 20 - 30 Å by using a long chained amine compound. And then metal oxide compounds are added in the spacing interval of the pillared silica. The added content of metal oxide is optimally 2 - 10 wt% and the surface area is 100 - 300 m2/g. The pillared silica is precipitated from kanemite, kenyaite, magadite, illite, octosilicate and Ta2O5, Nb2O5, TiO2 or SiO2 are used as metal oxides.

    Abstract translation: 目的：公开了由二氧化硅和金属氧化物组成的多孔催化剂和由环己酮肟制备的ε-己内酰胺的制备方法。 构成：多孔催化剂主要由二氧化硅和金属氧化物组成。 使用长链胺化合物，将二氧化硅上的钠离子（Na +）用无机酸溶液的氢离子（H +）代替，并将二氧化硅的间隔宽度扩大至20〜30。 然后在柱状二氧化硅的间隔间隔中加入金属氧化物。 金属氧化物的添加量最好为2〜10重量％，表面积为100〜300m2 / g。 柱状二氧化硅从可卡因，肯尼亚，magadite，伊利石，八硅酸盐和Ta 2 O 5，Nb 2 O 5，TiO 2或SiO 2中析出用作金属氧化物。

    제올라이트 촉매의 제조 방법 및 이를 이용한 ε-카프로락탐의제조 방법
    10.
    发明公开
    제올라이트 촉매의 제조 방법 및 이를 이용한 ε-카프로락탐의제조 방법 失效
    制备沸石催化剂的方法及其制备方法

    公开(公告)号：KR1020010004825A

    公开(公告)日：2001-01-15

    申请号：KR1019990025559

    申请日：1999-06-30

    Applicant: 한국과학기술연구원

    Inventor： 어용선 ,  김선진 ,  김명훈 ,  김영희

    IPC: B01J29/70

    CPC classification number: B01J37/0009 ,  B01J29/70 ,  C07D201/04

    Abstract: PURPOSE: Provided are a process for preparing a zeolite catalyst and a process for preparing ε-caprolactam from cyclohexanone oxime in the presence of the zeolite catalyst by Beckmann conversion reaction. CONSTITUTION: The MFI and MEL type zeolite catalysts having a molar ratio of Si/Al being more than 500 is treated at 20-150 °C with 0.01-0.5 N by concentration of an acid selected from the group consisting of hydrochloric acid, nitric acid, sulfuric acid, phosphoric acid, and acetic acid. The ε-caprolactam is prepared from cyclohexanone oxime by Beckman conversion reaction at 250-400 °C in the presence of the acid treated zeolite catalyst.

    Abstract translation: 目的：提供一种沸石催化剂的制备方法以及通过Beckmann转化反应在沸石催化剂存在下由环己酮肟制备ε-己内酰胺的方法。 构成：将Si / Al的摩尔比大于500的MFI和MEL型沸石催化剂在20-150℃下通过浓度为0.01-0.5N的酸处理，所述酸选自盐酸，硝酸 ，硫酸，磷酸和乙酸。 通过Beckman转化反应在250-400℃，在酸处理的沸石催化剂的存在下，由环己酮肟制备ε-己内酰胺。

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