公开(公告)号：JPH10279520A

公开(公告)日：1998-10-20

申请号：JP1658498

申请日：1998-01-29

Applicant: BASF AG

Inventor： FREDE MARKUS DR ,  DULLY CHRISTIAN ,  DITRICH KLAUS DR ,  MELDER JOHANN-PETER DR ,  WEYER HANS-JUERGEN DR ,  WEITZE ACHIM

IPC: C12P41/00 ,  B01D61/44 ,  C07C51/42 ,  C07C51/43 ,  C07C59/125 ,  C07C209/88 ,  C07C211/27 ,  C07C211/29 ,  C25B3/00

Abstract: PROBLEM TO BE SOLVED: To easily purify an α-, β- or γ-substituted carboxylic acid mixture from an aqueous solution by electrodialyzing an aqueous solution containing the mixture and a polyol. SOLUTION: An a-, β- or γ-substituted carboxylic acid is purified from an aqueous solution containing the α-, β- or γ-substituted carboxylic acid, its salt or ester or their mixture and at least one kind of polyol or at least one kind of amino alcohol and optionally a cation of at least one kind of a strong base by electrodialyzing the solution by conventional two-cycle electrodialysis, dipolar two-cycle electrodialysis and/ or dipolar three-cycle electrodialysis.

公开(公告)号：ES2153693T3

公开(公告)日：2001-03-01

申请号：ES98101536

申请日：1998-01-29

Applicant: BASF AG

Inventor： FREDE MARKUS DR ,  DULLY CHRISTIAN ,  DITRICH KLAUS DR ,  MELDER JOHANN-PETER ,  WEYER HANS-JURGEN DR ,  WEITZE ACHIM

IPC: C12P41/00 ,  B01D61/44 ,  C07C51/42 ,  C07C51/43 ,  C07C59/125 ,  C07C209/88 ,  C07C211/27 ,  C07C211/29 ,  C25B3/00

Abstract: Purification of alpha , beta , gamma -substituted carboxylic acids of formula (I), their salts and esters or a mixture of these and one or more polyol and one or more aminoalcohol in aqueous solution comprises treatment by electrodialysis. R1 = H, 1-10C alkyl, Na or K ; R2 = H or 1-10C alkyl; R3 = H, 1-10C alkyl (optionally substituted by NH2, OH, 1-4C alkyl, 1-4C alkoxy or halo-substituted phenyl); X = halo (when R3 is absent), N, O, P, S; and m = 0-2. Also claimed are: (i) cleavage of an optically active amide to an optically active amine and (I); and (ii) resolution of a racemic primary or secondary amine by reacting (I) with a hydrolase, separating the unreacted enantiomer of the amine from the amide and hydrolysing the amide to give the amine enantiomer and (I).

公开(公告)号：ES2221423T3

公开(公告)日：2004-12-16

申请号：ES99941616

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: Procedimiento para la obtención de aminas primarias con actividad óptica de la fórmula 2 en la que significan n = 0 o 1 R4, R5 independientemente entre sí, H, alquilo con 1 a 8 átomos de carbono o fenilo, R6 = alquilo con 1 a 6 átomos de carbono o bencilo, mediante a) reacción de las aminas primarias con un éster de la fórmula 1 en la que significan m = 0 o 1, R1 = alquilo con 6 a 20 átomos de carbono ramificado o no ramificado, o heteroalquilo con 6 a 20 átomos de esqueleto, pudiendo estar substituido el resto alquilo o heteroalquilo, independientemente entre sí, por 1 a 5 átomos de halógeno, y/o un grupo oxo, R2 = alquilo con 1 a 8 átomos de carbono o fenilo, R3 = H, alquilo con 1 a 4 átomos de carbono, en presencia de una lipasa, y subsiguiente b) separación de la amina acilada por vía enantioselectiva y de la amina no transformada.

公开(公告)号：AT267874T

公开(公告)日：2004-06-15

申请号：AT99941616

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: The present invention relates to a process for resolving racemates of alkoxy-substituted primary amines by reacting with an ester in the presence of a lipase and subsequently separating the optically active amide which is formed from the unreacted optically active amine. This is followed where appropriate by hydrolysis of the optically active amide, separation of the optically active amine produced thereby from the acid from which the ester is derived, racemization and recycling of the unwanted enantiomer of the amine, and esterification and recycling of the acid.

公开(公告)号：DK1119634T3

公开(公告)日：2004-06-28

申请号：DK99941616

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: The present invention relates to a process for resolving racemates of alkoxy-substituted primary amines by reacting with an ester in the presence of a lipase and subsequently separating the optically active amide which is formed from the unreacted optically active amine. This is followed where appropriate by hydrolysis of the optically active amide, separation of the optically active amine produced thereby from the acid from which the ester is derived, racemization and recycling of the unwanted enantiomer of the amine, and esterification and recycling of the acid.

公开(公告)号：DE59800397D1

公开(公告)日：2001-02-01

申请号：DE59800397

申请日：1998-01-29

Applicant: BASF AG

Inventor： FREDE DR ,  DULLY CHRISTIAN ,  DITRICH DR ,  MELDER JOHANN-PETER ,  WEYER DR ,  WEITZE ACHIM

IPC: C12P41/00 ,  B01D61/44 ,  C07C51/42 ,  C07C51/43 ,  C07C59/125 ,  C07C209/88 ,  C07C211/27 ,  C07C211/29 ,  C25B3/00

Abstract: Purification of alpha , beta , gamma -substituted carboxylic acids of formula (I), their salts and esters or a mixture of these and one or more polyol and one or more aminoalcohol in aqueous solution comprises treatment by electrodialysis. R1 = H, 1-10C alkyl, Na or K ; R2 = H or 1-10C alkyl; R3 = H, 1-10C alkyl (optionally substituted by NH2, OH, 1-4C alkyl, 1-4C alkoxy or halo-substituted phenyl); X = halo (when R3 is absent), N, O, P, S; and m = 0-2. Also claimed are: (i) cleavage of an optically active amide to an optically active amine and (I); and (ii) resolution of a racemic primary or secondary amine by reacting (I) with a hydrolase, separating the unreacted enantiomer of the amine from the amide and hydrolysing the amide to give the amine enantiomer and (I).

公开(公告)号：DE19837745A1

公开(公告)日：2000-02-24

申请号：DE19837745

申请日：1998-08-20

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00 ,  C07C209/88 ,  C07B57/00

Abstract: Process for preparing optically active primary amines comprises: (a) reacting a primary amine with a long-chain alkoxyalkanoate or phenoxyalkanoate ester (I) in the presence of a lipase; and (b) separating the enantioselectively acylated amine from the unreacted amine. Process for preparing optically active primary amines comprises: (a) reacting a primary amine with an ester of formula (I) in the presence of a lipase; and (b) separating the enantioselectively acylated amine from the unreacted amine: m = 0 or 1; R = 6-20C alkyl or 6- to 20-membered heteroalkyl, optionally substituted by 1-5 halogen atoms and/or an oxo group; R = 1-8C alkyl or phenyl; R = H or 1-8C alkyl. An Independent claim is also included for a process for acylating primary amines of formula (II), comprising reacting (II) with (I) in the presence of a lipase: n = 0 or 1; R , R = H, 1-8C alkyl or phenyl; R = 1-6C alkyl or benzyl.

公开(公告)号：CA2341345C

公开(公告)日：2010-10-26

申请号：CA2341345

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C12P41/00 ,  C07C213/08 ,  C07C217/08 ,  C12P13/02

Abstract: The invention relates to a method for the racemic cleavage of alkoxy-substituted primary amines by reaction with an ester in the presence of a lipase and subsequent separation of the resulting optically active amide from the optically active unreacted amine. This is possibly followed by hydrolysis of the optically active amide, separation of the resulting optically active amine from the acid at the origin of the ester, racemization and recirculation of the undesirable enantiomer of the amine and esterification and recirculation of the acid.

公开(公告)号：DE59909610D1

公开(公告)日：2004-07-01

申请号：DE59909610

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: The present invention relates to a process for resolving racemates of alkoxy-substituted primary amines by reacting with an ester in the presence of a lipase and subsequently separating the optically active amide which is formed from the unreacted optically active amine. This is followed where appropriate by hydrolysis of the optically active amide, separation of the optically active amine produced thereby from the acid from which the ester is derived, racemization and recycling of the unwanted enantiomer of the amine, and esterification and recycling of the acid.

公开(公告)号：AU5516499A

公开(公告)日：2000-03-14

申请号：AU5516499

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: The present invention relates to a process for resolving racemates of alkoxy-substituted primary amines by reacting with an ester in the presence of a lipase and subsequently separating the optically active amide which is formed from the unreacted optically active amine. This is followed where appropriate by hydrolysis of the optically active amide, separation of the optically active amine produced thereby from the acid from which the ester is derived, racemization and recycling of the unwanted enantiomer of the amine, and esterification and recycling of the acid.