公开(公告)号：JP2002047262A

公开(公告)日：2002-02-12

申请号：JP2001207021

申请日：2001-07-06

Applicant: BASF AG

Inventor： GYPSER ANDREAS ,  GROTE THOMAS ,  RHEINHEIMER JOACHIM ,  ROSE INGO ,  CULLMANN OLIVER ,  GEWEHR MARKUS ,  GRAMMENOS WASSILIOS ,  TORMO I BLASCO JORDI ,  MUELLER BERND ,  SAUTER HUBERT ,  AMMERMANN EBERHARD ,  STRATHMANN SIEGFRIED ,  LORENZ GISELA ,  STIERL REINHARD

IPC: C07C251/80 ,  A01N33/26 ,  A01N37/50 ,  C07C249/16 ,  C07C251/86

Abstract: PROBLEM TO BE SOLVED: To provide a compound that has increased controlling effect against harmful fungi. SOLUTION: The objective salicylic acid derivative is represented by formula I [wherein X is a halogen, NO2, cyano, an alkyl or an alkoxy; (m) is 0, 1, 2 or 3 where in the case m >=2, X may differ from each other; A is OH, an alkoxy, NH2, NHCH3 or N(CH3)2, R1 is phenyl, naphthyl, cycloalkyl, one to three N-atoms and/or one O or S atom or one or two O and/or S atoms- including 5-membered or 5-membered ring heteroaryl or 5-membered or 6-membered heterocyclyl where the ring structure may be unsubstituted or substituted; and R2 is H, cyano, an alkyl, an alkenyl, an alkynyl, a haloalkyl, an alkoxy or an alkylthio]. This invention further provides a method of producing the derivative, a composition including the derivative and the use of the composition for controlling harmful fungi.

公开(公告)号：JP2003201289A

公开(公告)日：2003-07-18

申请号：JP2002272397

申请日：2002-09-19

Applicant: BASF AG

Inventor： ROSE INGO ,  BLASCO JORDI TORMO I ,  GEWEHR MARKUS ,  GRAMMENOS WASSILIOS ,  MUELLER BERND ,  RHEINHEIMER JOACHIM ,  SCHAEFER PETER ,  SCHIEWECK FRANK ,  GROTE THOMAS ,  GYPSER ANDREAS ,  AMMERMANN EBERHARD ,  LORENZ GISELA ,  STIERL REINHARD ,  STRATHMANN SIEGFRIED

IPC: A01N43/16 ,  C07C45/46 ,  C07C45/54 ,  C07C49/84 ,  C07D311/86

Abstract: PROBLEM TO BE SOLVED: To provide a compound effective for controlling hazardous phytopathogenic fungi, to provide a method for producing the compound, to provide a composition containing the compound, and to provide a method for using the composition. SOLUTION: This compound comprises a xanthone derivative expressed by general formula (I) (n is 0, 1 or 2; R 1 is an alkyl or the like; R 2 and R 3 are each an alkoxy or the like, or together form an oxyalkyleneoxy which may be substituted; R 4 is a halogen or the like; R 5 is equal to the R 4 , provided that R 5 s may be different from each other when n is 2; and X and Y are each O or S). The method for producing the compound and the composition containing the compound are provided in the specification, respectively. The composition is used for controlling the hazardous phytopathogenic fungi. COPYRIGHT: (C)2003,JPO

公开(公告)号：JP2002030058A

公开(公告)日：2002-01-29

申请号：JP2001182539

申请日：2001-06-15

Applicant: BASF AG

Inventor： GYPSER ANDREAS ,  GROTE THOMAS ,  RHEINHEIMER JOACHIM ,  ROSE INGO ,  SCHAEFER PETER ,  CULLMANN OLIVER ,  GEWEHR MARKUS ,  GRAMMENOS WASSILIOS ,  TORMO I BLASCO JORDI ,  MUELLER BERND ,  SAUTER HUBERT ,  AMMERMANN EBERHARD ,  STRATHMANN SIEGFRIED ,  LORENZ GISELA ,  STIERL REINHARD

IPC: A01N37/28 ,  A01N37/34 ,  A01N37/40 ,  A01N37/46 ,  A01N47/20 ,  A01N47/30 ,  C07B61/00 ,  C07C249/16 ,  C07C251/86 ,  C07C253/30 ,  C07C255/59 ,  C07C255/64 ,  C07C255/66 ,  C07C269/04 ,  C07C271/28 ,  C07C273/18 ,  C07C275/42

Abstract: PROBLEM TO BE SOLVED: To provide a compound improved in controlling actions on noxious fungi. SOLUTION: This salicylohydrazide derivative is represented by the formula I (wherein, X is a halogen, NO2, cyano, a 1-4C alkyl or a 1-4C alkoxy; (m) is 0, 1, 2 or 3; R1 is NO2, NH2 or NH-CO-A; A is hydrogen, 1-4C alkyl, a 1-4C alkoxy, NH2, NHCH3 or N(CH3)2; R2 is hydrogen, cyano, a 1-6C alkyl, a 2-6C alkeiyl, a 2-6C alkynyl, a 1-6C haloalkyl, a 1-6C alkoxy or a 1-6C alkylthio; and R3 is phenyl, naphthyl, a 3-10C cycloalkyl, a 5- or a 6-membered ring heteroaryl or a 5- or a 6-membered ring heterocyclyl). The method for producing the salicylohydrazide derivative is provided and an intermediate for producing the derivative is obtained. The composition for controlling the noxious fungi comprises the derivative.

公开(公告)号：JPH07188217A

公开(公告)日：1995-07-25

申请号：JP26996494

申请日：1994-11-02

Applicant: BASF AG

Inventor： RHEINHEIMER JOACHIM ,  VOGELBACHER UWE JOSEF ,  BAUMANN ERNST ,  GERBER MATTHIAS ,  WESTPHALEN KARL-OTTO ,  WALTER HELMUT

IPC: A01N43/54 ,  A01N43/66 ,  C07D401/12 ,  C07D407/14 ,  C07D491/04 ,  C07D491/048

公开(公告)号：JPH11292837A

公开(公告)日：1999-10-26

申请号：JP6327199

申请日：1999-03-10

Applicant: BASF AG

Inventor： EICKEN KARL ,  RHEINHEIMER JOACHIM ,  ROSE INGO DR ,  RACK MICHAEL DR ,  AMMERMANN EBERHARD ,  LORENZ GISELA ,  STRATHMANN SIEGFRIED DR

IPC: C07D333/24 ,  A01N37/52 ,  C07C259/18

Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound useful as a fungicide for foliage and soil, etc. SOLUTION: This compound is shown by formula I (R is F; R is a phenyl 1-6C alkyl which may contain one or more substituent groups selected from a halogen, a 1-4C alkyl, a 1-4C haloalkyl, a 1-4C alkoxy and a 1-4C haloalkoxy or the like) such as N-phenylacetyl-2,6-dichloro-5-fluorobenzamido[O- cyclopropylmethyl]oxime. The compound of formula I is obtained by reacting a compound of formula II with hydroxylamine in an aqueous solution (e.g. water, a mixture of water/an alkanol or the like) optionally in the presence of a base to give a compound of formula III, reacting the compound with a cyclopropylmethyl halide in the presence of a base and further heating the reaction product by using an acyl halide, preferably an acyl chloride in an inert solvent.

公开(公告)号：JP2003206252A

公开(公告)日：2003-07-22

申请号：JP2002313232

申请日：2002-10-28

Applicant: BASF AG

Inventor： ROSE INGO ,  BLASCO JORDI TORMO I ,  GEWEHR MARKUS ,  GRAMMENOS WASSILIOS ,  MUELLER BERND ,  RHEINHEIMER JOACHIM ,  SCHAEFER PETER ,  SCHIEWECK FRANK ,  GROTE THOMAS ,  GYPSER ANDREAS ,  AMMERMANN EBERHARD ,  LORENZ GISELA ,  STIERL REINHARD ,  STRATHMANN SIEGFRIED ,  CARTER PAUL ,  CURTZE JUERGEN

IPC: A01N31/14 ,  A01N31/16 ,  A01N33/10 ,  A01N37/38 ,  A01N37/40 ,  C07B61/00 ,  C07C39/42 ,  C07C41/26 ,  C07C43/23 ,  C07C69/017 ,  C07C69/14 ,  C07C323/19 ,  C07C323/25

Abstract: PROBLEM TO BE SOLVED: To provide a benzhydryl derivative that exhibits high effect in the control of deleterious fungi. SOLUTION: The benzhydryl derivative is represented by formula I (wherein X is O or S; R 1 , R 3 are each a halogen, cyano, nitro, hydroxyl, mercapto, an amino, an alkyl, an alkenyl, an alkynyl, an alkoxy, an alkenyloxy, an alkynyloxy, an alkyklcarbonyloxy, formyloxy or alkylthio or the like; R 2 is a halogen, cyano, nitro, hydroxyl, mercapto, an amino, an alkyl, an alkoxy, a haloalkyl, or a haloalkoxy wherein in the case that n=2, R 2 may differ from each other; R 4 is an alkyl, an alkenyl or an alkynyl; R 5 and R 6 are each hydroxyl, an alkyl, an alkenyl, a haloalkyl, a haloalkenyl, an alkoxy or an alkenyloxy; m is 0, 1 or 2). COPYRIGHT: (C)2003,JPO

公开(公告)号：JPH07188219A

公开(公告)日：1995-07-25

申请号：JP26879194

申请日：1994-11-01

Applicant: BASF AG

Inventor： WALTER HELMUT ,  RHEINHEIMER JOACHIM ,  VOGELBACHER UWE JOSEF ,  BAUMANN ERNST ,  KOENIG HARTMANNN ,  GERBER MATTHIAS ,  WESTPHALEN KARL-OTTO

IPC: A01N43/14 ,  A01N43/32 ,  A01N43/36 ,  A01N43/40 ,  A01N43/42 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/647 ,  A01N43/653 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  A01N43/824 ,  A01N43/828 ,  A01N43/832 ,  A01N43/836 ,  A01N43/90 ,  C07D239/60 ,  C07D263/56 ,  C07D319/08 ,  C07D319/18 ,  C07D327/06 ,  C07D401/12 ,  C07D405/04 ,  C07D407/04 ,  C07D411/04 ,  C07D413/04 ,  C07D417/04 ,  C07F7/08

公开(公告)号：WO2006079556A2

公开(公告)日：2006-08-03

申请号：PCT/EP2006000774

申请日：2006-01-30

Applicant: BASF AG ,  RHEINHEIMER JOACHIM ,  GROTE THOMAS ,  MUELLER BERND ,  NAVE BARBARA ,  SCHIEWECK FRANK ,  SCHWOEGLER ANJA ,  JABS THORSTEN ,  BLETTNER CARSTEN

Inventor： RHEINHEIMER JOACHIM ,  GROTE THOMAS ,  MUELLER BERND ,  NAVE BARBARA ,  SCHIEWECK FRANK ,  SCHWOEGLER ANJA ,  JABS THORSTEN ,  BLETTNER CARSTEN

IPC: A61K31/506 ,  A61K31/505 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04

CPC classification number: C07D239/48 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04

Abstract: The present invention relates to substituted 5-phenyl pyrimidines I, which carry a radical X in the 4-position of the pyrimidine ring, a radical Y in the 6-position of the pyrimidine ring, the radical X denoting a group of the formula NR 1 R 2 , OR 1a or SR 1a , in which R 1 , R 2 , independently of each other, denote hydrogen, C 1 -C 10 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 10 -haloalkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -halocycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which radicals may be unsubstituted or may carry 1, 2, 3 or 4 radicals R a1 ; or the radical NR 1 R 2 may also form a 5- or 6-membered optionally substituted heterocyclic ring, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which are non-adjacent to the nitrogen of NR 1 R 2 , in which two adjacent C atoms or one N atom and one adjacent C atom can be linked by a C 1 -C 4 -alkylene chain and wherein the heterocyclic ring may be unsubstituted or may carry 1, 2, 3 or 4 radicals R a1 as defined in claim 1, R 1a has one of the meanings given for R 1 except for hydrogen; the radical Y being selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, C 3 -C 4 -alkenyloxy, C 3 -C 4 -alkynyloxy, C 1 -C 6 -alkylthio, di-(C 1 -C 6 -alkyl)amino or C 1 -C 6 -alkylamino, where the alkyl, alkenyl and alkynyl radicals of Y may be substituted by halogen, cyano, nitro, C 1 -C 2 -alkoxy or C 1 -C 4 -alkoxycarbonyl; and wherein the pyrimidine radical may also carry a radical different from hydrogen in the 2-position and wherein the phenyl ring in the 5-position of the pyrimidine ring may be unsubstituted or carry 1, 2, 3, 4 or 5 radicals L which are different from hydrogen, and the pharmaceutically acceptable salts substituted 5-phenyl pyrimidines for use in therapy, in particular in therapy or treatment of cancerous diseases.

Abstract translation: 本发明涉及取代的5-苯基嘧啶I，其在嘧啶环的4-位上携带基团X，嘧啶环的6-位的基团Y，基团X表示式NR的基团 其中R 1，R 2，R 2，R 1，R 2， R 2彼此独立地表示氢，C 1 -C 10 - 烷基，C 2 - C 6 - 烯基，C 2 -C 6 - 炔基，C 1 -C 10 - C 1 -C 3烷基，C 3 -C 8 - 环烷基，C 3 -C 8 - 卤代烷基，C 3 -C 8 - 苯基或含有1,2,3或4个氮原子或1,2或3个氮原子和一个硫或氧原子作为环成员的5-或6-元杂芳基或5-或6-元杂环基，该基团可以 未被取代或可以携带1,2,3或4个基团R a1a; 或自由基NR 1 R 2还可以形成含有1,2,3或4个氮原子或1,2或2个氮原子的5或6元任选取代的杂环 或3个氮原子和一个硫或氧原子作为环成员，其与NR 1 R 2 O 2的氮不相邻，其中两个相邻的C原子或一个 N原子和一个相邻的C原子可以通过C 1 -C 4 - 亚烷基链连接，并且其中杂环可以是未取代的或可以携带1,2,3 或如权利要求1所定义的4个基团R a1，其中R 1a除了氢之外具有R 1给出的含义之一; 基团Y选自卤素，氰基，C 1 -C 4 - 亚烷基，C 2 -C 3 - 烷基， 4 - 烯基，C 2 -C 4 - 炔基，C 3 -C 6 - 环烷基，C 1 -C 4 - 烷氧基，C 3 -C 4 - 炔基氧基，C 1 -C 4 - 3-C 4 - 炔基氧基，C 1 -C 6 - 烷硫基，二 - （C 1 -C 6） C 1 -C 6 - 烷基）氨基或C 1 -C 6 - 烷基氨基，其中Y的烷基，烯基和炔基可以 被卤素，氰基，硝基取代，C 1 -C 2 - 烷氧基或C 1 -C 4 - - 烷氧基; 并且其中嘧啶基团还可以携带2-位上与氢不同的基团，其中嘧啶环的5-位上的苯环可以是未取代的或携带1,2,3,4或5个基团L，其为 不同于氢，以及用于治疗，特别是治疗或治疗癌性疾病的药学上可接受的盐取代的5-苯基嘧啶。

公开(公告)号：WO0238565A3

公开(公告)日：2003-10-09

申请号：PCT/EP0112977

申请日：2001-11-09

Applicant: BASF AG ,  TORMO I BLASCO JORDI ,  DITRICH KLAUS ,  SAUTER HUBERT ,  CULLMANN OLIVER ,  GEWEHR MARKUS ,  GRAMMENOS WASSILIOS ,  MUELLER BERND ,  GROTE THOMAS ,  GYPSER ANDREAS ,  RHEINHEIMER JOACHIM ,  ROSE INGO ,  SCHAEFER PETER ,  SCHIEWECK FRANK ,  AMMERMANN EBERHARD ,  STRATHMANN SIEGFRIED ,  LORENZ GISELA ,  STIERL REINHARD

Inventor： TORMO I BLASCO JORDI ,  DITRICH KLAUS ,  SAUTER HUBERT ,  CULLMANN OLIVER ,  GEWEHR MARKUS ,  GRAMMENOS WASSILIOS ,  MUELLER BERND ,  GROTE THOMAS ,  GYPSER ANDREAS ,  RHEINHEIMER JOACHIM ,  ROSE INGO ,  SCHAEFER PETER ,  SCHIEWECK FRANK ,  AMMERMANN EBERHARD ,  STRATHMANN SIEGFRIED ,  LORENZ GISELA ,  STIERL REINHARD

IPC: A01N43/90 ,  C07B53/00 ,  C07C209/62 ,  C07C211/03 ,  C07D487/04

CPC classification number: C07D487/04 ,  A01N43/90

Abstract: The invention relates to 7-(R) aminotriazolopyrimidines of formula (I), in which the substituents and index have the following definitions: R represents hydrogen or methyl; R represents methyl; R represents C2-C10 alkyl, C1-C4 alkoxymethyl, or C3-C10 cycloalkyl; R represents halogen, C1-C4 alkyl, C1-C4 haloalkyl or C1-C4 alkoxy; n represents a number between 1 and 5; Y represents halogen, cyano, C1-C4 alkyl or C1-C4 alkoxy; whereby * is a chirality centre with an R-configuration. The invention also relates to a method for producing said compounds, to agents containing the compounds and to the use thereof for combating harmful fungi.

Abstract translation: 7-（R）式（I）的-aminotriazolopyrimidine其中取代基和指数具有以下含义：R t <1>是氢或甲基; [R <2>是甲基; [R <3> C2-C10烷基，C1-C4烷氧基，C3-C10环烷基; [R <4>为卤素，C1-C4烷基，C1-C4卤代烷基或C1-C4烷氧基; n是从1到5的数; Y是卤素，氰基，C1-C4烷基或C1-C4烷氧基; 其中*是R构型的手性中心。 一种用于制备这些化合物，含有它们以及它们在防治有害真菌中的用途的组合物的过程。

公开(公告)号：WO0130154A3

公开(公告)日：2002-04-11

申请号：PCT/EP0010468

申请日：2000-10-24

Applicant: BASF AG ,  RHEINHEIMER JOACHIM ,  EICKEN KARL ,  ROSE INGO ,  GROTE THOMAS ,  AMMERMANN EBERHARD ,  SPEAKMAN JOHN BRYAN ,  STRATHMANN SIEGFRIED ,  LORENZ GISELA

Inventor： RHEINHEIMER JOACHIM ,  EICKEN KARL ,  ROSE INGO ,  GROTE THOMAS ,  AMMERMANN EBERHARD ,  SPEAKMAN JOHN-BRYAN ,  STRATHMANN SIEGFRIED ,  LORENZ GISELA

IPC: A01N43/56

CPC classification number: A01N43/56

Abstract: The invention relates to agrochemical compositions with a fungicidal action, containing compounds of formula (I) as their active agents, the radicals having the following meanings: R is hydrogen, C1-C6-alkyl, C1-C6-alkylcarbonyl, C1-C4-alkoxy-C1-C6-alkyl, C1-C6-halogenalkyl, C3-C6-alkenyl, C3-C6-halogenalkenyl or phenyl-C1-C6-alkyl, wherein the phenyl group can be substituted by C1-C6-alkyl, halogen or C1-C6-halogenalkyl; R is hydrogen, C1-C6-alkyl, C1-C6-halogenalkyl, C1-C6-alkoxy, C1-C6-halogenalkoxy or halogen; R is phenyl that is optionally substituted by halogen, C1-C6-alkyl, C1-C6-halogenalkyl, C1-C6-alkoxy, C1-C6-halogenalkoxy, C1-C6-alkylthio, C1-C6-alkylsulfonyl, C1-C6-halogenalkylsulfonyl; and R is a heterocyclic radical with one or two nitrogen atoms - said heterocyclic radical can be substituted by halogen, C1-C6-alkyl or C1-C6-halogenalkyl. The invention also relates to methods for combating harmful fungi on plants using this fungicidal agent.

Abstract translation: 本发明涉及具有含有（I），其中各基团具有以下含义的式作为活性成分的化合物的杀真菌活性农业化学组合物，R <1>是氢，C1-C6烷基，C1-C6烷基羰基，C1-C4烷氧基 -C1-C6-烷基，C1-C6卤代烷基，C3-C6烯基，C3-C6卤代链烯基或苯基-C 1 -C 6 - 烷基，其中，由C1-C6烷基，卤素或C 1 -C 6卤代烷基的苯基 可以被取代; [R <2>是氢，C1-C6烷基，C1-C6卤代烷基，C1-C6-烷氧基，C1-C6卤代烷氧基或卤素; [R <3>是其任选地被卤素取代的，C1-C6-烷基，C1-C6卤代烷基，C1-C6-烷氧基，C1-C6卤代烷氧基，C1-C6-烷硫基，C1-C6-烷基磺酰基，C1苯基 C6卤代烷基磺酰基; [R <4>杂环基团具有一个或两个氮原子，其中杂环部分可以被卤素，C1-C6烷基或C1-C6卤代烷基。 此外，本发明提供用于在植物中防治有害真菌涉及使用这些杀真菌剂的方法。